Search Results - "ANDERSEN, Mads H"

Reorienting the immune system in the treatment of cancer by using anti-PD-1 and anti-PD-L1 antibodies by Borch, Troels H., Donia, Marco, Andersen, Mads H., Svane, Inge M.

“…•We review PD-1 pathway blockade in the context of immunotherapy of cancer.•PD-1 and its ligands are excellent targets in anti-cancer therapy.•Anti-PD-1 and…”
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Case Report: First longitudinal study of a patient with CALR positive clonal hematopoiesis of indeterminate potential developing into pre-fibrotic myelofibrosis by Kjær, Lasse, Skov, Vibe, Larsen, Morten Kranker, Boklund, Tobias Idor, Andersen, Morten, Kefala, Maria, Knudsen, Trine A, Schjellerup Eickhardt-Dalbøge, Christina, Stiehl, Thomas, Gudmand-Høyer, Johanne, Snyder, Jordan, Holmström, Morten, Andersen, Mads H, Ottesen, Johnny T, Ellervik, Christina, Hasselbalch, Hans C

“…Initial diagnosis of overt myeloproliferative neoplasms (MPNs) represents the juncture during clonal evolution when symptoms or complications prompt an…”
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ABO blood types and sepsis mortality by Itenov, Theis S., Sessler, Daniel I., Khanna, Ashish K., Ostrowski, Sisse R., Johansson, Pär I., Erikstrup, Christian, Pedersen, Ole B., Rygård, Sofie L., Holst, Lars B., Bestle, Morten H., Hein, Lars, Lindhardt, Anne, Tousi, Hami, Andersen, Mads H., Mohr, Thomas, Lundgren, Jens D., Jensen, Jens-Ulrik

“…Background We aimed to determine if the ABO blood types carry different risks of 30-day mortality, acute kidney injury (AKI), and endothelial damage in…”
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Oncogenic cancer/testis antigens: prime candidates for immunotherapy by Gjerstorff, Morten F, Andersen, Mads H, Ditzel, Henrik J

“…Recent developments have set the stage for immunotherapy as a supplement to conventional cancer treatment. Consequently, a significant effort is required to…”
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Predicting recovery from acute kidney injury in critically ill patients: development and validation of a prediction model by Itenov, Theis S, Berthelsen, Rasmus Ehrenfried, Jensen, Jens-Ulrik, Gerds, Thomas A, Pedersen, Lars M, Strange, Ditte, Thormar, Katrin, Løken, Jesper, Andersen, Mads H, Tousi, Hamid, Reiter, Nanna, Lundgren, Jens D, Bestle, Morten H

“…Objective: Intensive care unit (ICU) patients with acute kidney injury (AKI) who recover kidney function within 28 days experience less severe chronic kidney…”
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642 TGFβ-based immune modulatory vaccines by Andersen, Mads H

“…BackgroundImmune modulatory vaccines (IMVs) are a novel therapeutic treatment modality that aims to activate anti-regulatory T cells (anti-Tregs).1 Anti-Tregs…”
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Procalcitonin-guided interventions against infections to increase early appropriate antibiotics and improve survival in the intensive care unit: A randomized trial by Jensen, Jens U, Hein, Lars, Lundgren, Bettina, Bestle, Morten H, Mohr, Thomas T, Andersen, Mads H, Thornberg, Klaus J, Løken, Jesper, Steensen, Morten, Fox, Zoe, Tousi, Hamid, Søe-Jensen, Peter, Lauritsen, Anne Ø, Strange, Ditte, Petersen, Pernille L, Reiter, Nanna, Hestad, Søren, Thormar, Katrin, Fjeldborg, Paul, Larsen, Kim M, Drenck, Niels E, Østergaard, Christian, Kjær, Jesper, Grarup, Jesper, Lundgren, Jens D

“…OBJECTIVE:For patients in intensive care units, sepsis is a common and potentially deadly complication and prompt initiation of appropriate antimicrobial…”
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Uncoupling CD4+ TIL-mediated tumor killing from JAK-signaling in melanoma by Draghi, Arianna, Presti, Mario, Jensen, Agnete W P, Chamberlain, Christopher A, Albieri, Benedetta, Rasmussen, Anne-Christine K, Andersen, Mads H, Crowther, Michael D, Svane, Inge Marie, Donia, Marco

