Search Results - "ANTRILLI, T. M."

Effect of tiplaxtinin (PAI‐039), an orally bioavailable PAI‐1 antagonist, in a rat model of thrombosis by HENNAN, J. K., MORGAN, G. A., SWILLO, R. E., ANTRILLI, T. M., MUGFORD, C., VLASUK, G. P., GARDELL, S. J., CRANDALL, D. L.

“…Objective: To assess the antithrombotic and profibrinolytic effects of tiplaxtinin (PAI‐039), an orally bioavailable antagonist of PAI‐1, in rat models of…”
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Release of PAI-1 by Human Preadipocytes and Adipocytes Independent of Insulin and IGF-1 by Crandall, David L., Groeling, Thomas M., Busler, Dennis E., Antrilli, Thomas M.

“…The effect of insulin and insulin-like growth factor-1 (IGF-1) on plasminogen activator inhibitor-1 (PAI-1) release from primary cultures of human…”
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Evaluation of PAI-039 [{1-benzyl-5-[4-(trifluoromethoxy)phenyl]-1H-indol-3-yl}(oxo)acetic acid], a novel plasminogen activator inhibitor-1 inhibitor, in a canine model of coronary artery thrombosis by Hennan, James K, Elokdah, Hassan, Leal, Mauricio, Ji, Allena, Friedrichs, Gregory S, Morgan, Gwen A, Swillo, Robert E, Antrilli, Thomas M, Hreha, Amy, Crandall, David L

“…We tested a novel, orally active inhibitor of plasminogen activator inhibitor-1 (PAI-1) in a canine model of electrolytic injury. Dogs received by oral gavage…”
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Synthesis and SAR of 2-carboxylic acid indoles as inhibitors of plasminogen activator inhibitor-1 by Hu, Baihua, Jetter, James W., Wrobel, Jay E., Antrilli, Thomas M., Bauer, Jean S., Di, Li, Polakowski, Sergiusz, Jain, Uday, Crandall, David L.

“…[Display omitted] We synthesized and evaluated a novel series of 2-carboxylic acid indole-based inhibitors of plasminogen activator inhibitor-1 (PAI-1)…”
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WAY-140312 reduces plasma PAI-1 while maintaining normal platelet aggregation by Crandall, David L, Hennan, James K, Elokdah, Hassan, Krishnamurthy, Girija, Antrilli, Thomas M, Bauer, Jean S, Morgan, Gwen A, Swillo, Robert E

“…Plasminogen activator inhibitor-1 (PAI-1) is the major physiological inhibitor of tissue plasminogen activator (tPA) and is elevated in diseases of vascular…”
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Design and synthesis of oxadiazolidinediones as inhibitors of plasminogen activator inhibitor-1 by Gopalsamy, Ariamala, Kincaid, Scott L., Ellingboe, John W., Groeling, Thomas M., Antrilli, Thomas M., Krishnamurthy, Girija, Aulabaugh, Ann, Friedrichs, Gregory S., Crandall, David L.

“…Graphic A novel series of PAI-1 inhibitors containing an oxadiazolidinedione moiety were identified by high through-put screening. Optimization of substituents…”
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