Search Results - "ANNEX, Brian H"

New Directions in Therapeutic Angiogenesis and Arteriogenesis in Peripheral Arterial Disease by Annex, Brian H., Cooke, John P.

“…The prevalence of peripheral arterial disease (PAD) in the United States exceeds 10 million people, and PAD is a significant cause of morbidity and mortality…”
Get full text

Epidemiology of peripheral arterial disease and critical limb ischemia in an insured national population by Nehler, Mark R., MD, Duval, Sue, PhD, Diao, Lihong, MS, Annex, Brian H., MD, Hiatt, William R., MD, Rogers, Kevin, MD, Zakharyan, Armen, PhD, Hirsch, Alan T., MD

“…Background Critical limb ischemia (CLI) represents the most severe clinical manifestation of peripheral arterial disease (PAD) and is the major cause of…”
Get full text

VEGF165b Modulates Endothelial VEGFR1–STAT3 Signaling Pathway and Angiogenesis in Human and Experimental Peripheral Arterial Disease by Ganta, Vijay Chaitanya, Choi, Min, Kutateladze, Anna, Annex, Brian H

“…RATIONALE:Atherosclerotic-arterial occlusions decrease tissue perfusion causing ischemia to lower limbs in patients with peripheral arterial disease (PAD)…”
Get full text

A mechanistic integrative computational model of macrophage polarization: Implications in human pathophysiology by Zhao, Chen, Mirando, Adam C, Sové, Richard J, Medeiros, Thalyta X, Annex, Brian H, Popel, Aleksander S

“…Macrophages respond to signals in the microenvironment by changing their functional phenotypes, a process known as polarization. Depending on the context, they…”
Get full text

Endothelial cells signaling and patterning under hypoxia: a mechanistic integrative computational model including the Notch-Dll4 pathway by Oliveira, Rebeca Hannah de Melo, Annex, Brian H, Popel, Aleksander S

“…Several signaling pathways are activated during hypoxia to promote angiogenesis, leading to endothelial cell patterning, interaction, and downstream signaling…”
Get full text

Trafficking dynamics of VEGFR1, VEGFR2, and NRP1 in human endothelial cells by Sarabipour, Sarvenaz, Kinghorn, Karina, Quigley, Kaitlyn M, Kovacs-Kasa, Anita, Annex, Brian H, Bautch, Victoria L, Mac Gabhann, Feilim

“…The vascular endothelial growth factor (VEGF) family of cytokines are key drivers of blood vessel growth and remodeling. These ligands act via multiple VEGF…”
Get full text

Peripheral arterial disease: A small and large vessel problem by Bethel, Monique, Annex, Brian H.

“…Peripheral arterial disease (PAD) is one clinical manifestation of systemic atherosclerosis and is very common. Despite its prevalence, PAD remains…”
Get full text

Pentose Pathway Activation Is Superior to Increased Glycolysis for Therapeutic Angiogenesis in Peripheral Arterial Disease by Zaied, Abdelrahman A, Ushio-Fukai, Masuko, Fukai, Tohru, Kovacs-Kasa, Anita, Alhusban, Suhib, Sudhahar, Varadarajan, Ganta, Vijay C, Annex, Brian H

“…Background In endothelial cells (ECs), glycolysis, regulated by PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, isoform-3), is the major metabolic…”
Get full text

MicroRNA-93 Controls Perfusion Recovery After Hindlimb Ischemia by Modulating Expression of Multiple Genes in the Cell Cycle Pathway by HAZARIKA, Surovi, FARBER, Charles R, DOKUN, Ayotunde O, PITSILLIDES, Achillieas N, TAO WANG, LYE, R. John, ANNEX, Brian H

“…MicroRNAs are key regulators of gene expression in response to injury, but there is limited knowledge of their role in ischemia-induced angiogenesis, such as…”
Get full text

Machine Learning Approach to Predict In‐Hospital Mortality in Patients Admitted for Peripheral Artery Disease in the United States by Zhang, Donglan, Li, Yike, Kalbaugh, Corey Andrew, Shi, Lu, Divers, Jasmin, Islam, Shahidul, Annex, Brian H.