“…Impaired MHCI-presentation and insensitivity to immune effector molecules are common features of immune checkpoint blockade(ICB)-resistant tumors and can be…”
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Calreticulin mutant myeloproliferative neoplasms induce MHC-I skewing, which can be overcome by an optimized peptide cancer vaccine by Gigoux, Mathieu, Holmström, Morten O, Zappasodi, Roberta, Park, Joseph J, Pourpe, Stephane, Bozkus, Cansu Cimen, Mangarin, Levi M B, Redmond, David, Verma, Svena, Schad, Sara, George, Mariam M, Venkatesh, Divya, Ghosh, Arnab, Hoyos, David, Molvi, Zaki, Kamaz, Baransel, Marneth, Anna E, Duke, William, Leventhal, Matthew J, Jan, Max, Ho, Vincent T, Hobbs, Gabriela S, Knudsen, Trine Alma, Skov, Vibe, Kjær, Lasse, Larsen, Thomas Stauffer, Hansen, Dennis Lund, Lindsley, R Coleman, Hasselbalch, Hans, Grauslund, Jacob H, Lisle, Thomas L, Met, Özcan, Wilkinson, Patrick, Greenbaum, Benjamin, Sepulveda, Manuel A, Chan, Timothy, Rampal, Raajit, Andersen, Mads H, Abdel-Wahab, Omar, Bhardwaj, Nina, Wolchok, Jedd D, Mullally, Ann, Merghoub, Taha

“…The majority of JAK2 -negative myeloproliferative neoplasms (MPNs) have disease-initiating frameshift mutations in calreticulin ( ), resulting in a common…”
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Low antigen dose formulated in CAF09 adjuvant Favours a cytotoxic T-cell response following intraperitoneal immunization in Göttingen minipigs by Overgaard, Nana H., Frøsig, Thomas M., Jakobsen, Jeanne T., Buus, Søren, Andersen, Mads H., Jungersen, Gregers

“…•The immune response following immunization is affected by antigen dose.•The antigen dose inversely correlates with the amount of cytokine-producing T cells.•A…”
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Identification and characterization of survivin-derived H-2Kb-restricted CTL epitopes by Hofmann, Uta B, Voigt, Heike, Andersen, Mads H, Straten, Per thor, Becker, Jürgen C, Eggert, Andreas O

“…Survivin is overexpressed in several malignancies and in tumor-associated endothelium making it an attractive target for therapeutic cytotoxic T-cell…”
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Profound endothelial damage predicts impending organ failure and death in sepsis by Johansen, Maria E, Johansson, Pär I, Ostrowski, Sisse R, Bestle, Morten H, Hein, Lars, Jensen, Anne L G, Søe-Jensen, Peter, Andersen, Mads H, Steensen, Morten, Mohr, Thomas, Thormar, Katrin, Lundgren, Bettina, Cozzi-Lepri, Alessandro, Lundgren, Jens D, Jensen, Jens-Ulrik

“…Endothelial damage contributes to organ failure and mortality in sepsis, but the extent of the contribution remains poorly quantified. Here, we examine the…”
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Invasive Candida Infections and the Harm From Antibacterial Drugs in Critically Ill Patients: Data From a Randomized, Controlled Trial to Determine the Role of Ciprofloxacin, Piperacillin-Tazobactam, Meropenem, and Cefuroxime by Jensen, Jens-Ulrik S, Hein, Lars, Lundgren, Bettina, Bestle, Morten H, Mohr, Thomas, Andersen, Mads H, Løken, Jesper, Tousi, Hamid, Søe-Jensen, Peter, Lauritsen, Anne Ø, Strange, Ditte, Petersen, John A, Thormar, Katrin, Larsen, Kim M, Drenck, Niels-Erik, Helweg-Larsen, Jannik, Johansen, Maria E, Reinholdt, Kristian, Møller, Jens K, Olesen, Bente, Arendrup, Maiken C, Østergaard, Christian, Cozzi-Lepri, Alessandro, Grarup, Jesper, Lundgren, Jens D

