Search Results - "AMROLIA, Persis J"

Impact of thymoglobulin prior to pediatric unrelated umbilical cord blood transplantation on immune reconstitution and clinical outcome by Lindemans, Caroline A., Chiesa, Robert, Amrolia, Persis J., Rao, Kanchan, Nikolajeva, Olga, de Wildt, Arianne, Gerhardt, Corinne E., Gilmour, Kimberly C., B. Bierings, Marc, Veys, Paul, Boelens, Jaap J.

“…In vivo T-cell depletion might contribute to the delayed immune reconstitution observed after unrelated umbilical cord blood transplantation (UCBT). We studied…”
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Proposed Therapeutic Range of Treosulfan in Reduced Toxicity Pediatric Allogeneic Hematopoietic Stem Cell Transplant Conditioning: Results From a Prospective Trial by Chiesa, Robert, Standing, Joseph F., Winter, Robert, Nademi, Zohreh, Chu, Jan, Pinner, Danielle, Kloprogge, Frank, McLellen, Susan, Amrolia, Persis J., Rao, Kanchan, Lucchini, Giovanna, Silva, Juliana, Ciocarlie, Oana, Lazareva, Arina, Gennery, Andrew R., Doncheva, Bilyana, Cant, Andrew J., Hambleton, Sophie, Flood, Terence, Rogerson, Elizabeth, Devine, Kirsty, Prunty, Helen, Heales, Simon, Veys, Paul, Slatter, Mary

“…Treosulfan is given off‐label in pediatric allogeneic hematopoietic stem cell transplant. This study investigated treosulfan's pharmacokinetics (PKs),…”
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How I treat severe combined immunodeficiency by Gaspar, H. Bobby, Qasim, Waseem, Davies, E. Graham, Rao, Kanchan, Amrolia, Persis J., Veys, Paul

“…Severe combined immunodeficiency (SCID) arises from different genetic defects associated with lymphocyte development and function and presents with severe…”
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Allogeneic hematopoietic cell transplantation for XIAP deficiency: an international survey reveals poor outcomes by Marsh, Rebecca A., Rao, Kanchan, Satwani, Prakash, Lehmberg, Kai, Müller, Ingo, Li, Dandan, Kim, Mi-Ok, Fischer, Alain, Latour, Sylvain, Sedlacek, Petr, Barlogis, Vincent, Hamamoto, Kazuko, Kanegane, Hirokazu, Milanovich, Sam, Margolis, David A., Dimmock, David, Casper, James, Douglas, Dorothea N., Amrolia, Persis J., Veys, Paul, Kumar, Ashish R., Jordan, Michael B., Bleesing, Jack J., Filipovich, Alexandra H.

“…There have been no studies on patient outcome after allogeneic hematopoietic cell transplantation (HCT) in patients with X-linked inhibitor of apoptosis (XIAP)…”
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Epstein–Barr virus (EBV) deletions as biomarkers of response to treatment of chronic active EBV by Venturini, Cristina, Houldcroft, Charlotte J., Lazareva, Arina, Wegner, Fanny, Morfopoulou, Sofia, Amrolia, Persis J., Golwala, Zainab, Rao, Anupama, Marks, Stephen D., Simmonds, Jacob, Yoshikawa, Tetsushi, Farrell, Paul J., Cohen, Jeffrey I., Worth, Austen J., Breuer, Judith

“…Summary Chronic active Epstein–Barr virus (CAEBV) disease is a rare condition characterised by persistent EBV infection in previously healthy individuals…”
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Epstein-Barr Virus Reactivation After Paediatric Haematopoietic Stem Cell Transplantation: Risk Factors and Sensitivity Analysis of Mathematical Model by Kania, Soumya P, Silva, Juliana M F, Charles, Oscar J, Booth, John, Cheung, S Y Amy, Yates, James W T, Worth, Austen, Breuer, Judith, Klein, Nigel, Amrolia, Persis J, Veys, Paul, Standing, Joseph F

