Search Results - "AN, W. G"

A Novel Polarization Splitter Based on Dual-Core Photonic Crystal Fiber With a Liquid Crystal Modulation Core by Chen, H. L., Li, S. G., Fan, Z. K., An, G. W., Li, J. S., Han, Y.

“…A novel polarization splitter based on dual-core silica glass photonic crystal fiber with a liquid crystal modulation core is studied by the finite-element…”
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Effects of dietary levels of glycine, threonine and protein on threonine efficiency and threonine dehydrogenase activity in hepatic mitochondria of chicks by Lee, C W, Cho, I J, Lee, Y J, Son, Y S, Kwak, I, Ahn, Y T, Kim, S C, An, W G

“…This study was carried out to evaluate the relationship between threonine (Thr) efficiency and Thr dehydrogenase (TDG) activity as an indicator of Thr…”
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Nickel-induced transformation shifts the balance between HIF-1 and p53 transcription factors by Salnikow, Konstantin, An, Won G., Melillo, Giovanni, Blagosklonny, Mikhail V., Costa, Max

“…Nickel (Ni) compounds are potent carcinogens and can induce malignant transformation of rodent and human cells. In an attempt to unravel the molecular…”
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Geldanamycin-stimulated destabilization of mutated p53 is mediated by the proteasome in vivo by WHITESELL, L, SUTPHIN, P, AN, W. G, SCHULTE, T, BLAGOSKLONNY, M. V, NECKERS, L

“…Mutation of the tumor suppressor gene p53 is the most common genetic abnormality detected in human cancers. Wild type p53 is a short-lived protein with very…”
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Regulation of BRCA1 by protein degradation by BLAGOSKLONNY, M. V, AN, W. G, MELILLO, G, NGUYEN, P, TREPEL, J. B, NECKERS, L. M

“…BRCA1, a tumor suppressor protein implicated in hereditary forms of breast and ovarian cancer, is transcriptionally regulated in a proliferation-dependent…”
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Protease inhibitor-induced apoptosis : accumulation of wt p53, p21WAF1/CIP1, and induction of apoptosis are independent markers of proteasome inhibition by AN, W. G, HWANG, S.-G, TREPEL, J. B, BLAGOSKLONNY, M. V

“…Inhibitors of proteases are currently emerging as a potential anti-cancer modality. Nonselective protease inhibitors are cytotoxic to leukemia and cancer cell…”
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p53 Inhibits Hypoxia-inducible Factor-stimulated Transcription by Blagosklonny, Mikhail V., An, Won G., Romanova, Larisa Y., Trepel, Jane, Fojo, Tito, Neckers, Len

“…p53 is required for hypoxia-induced apoptosisin vivo, although the mechanism by which this occurs is not known. Conversely, induction of the hypoxia-inducible…”
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Geldanamycin-Induced Destabilization of Raf-1 Involves the Proteasome by Schulte, Theodor W., An, Won G., Neckers, Leonard M.

“…The Raf-1-MEK-MAPK pathway plays an important role in transducing extracellular growth factor signaling into altered nuclear transcription factor function. The…”
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Novel oxime derivatives of radicicol induce erythroid differentiation associated with preferential G(1) phase accumulation against chronic myelogenous leukemia cells through destabilization of Bcr-Abl with Hsp90 complex by Shiotsu, Y, Neckers, L M, Wortman, I, An, W G, Schulte, T W, Soga, S, Murakata, C, Tamaoki, T, Akinaga, S

“…Chronic myelogenous leukemia (CML) is a clonal disorder of a pluripotent hematopoietic stem cells characterized by a chimeric bcr-abl gene giving rise to a…”
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Geldanamycin abrogates ErbB2 association with proteasome-resistant β-catenin in melanoma cells, increases β-catenin-e-cadherin association, and decreases β-catenin-sensitive transcription by BONVINI, Paolo, AN, Won G, ROSOLEN, Angelo, NGUYEN, Phongmai, TREPEL, Jane, GARCIA DE HERREROS, Antonio, DUNACH, Mireia, NECKERS, Leonard M

“…Beta-catenin undergoes both serine and tyrosine phosphorylation. Serine phosphorylation in the amino terminus targets beta-catenin for proteasome degradation,…”
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Stabilization of wild-type p53 by hypoxia-inducible factor 1α by Neckers, Leonard M, An, Won G, Kanekal, Meera, Simon, M. Celeste, Maltepe, Emin, Blagosklonny, Mikhail V

