Search Results - "ANDRUSS, Bernard F"
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miRNA Biomarkers in Cyst Fluid Augment the Diagnosis and Management of Pancreatic Cysts
Published in Clinical cancer research (01-09-2012)“…The diagnosis of pancreatic cystic lesions has increased dramatically. Most are benign, whereas some, such as intraductal papillary mucinous neoplasms (IPMN),…”
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Autonomous Control of Cell and Organ Size by CHICO, a Drosophila Homolog of Vertebrate IRS1–4
Published in Cell (25-06-1999)“…The control of growth is fundamental to the developing metazoan. Here, we show that CHICO, a Drosophila homolog of vertebrate IRS1–4, plays an essential role…”
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Investigating MicroRNA Expression Profiles in Pancreatic Cystic Neoplasms
Published in Clinical and translational gastroenterology (01-01-2014)“…Current diagnostic tools for pancreatic cysts fail to reliably differentiate mucinous from nonmucinous cysts. Reliable biomarkers are needed. MicroRNAs (miRNA)…”
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Applying small RNA molecules to the directed treatment of human diseases: realizing the potential
Published in Expert opinion on therapeutic targets (01-01-2008)“…Small interfering RNAs (siRNA) and microRNAs (miRNA) are gaining considerable attention in the pharmaceutical and biotechnology industries, as research has…”
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Analytical Validation of a Highly Sensitive, Multiplexed Chronic Myeloid Leukemia Monitoring System Targeting BCR-ABL1 RNA
Published in The Journal of molecular diagnostics : JMD (01-07-2019)“…This study describes the analytical performance of the QuantideX qPCR BCR-ABL IS Kit, the first Food and Drug Administration–cleared assay designed to monitor…”
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A MicroRNA-Based Test Improves Endoscopic Ultrasound–Guided Cytologic Diagnosis of Pancreatic Cancer
Published in Clinical gastroenterology and hepatology (01-10-2014)“…Background & Aims Endoscopic ultrasound–guided fine-needle aspiration (EUS-FNA) in combination with cytopathology is the optimal method for diagnosis and…”
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Development of a miRNA-based diagnostic assay for pancreatic ductal adenocarcinoma
Published in Expert review of molecular diagnostics (01-04-2011)“…Diagnosis of pancreatic cancer remains a clinical challenge. Both chronic pancreatitis and pancreatic cancer may present with similar symptoms and similar…”
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Differential expression of GNAS and KRAS mutations in pancreatic cysts
Published in Journal of the Pancreas (28-11-2014)“…KRAS mutations play an important role in pancreatic cancer. GNAS mutations were discovered in intraductal papillary mucinous neoplasms (IPMN). Our aim was to…”
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Analyzing micro-RNA expression using microarrays
Published in Methods in enzymology (2006)“…The discovery of micro-RNAs (miRNAs) and the growing appreciation of the importance of micro-RNAs in the regulation of gene expression are driving increasing…”
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RNA extraction for arrays
Published in Methods in enzymology (2006)“…DNA microarrays enable insights into global gene expression by capturing a snapshot of cellular expression levels at the time of sample collection. Careful RNA…”
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Movement of calmodulin between cells in the ovary and embryo of drosophila
Published in Genesis (New York, N.Y. : 2000) (01-02-2004)“…Calmodulin (CaM) is an essential component of calcium signaling in multicellular organisms. We used null mutations of the Drosophila CaM gene (Cam) in…”
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Adoption of array technologies into the clinical laboratory
Published in Expert review of molecular diagnostics (01-05-2005)“…Array-based methods are making substantial contributions to the discovery of disease biomarkers and are fueling the growth of multianalyte testing for disease…”
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Control of T lymphocyte morphology by the GTPase Rho
Published in BMC cell biology (24-02-2003)“…Rho family GTPase regulation of the actin cytoskeleton governs a variety of cell responses. In this report, we have analyzed the role of the GTPase Rho in…”
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Diverse roles of integrins in human T lymphocyte biology
Published in Immunologic research (01-01-2003)“…T lymphocytes are the primary cells responsible for maintaining the immune system. There are many intricate mechanisms involved in the regulation of T cells…”
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Spontaneous avoidance behavior in Drosophila null for calmodulin expression
Published in Proceedings of the National Academy of Sciences - PNAS (19-03-1996)“…The regulatory protein calmodulin is a major mediator of calcium-induced changes in cellular activity. To analyze the roles of calmodulin in an intact animal,…”
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Calcium-binding proteins and development
Published in Biometals (01-12-1998)“…The known roles for calcium-binding proteins in developmental signaling pathways are reviewed. Current information on the calcium-binding characteristics of…”
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A genetic enrichment strategy for delay of onset of Alzheimer’s disease clinical trials
Published in Alzheimer's & dementia (01-12-2020)“…Background A challenge with AD prevention is the timely identification of subjects at risk of cognitive symptom onset, mitigating prohibitive costs associated…”
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A genetic enrichment strategy for delay of onset of Alzheimer’s disease clinical trials: Biomarkers (non‐neuroimaging)/Use in clinical trial design and evaluation
Published in Alzheimer's & dementia (01-12-2020)“…Abstract Background A challenge with AD prevention is the timely identification of subjects at risk of cognitive symptom onset, mitigating prohibitive costs…”
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Expression of calmodulin in Drosophila is highly regulated in a stage- and tissue-specific manner
Published in Development genes and evolution (01-05-1997)“…The expression of the Drosophila calmodulin (CAM) gene is surprisingly complex. The nervous system, which shows intense transcription in embryogenesis,…”
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No miR quirk: dysregulation of microRNAs in pancreatic ductal adenocarcinoma
Published in MicroRNA (Shariqah, United Arab Emirates) (2012)“…MicroRNAs are post-transcriptional regulators of gene expression with tissue-specific expression profiles. Dysregulation of microRNAs has been shown to play a…”
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