Search Results - "ANDRÄ, Jörg"

Phosphatidylserine exposure is required for ADAM17 sheddase function by Sommer, Anselm, Kordowski, Felix, Büch, Joscha, Maretzky, Thorsten, Evers, Astrid, Andrä, Jörg, Düsterhöft, Stefan, Michalek, Matthias, Lorenzen, Inken, Somasundaram, Prasath, Tholey, Andreas, Sönnichsen, Frank D., Kunzelmann, Karl, Heinbockel, Lena, Nehls, Christian, Gutsmann, Thomas, Grötzinger, Joachim, Bhakdi, Sucharit, Reiss, Karina

“…ADAM17, a prominent member of the ‘Disintegrin and Metalloproteinase’ (ADAM) family, controls vital cellular functions through cleavage of transmembrane…”
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ADAM10 sheddase activation is controlled by cell membrane asymmetry by Bleibaum, Florian, Sommer, Anselm, Veit, Martin, Rabe, Björn, Andrä, Jörg, Kunzelmann, Karl, Nehls, Christian, Correa, Wilmar, Gutsmann, Thomas, Grötzinger, Joachim, Bhakdi, Sucharit, Reiss, Karina

“…Dysregulation of the disintegrin-metalloproteinase ADAM10 may contribute to the development of diseases including tumorigenesis and Alzheimer's disease. The…”
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The Antimicrobial Peptide NK-2, the Core Region of Mammalian NK-Lysin, Kills Intraerythrocytic Plasmodium falciparum by GELHAUS, Christoph, JACOBS, Thomas, ANDRÄ, Jörg, LEIPPE, Matthias

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Peptide-based treatment of sepsis by Brandenburg, Klaus, Andrä, Jörg, Garidel, Patrick, Gutsmann, Thomas

“…Sepsis (blood poisoning) is a severe infectious disease with high mortality, and no effective therapy is actually known. In the case of Gram-negative bacteria,…”
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The NK-lysin derived peptide NK-2 preferentially kills cancer cells with increased surface levels of negatively charged phosphatidylserine by Schröder-Borm, Hannah, Bakalova, Rumiana, Andrä, Jörg

“…The NK-lysin derived peptide NK-2 is a potent antibacterial, but non-toxic to a human keratinocyte cell line and of low hemolytic activity. Its target…”
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Influence of Arenicin on Phase Transitions and Ordering of Lipids in 2D Model Membranes by Travkova, Oksana G, Andrä, Jörg, Möhwald, Helmuth, Brezesinski, Gerald

“…Antimicrobial peptides (AMPs) are important effector molecules of the innate immune system of all species. AMPs are highly selective and can be used as lead…”
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Structural Features Governing the Activity of Lactoferricin-Derived Peptides That Act in Synergy with Antibiotics against Pseudomonas aeruginosa In Vitro and In Vivo by SANCHEZ-GOMEZ, Susana, JAPELJ, Bostjan, MARTINEZ DE TEJADA, Guillermo, JERALA, Roman, MORIYON, Ignacio, FERNANDEZ ALONSO, Mirian, LEIVA, José, BLONDELLE, Sylvie E, ANDRÄ, Jörg, BRANDENBURG, Klaus, LOHNER, Karl

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Biophysical Characterization of Endotoxin Inactivation by NK-2, an Antimicrobial Peptide Derived from Mammalian NK-Lysin by Andrä, Jörg, Koch, Michel H J, Bartels, Rainer, Brandenburg, Klaus

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Online monitoring of metabolism and morphology of peptide-treated neuroblastoma cancer cells and keratinocytes by Drechsler, Sabine, Andrä, Jörg

“…Antimicrobial peptides are promising anti-cancer agents with a unique mode of action. We established the usage of a chip-based sensor to monitor the dynamic…”
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PharmCycle: a holistic approach to reduce the contamination of the aquatic environment with antibiotics by developing sustainable antibiotics, improving the environmental risk assessment of antibiotics, and reducing the discharges of antibiotics in the wastewater outlet by Andrä, Jörg, Beyer, Falk, Cornelissen, Gesine, Einfeldt, Jörn, Heseding, Jens, Kümmerer, Klaus, Oelkers, Kim, Floeter, Carolin

