Search Results - "AMMATUNA, Emanuele"

Stepwise discriminant function analysis for rapid identification of acute promyelocytic leukemia: should this be the first choice to establish the diagnosis of APL? by Ammatuna, Emanuele

“…Issue Title: Including PIH Articles on Current Gene therapy for hematological disorders…”
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Cancer cell-expressed SLAMF7 is not required for CD47-mediated phagocytosis by He, Yuan, Bouwstra, Renee, Wiersma, Valerie R., de Jong, Mathilde, Jan Lourens, Harm, Fehrmann, Rudolf, de Bruyn, Marco, Ammatuna, Emanuele, Huls, Gerwin, van Meerten, Tom, Bremer, Edwin

“…CD47 is a prominent new target in cancer immunotherapy, with antagonistic antibodies currently being evaluated in clinical trials. For effective evaluation of…”
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Clinical characteristics and outcome of SARS-CoV-2-infected patients with haematological diseases: a retrospective case study in four hospitals in Italy, Spain and the Netherlands by van Doesum, Jaap, Chinea, Anabelle, Pagliaro, Maria, Pasquini, Maria Cristina, van Meerten, Tom, Bakker, Martijn, Ammatuna, Emanuele

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Bone marrow necrosis as complication of treatment with all-trans retinoic acid and arsenic trioxide: case report and implications for treatment by Hazenberg, Carin L. E., Diepstra, Arjan, Santing, Michiel, Huls, Gerwin A., Ammatuna, Emanuele

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Epigenetic Silencing of the Myelopoiesis Regulator microRNA-223 by the AML1/ETO Oncoprotein by Fazi, Francesco, Racanicchi, Serena, Zardo, Giuseppe, Starnes, Linda M., Mancini, Marco, Travaglini, Lorena, Diverio, Daniela, Ammatuna, Emanuele, Cimino, Giuseppe, Lo-Coco, Francesco, Grignani, Francesco, Nervi, Clara

“…Hematopoietic transcription factors are involved in chromosomal translocations, which generate fusion proteins contributing to leukemia pathogenesis. Analysis…”
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Editorial: Metabolic Rewiring in Leukemias by Noguera, Nelida I., Hasan, Syed K., Ammatuna, Emanuele, Venditti, Adriano

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Passive pre-exposure immunization by tixagevimab/cilgavimab in patients with hematological malignancy and COVID-19: matched-paired analysis in the EPICOVIDEHA registry by Marchesi, Francesco, Salmanton-García, Jon, Buquicchio, Caterina, Itri, Federico, Besson, Caroline, Dávila-Valls, Julio, Martín-Pérez, Sonia, Fianchi, Luana, Rahimli, Laman, Tarantini, Giuseppe, Grifoni, Federica Irene, Sciume, Mariarita, Labrador, Jorge, Cordoba, Raul, López-García, Alberto, Fracchiolla, Nicola S, Farina, Francesca, Ammatuna, Emanuele, Cingolani, Antonella, García-Bordallo, Daniel, Gräfe, Stefanie K, Bilgin, Yavuz M, Dargenio, Michelina, González-López, Tomás José, Guidetti, Anna, Lahmer, Tobias, Lavilla-Rubira, Esperanza, Méndez, Gustavo-Adolfo, Prezioso, Lucia, Schönlein, Martin, Van Doesum, Jaap, Wolf, Dominik, Hersby, Ditte Stampe, Magyari, Ferenc, Van Praet, Jens, Petzer, Verena, Tascini, Carlo, Falces-Romero, Iker, Glenthøj, Andreas, Cornely, Oliver A, Pagano, Livio

“…Only few studies have analyzed the efficacy of tixagevimab/cilgavimab to prevent severe Coronavirus disease 2019 (COVID-19) and related complications in…”
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CD20-selective inhibition of CD47-SIRPα "don't eat me" signaling with a bispecific antibody-derivative enhances the anticancer activity of daratumumab, alemtuzumab and obinutuzumab by van Bommel, Peter E, He, Yuan, Schepel, Ilona, Hendriks, Mark A J M, Wiersma, Valerie R, van Ginkel, Robert J, van Meerten, Tom, Ammatuna, Emanuele, Huls, Gerwin, Samplonius, Douwe F, Helfrich, Wijnand, Bremer, Edwin

