Search Results - "AMIRBEKIAN, Vardan"

Noninvasive detection of macrophages using a nanoparticulate contrast agent for computed tomography by Fayad, Zahi A, Hyafil, Fabien, Cornily, Jean-Christophe, Feig, Jonathan E, Gordon, Ronald, Vucic, Esad, Amirbekian, Vardan, Fisher, Edward A, Fuster, Valentin, Feldman, Laurent J

“…Sudden fibrous cap disruption of 'high-risk' atherosclerotic plaques can trigger the formation of an occlusive thrombus in coronary arteries, causing acute…”
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Detecting and assessing macrophages in vivo to evaluate atherosclerosis noninvasively using molecular MRI by Amirbekian, Vardan, Lipinski, Michael J, Briley-Saebo, Karen C, Amirbekian, Smbat, Aguinaldo, Juan Gilberto S, Weinreb, David B, Vucic, Esad, Frias, Juan C, Hyafil, Fabien, Mani, Venkatesh, Fisher, Edward A, Fayad, Zahi A

“…We investigated the ability of targeted immunomicelles to detect and assess macrophages in atherosclerotic plaque using MRI in vivo. There is a large clinical…”
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An MRI study of symptomatic adhesive capsulitis by Zhao, Wen, Zheng, Xiaofeng, Liu, Yuying, Yang, Wenlu, Amirbekian, Vardan, Diaz, Luis E, Huang, Xudong

“…Appilication of MR imaging to diagnose Adhesive Capsulitis (AC) has previously been described. However, there is insufficient information available for the MRI…”
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Molecular imaging of macrophages in atherosclerotic plaques using bimodal PEG-micelles by Mulder, Willem J. M., Strijkers, Gustav J., Briley-Saboe, Karen C., Frias, Juan C., Aguinaldo, Juan Gilberto S., Vucic, Esad, Amirbekian, Vardan, Tang, Cheuk, Chin, Patrick T. K., Nicolay, Klaas, Fayad, Zahi A.

“…Pegylated, fluorescent, and paramagnetic micelles were developed. The micelles were conjugated with macrophage scavenger receptor (MSR)‐specific antibodies…”
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Evaluation of Matrix Metalloproteinases in Atherosclerosis Using a Novel Noninvasive Imaging Approach by Lancelot, Eric, Amirbekian, Vardan, Brigger, Irène, Raynaud, Jean-Sébastien, Ballet, Sébastien, David, Christelle, Rousseaux, Olivier, Le Greneur, Soizic, Port, Marc, Lijnen, Henri R, Bruneval, Patrick, Michel, Jean-Baptiste, Ouimet, Tanja, Roques, Bernard, Amirbekian, Smbat, Hyafil, Fabien, Vucic, Esad, Aguinaldo, Juan Gilberto S, Corot, Claire, Fayad, Zahi A

“…OBJECTIVE—Despite great advances in our knowledge, atherosclerosis continues to kill more people than any other disease in the Western world. This is because…”
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Atherosclerosis and Matrix Metalloproteinases : Experimental Molecular MR Imaging in Vivo by AMIRBEKIAN, Vardan, AGUINALDO, Juan Gilberto S, FISHER, Edward A, GALIS, Zorina S, FAYAD, Zahi A, AMIRBEKIAN, Smbat, HYAFIL, Fabien, VUCIC, Esad, SIROL, Marc, WEINREB, David B, LE GRENEUR, Soizic, LANCELOT, Eric, COROT, Claire

“…To evaluate the capability of P947, a magnetic resonance (MR) imaging contrast agent that molecularly targets matrix metalloproteinases (MMPs), to aid…”
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Macrophage-Specific Lipid-Based Nanoparticles Improve Cardiac Magnetic Resonance Detection and Characterization of Human Atherosclerosis by Lipinski, Michael J., MD, Frias, Juan C., PhD, Amirbekian, Vardan, MD, Briley-Saebo, Karen C., PhD, Mani, Venkatesh, PhD, Samber, Daniel, PE, Abbate, Antonio, MD, Aguinaldo, Juan Gilberto S., MD, Massey, Davis, DDS, MD, PhD, Fuster, Valentin, MD, PhD, Vetrovec, George W., MD, Fayad, Zahi A., PhD