“…Background The overall aim of the interdisciplinary research project “PharmCycle” is to reduce the contamination of the aquatic environment with antibiotics by…”
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Comparative analysis of selected methods for the assessment of antimicrobial and membrane-permeabilizing activity: a case study for lactoferricin derived peptides by Sánchez-Gómez, Susana, Lamata, Marta, Leiva, José, Blondelle, Sylvie E, Jerala, Roman, Andrä, Jörg, Brandenburg, Klaus, Lohner, Karl, Moriyón, Ignacio, Martínez-de-Tejada, Guillermo

“…Growing concerns about bacterial resistance to antibiotics have prompted the development of alternative therapies like those based on cationic antimicrobial…”
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Surface Acoustic Wave Biosensor as a Tool to Study the Interaction of Antimicrobial Peptides with Phospholipid and Lipopolysaccharide Model Membranes by Andrä, Jörg, Böhling, Arne, Gronewold, Thomas M. A, Schlecht, Ulrich, Perpeet, Markus, Gutsmann, Thomas

“…Surface acoustic wave biosensors are a powerful tool for the study of biomolecular interactions. The modulation of a surface-confined acoustic wave is utilized…”
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Enhancement of endotoxin neutralization by coupling of a C12-alkyl chain to a lactoferricin-derived peptide by Andrä, Jörg, Lohner, Karl, Blondelle, Sylvie E, Jerala, Roman, Moriyon, Ignacio, Koch, Michel H J, Garidel, Patrick, Brandenburg, Klaus

“…Antibacterial peptide acylation, which mimics the structure of the natural lipopeptide polymyxin B, increases antimicrobial and endotoxin-neutralizing…”
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Divalent cations affect chain mobility and aggregate structure of lipopolysaccharide from Salmonella minnesota reflected in a decrease of its biological activity by Garidel, Patrick, Rappolt, Michael, Schromm, Andra B., Howe, Jörg, Lohner, Karl, Andrä, Jörg, Koch, Michel H.J., Brandenburg, Klaus

“…The physicochemical properties and biological activities of rough mutant lipopolysaccharides Re (LPS Re) as preformed divalent cation (Mg 2+, Ca 2+, Ba 2+)…”
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Interfacial properties and structural analysis of the antimicrobial peptide NK-2 by Olak, Claudia, Muenter, Annabel, Andrä, Jörg, Brezesinski, Gerald

“…The structure of the antimicrobial peptide NK‐2 has been studied at the air–water interface and in different solutions using spectroscopic methods such as…”
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Physicochemical properties of bacterial glycopolymers in relation to bioactivity by Brandenburg, Klaus, Andrä, Jörg, Müller, Mareike, Koch, Michel H.J, Garidel, Patrick

“…An overview is given on the physicochemical properties of bacterial glycopolymers, i.e., pure oligo- and polysaccharides as well as glycolipids. Data from…”
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Temperature Dependence of the Binding of Endotoxins to the Polycationic Peptides Polymyxin B and Its Nonapeptide by Brandenburg, Klaus, David, Alexander, Howe, Jörg, Koch, Michel H.J., Andrä, Jörg, Garidel, Patrick

“…The interaction between endotoxins—free lipid A and various lipopolysaccharide (LPS) chemotypes with different sugar chain lengths—and the polycationic…”
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Membrane lipid composition protects Entamoeba histolytica from self-destruction by its pore-forming toxins by Andrä, Jörg, Berninghausen, Otto, Leippe, Matthias

“…The protozoan parasite and human pathogen Entamoeba histolytica is protected against killing by its own lytic effector proteins. Amoebae withstand doses of…”
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Influence of N-acylation of a peptide derived from human lactoferricin on membrane selectivity by Zweytick, Dagmar, Pabst, Georg, Abuja, Peter M., Jilek, Alexander, Blondelle, Sylvie E., Andrä, Jörg, Jerala, Roman, Monreal, Daniel, Martinez de Tejada, Guillermo, Lohner, Karl

“…Increasing numbers of bacterial strains being resistant to conventional antibiotics emphasize the urgent need for new antimicrobial agents. One strategy is…”
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Cyclic antimicrobial peptides based on Limulus anti-lipopolysaccharide factor for neutralization of lipopolysaccharide by Andrä, Jörg, Lamata, Marta, Martinez de Tejada, Guillermo, Bartels, Rainer, Koch, Michel H.J., Brandenburg, Klaus

“…Bacterial endotoxin (lipopolysaccharide, LPS) is responsible for the septic shock syndrom. As potential therapeutic agents cyclic cationic antimicrobial…”
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