Search Results - "AMHERDT, M"

A Major Transmembrane Protein of Golgi-Derived COPI-Coated Vesicles Involved in Coatomer Binding by Sohn, Kai, Orci, Lelio, Ravazzola, Mariella, Amherdt, Mylène, Bremser, Martina, Lottspeich, Friedrich, Fiedler, Klaus, Helms, J. Bernd, Wieland, Felix T.

“…Formation of non-clathrin-coated vesicles requires the recruitment of several cytosolic factors to the Golgi membrane. To identify membrane proteins involved…”
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Hydrolysis of Bound GTP by ARF Protein Triggers Uncoating of Golgi-Derived COP-Coated Vesicles by Tanigawa, Gary, Orci, Lelio, Amherdt, Mylene, Ravazzola, Mariella, Helms, J. Bernd, Rothman, James E.

“…The cycle of nucleotide exchange and hydrolysis by a small GTP-binding protein, ADP-ribosylation factor (ARF), helps to provide vectoriality to vesicle…”
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Cloning and functional characterization of mammalian homologues of the COPII component Sec23 by Paccaud, J P, Reith, W, Carpentier, J L, Ravazzola, M, Amherdt, M, Schekman, R, Orci, L

“…We screened a human cDNA library with a probe derived from a partial SEC23 mouse homologue and isolated two different cDNA clones (hSec23A and hSec23B)…”
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Nitric oxide production within rat urothelial cells by Mastrangelo, D, Baertschi, A J, Roatti, A, Amherdt, M, Iselin, C E

“…Recent studies have suggested that nitric oxide (NO) synthase (NOS) may be localized in the urothelium of the proximal part of the mammalian ureter. We…”
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The amino terminus of ADP-ribosylation factor (ARF) is a critical determinant of ARF activities and is a potent and specific inhibitor of protein transport by KAHN, R. A, RANDAZZO, P, SERAFINI, T, WEISS, O, RULKA, C, CLARK, J, AMHERDT, M, ROLLER, P, ORCI, L, ROTHMAN, J. E

“…Deletion of the amino-terminal 17 residues from human ADP-ribosylation factor (ARF) resulted in a protein ([delta 1-17]mARF1p) devoid of ARF activity but which…”
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A v-SNARE Implicated in Intra-Golgi Transport by Nagahama, Masami, Orci, Lelio, Ravazzola, Mariella, Amherdt, Mylène, Lacomis, Lynne, Tempst, Paul, Rothman, James E., Söllner, Thomas H.

“…We report the identification of a putative v-SNARE (GOS-28), localized primarily to transport vesicles at the terminal rims of Golgi stacks. In vitro, GOS-28,…”
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Evidence that Down-Regulation of β-Cell Glucose Transporters in Non-Insulin-Dependent Diabetes May be the Cause of Diabetic Hyperglycemia by Orci, L., Ravazzola, M., Baetens, D., Inman, L., Amherdt, M., Peterson, R. G., Newgard, C. B., Johnson, J. H., Unger, R. H.

“…Non-insulin-dependent diabetes mellitus (NIDDM) is attributed to a failure of pancreatic β cells to maintain insulin secretion at a level sufficient to…”
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pH-Independent and -Dependent Cleavage of Proinsulin in the Same Secretory Vesicle by Orci, Lelio, Halban, Philippe, Perrelet, Alain, Amherdt, Mylène, Ravazzola, Mariella, Richard G. W. Anderson

“…By quantitative immunoelectron microscopy and HPLC, we have studied the effect of disrupting pH gradients, by ammonium chloride, on proinsulin conversion in…”
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Non-clathrin-coat protein alpha is a conserved subunit of coatomer and in Saccharomyces cerevisiae is essential for growth by Gerich, B. (Institut fur Biochemie I, Heidelberg, Germany.), Orci, L, Tschochner, H, Lottspeich, F, Ravazzola, M, Amherdt, M, Wieland, F, Harter, C

“…To complete the molecular characterization of coatomer, the preformed cytosolic complex that is involved in the formation of biosynthetic transport vesicles,…”
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Collagen Matrix Promotes Reorganization of Pancreatic Endocrine Cell Monolayers into Islet-Like Organoids by Montesano, R., Mouron, P., Amherdt, M., Orci, L.