“…Here, we report on a novel bispecific antibody-derivative, designated RTX-CD47, with unique capacity for CD20-directed inhibition of CD47-SIRPα "don't eat me"…”
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Characteristics and clinical correlates of MPL 515W>L/K mutation in essential thrombocythemia by Vannucchi, Alessandro M., Antonioli, Elisabetta, Guglielmelli, Paola, Pancrazzi, Alessandro, Guerini, Vittoria, Barosi, Giovanni, Ruggeri, Marco, Specchia, Giorgina, Lo-Coco, Francesco, Delaini, Federica, Villani, Laura, Finotto, Silvia, Ammatuna, Emanuele, Alterini, Renato, Carrai, Valentina, Capaccioli, Gloria, Lollo, Simonetta Di, Liso, Vincenzo, Rambaldi, Alessandro, Bosi, Alberto, Barbui, Tiziano

“…Among 994 patients with essential thrombocythemia (ET) who were genotyped for the MPLW515L/K mutation, 30 patients carrying the mutation were identified…”
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Identification of relevant drugable targets in diffuse large B-cell lymphoma using a genome-wide unbiased CD20 guilt-by association approach by de Jong, Mathilde R W, Visser, Lydia, Huls, Gerwin, Diepstra, Arjan, van Vugt, Marcel, Ammatuna, Emanuele, van Rijn, Rozemarijn S, Vellenga, Edo, van den Berg, Anke, Fehrmann, Rudolf S N, van Meerten, Tom

“…Forty percent of patients with diffuse large B-cell lymphoma (DLBCL) show resistant disease to standard chemotherapy (CHOP) in combination with the anti-CD20…”
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Toward Optimization of Postremission Therapy for Residual Disease–Positive Patients With Acute Myeloid Leukemia by MAURILLO, Luca, BUCCISANO, Francesco, VENDITTI, Daniela, QUARESIMA, Micol, CERRETTI, Raffaella, RIZZO, Manuela, DE FABRITIIS, Paolo, LO COCO, Francesco, ARCESE, William, AMADORI, Sergio, VENDITTI, Adriano, ILARIA DEL PRINCIPE, Maria, DEL POETA, Giovanni, SPAGNOLI, Alessandra, PANETTA, Paola, AMMATUNA, Emanuele, NERI, Benedetta, OTTAVIANI, Licia, SARLO, Chiara

“…Despite the identification of several baseline prognostic indicators, the outcome of patients with acute myeloid leukemia (AML) is generally heterogeneous. The…”
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VISTA drives macrophages towards a pro-tumoral phenotype that promotes cancer cell phagocytosis yet down-regulates T cell responses by Lin, Yusheng, Choukrani, Ghizlane, Dubbel, Lena, Rockstein, Lena, Freile, Jimena Alvarez, Qi, Yuzhu, Wiersma, Valerie, Zhang, Hao, Koch, Karl-Wilhelm, Ammatuna, Emanuele, Schuringa, Jan Jacob, van Meerten, Tom, Huls, Gerwin, Bremer, Edwin

“…VISTA is a well-known immune checkpoint in T cell biology, but its role in innate immunity is less established. Here, we investigated the role of VISTA on…”
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The biology of acute promyelocytic leukemia and its impact on diagnosis and treatment by Lo-Coco, Francesco, Ammatuna, Emanuele

“…Several genetic and phenotypic characteristics of acute promyelocytic leukemia (APL) blasts provide relevant targets and the rationale for tailored treatment…”
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Improved Clinical Outcome of COVID‐19 in Hematologic Malignancy Patients Receiving a Fourth Dose of Anti‐SARS‐CoV‐2 Vaccine: An EPICOVIDEHA Report by Salmanton‐García, Jon, Marchesi, Francesco, Glenthøj, Andreas, Bilgin, Yavuz M., Praet, Jens, Dávila‐Valls, Julio, Martín‐Pérez, Sonia, Labrador, Jorge, Doesum, Jaap, Falces‐Romero, Iker, Farina, Francesca, Schönlein, Martin, Chanut, Mathilde, Petzer, Verena, Espigado, Ildefonso, Dargenio, Michelina, Aujayeb, Avinash, Sili, Uluhan, Serrano, Laura, Pinczés, László Imre, Jonge, Nick, Soto‐Silva, Andrés, Buquicchio, Caterina, Prezioso, Lucia, Marchetti, Monia, Meers, Stef, Busca, Alessandro, Corradini, Paolo, Hoenigl, Martin, Koehler, Philipp, Rahimli, Laman, Çolak, Gökçe Melis, Arellano, Elena, Wolf, Dominik, Gräfe, Stefanie, Ammatuna, Emanuele, Berg Venemyr, Caroline, Cornely, Oliver A., Pagano, Livio