“…Objectives We sought to determine whether gadolinium (Gd)-containing lipid-based nanoparticles (NPs) targeting the macrophage scavenger receptor-B (CD36)…”
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MR imaging of human atherosclerosis using immunomicelles molecularly targeted to macrophages by Amirbekian, Vardan, Lipinski, Michael J, Frias, Juan C, Amirbekian, Smbat, Briley-Saebo, Karen C, Mani, Venkatesh, Samber, Daniel, Abbate, Antonio, Aguinaldo, Juan GS, Masey, David, Fuster, Valentin, Vetrovec, George, Fayad, Zahi A

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Monitoring of arterial wall remodelling in atherosclerotic rabbits with a magnetic resonance imaging contrast agent binding to matrix metalloproteinases by Hyafil, Fabien, Vucic, Esad, Cornily, Jean-Christophe, Sharma, Rahul, Amirbekian, Vardan, Blackwell, Francis, Lancelot, Eric, Corot, Claire, Fuster, Valentin, Galis, Zorina S., Feldman, Laurent J., Fayad, Zahi A.

“…Aims P947 is a gadolinium-based magnetic resonance imaging (MRI) contrast agent with high affinity for several matrix metalloproteinases (MMPs) involved in…”
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MRI to detect atherosclerosis with gadolinium-containing immunomicelles targeting the macrophage scavenger receptor by Lipinski, Michael J., Amirbekian, Vardan, Frias, Juan C., Aguinaldo, Juan Gilberto S., Mani, Venkatesh, Briley-Saebo, Karen C., Fuster, Valentin, Fallon, John T., Fisher, Edward A., Fayad, Zahi A.

“…The ability to specifically image macrophages may enable improved detection and characterization of atherosclerosis. In this study we evaluated the in vitro…”
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Magnetic resonance imaging of vulnerable atherosclerotic plaques: Current imaging strategies and molecular imaging probes by Briley-Saebo, Karen C., Mulder, Willem J.M., Mani, Venkatesh, Hyafil, Fabien, Amirbekian, Vardan, Aguinaldo, Juan Gilberto S., Fisher, Edward A., Fayad, Zahi A.

“…The vulnerability or destabilization of atherosclerotic plaques has been directly linked to plaque composition. Imaging modalities, such as magnetic resonance…”
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Increased neovascularization in advanced lipid-rich atherosclerotic lesions detected by gadofluorine-M-enhanced MRI: implications for plaque vulnerability by Sirol, Marc, Moreno, Pedro R, Purushothaman, K-Raman, Vucic, Esad, Amirbekian, Vardan, Weinmann, Hanns-Joachim, Muntner, Paul, Fuster, Valentin, Fayad, Zahi A

“…Inflammation and neovascularization may play a significant role in atherosclerotic plaque progression and rupture. We evaluated gadofluorine-M-enhanced MRI for…”
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Gadolinium mixed-micelles: Effect of the amphiphile on in vitro and in vivo efficacy in apolipoprotein E knockout mouse models of atherosclerosis by Briley-Saebo, Karen C., Amirbekian, Vardan, Mani, Venkatesh, Aguinaldo, Juan Gilberto S., Vucic, Esad, Carpenter, David, Amirbekian, Smbat, Fayad, Zahi A.

“…Gadolinium (Gd) micelles are nanoparticles that incorporate phospholipids, surfactants, and lipophilic Gd complexes. Preliminary studies have shown that…”
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Atherosclerosis and Matrix Metalloproteinases: Experimental Molecular MR Imaging in Vivo1 by Vardan Amirbekian, Juan Gilberto S. Aguinaldo, Smbat Amirbekian, Fabien Hyafil, Esad Vucic, Marc Sirol, David B. Weinreb, Soizic Le Greneur, Eric Lancelot, Claire Corot, Edward A. Fisher, Zorina S. Galis, Zahi A. Fayad

“…Purpose: To evaluate the capability of P947, a magnetic resonance (MR) imaging contrast agent that molecularly targets matrix metalloproteinases (MMPs), to aid…”
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Macrophage-Specific Lipid-Based Nanoparticles Improve MRI Detection and Characterization of Human Atherosclerosis by Lipinski, Michael J., Frias, Juan C., Amirbekian, Vardan, Briley-Saebo, Karen C., Mani, Venkatesh, Samber, Daniel, Abbate, Antonio, Aguinaldo, Juan Gilberto S., Massey, Davis, Fuster, Valentin, Vetrovec, George W., Fayad, Zahi A.

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Identification of interleukin-2 for imaging atherosclerotic inflammation by Fayad, Zahi A, Amirbekian, Vardan, Toussaint, Jean-François, Fuster, Valentin

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