Search Results - "ANGUITA, Juan"

The DisGeNET knowledge platform for disease genomics: 2019 update by Piñero, Janet, Ramírez-Anguita, Juan Manuel, Saüch-Pitarch, Josep, Ronzano, Francesco, Centeno, Emilio, Sanz, Ferran, Furlong, Laura I

“…Abstract One of the most pressing challenges in genomic medicine is to understand the role played by genetic variation in health and disease. Thanks to the…”
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MEMBPLUGIN: studying membrane complexity in VMD by Guixà-González, Ramon, Rodriguez-Espigares, Ismael, Ramírez-Anguita, Juan Manuel, Carrió-Gaspar, Pau, Martinez-Seara, Hector, Giorgino, Toni, Selent, Jana

“…Computer simulations are giving way to more complex and accurate studies of biological membranes by molecular dynamics (MD) simulations. The analysis of MD…”
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Metabolomic Identification of Subtypes of Nonalcoholic Steatohepatitis by Alonso, Cristina, Fernández-Ramos, David, Varela-Rey, Marta, Martínez-Arranz, Ibon, Navasa, Nicolás, Van Liempd, Sebastiaan M, Lavin, José L, Mayo, Rebeca, Ilisso, Concetta P, de Juan, Virginia G, Iruarrizaga-Lejarreta, Marta, delaCruz-Villar, Laura, Mincholé, Itziar, Robinson, Aaron, Crespo, Javier, Martín-Duce, Antonio, Romero-Gomez, Manuel, Sann, Holger, Platon, Julian, Van Eyk, Jennifer, Aspichueta, Patricia, Noureddin, Mazen, Falcón-Pérez, Juan M, Anguita, Juan, Aransay, Ana M, Martínez-Chantar, María Luz, Lu, Shelly C, Mato, José M

“…Background & Aims Nonalcoholic fatty liver disease (NAFLD) is a consequence of defects in diverse metabolic pathways that involve hepatic accumulation of…”
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Calculating daily dose in the Observational Medical Outcomes Partnership Common Data Model by Burkard, Theresa, López‐Güell, Kim, Gorbachev, Artem, Bellas, Lucía, Jödicke, Annika M., Burn, Edward, Ridder, Maria, Mosseveld, Mees, Gratton, Jasmine, Seager, Sarah, Vojinovic, Dina, Mayer, Miguel Angel, Ramírez‐Anguita, Juan Manuel, Machín, Angela Leis, Oja, Marek, Kolde, Raivo, Bonadt, Klaus, Prieto‐Alhambra, Daniel, Reich, Chistian, Català, Martí

“…Purpose We aimed to develop a standardized method to calculate daily dose (i.e., the amount of drug a patient was exposed to per day) of any drug on a global…”
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Silencing hepatic MCJ attenuates non-alcoholic fatty liver disease (NAFLD) by increasing mitochondrial fatty acid oxidation by Barbier-Torres, Lucía, Fortner, Karen A., Iruzubieta, Paula, Delgado, Teresa C., Giddings, Emily, Chen, Youdinghuan, Champagne, Devin, Fernández-Ramos, David, Mestre, Daniela, Gomez-Santos, Beatriz, Varela-Rey, Marta, de Juan, Virginia Gutiérrez, Fernández-Tussy, Pablo, Zubiete-Franco, Imanol, García-Monzón, Carmelo, González-Rodríguez, Águeda, Oza, Dhaval, Valença-Pereira, Felipe, Fang, Qian, Crespo, Javier, Aspichueta, Patricia, Tremblay, Frederic, Christensen, Brock C., Anguita, Juan, Martínez-Chantar, María Luz, Rincón, Mercedes

“…Nonalcoholic fatty liver disease (NAFLD) is considered the next major health epidemic with an estimated 25% worldwide prevalence. No drugs have yet been…”
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Incident Use of Hydroxychloroquine for the Treatment of Rheumatoid Arthritis and Systemic Lupus Erythematosus During the COVID‐19 Pandemic by Mercadé‐Besora, Núria, Guo, Yuchen, Du, Mike, Li, Xintong, Ramírez‐Anguita, Juan Manuel, Moreno, Alberto, Valente, António, Villalobos, Felipe, Cheng, Iek Leng, Carrasco‐Ribelles, Lucía A., Swieten, Maaike M. H., Merkelbach, Manon, Magoya, Mary, Lasalvia, Paolo, Pericàs‐Pulido, Pau, Berg, Paul, Bosco‐Lévy, Pauline, Lillini, Roberto, Ribeiro, Rogerio, Bagga, Trinamjot Kaur, Ramella, Vittoria, Khalid, Sara, Mayer, Miguel Angel, Leis, Angela, Jödicke, Annika M., Burn, Edward, Prieto‐Alhambra, Daniel, Català, Martí, Prats‐Uribe, Albert