“…To evaluate the capacity of pancreatic endocrine cells to reassociate in vitro according to the characteristic topographical pattern observed in the islets of…”
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Coatomer-Rich Endoplasmic Reticulum by Orci, Lelio, Perrelet, Alain, Ravazzola, Mariella, Amherdt, Mylene, Rothman, James E., Schekman, Randy

“…We identify in normal cells the existence of two distinct sites of the transitional endoplasmic reticulum (ER), one housing the Sec23p protein complex (the…”
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Clathrin-Immunoreactive Sites in the Golgi Apparatus are Concentrated at the trans Pole in Polypeptide Hormone-Secreting Cells by Orci, L., Ravazzola, M., Amherdt, M., Louvard, D., Perrelet, A.

“…By analogy with receptor-mediated endocytosis, clathrin-coated membrane segments at locations other than at the plasma membrane have been implicated in…”
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COPII-Coated Vesicle Formation Reconstituted with Purified Coat Proteins and Chemically Defined Liposomes by Matsuoka, Ken, Orci, Lelio, Amherdt, Mylène, Bednarek, Sebastian Y, Hamamoto, Susan, Schekman, Randy, Yeung, Thomas

“…COPII vesicle formation requires only three coat assembly subunits: Sar1p, Sec13/31p, and Sec23/24p. PI 4-phosphate or PI 4,5-bisphosphate is required for the…”
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Binding and internalization of somatostatin, insulin, and glucagon by cultured rat islet cells by AMHERDT, M, PATEL, Y. C, ORCI, L

“…The pathways by which islet B, A, and D cells bind and internalize homologous (self) and heterologous (other) islet hormones were compared…”
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A clathrin-coated, Golgi-related compartment of the insulin secreting cell accumulates proinsulin in the presence of monensin by Orci, L, Halban, P, Amherdt, M, Ravazzola, M, Vassalli, J D, Perrelet, A

“…When the intracellular transit of 3H-labeled (pro)-insulin polypeptides is perturbed by monensin in the pancreatic B-cell, proinsulin conversion is impaired…”
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Insulin, Not C-Peptide (Proinsulin), Is Present in Crinophagic Bodies of the Pancreatic B-Cell by Orci, L., Ravazzola, M., Amherdt, M., Yanaihara, C., Yanaihara, N., Halban, P., Renold, A. E., Perrelet, A.

“…We have obtained evidence by autoradiography and immunocytochemistry that mature secretory granules of the pancreatic B-cell gain access to a lysosomal…”
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Selective binding of somatostatin-14 and somatostatin-28 to islet cells revealed by quantitative electron microscopic autoradiography by AMHERDT, M, PATEL, Y. C, ORCI, L

“…Quantitative electron microscopic autoradiography was used for comparing the binding of labeled somatostatin-14 (S-14) and somatostatin-28 (S-28 section) to…”
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Transport of horseradish peroxidase from the cell surface to the Golgi in insulin‐secreting cells: preferential labelling of cisternae located in an intermediate position in the stack by Orci, L., Ravazzola, M., Amherdt, M., Brown, D., Perrelet, A.

“…We have used serial sectioning to study the topology of Golgi cisternae in insulin‐secreting cells during secretion‐stimulated endocytotic uptake of exogenous…”
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Lst1p and Sec24p Cooperate in Sorting of the Plasma Membrane ATPase into COPII Vesicles in Saccharomyces cerevisiae by Shimoni, Yuval, Kurihara, Tatsuo, Ravazzola, Mariella, Amherdt, Mylène, Orci, Lelio, Schekman, Randy

“…Formation of ER-derived protein transport vesicles requires three cytosolic components, a small GTPase, Sar1p, and two heterodimeric complexes, Sec23/24p and…”
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Hypertrophy and Hyperplasia of Somatostatin-Containing D-Cells in Diabetes by Orci, Lelio, Baetens, Danielle, Rufener, Claude, Amherdt, Mylene, Ravazzola, Mariella, Studer, Peter, Malaisse-Lagae, Francine, Unger, Roger H.

“…Insulin-, glucagon-, and somatostatin-containing cells, identified by immunofluorescent staining, were quantitated morphometrically in sections of pancreas…”
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