“…Background Peripheral artery disease (PAD) affects >10 million people in the United States. PAD is associated with poor outcomes, including premature death…”
Get full text

MicroRNA-30b Is Both Necessary and Sufficient for Interleukin-21 Receptor-Mediated Angiogenesis in Experimental Peripheral Arterial Disease by Wang, Tao, Yang, Liang, Yuan, Mingjie, Farber, Charles R, Spolski, Rosanne, Leonard, Warren J, Ganta, Vijay C, Annex, Brian H

“…The interleukin-21 receptor (IL-21R) can be upregulated in endothelial cells (EC) from ischemic muscles in mice following hind-limb ischemia (HLI), an…”
Get full text

Perivascular cell-specific knockout of the stem cell pluripotency gene Oct4 inhibits angiogenesis by Hess, Daniel L., Kelly-Goss, Molly R., Cherepanova, Olga A., Nguyen, Anh T., Baylis, Richard A., Tkachenko, Svyatoslav, Annex, Brian H., Peirce, Shayn M., Owens, Gary K.

“…The stem cell pluripotency factor Oct4 serves a critical protective role during atherosclerotic plaque development by promoting smooth muscle cell (SMC)…”
Get full text

Safety and efficacy of patient specific intramuscular injection of HGF plasmid gene therapy on limb perfusion and wound healing in patients with ischemic lower extremity ulceration: Results of the HGF-0205 trial by Powell, Richard J., MD, Goodney, Phillip, MD, Mendelsohn, Farrell O., MD, Moen, Elaine K., MD, Annex, Brian H., MD

“…Objectives We have previously reported the results of a dose-finding phase II trial showing that HGF angiogenic gene therapy can increase TcPO2 compared with…”
Get full text

Computer Simulation of TSP1 Inhibition of VEGF-Akt-eNOS: An Angiogenesis Triple Threat by Bazzazi, Hojjat, Zhang, Yu, Jafarnejad, Mohammad, Isenberg, Jeffrey S, Annex, Brian H, Popel, Aleksander S

“…The matricellular protein thrombospondin-1 (TSP1) is a potent inhibitor of angiogenesis. Specifically, TSP1 has been experimentally shown to inhibit signaling…”
Get full text

Acute psychological stress, autonomic function, and arterial stiffness among women by Logan, Jeongok G., Teachman, Bethany A., Liu, Xiaoyue, Farber, Charles R., Liu, Zhenqi, Annex, Brian H.

“…This study aimed to investigate the effect of acute psychological stress on autonomic function and arterial stiffness, and to test a mediating role of changes…”
Get full text

Endothelial cell-by-cell profiling reveals the temporal dynamics of VEGFR1 and VEGFR2 membrane localization after murine hindlimb ischemia by Imoukhuede, P I, Dokun, Ayotunde O, Annex, Brian H, Popel, Aleksander S

“…VEGF receptor (VEGFR) cell surface localization plays a critical role in transducing VEGF signaling toward angiogenic outcomes, and quantitative…”
Get more information

BAG3 (Bcl-2–Associated Athanogene-3) Coding Variant in Mice Determines Susceptibility to Ischemic Limb Muscle Myopathy by Directing Autophagy by McClung, Joseph M, McCord, Timothy J, Ryan, Terence E, Schmidt, Cameron A, Green, Tom D, Southerland, Kevin W, Reinardy, Jessica L, Mueller, Sarah B, Venkatraman, Talaignair N, Lascola, Christopher D, Keum, Sehoon, Marchuk, Douglas A, Spangenburg, Espen E, Dokun, Ayotunde, Annex, Brian H, Kontos, Christopher D

“…BACKGROUND:Critical limb ischemia is a manifestation of peripheral artery disease that carries significant mortality and morbidity risk in humans, although its…”
Get full text

Therapeutic angiogenesis for critical limb ischaemia by Annex, Brian H.

“…Critical limb ischaemia (CLI) is the most-severe clinical manifestation of peripheral arterial disease (PAD), and is associated with a high risk of amputation…”
Get full text

Experiment-based computational model predicts that IL-6 classic and trans-signaling exhibit similar potency in inducing downstream signaling in endothelial cells by Song, Min, Wang, Youli, Annex, Brian H., Popel, Aleksander S.

“…Inflammatory cytokine mediated responses are important in the development of many diseases that are associated with angiogenesis. Targeting angiogenesis as a…”
Get full text

Angiopoietin-Tie Signaling Pathway in Endothelial Cells: A Computational Model by Zhang, Yu, Kontos, Christopher D., Annex, Brian H., Popel, Aleksander S.

“…The angiopoietin-Tie signaling pathway is an important vascular signaling pathway involved in angiogenesis, vascular stability, and quiescence. Dysregulation…”
Get full text