“…Objective We studied whether the use of hydroxychloroquine (HCQ) for COVID‐19 resulted in supply shortages for patients with rheumatoid arthritis (RA) and…”
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Air cargo transport demand forecasting using ConvLSTM2D, an artificial neural network architecture approach by Gerardo Muros Anguita, Juan, Díaz Olariaga, Oscar

“…•The prediction of air traffic demand (passengers and cargo) in a regional/national air transport system is essential. Knowing the behavior of future demand…”
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Uneven metabolic and lipidomic profiles in recovered COVID‐19 patients as investigated by plasma NMR metabolomics by Bizkarguenaga, Maider, Bruzzone, Chiara, Gil‐Redondo, Rubén, SanJuan, Itxaso, Martin‐Ruiz, Itziar, Barriales, Diego, Palacios, Ainhoa, Pasco, Samuel T., González‐Valle, Beatriz, Laín, Ana, Herrera, Lara, Azkarate, Aida, Vesga, Miguel Angel, Eguizabal, Cristina, Anguita, Juan, Embade, Nieves, Mato, José M., Millet, Oscar

“…COVID‐19 is a systemic infectious disease that may affect many organs, accompanied by a measurable metabolic dysregulation. The disease is also associated with…”
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Characterising the treatment of thromboembolic events after COVID-19 vaccination in 4 European countries and the US: An international network cohort study by Markus, Aniek F, Strauss, Victoria Y, Burn, Edward, Li, Xintong, Delmestri, Antonella, Reich, Christian, Yin, Can, Mayer, Miguel A, Ramírez-Anguita, Juan-Manuel, Marti, Edelmira, Verhamme, Katia M C, Rijnbeek, Peter R, Prieto-Alhambra, Daniel, Jödicke, Annika M

“…Thrombosis with thrombocytopenia syndrome (TTS) has been identified as a rare adverse event following some COVID-19 vaccines. Various guidelines have been…”
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New Glucosamine-Based TLR4 Agonists: Design, Synthesis, Mechanism of Action, and In Vivo Activity as Vaccine Adjuvants by Romerio, Alessio, Gotri, Nicole, Franco, Ana Rita, Artusa, Valentina, Shaik, Mohammed Monsoor, Pasco, Samuel T., Atxabal, Unai, Matamoros-Recio, Alejandra, Mínguez-Toral, Marina, Zalamea, Juan Diego, Franconetti, Antonio, Abrescia, Nicola G. A., Jimenez-Barbero, Jesus, Anguita, Juan, Martín-Santamaría, Sonsoles, Peri, Francesco

“…We disclose here a panel of small-molecule TLR4 agonists (the FP20 series) whose structure is derived from previously developed TLR4 ligands (FP18 series). The…”
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Membrane cholesterol effect on the 5‐HT2A receptor: Insights into the lipid‐induced modulation of an antipsychotic drug target by Ramírez‐Anguita, Juan Manuel, Rodríguez‐Espigares, Ismael, Guixà‐González, Ramon, Bruno, Agostino, Torrens‐Fontanals, Mariona, Varela‐Rial, Alejandro, Selent, Jana

“…The serotonin 5‐hydroxytryptamine 2A (5‐HT2A) receptor is a G‐protein‐coupled receptor (GPCR) relevant for the treatment of CNS disorders. In this regard,…”
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Standardised and Reproducible Phenotyping Using Distributed Analytics and Tools in the Data Analysis and Real World Interrogation Network (DARWIN EU) by Dernie, Francesco, Corby, George, Robinson, Abigail, Bezer, James, Mercade‐Besora, Nuria, Griffier, Romain, Verdy, Guillaume, Leis, Angela, Ramirez‐Anguita, Juan Manuel, Mayer, Miguel A., Brash, James T., Seager, Sarah, Parry, Rowan, Jodicke, Annika, Duarte‐Salles, Talita, Rijnbeek, Peter R., Verhamme, Katia, Pacurariu, Alexandra, Morales, Daniel, Pinheiro, Luis, Prieto‐Alhambra, Daniel, Prats‐Uribe, Albert

“…ABSTRACT Purpose The generation of representative disease phenotypes is important for ensuring the reliability of the findings of observational studies. The…”
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The mitochondrial negative regulator MCJ is a therapeutic target for acetaminophen-induced liver injury by Barbier-Torres, Lucía, Iruzubieta, Paula, Fernández-Ramos, David, Delgado, Teresa C., Taibo, Daniel, Guitiérrez-de-Juan, Virginia, Varela-Rey, Marta, Azkargorta, Mikel, Navasa, Nicolas, Fernández-Tussy, Pablo, Zubiete-Franco, Imanol, Simon, Jorge, Lopitz-Otsoa, Fernando, Lachiondo-Ortega, Sofia, Crespo, Javier, Masson, Steven, McCain, Misti Vanette, Villa, Erica, Reeves, Helen, Elortza, Felix, Lucena, Maria Isabel, Hernández-Alvarez, Maria Isabel, Zorzano, Antonio, Andrade, Raúl J., Lu, Shelly C., Mato, José M., Anguita, Juan, Rincón, Mercedes, Martínez-Chantar, María Luz