“…Epstein-Barr virus (EBV) establishes a lifelong latent infection in healthy humans, kept under immune control by cytotoxic T cells (CTLs). Following paediatric…”
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Cord blood transplantation recapitulates fetal ontogeny with a distinct molecular signature that supports CD4+ T-cell reconstitution by Hiwarkar, Prashant, Hubank, Mike, Qasim, Waseem, Chiesa, Robert, Gilmour, Kimberly C., Saudemont, Aurore, Amrolia, Persis J., Veys, Paul

“…Omission of in vivo T-cell depletion promotes rapid, thymic-independent CD4+-biased T-cell recovery after cord blood transplant. This enhanced T-cell…”
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High-dimensional functional phenotyping of preclinical human CAR T cells using mass cytometry by Michelozzi, Ilaria M., Sufi, Jahangir, Adejumo, Thomas A., Amrolia, Persis J., Tape, Christopher J., Giustacchini, Alice

“…Here, we present a comprehensive protocol for the generation and functional characterization of chimeric antigen receptor (CAR) T cells and their products by…”
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Allogeneic hematopoietic stem cell transplantation for severe, refractory juvenile idiopathic arthritis by M. F. Silva, Juliana, Ladomenou, Fani, Carpenter, Ben, Chandra, Sharat, Sedlacek, Petr, Formankova, Renata, Grandage, Vicky, Friswell, Mark, Cant, Andrew J., Nademi, Zohreh, Slatter, Mary A., Gennery, Andrew R., Hambleton, Sophie, Flood, Terence J., Lucchini, Giovanna, Chiesa, Robert, Rao, Kanchan, Amrolia, Persis J., Brogan, Paul, Wedderburn, Lucy R., Glanville, Julie M., Hough, Rachael, Marsh, Rebecca, Abinun, Mario, Veys, Paul

“…Patients with juvenile idiopathic arthritis (JIA) can experience a severe disease course, with progressive destructive polyarthritis refractory to conventional…”
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Enhanced CAR T cell expansion and prolonged persistence in pediatric patients with ALL treated with a low-affinity CD19 CAR by Ghorashian, Sara, Kramer, Anne Marijn, Onuoha, Shimobi, Wright, Gary, Bartram, Jack, Richardson, Rachel, Albon, Sarah J., Casanovas-Company, Joan, Castro, Fernanda, Popova, Bilyana, Villanueva, Krystle, Yeung, Jenny, Vetharoy, Winston, Guvenel, Aleks, Wawrzyniecka, Patrycja A., Mekkaoui, Leila, Cheung, Gordon Weng-Kit, Pinner, Danielle, Chu, Jan, Lucchini, Giovanna, Silva, Juliana, Ciocarlie, Oana, Lazareva, Arina, Inglott, Sarah, Gilmour, Kimberly C., Ahsan, Gulrukh, Ferrari, Mathieu, Manzoor, Somayya, Champion, Kim, Brooks, Tony, Lopes, Andre, Hackshaw, Allan, Farzaneh, Farzin, Chiesa, Robert, Rao, Kanchan, Bonney, Denise, Samarasinghe, Sujith, Goulden, Nicholas, Vora, Ajay, Veys, Paul, Hough, Rachael, Wynn, Robert, Pule, Martin A., Amrolia, Persis J.

