Search Results - "ANTOCH, Marina P"

LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation by Simon, Matthew, Van Meter, Michael, Ablaeva, Julia, Ke, Zhonghe, Gonzalez, Raul S., Taguchi, Taketo, De Cecco, Marco, Leonova, Katerina I., Kogan, Valeria, Helfand, Stephen L., Neretti, Nicola, Roichman, Asael, Cohen, Haim Y., Meer, Margarita V., Gladyshev, Vadim N., Antoch, Marina P., Gudkov, Andrei V., Sedivy, John M., Seluanov, Andrei, Gorbunova, Vera

“…Mice deficient for SIRT6 exhibit a severely shortened lifespan, growth retardation, and highly elevated LINE1 (L1) activity. Here we report that…”
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Unsupervised learning of aging principles from longitudinal data by Avchaciov, Konstantin, Antoch, Marina P., Andrianova, Ekaterina L., Tarkhov, Andrei E., Menshikov, Leonid I., Burmistrova, Olga, Gudkov, Andrei V., Fedichev, Peter O.

“…Age is the leading risk factor for prevalent diseases and death. However, the relation between age-related physiological changes and lifespan is poorly…”
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Senescent cells expose and secrete an oxidized form of membrane-bound vimentin as revealed by a natural polyreactive antibody by Frescas, David, Roux, Christelle M., Aygun-Sunar, Semra, Gleiberman, Anatoli S., Krasnov, Peter, Kurnasov, Oleg V., Strom, Evguenia, Virtuoso, Lauren P., Wrobel, Michelle, Osterman, Andrei L., Antoch, Marina P., Mett, Vadim, Chernova, Olga B., Gudkov, Andrei V.

“…Studying the phenomenon of cellular senescence has been hindered by the lack of senescence-specific markers. As such, detection of proteins informally…”
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Core circadian protein CLOCK is a positive regulator of NF-κB–mediated transcription by Spengler, Mary L, Kuropatwinski, Karen K, Comas, Maria, Gasparian, Alexander V, Fedtsova, Natalia, Gleiberman, Anatoli S, Gitlin, Ilya I, Artemicheva, Natalia M, Deluca, Krysta A, Gudkov, Andrei V, Antoch, Marina P

“…The circadian clock controls many physiological parameters including immune response to infectious agents, which is mediated by activation of the transcription…”
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Circadian and CLOCK-controlled regulation of the mouse transcriptome and cell proliferation by Miller, Brooke H, McDearmon, Erin L, Panda, Satchidananda, Hayes, Kevin R, Zhang, Jie, Andrews, Jessica L, Antoch, Marina P, Walker, John R, Esser, Karyn A, Hogenesch, John B, Takahashi, Joseph S

“…Circadian rhythms of cell and organismal physiology are controlled by an autoregulatory transcription-translation feedback loop that regulates the expression…”
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Circadian proteins in the regulation of cell cycle and genotoxic stress responses by Kondratov, Roman V, Antoch, Marina P

“…The mammalian circadian system has been implicated in the regulation of the genotoxic stress response of an organism; however, the underlying molecular…”
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Circadian clock proteins control adaptation to novel environment and memory formation by Kondratova, Anna A, Dubrovsky, Yuliya V, Antoch, Marina P, Kondratov, Roman V

“…Deficiency of the transcription factor BMAL1, a core component of the circadian clock, results in an accelerated aging phenotype in mice. The circadian clock…”
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Circadian Proteins and Genotoxic Stress Response by Antoch, Marina P, Kondratov, Roman V

“…The circadian clock is an evolutionarily conserved time-keeping system that coordinates the physiology of the organism with daily changes in the environment. A…”
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Coordinated Transcription of Key Pathways in the Mouse by the Circadian Clock by Panda, Satchidananda, Antoch, Marina P., Miller, Brooke H., Su, Andrew I., Schook, Andrew B., Straume, Marty, Schultz, Peter G., Kay, Steve A., Takahashi, Joseph S., Hogenesch, John B.

“…In mammals, circadian control of physiology and behavior is driven by a master pacemaker located in the suprachiasmatic nuclei (SCN) of the hypothalamus. We…”
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Pharmacological modulators of the circadian clock as potential therapeutic drugs: focus on genotoxic/anticancer therapy by Antoch, Marina P, Kondratov, Roman V

“…The circadian clock is an evolutionary conserved intrinsic timekeeping mechanism that controls daily variations in multiple biological processes. One important…”
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The Mouse Clock Mutation Reduces Circadian Pacemaker Amplitude and Enhances Efficacy of Resetting Stimuli and Phase-Response Curve Amplitude by Vitaterna, Martha Hotz, Ko, Caroline H., Chang, Anne-Marie, Buhr, Ethan D., Fruechte, Ethan M., Schook, Andrew, Antoch, Marina P., Turek, Fred W., Takahashi, Joseph S.

