Search Results - "ANDRE OLAUSSEN, Ken"

Cisplatin Resistance Associated with PARP Hyperactivation by MICHELS, Judith, VITALE, Ilio, TALBOT, Monique, ROBIN, Angélique, GIRARD, Philippe, OREAR, Cedric, LISSA, Delphine, ABDUL QADER SUKKURWALA, GARCIA, Pauline, BEHNAM-MOTLAGH, Parviz, KOHNO, Kimitoshi, GEN SHENG WU, GALLUZZI, Lorenzo, BRENNER, Catherine, DESSEN, Philippe, SAPARBAEV, Murat, SORIA, Jean-Charles, CASTEDO, Maria, KROEMER, Guido, ADAM, Julien, ANDRE OLAUSSEN, Ken, KEPP, Oliver, SENOVILLA, Laura, TALHAOUI, Ibtissam, GUEGAN, Justine, PIERRE ENOT, David

“…Non-small cell lung carcinoma patients are frequently treated with cisplatin (CDDP), most often yielding temporary clinical responses. Here, we show that PARP1…”
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Molecular Characteristics of ERCC1-Negative versus ERCC1-Positive Tumors in Resected NSCLC by FRIBOULET, Luc, BARRIOS-GONZALES, Daniel, BESSE, Benjamin, VALIDIRE, Pierre, GIRARD, Philippe, LACROIX, Ludovic, HASMATS, Johanna, DUFOUR, Fabienne, ANDRE, Fabrice, SORIA, Jean-Charles, COMMO, Frédéric, ANDRE OLAUSSEN, Ken, VAGNER, Stephan, ADAM, Julien, GOUBAR, Aïcha, DORVAULT, Nicolas, LAZAR, Vladimir, JOB, Bastien

“…Excision repair cross-complementation group 1 (ERCC1) is a protein involved in repair of DNA platinum adducts and stalled DNA replication forks. We and others…”
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ERCC1 function in nuclear excision and interstrand crosslink repair pathways is mediated exclusively by the ERCC1-202 isoform by Friboulet, Luc, Postel-Vinay, Sophie, Sourisseau, Tony, Adam, Julien, Stoclin, Annabelle, Ponsonnailles, Florence, Dorvault, Nicolas, Commo, Frédéric, Saulnier, Patrick, Salome-Desmoulez, Sophie, Pottier, Géraldine, André, Fabrice, Kroemer, Guido, Soria, Jean Charles, Olaussen, Ken André

“…ERCC1 (excision repair cross-complementation group 1) plays essential roles in the removal of DNA intrastrand crosslinks by nucleotide excision repair, and…”
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Are RAS mutations predictive markers of resistance to standard chemotherapy? by Soria, Jean-Charles, Loriot, Yohann, Mordant, Pierre, Deutsch, Eric, Olaussen, Ken André

“…KRAS mutations can be predictive of resistance to anti-EGFR monoclonal-based therapy in patients with colorectal cancer. Only limited studies, however, have…”
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PARP inhibitors: an interesting pathway also for non-small cell lung cancer? by Levra, Matteo Giaj, Olaussen, Ken Andre, Novello, Silvia, Soria, Jean-Charles

“…Treatment of lung cancer is improving, also based on the identification of molecular characteristics of the tumor, of which some already constitute promising…”
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A new step ahead for the consideration of ERCC1 as a candidate biomarker to select NSCLC patients for the treatment of cetuximab in combination with cisplatin by Olaussen, Ken André

“…Commentary to: The overexpression of ERCC-1 is involved in the resistance of lung cancer cells to cetuximab combined with DDP Jing-Jing Li, Ya Ding, Dan-Dan…”
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Prognostic value of LIPC in non-small cell lung carcinoma by Galluzzi, Lorenzo, Goubar, Aicha, Olaussen, Ken, Vitale, Ilio, Senovilla, Laura, Michels, Judith, Robin, Angélique, Dorvault, Nicolas, Besse, Benjamin, Validire, Pierre, fouret, Pierre, Behrens, Carmen, Wistuba, Ignacio, Soria, Jean-Charles, Kroemer, Guido

“…Non-small cell lung carcinoma (NSCLC) is the most common form of lung cancer and is associated with a high mortality rate worldwide. The majority of…”
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The "Guardian of the Genome"-An Old Key to Unlock the ERCC1 Issue by Friboulet, Luc, Soria, Jean-Charles, Olaussen, Ken André

“…Excision Repair Cross-Complementation Group 1 (ERCC1) participates in the repair of DNA intrastrand adducts (ISA) and interstrand cross-links, but its role as…”
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ERCC1 Isoform Expression and DNA Repair in Non–Small-Cell Lung Cancer by Friboulet, Luc, Olaussen, Ken André, Pignon, Jean-Pierre, Shepherd, Frances A, Tsao, Ming-Sound, Graziano, Stephen, Kratzke, Robert, Douillard, Jean-Yves, Seymour, Lesley, Pirker, Robert, Filipits, Martin, André, Fabrice, Solary, Eric, Ponsonnailles, Florence, Robin, Angélique, Stoclin, Annabelle, Dorvault, Nicolas, Commo, Frédéric, Adam, Julien, Vanhecke, Elsa, Saulnier, Patrick, Thomale, Jürgen, Le Chevalier, Thierry, Dunant, Ariane, Rousseau, Vanessa, Le Teuff, Gwénaël, Brambilla, Elisabeth, Soria, Jean-Charles

