Search Results - "ANLAI WANG"

Isatuximab Acts Through Fc-Dependent, Independent, and Direct Pathways to Kill Multiple Myeloma Cells by Zhu, Chen, Song, Zhili, Wang, Anlai, Srinivasan, Srimathi, Yang, Guang, Greco, Rita, Theilhaber, Joachim, Shehu, Elvis, Wu, Lan, Yang, Zhi-Yong, Passe-Coutrin, Wilfried, Fournier, Alain, Tai, Yu-Tzu, Anderson, Kenneth C, Wiederschain, Dmitri, Bahjat, Keith, Adrián, Francisco J, Chiron, Marielle

“…Isatuximab is a monoclonal antibody targeting the transmembrane receptor and ectoenzyme CD38, a protein highly expressed on hematological malignant cells,…”
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Discovery and Pharmacological Characterization of a Novel Rodent-Active CCR2 Antagonist, INCB3344 by Brodmerkel, Carrie M, Huber, Reid, Covington, Maryanne, Diamond, Sharon, Hall, Leslie, Collins, Robert, Leffet, Lynn, Gallagher, Karen, Feldman, Patricia, Collier, Paul, Stow, Mark, Gu, Xiaomei, Baribaud, Frederic, Shin, Niu, Thomas, Beth, Burn, Tim, Hollis, Greg, Yeleswaram, Swamy, Solomon, Kim, Friedman, Steve, Wang, Anlai, Xue, Chu Biao, Newton, Robert C, Scherle, Peggy, Vaddi, Kris

“…This report describes the characterization of INCB3344, a novel, potent and selective small molecule antagonist of the mouse CCR2 receptor. The lack of rodent…”
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Combination of PIM and JAK2 inhibitors synergistically suppresses cell proliferation and overcomes drug resistance of myeloproliferative neoplasms by Huang, Shih-Min A., Wang, Anlai, Greco, Rita, Li, Zhifang, Sun, Fangxian, Barberis, Claude, Tabart, Michel, Patel, Vinod, Schio, Laurent, Hurley, Raelene, Chen, Bo, Cheng, Hong, Lengauer, Christoph, Pollard, Jack, Watters, James, Garcia-Echeverria, Carlos, Wiederschain, Dmitri, Adrian, Francisco, Zhang, JingXin

“…Inhibitors of JAK2 kinase are emerging as an important treatment modality for myeloproliferative neoplasms (MPN). However, similar to other kinase inhibitors,…”
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Discovery of INCB3344, a potent, selective and orally bioavailable antagonist of human and murine CCR2 by Xue, Chu-Biao, Wang, Anlai, Meloni, David, Zhang, Ke, Kong, Ling, Feng, Hao, Glenn, Joseph, Huang, Taisheng, Zhang, Yingxin, Cao, Ganfeng, Anand, Rajan, Zheng, Changsheng, Xia, Michael, Han, Qi, Robinson, D.J., Storace, Lou, Shao, Lixin, Li, Mei, Brodmerkel, Carrie M., Covington, Maryanne, Scherle, Peggy, Diamond, Sharon, Yeleswaram, Swamy, Vaddi, Kris, Newton, Robert, Hollis, Greg, Friedman, Steven, Metcalf, Brian

“…We report the discovery of a novel series of CCR2 antagonists through rational design based on a pharmacophore reported in the literature. SAR studies led to…”
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Identification of a regulatory autophosphorylation site in the serine–threonine kinase RIP2 by Dorsch, Marion, Wang, Anlai, Cheng, Hong, Lu, Chafen, Bielecki, Andrew, Charron, Kathryn, Clauser, Karl, Ren, Hong, Polakiewicz, Roberto D., Parsons, Tom, Li, Ping, Ocain, Tim, Xu, Yajun