“…The mouse Clock gene encodes a basic helix-loop-helix-PAS transcription factor, CLOCK, that acts in concert with BMAL1 to form the positive elements of the…”
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Disruption of the circadian clock due to the Clock mutation has discrete effects on aging and carcinogenesis by Antoch, Marina P., Gorbacheva, Victoria Y., Vykhovanets, Olena, Toshkov, Illia A., Kondratov, Roman V., Kondratova, Anna A., Lee, Choogon, Nikitin, Alexander Yu

“…The mammalian circadian system has been implicated in the regulation of various biological processes including those involved in genotoxic stress responses and…”
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Circadian Sensitivity to the Chemotherapeutic Agent Cyclophosphamide Depends on the Functional Status of the CLOCK/BMAL1 Transactivation Complex by Gorbacheva, Victoria Y., Kondratov, Roman V., Zhang, Renliang, Cherukuri, Srujana, Gudkov, Andrei V., Takahashi, Joseph S., Antoch, Marina P.

“…The circadian clock controls many aspects of mammalian physiology, including responses to cancer therapy. We find that wild-type and circadian mutant mice…”
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BMAL1-dependent circadian oscillation of nuclear CLOCK: posttranslational events induced by dimerization of transcriptional activators of the mammalian clock system by Kondratov, Roman V, Chernov, Mikhail V, Kondratova, Anna A, Gorbacheva, Victoria Y, Gudkov, Andrei V, Antoch, Marina P

“…Mammalian CLOCK and BMAL1 are two members of bHLH-PAS-containing family of transcription factors that represent the positive elements of circadian…”
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Dual role of the CLOCK/BMAL1 circadian complex in transcriptional regulation by Kondratov, Roman V, Shamanna, Rashmi K, Kondratova, Anna A, Gorbacheva, Victoria Y, Antoch, Marina P

“…The basic helix–loop–helix (bHLH) –PAS domain containing transcription factors CLOCK and BMAL1 are two major components of the circadian molecular oscillator…”
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The Role of Mammalian Circadian Proteins in Normal Physiology and Genotoxic Stress Responses by Kondratov, Roman V., Gorbacheva, Victoria Y., Antoch, Marina P.

“…The last two decades have significantly advanced our understanding of the organization of the circadian system at all levels of regulation–molecular, cellular,…”
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The orphan receptor Rev-erbα gene is a target of the circadian clock pacemaker by Triqueneaux, Gérard, Thenot, Sandrine, Kakizawa, Tomoko, Antoch, Marina P, Safi, Rachid, Takahashi, Joseph S, Delaunay, Franck, Laudet, Vincent

“…Rev-erbα is a ubiquitously expressed orphan nuclear receptor which functions as a constitutive transcriptional repressor and is expressed in vertebrates…”
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A small molecule inhibitor of p53 stimulates amplification of hematopoietic stem cells but does not promote tumor development in mice by Leonova, Katerina I., Shneyder, Jelena, Antoch, Marina P., Toshkov, Illia A., Novototskaya, Liliya R., Komarov, Pavel G., Komarova, Elena A., Gudkov, Andrei V.

“…It has been shown that genetic inhibition of p53 leads to enhanced proliferation of hematopoietic stem cells (HSCs). This could, in theory, contribute to the…”
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Tissue-Specific Changes in Molecular Clocks During the Transition from Pregnancy to Lactation in Mice1 by Casey, Theresa M, Crodian, Jennifer, Erickson, Emily, Kuropatwinski, Karen K, Gleiberman, Anatoli S, Antoch, Marina P

“…Circadian clocks regulate homeostasis and mediate responses to stressors. Lactation is one of the most energetically demanding periods of an adult female's…”
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Circadian Clock Genes as Modulators of Sensitivity to Genotoxic Stress by Antoch, Marina P., Kondratov, Roman V., Takahashi, Joseph S.

“…A broad variety of organisms display circadian rhythms (i.e. oscillations with 24-hr periodicities) in many aspects of their behavior, physiology and…”
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