“…Earlier studies suggested that the response to platinum treatment in lung cancer might be predicted according to the presence or absence of the DNA repair…”
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Deciphering resistance mechanisms in cancer: final report of MATCH-R study with a focus on molecular drivers and PDX development by Vasseur, Damien, Bigot, Ludovic, Beshiri, Kristi, Flórez-Arango, Juan, Facchinetti, Francesco, Hollebecque, Antoine, Tselikas, Lambros, Aldea, Mihaela, Blanc-Durand, Felix, Gazzah, Anas, Planchard, David, Lacroix, Ludovic, Pata-Merci, Noémie, Nobre, Catline, Da Silva, Alice, Nicotra, Claudio, Ngo-Camus, Maud, Braye, Floriane, Nikolaev, Sergey I, Michiels, Stefan, Jules-Clement, Gérôme, Olaussen, Ken André, André, Fabrice, Scoazec, Jean-Yves, Barlesi, Fabrice, Ponce, Santiago, Soria, Jean-Charles, Besse, Benjamin, Loriot, Yohann, Friboulet, Luc

“…Understanding the resistance mechanisms of tumor is crucial for advancing cancer therapies. The prospective MATCH-R trial (NCT02517892), led by Gustave Roussy,…”
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Association of Molecular Profiles and Mutational Status With Distinct Histological Lung Adenocarcinoma Subtypes. An Analysis of the LACE-Bio Data by Ashok Kumar, Prashanth, Karimi, Maryam, Basnet, Alina, Seymour, Lesley, Kratzke, Robert, Brambilla, Elizabeth, Le-Chevalier, Thierry, Soria, Jean-Charles, Olaussen, Ken André, Devarakonda, Siddhartha, Govindan, Ramaswamy, Tsao, Ming-Sound, Shepherd, Frances A, Michiels, Stefan, Graziano, Stephen

“…•Micropapillary/Solid subtype of lung adenocarcinoma is commonly associated with genetic alterations and shows positivity for several biomarkers.•High TMB is…”
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Osteopontin and thrombospondin-1 play opposite roles in promoting tumor aggressiveness of primary resected non-small cell lung cancer by Rouanne, Mathieu, Adam, Julien, Goubar, Aïcha, Robin, Angélique, Ohana, Caroline, Louvet, Emilie, Cormier, Jiemin, Mercier, Olaf, Dorfmüller, Peter, Fattal, Soly, de Montpreville, Vincent Thomas, Lebret, Thierry, Dartevelle, Philippe, Fadel, Elie, Besse, Benjamin, Olaussen, Ken André, Auclair, Christian, Soria, Jean-Charles

“…Osteopontin (OPN) and thrombospondin-1 (TSP-1) are extracellular matrix proteins secreted by stromal and tumor cells. These proteins appear to have a key role…”
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Telomere length, telomeric proteins and genomic instability during the multistep carcinogenic process by Raynaud, Christophe Michel, Sabatier, Laure, Philipot, Ophelie, Olaussen, Ken André, Soria, Jean-Charles

“…Abstract Telomeres form specialized structures at the ends of eukaryotic chromosomes, preventing them from being wrongly recognized as DNA damage. The human…”
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ERCC1 and RRM1 in the International Adjuvant Lung Trial by Automated Quantitative in Situ Analysis by Bepler, Gerold, Olaussen, Ken André, Vataire, Anne-Lise, Soria, Jean-Charles, Zheng, Zhong, Dunant, Ariane, Pignon, Jean-Pierre, Schell, Michael J, Fouret, Pierre, Pirker, Robert, Filipits, Martin, Brambilla, Elisabeth

“…The excision repair cross completing group 1 gene product (ERCC1) and the regulatory subunit of ribonucleotide reductase (RRM1) have been reported as being…”
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DNA repair capacity in circulating lymphocytes and influence on platinum effect in tumor cells by Olaussen, Ken André, André, Fabrice, Soria, Jean-Charles

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No evidence for viral sequences in five lepidic adenocarcinomas (former "BAC") by a high-throughput sequencing approach by Berthet, Nicolas, Frangeul, Lionel, Olaussen, Ken André, Brambilla, Elisabeth, Dorvault, Nicolas, Girard, Philippe, Validire, Pierre, Fadel, Elie, Bouchier, Christiane, Gessain, Antoine, Soria, Jean-Charles