“…Chimeric antigen receptor (CAR)-modified T cells targeting CD19 demonstrate unparalleled responses in relapsed/refractory acute lymphoblastic leukemia (ALL) 1…”
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Betibeglogene Autotemcel Gene Therapy for Non–β0/β0 Genotype β-Thalassemia by Locatelli, Franco, Thompson, Alexis A, Kwiatkowski, Janet L, Porter, John B, Thrasher, Adrian J, Hongeng, Suradej, Sauer, Martin G, Thuret, Isabelle, Lal, Ashutosh, Algeri, Mattia, Schneiderman, Jennifer, Olson, Timothy S, Carpenter, Ben, Amrolia, Persis J, Anurathapan, Usanarat, Schambach, Axel, Chabannon, Christian, Schmidt, Manfred, Labik, Ivan, Elliot, Heidi, Guo, Ruiting, Asmal, Mohammed, Colvin, Richard A, Walters, Mark C

“…Of 23 patients with transfusion-dependent β-thalassemia who received gene-transfected autologous hematopoietic cells, 91% became transfusion independent; the…”
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CAR T cells with dual targeting of CD19 and CD22 in pediatric and young adult patients with relapsed or refractory B cell acute lymphoblastic leukemia: a phase 1 trial by Cordoba, Shaun, Onuoha, Shimobi, Thomas, Simon, Pignataro, Daniela Soriano, Hough, Rachael, Ghorashian, Sara, Vora, Ajay, Bonney, Denise, Veys, Paul, Rao, Kanchan, Lucchini, Giovanna, Chiesa, Robert, Chu, Jan, Clark, Liz, Fung, Mei Mei, Smith, Koval, Peticone, Carlotta, Al-Hajj, Muhammad, Baldan, Vania, Ferrari, Mathieu, Srivastava, Saket, Jha, Ram, Arce Vargas, Frederick, Duffy, Kevin, Day, William, Virgo, Paul, Wheeler, Lucy, Hancock, Jeremy, Farzaneh, Farzin, Domning, Sabine, Zhang, Yiyun, Khokhar, Nushmia Z., Peddareddigari, Vijay G. R., Wynn, Robert, Pule, Martin, Amrolia, Persis J.

“…Chimeric antigen receptor (CAR) T cells targeting CD19 or CD22 have shown remarkable activity in B cell acute lymphoblastic leukemia (B-ALL). The major cause…”
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Transcriptional signatures associated with persisting CD19 CAR-T cells in children with leukemia by Anderson, Nathaniel D., Birch, Jack, Accogli, Theo, Criado, Ignacio, Khabirova, Eleonora, Parks, Conor, Wood, Yvette, Young, Matthew D., Porter, Tarryn, Richardson, Rachel, Albon, Sarah J., Popova, Bilyana, Lopes, Andre, Wynn, Robert, Hough, Rachael, Gohil, Satyen H., Pule, Martin, Amrolia, Persis J., Behjati, Sam, Ghorashian, Sara

“…In the context of relapsed and refractory childhood pre-B cell acute lymphoblastic leukemia (R/R B-ALL), CD19-targeting chimeric antigen receptor (CAR)-T cells…”
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Chimeric antigen receptor T cells for ALL by Amrolia, Persis J, Pule, Martin

“…In adult patients, relapse is more frequent and often unsalvageable. Since such patients have often had the maximum tolerable dose of chemotherapy and…”
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Long-term outcome of EBV-specific T-cell infusions to prevent or treat EBV-related lymphoproliferative disease in transplant recipients by Heslop, Helen E., Slobod, Karen S., Pule, Martin A., Hale, Gregory A., Rousseau, Alexandra, Smith, Colton A., Bollard, Catherine M., Liu, Hao, Wu, Meng-Fen, Rochester, Richard J., Amrolia, Persis J., Hurwitz, Julia L., Brenner, Malcolm K., Rooney, Cliona M.

“…T-cell immunotherapy that takes advantage of Epstein-Barr virus (EBV)–stimulated immunity has the potential to fill an important niche in targeted therapy for…”
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Practice guideline: Preparation for CAR T‐cell therapy in children and young adults with B‐acute lymphoblastic leukaemia by Mishra, Avijeet Kumar, Burridge, Saskia, Espuelas, Macarena Oporto, O'Reilly, Maeve, Cummins, Michelle, Nicholson, Emma, Wheldon, Sophie, Bonney, Denise, Shenton, Geoff, Marks, David I., Amrolia, Persis J., Hough, Rachael, Ghorashian, Sara