“…Acetaminophen (APAP) is the active component of many medications used to treat pain and fever worldwide. Its overuse provokes liver injury and it is the second…”
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Antimycobacterial Effect of Selenium Nanoparticles on Mycobacterium tuberculosis by Estevez, Hector, Palacios, Ainhoa, Gil, David, Anguita, Juan, Vallet-Regi, Maria, González, Blanca, Prados-Rosales, Rafael, Luque-Garcia, Jose L

“…Tuberculosis (TB) remains the leading cause of death from a single infection agent worldwide. In recent years, the occurrence of TB cases caused by…”
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Self-assembly of Mutant Huntingtin Exon-1 Fragments into Large Complex Fibrillar Structures Involves Nucleated Branching by Wagner, Anne S., Politi, Antonio Z., Ast, Anne, Bravo-Rodriguez, Kenny, Baum, Katharina, Buntru, Alexander, Strempel, Nadine U., Brusendorf, Lydia, Hänig, Christian, Boeddrich, Annett, Plassmann, Stephanie, Klockmeier, Konrad, Ramirez-Anguita, Juan M., Sanchez-Garcia, Elsa, Wolf, Jana, Wanker, Erich E.

“…Huntingtin (HTT) fragments with extended polyglutamine tracts self-assemble into amyloid-like fibrillar aggregates. Elucidating the fibril formation mechanism…”
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Multiserotype protection elicited by a combinatorial prime-boost vaccination strategy against bluetongue virus by Calvo-Pinilla, Eva, Navasa, Nicolás, Anguita, Juan, Ortego, Javier

“…Bluetongue virus (BTV) belongs to the genus Orbivirus within the family Reoviridae. The development of vector-based vaccines expressing conserved protective…”
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Lessons from Bacillus Calmette-Guérin: Harnessing Trained Immunity for Vaccine Development by Pasco, Samuel T, Anguita, Juan

“…Vaccine design traditionally focuses on inducing adaptive immune responses against a sole target pathogen. Considering that many microbes evade innate immune…”
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Counterattacking the tick bite: towards a rational design of anti-tick vaccines targeting pathogen transmission by Rego, Ryan O M, Trentelman, Jos J A, Anguita, Juan, Nijhof, Ard M, Sprong, Hein, Klempa, Boris, Hajdusek, Ondrej, Tomás-Cortázar, Julen, Azagi, Tal, Strnad, Martin, Knorr, Sarah, Sima, Radek, Jalovecka, Marie, Fumačová Havlíková, Sabína, Ličková, Martina, Sláviková, Monika, Kopacek, Petr, Grubhoffer, Libor, Hovius, Joppe W

“…Hematophagous arthropods are responsible for the transmission of a variety of pathogens that cause disease in humans and animals. Ticks of the Ixodes ricinus…”
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Restoring cellular magnesium balance through Cyclin M4 protects against acetaminophen-induced liver damage by González-Recio, Irene, Simón, Jorge, Goikoetxea-Usandizaga, Naroa, Serrano-Maciá, Marina, Mercado-Gómez, Maria, Rodríguez-Agudo, Rubén, Lachiondo-Ortega, Sofía, Gil-Pitarch, Clàudia, Fernández-Rodríguez, Carmen, Castellana, Donatello, Latasa, Maria U., Abecia, Leticia, Anguita, Juan, Delgado, Teresa C., Iruzubieta, Paula, Crespo, Javier, Hardy, Serge, Petrov, Petar D., Jover, Ramiro, Avila, Matías A., Martín, César, Schaeper, Ute, Tremblay, Michel L., Dear, James W., Masson, Steven, McCain, Misti Vanette, Reeves, Helen L., Andrade, Raul J., Lucena, M. Isabel, Buccella, Daniela, Martínez-Cruz, Luis Alfonso, Martínez-Chantar, Maria L

“…Acetaminophen overdose is one of the leading causes of acute liver failure and liver transplantation in the Western world. Magnesium is essential in several…”
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Bovine Neutrophils Release Extracellular Traps and Cooperate With Macrophages in Mycobacterium avium subsp. paratuberculosis clearance In Vitro by Ladero-Auñon, Iraia, Molina, Elena, Holder, Angela, Kolakowski, Jeannine, Harris, Heather, Urkitza, Alfonso, Anguita, Juan, Werling, Dirk, Elguezabal, Natalia

“…subsp. (Map) is the underlying pathogen causing bovine paratuberculosis (PTB), an enteric granulomatous disease that mainly affects ruminants and for which an…”
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