“…Receptor-interacting protein 2 (RIP2) is a serine–threonine kinase that mediates signaling for many receptors of the innate and adaptive immune systems. Toll…”
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Discovery of INCB10820/PF-4178903, a potent, selective, and orally bioavailable dual CCR2 and CCR5 antagonist by Zheng, Changsheng, Cao, Ganfeng, Xia, Michael, Feng, Hao, Glenn, Joseph, Anand, Rajan, Zhang, Ke, Huang, Taisheng, Wang, Anlai, Kong, Ling, Li, Mei, Galya, Laurine, Hughes, Robert O., Devraj, Rajesh, Morton, Phillip A., Rogier, D. Joseph, Covington, Maryanne, Baribaud, Fred, Shin, Niu, Scherle, Peggy, Diamond, Sharon, Yeleswaram, Swamy, Vaddi, Kris, Newton, Robert, Hollis, Greg, Friedman, Steven, Metcalf, Brian, Xue, Chu-Biao

“…We report the discovery of a potent, selective, and orally bioavailable dual CCR2 and CCR5 antagonist (3 S,4 S)- N-[(1 R,3…”
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Pharmacological characterization of INCB3344, a small molecule antagonist of human CCR2 by Shin, Niu, Baribaud, Frédéric, Wang, Kathy, Yang, Genjie, Wynn, Rich, Covington, Maryanne B., Feldman, Patricia, Gallagher, Karen B., Leffet, Lynn M., Lo, Yvonne Y., Wang, Anlai, Xue, Chu-Biao, Newton, Robert C., Scherle, Peggy A.

“…The chemokine receptor 2 (CCR2) directs migration of monocytes and has been proposed to be a drug target for chronic inflammatory diseases. INCB3344 was first…”
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Participation of Rip2 in Lipopolysaccharide Signaling Is Independent of Its Kinase Activity by Lu, Chafen, Wang, Anlai, Dorsch, Marion, Tian, Jane, Nagashima, Kumiko, Coyle, Anthony J., Jaffee, Bruce, Ocain, Timothy D., Xu, Yajun

“…Rip2 (Rick, Cardiak, CCK2, and CARD3) is a serine/threonine kinase containing a caspase recruitment domain (CARD) at the C terminus. Previous reports have…”
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Discovery of INCB3284, a Potent, Selective, and Orally Bioavailable hCCR2 Antagonist by Xue, Chu-Biao, Feng, Hao, Cao, Ganfeng, Huang, Taisheng, Glenn, Joseph, Anand, Rajan, Meloni, David, Zhang, Ke, Kong, Lingquan, Wang, Anlai, Zhang, Yingxin, Zheng, Changsheng, Xia, Michael, Chen, Lihua, Tanaka, Hiroyuki, Han, Qi, Robinson, D. J, Modi, Dilip, Storace, Lou, Shao, Lixin, Sharief, Vaqar, Li, Mei, Galya, Laurine G, Covington, Maryanne, Scherle, Peggy, Diamond, Sharon, Emm, Tom, Yeleswaram, Swamy, Contel, Nancy, Vaddi, Kris, Newton, Robert, Hollis, Greg, Friedman, Steven, Metcalf, Brian

“…We report the identification of 13 (INCB3284) as a potent human CCR2 (hCCR2) antagonist. INCB3284 exhibited an IC50 of 3.7 nM in antagonism of monocyte…”
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Functional Isolation and Characterization of Human Hematopoietic Stem Cells by Berardi, Anna C., Wang, Anlai, Levine, James D., Lopez, Peter, Scadden, David T.

“…Hematopoietic cells differentiate in steps marked by the acquisition or loss of specific phenotypic characteristics. Human bone marrow cells that were…”
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A new chiral diphosphine ligand and its asymmetric induction in catalytic hydroformylation of olefins by Lu, Shijie, Li, Xiaodong, Wang, Anlai

“…A new chiral ligand, 1,6-anhydro-2,4-bis(diphenylphosphino)pyranose (ABDPP), was prepared from d-glucose. The ligand was used to prepare a chiral rhodium…”
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Abstract 1632: Antibody mediated crosslinking of CD38 triggers costimulatory signaling and promotes T cell effector function by Hwang, Mun Kyung, Wang, Anlai, Song, Zhili, Dai, Shujia, Zhang, Bailin, Theilhaber, Joachim, Pao, Lily, Wiederschain, Dmitri, Zhu, Chen

“…Abstract CD38 is a multi-functional ecto-enzyme that regulates NAD+ metabolism. Monoclonal antibodies against CD38, including daratumumab and isatuximab have…”
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Recombinant Human Interleukin-11 Directly Promotes Megakaryocytopoiesis In Vitro by Weich, Nadine S., Wang, Anlai, Fitzgerald, Michael, Neben, Tamlyn Yee, Donaldson, Debra, Giannotti, JoAnn, Yetz-Aldape, Joanne, Leven, Robert M., Turner, Katherine J.