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The PIP4K2 inhibitor THZ-P1-2 exhibits antileukemia activity by disruption of mitochondrial homeostasis and autophagy by Lima, Keli, Pereira-Martins, Diego Antonio, de Miranda, Lívia Bassani Lins, Coelho-Silva, Juan Luiz, Leandro, Giovana da Silva, Weinhäuser, Isabel, Cavaglieri, Rita de Cássia, Leal, Aline de Medeiros, da Silva, Wellington Fernandes, Lange, Ana Paula Alencar de Lima, Velloso, Elvira Deolinda Rodrigues Pereira, Griessinger, Emmanuel, Hilberink, Jacobien R., Ammatuna, Emanuele, Huls, Gerwin, Schuringa, Jan Jacob, Rego, Eduardo Magalhães, Machado-Neto, João Agostinho

“…The treatment of acute leukemia is challenging because of the genetic heterogeneity between and within patients. Leukemic stem cells (LSCs) are relatively…”
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Identification of the estrogen receptor beta as a possible new tamoxifen-sensitive target in diffuse large B-cell lymphoma by Langendonk, Myra, de Jong, Mathilde R. W., Smit, Nienke, Seiler, Jonas, Reitsma, Bart, Ammatuna, Emanuele, Glaudemans, Andor W. J. M., van den Berg, Anke, Huls, Gerwin A., Visser, Lydia, van Meerten, Tom

“…Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma subtype. Despite the proven efficacy of combined immunochemotherapy (R-CHOP) in the majority…”
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WEE1 inhibition synergizes with CHOP chemotherapy and radiation therapy through induction of premature mitotic entry and DNA damage in diffuse large B-cell lymphoma by de Jong, Mathilde R. W., Langendonk, Myra, Reitsma, Bart, Herbers, Pien, Lodewijk, Monique, Nijland, Marcel, van den Berg, Anke, Ammatuna, Emanuele, Visser, Lydia, van Meerten, Tom

“…Background: Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease, characterized by high levels of genomic instability and the activation of DNA…”
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Galectin-9 Triggers Neutrophil-Mediated Anticancer Immunity by Ustyanovska Avtenyuk, Natasha, Choukrani, Ghizlane, Ammatuna, Emanuele, Niki, Toshiro, Cendrowicz, Ewa, Lourens, Harm Jan, Huls, Gerwin, Wiersma, Valerie R, Bremer, Edwin

“…In earlier studies, galectin-9 (Gal-9) was identified as a multifaceted player in both adaptive and innate immunity. Further, Gal-9 had direct cytotoxic and…”
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Galectin-9 has non-apoptotic cytotoxic activity toward acute myeloid leukemia independent of cytarabine resistance by Choukrani, Ghizlane, Visser, Nienke, Ustyanovska Avtenyuk, Natasha, Olthuis, Mirjam, Marsman, Glenn, Ammatuna, Emanuele, Lourens, Harm Jan, Niki, Toshiro, Huls, Gerwin, Bremer, Edwin, Wiersma, Valerie R.

“…Acute myeloid leukemia (AML) is a malignancy still associated with poor survival rates, among others, due to frequent occurrence of therapy-resistant relapse…”
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Age and sex associate with outcome in older AML and high risk MDS patients treated with 10-day decitabine by Hilberink, Jacobien R., van Zeventer, Isabelle A., Chitu, Dana A., Pabst, Thomas, Klein, Saskia K., Stussi, Georg, Griskevicius, Laimonas, Valk, Peter J. M., Cloos, Jacqueline, van de Loosdrecht, Arjan A., Breems, Dimitri, van Lammeren-Venema, Danielle, Boersma, Rinske, Jongen-Lavrencic, Mojca, Fehr, Martin, Hoogendoorn, Mels, Manz, Markus G., Söhne, Maaike, van Marwijk Kooy, Rien, Deeren, Dries, van der Poel, Marjolein W. M., Legdeur, Marie Cecile, Tick, Lidwine, Chalandon, Yves, Ammatuna, Emanuele, Blum, Sabine, Löwenberg, Bob, Ossenkoppele, Gert J., Huls, Gerwin

“…Treatment choice according to the individual conditions remains challenging, particularly in older patients with acute myeloid leukemia (AML) and high risk…”
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