“…The hypothesis of an infectious etiology of the formerly named bronchiolo-alveolar carcinoma (BAC) has raised controversy. We investigated tumor lung tissues…”
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Expression of Chemokine Receptor CCR6 as a Molecular Determinant of Adrenal Metastatic Relapse in Patients With Primary Lung Cancer by Raynaud, Christophe M, Mercier, Olaf, Dartevelle, Philippe, Commo, Frédéric, Olaussen, Ken André, de Montpreville, Vincent, André, Fabrice, Sabatier, Laure, Sorial, Jean-Charles

“…Abstract Background Recent studies suggest that chemokines are involved in organ-specific metastatic relapse. We evaluated the potential implications of…”
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DNA repair pathways and non-small cell lung cancer: clinical perspectives by Olaussen, Ken André, Planchard, David, Adam, Julien, Soria, Jean-Charles

“…The role of DNA repair pathways is to maintain cellular integrity. However, genetic instability is a driving force in the development of tumor cells and many…”
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Prognostic Impact of Vitamin B6 Metabolism in Lung Cancer by Galluzzi, Lorenzo, Vitale, Ilio, Senovilla, Laura, Olaussen, Ken André, Pinna, Guillaume, Eisenberg, Tobias, Goubar, Aïcha, Martins, Isabelle, Michels, Judith, Kratassiouk, Gueorgui, Carmona-Gutierrez, Didac, Scoazec, Marie, Vacchelli, Erika, Schlemmer, Frederic, Kepp, Oliver, Shen, Shensi, Tailler, Maximilien, Niso-Santano, Mireia, Morselli, Eugenia, Criollo, Alfredo, Adjemian, Sandy, Jemaà, Mohamed, Chaba, Kariman, Pailleret, Claire, Michaud, Mickaël, Pietrocola, Federico, Tajeddine, Nicolas, de La Motte Rouge, Thibault, Araujo, Natalia, Morozova, Nadya, Robert, Thomas, Ripoche, Hugues, Commo, Frederic, Besse, Benjamin, Validire, Pierre, Fouret, Pierre, Robin, Angélique, Dorvault, Nicolas, Girard, Philippe, Gouy, Sébastien, Pautier, Patricia, Jägemann, Nora, Nickel, Ann-Christin, Marsili, Sabrina, Paccard, Caroline, Servant, Nicolas, Hupé, Philippe, Behrens, Carmen, Behnam-Motlagh, Parviz, Kohno, Kimitoshi, Cremer, Isabelle, Damotte, Diane, Alifano, Marco, Midttun, Øivind, Ueland, Per Magne, Lazar, Vladimir, Dessen, Philippe, Zischka, Hans, Chatelut, Etienne, Castedo, Maria, Madeo, Frank, Barillot, Emmanuel, Thomale, Juergen, Wistuba, Ignacio Ivan, Sautès-Fridman, Catherine, Zitvogel, Laurence, Soria, Jean-Charles, Harel-Bellan, Annick, Kroemer, Guido

“…Patients with non-small cell lung cancer (NSCLC) are routinely treated with cytotoxic agents such as cisplatin. Through a genome-wide siRNA-based screen, we…”
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Prognostic Impact of Vitamin B6 Metabolism in Lung Cancer by Galluzzi, Lorenzo, Vitale, Ilio, Senovilla, Laura, Olaussen, Ken André, Pinna, Guillaume, Eisenberg, Tobias, Goubar, Aïcha, Martins, Isabelle, Michels, Judith, Kratassiouk, Gueorgui, Carmona-Gutierrez, Didac, Scoazec, Marie, Vacchelli, Erika, Schlemmer, Frederic, Kepp, Oliver, Shen, Shensi, Tailler, Maximilien, Niso-Santano, Mireia, Morselli, Eugenia, Criollo, Alfredo, Adjemian, Sandy, Jemaà, Mohamed, Chaba, Kariman, Pailleret, Claire, Michaud, Mickaël, Pietrocola, Federico, Tajeddine, Nicolas, de La Motte Rouge, Thibault, Araujo, Natalia, Morozova, Nadya, Robert, Thomas, Ripoche, Hugues, Commo, Frederic, Besse, Benjamin, Validire, Pierre, Fouret, Pierre, Robin, Angélique, Dorvault, Nicolas, Girard, Philippe, Gouy, Sébastien, Pautier, Patricia, Jägemann, Nora, Nickel, Ann-Christin, Marsili, Sabrina, Paccard, Caroline, Servant, Nicolas, Hupé, Philippe, Behrens, Carmen, Behnam-Motlagh, Parviz, Kohno, Kimitoshi, Cremer, Isabelle, Damotte, Diane, Alifano, Marco, Midttun, Øivind, Ueland, Per Magne, Lazar, Vladimir, Dessen, Philippe, Zischka, Hans, Chatelut, Etienne, Castedo, Maria, Madeo, Frank, Barillot, Emmanuel, Thomale, Juergen, Wistuba, Ignacio Ivan, Sautès-Fridman, Catherine, Zitvogel, Laurence, Soria, Jean-Charles, Harel-Bellan, Annick, Kroemer, Guido

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