“…Although hypoxia (lack of oxygen in body tissues) is perhaps the most physiological inducer of the wild-type p53 gene, the mechanism of this induction is…”
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Nuclear localization of β-catenin is an important prognostic factor in hepatoblastoma by Sang Park, Won, Ra Oh, Ro, Young Park, Jik, Joon Kim, Pum, Sun Shin, Min, Heun Lee, Jong, Sug Kim, Hong, Hyung Lee, Sug, Young Kim, Su, Gyu Park, Yong, Gun An, Won, Seung Kim, Han, June Jang, Ja, Jin Yoo, Nam, Young Lee, Jung

“…In this study, mutational and immunohistochemical analyses of β‐catenin were performed in 30 hepatoblastomas, to assess the prevalence of alterations of the…”
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Phosphorylation of NF-κB by calmodulin-dependent kinase IV activates anti-apoptotic gene expression by Soon Bae, Jeum, Kyoo Jang, Moon, Hong, SunHwa, An, Won Gun, Choi, Yung Hyun, Kim, Han Do, Cheong, JaeHun

“…We previously presented that calmodulin-dependent kinase IV (CaMKIV) mutually interacts with NF-κB and phosphorylates it directly, inducing the increased…”
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Inhibitors of Transcription, Proteasome Inhibitors, and DNA-Damaging Drugs Differentially Affect Feedback of p53 Degradation by An, Won G., Chuman, Yutaka, Fojo, Tito, Blagosklonny, Mikhail V.

“…Mutations of the p53 gene are the most common abnormalities in human cancer. In contrast to mutant p53, wild-type (wt) p53 protein is present at low levels due…”
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Mapping of a new target region of allelic loss at 21q22 in primary gastric cancers by Park, Won Sang, Oh, Ro Ra, Park, Jik Young, Yoo, Nam Jin, Lee, Sug Hyung, Shin, Min Sun, Kim, Su Young, Kim, Young Sil, Lee, Jong Heun, Kim, Hong Sug, An, Won Gun, Lee, Jung Young

“…To determine the minimal region of deletion on 21q22 in gastric cancer, we performed a high-density loss of heterozygosity (LOH) study with eight polymorphic…”
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Hypoxia-Inducible Factor-1 (HIF-1) Up-Regulates Adrenomedullin Expression in Human Tumor Cell Lines during Oxygen Deprivation: A Possible Promotion Mechanism of Carcinogenesis by Garayoa, Mercedes, Martínez, Alfredo, Lee, Sunmin, Pío, Rubén, An, Won G, Neckers, Len, Trepel, Jane, Montuenga, Luis M, Ryan, Heather, Johnson, Randall, Gassmann, Max, Cuttitta, Frank

“…Little is known about the molecular mechanisms that control adrenomedullin (AM) production in human cancers. We demonstrate here that the expression of AM mRNA…”
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Novel oxime derivatives of radicicol induce erythroid differentiation associated with preferential G1 phase accumulation against chronic myelogenous leukemia cells through destabilization of Bcr-Abl with Hsp90 complex by Shiotsu, Yukimasa, Neckers, Leonard M., Wortman, Ivo, An, Won G., Schulte, Theodor W., Soga, Shiro, Murakata, Chikara, Tamaoki, Tatsuya, Akinaga, Shiro

“…Chronic myelogenous leukemia (CML) is a clonal disorder of a pluripotent hematopoietic stem cells characterized by a chimericbcr-abl gene giving rise to a…”
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Depletion of p185erbB2, Raf-1 and mutant p53 proteins by geldanamycin derivatives correlates with antiproliferative activity by AN, W. G, SCHNUR, R. C, NECKERS, L, BLAGOSKLONNY, M. V

“…Recently, it has been shown that geldanamycin (GA), a benzoquinone ansamycin, is able to deplete mutant p53, p185erbB2 and Raf-1 proteins in cancer cells…”
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A model study of artificial linker system using self-assembled calix[4]arene derivative monolayers for protein immobilization by Lee, Minsu, An, Won Gun, Kim, Jae-Ho, Choi, Heung-Jin, Kim, Sung-Hoon, Han, Moon-Hi, Koh, Kwangnak

“…The attachment of biomolecules, in particular proteins, onto solid supports is fundamental in the development of advanced biosensors, biochips, bioreactors,…”
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Activation of non-canonical NF-κB pathway mediated by STP-A11, an oncoprotein of Herpesvirus saimiri by Cho, Il-Rae, Jeong, Sunam, Jhun, Byung Hak, An, Won G, Lee, BokSoo, Kwak, Youn-Tae, Lee, Sun-Hwa, Jung, Jae U, Chung, Young-Hwa

“…Abstract Although Saimiri Transforming Protein (STP)-A11, an oncoprotein of Herpesvirus saimiri , has been known to activate NF-κB signaling pathway, the…”
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