“…OBJECTIVE:Use of antibiotics in critically ill patients may increase the risk of invasive Candida infection. The objective of this study was to determine…”
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Methods to Improve Adoptive T-Cell Therapy for Melanoma: IFN-γ Enhances Anticancer Responses of Cell Products for Infusion by Donia, Marco, Hansen, Morten, Sendrup, Sarah L., Iversen, Trine Zeeberg, Ellebæk, Eva, Andersen, Mads H., Straten, Per thor, Svane, Inge Marie

“…Further development of adoptive T-cell therapy (ACT) with autologous tumor-infiltrating lymphocytes (TILs) has the potential to markedly change the long-term…”
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Survivin-specific T-cell reactivity correlates with tumor response and patient survival: a phase-II peptide vaccination trial in metastatic melanoma by Becker, Jürgen C., Andersen, Mads H., Hofmeister-Müller, Valeska, Wobser, Marion, Frey, Lidia, Sandig, Christiane, Walter, Steffen, Singh-Jasuja, Harpreet, Kämpgen, Eckhart, Opitz, Andreas, Zapatka, Marc, Bröcker, Eva-B., thor Straten, Per, Schrama, David, Ugurel, Selma

“…Background Therapeutic vaccination directed to induce an anti-tumoral T-cell response is a field of extensive investigation in the treatment of melanoma…”
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Complete remission of liver metastasis of pancreatic cancer under vaccination with a HLA-A2 restricted peptide derived from the universal tumor antigen survivin by WOBSER, Marion, KEIKAVOUSSI, Petra, KUNZMANN, Volker, WEININGER, Markus, ANDERSEN, Mads H, BECKER, Juergen C

“…As prognosis of advanced pancreatic cancer remains gloomy, novel therapeutic modalities have to be developed. Immunotherapy, which targets tumor-associated…”
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High frequencies of circulating memory T cells specific for calreticulin exon 9 mutations in healthy individuals by Holmström, Morten O., Ahmad, Shamaila M., Klausen, Uffe, Bendtsen, Simone K., Martinenaite, Evelina, Riley, Caroline H., Svane, Inge M., Kjær, Lasse, Skov, Vibe, Ellervik, Christina, Pallisgaard, Niels, Hasselbalch, Hans C., Andersen, Mads H.

“…Mutations in exon 9 of the calreticulin gene ( CALR ) frequently occur in patients with chronic myeloproliferative neoplasms (MPN). Patients exhibit…”
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Progression of JAK2-mutant polycythemia vera to CALR-mutant myelofibrosis severely impacts on disease phenotype and response to therapy by Holmström, Morten Orebo, Novotny, Guy W., Petersen, Jesper, Aaboe-Jørgensen, Mia, Hasselbalch, Hans Carl, Andersen, Mads H., Nielsen, Signe Ledou, Fassi, Daniel El, Schöllkopf, Claudia

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1335 Arginase-1 vaccine promotes T cell immunity against arginase-1+ cells, controls tumor growth via immune modulation of tumor microenvironment by Carretta, Marco, Chapellier, Marion, Lecoq, Ines, Patel, Preeyam, Sutanto-Ward, Erika, Shen, Shih-Chun, Jørgensen, Mia Aaboe, Martinenaite, Evelina, Muller, Alex J, Andersen, Mads H, Pedersen, Ayako

“…BackgroundArginase-1 (ARG1) is involved in various processes that allow tumor cells to evade immune responses within the tumor microenvironment (TME). Numerous…”
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918 Functional heterogeneity of CD4+ tumor-infiltrating lymphocytes by Draghi, Arianna, Chamberlain, Christopher A, Khan, Shawez, Harbst, Katja, Presti, Mario, Lauss, Martin, Crowther, Michael D, Jensen, Agnete WP, Rasmussen, Anne-Christine K, Albieri, Benedetta, Lorentzen, Torben, Andersen, Mads H, Jönsson, Göran, Svane, Inge, Donia, Marco

“…BackgroundImmunotherapy has demonstrated impressive results in numerous metastatic solid tumors. However, while most studies have focused on immune responses…”
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