“…Summary The objective of this guideline, prepared by the ALL subgroup of the Advanced Cell Therapy Sub‐Committee of BSBMTCT (British Society of Blood and…”
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Similar outcome of upfront‐unrelated and matched sibling stem cell transplantation in idiopathic paediatric aplastic anaemia. A study on behalf of the UK Paediatric BMT Working Party, Paediatric Diseases Working Party and Severe Aplastic Anaemia Working Party of EBMT by Dufour, Carlo, Veys, Paul, Carraro, Elisa, Bhatnagar, Neha, Pillon, Marta, Wynn, Rob, Gibson, Brenda, Vora, Ajay J., Steward, Colin G., Ewins, Anna M., Hough, Rachael E., Fuente, Josu, Velangi, Mark, Amrolia, Persis J., Skinner, Roderick, Bacigalupo, Andrea, Risitano, Antonio M., Socie, Gerard, Peffault de Latour, Regis, Passweg, Jakob, Rovo, Alicia, Tichelli, André, Schrezenmeier, Hubert, Hochsmann, Britta, Bader, Peter, Biezen, Anja, Aljurf, Mahmoud D., Kulasekararaj, Austin, Marsh, Judith C., Samarasinghe, Sujith

“…Summary We explored the feasibility of unrelated donor haematopoietic stem cell transplant (HSCT) upfront without prior immunosuppressive therapy (IST) in…”
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Clonal expansion of T memory stem cells determines early anti-leukemic responses and long-term CAR T cell persistence in patients by Biasco, Luca, Izotova, Natalia, Rivat, Christine, Ghorashian, Sara, Richardson, Rachel, Guvenel, Aleks, Hough, Rachael, Wynn, Robert, Popova, Bilyana, Lopes, Andre, Pule, Martin, Thrasher, Adrian J, Amrolia, Persis J

“…Low-affinity CD19 chimeric antigen receptor (CAR) T cells display enhanced expansion and persistence, enabling fate tracking through integration site analysis…”
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Towards gene therapy for EBV-associated posttransplant lymphoma with genetically modified EBV-specific cytotoxic T cells by Ricciardelli, Ida, Blundell, Michael Patrick, Brewin, Jennifer, Thrasher, Adrian, Pule, Martin, Amrolia, Persis J.

“…Epstein-Barr virus (EBV)-associated posttransplant lymphoma (PTLD) is a major cause of morbidity/mortality after hematopoietic stem cell (SCT) or solid organ…”
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CD19/CD22 targeting with cotransduced CAR T cells to prevent antigen-negative relapse after CAR T-cell therapy for B-cell ALL by Ghorashian, Sara, Lucchini, Giovanna, Richardson, Rachel, Nguyen, Kyvi, Terris, Craig, Guvenel, Aleks, Oporto-Espuelas, Macarena, Yeung, Jenny, Pinner, Danielle, Chu, Jan, Williams, Lindsey, Ko, Ka-Yuk, Walding, Chloe, Watts, Kelly, Inglott, Sarah, Thomas, Rebecca, Connor, Christopher, Adams, Stuart, Gravett, Emma, Gilmour, Kimberly, Lal, Alka, Kunaseelan, Sangeetha, Popova, Bilyana, Lopes, Andre, Ngai, Yenting, Hackshaw, Allan, Kokalaki, Evangelia, Carulla, Milena Balasch, Mullanfiroze, Khushnuma, Lazareva, Arina, Pavasovic, Vesna, Rao, Anupama, Bartram, Jack, Vora, Ajay, Chiesa, Robert, Silva, Juliana, Rao, Kanchan, Bonney, Denise, Wynn, Robert, Pule, Martin, Hough, Rachael, Amrolia, Persis J

“…CD19-negative relapse is a leading cause of treatment failure after chimeric antigen receptor (CAR) T-cell therapy for acute lymphoblastic leukemia. We…”
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