“…We have investigated the mechanism of action of the thrombopoietic cytokine, recombinant human interleukin-11 (rhIL-11), on megakaryocytopoiesis in vitro. We…”
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Evaluation of Preclinical Activity of Isatuximab in Patients with Acute Lymphoblastic Leukemia by Wang, Anlai, Song, Zhili, Zheng, Gang, Nicolazzi, Celine, Fromm, Jonathan R, Shehu, Elvis, Srinivasan, Srimathi, Chen, Xueyan, Zhu, Chen, Blondel, Marielle Chiron, Adrian, Francisco J

“…This study reports the pharmacologic effects of isatuximab, a CD38 mAb, on T- and B-cell acute lymphoblastic leukemia (ALL). We analyzed CD38 expression in…”
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Interfering with resistance to smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma by Buonamici, Silvia, Williams, Juliet, Morrissey, Michael, Wang, Anlai, Guo, Ribo, Vattay, Anthony, Hsiao, Kathy, Yuan, Jing, Green, John, Ospina, Beatriz, Yu, Qunyan, Ostrom, Lance, Fordjour, Paul, Anderson, Dustin L, Monahan, John E, Kelleher, Joseph F, Peukert, Stefan, Pan, Shifeng, Wu, Xu, Maira, Sauveur-Michel, García-Echeverría, Carlos, Briggs, Kimberly J, Watkins, D Neil, Yao, Yung-mae, Lengauer, Christoph, Warmuth, Markus, Sellers, William R, Dorsch, Marion

“…The malignant brain cancer medulloblastoma is characterized by mutations in Hedgehog (Hh) signaling pathway genes, which lead to constitutive activation of the…”
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Lithium diisopropylamide (LDA) reduction of nitroarenes by Wang, Anlai, Biehl, Ed

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CD38 Protects Tumor Cells from NK Lysis by Wang, Anlai, Yang, Guang, Song, Zhili L, Adrian, Francisco J

“…Expression of the type II glycoprotein CD38 in hematological malignancies is abnormally high compared to that in normal cells of hematopoietic origin. Across…”
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Recombinant human interleukin-11 synergizes with steel factor and interleukin-3 to promote directly the early stages of murine megakaryocyte development in vitro by WELCH, N. S, FITZGERALD, M, ANLAI WANG, CALVETTI, J, YETZ-ALDAPE, J, NEBEN, S, TURNER, K. J

“…The authors studied the role that interleukin (IL)-11 plays during the early stages of megakaryocyte (MK) development by investigating its in vitro effects on…”
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Abstract 2966: Isatuximab-induced multiple myeloma cell killing through effector functions is dependent on CD38 expression and complement inhibitors by Song, Zhili, Yang, Guang, Wang, Anlai, Greco, Rita, Theilhaber, Joachim, Shehu, Elvis, Ajona, Daniel, Paiva, Bruno, Zhu, Chen, Wiederschain, Dmitri, Blondel, Marielle F. Chiron, Adrian, Francisco

“…Abstract Isatuximab (Isa) is an IgG1 monoclonal antibody (Ab) that specifically recognizes human CD38. Once Isa engages multiple myeloma (MM) cells expressing…”
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Basic Fibroblast Growth Factor Mediates Its Effects on Committed Myeloid Progenitors by Direct Action and Has No Effect on Hematopoietic Stem Cells by Berardi, Anna C., Wang, Anlai, Abraham, Judith, Scadden, David T.

“…Basic fibroblast growth factor or fibroblast growth factor-2 (FGF) has been shown to affect myeloid cell proliferation and hypothesized to stimulate primitive…”
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