Search Results - "AMBRUSO, D"

Proteomic analysis of the supernatant of red blood cell units: the effects of storage and leucoreduction by Dzieciatkowska, M., Silliman, C. C., Moore, E. E., Kelher, M. R., Banerjee, A., Land, K. J., Ellison, M., West, F. B., Ambruso, D. R., Hansen, K. C.

“…Background Red blood cell (RBC) transfusion is a life‐saving intervention for critically ill patients; however, it has been linked to increased morbidity and…”
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Dominant negative mutation of the hematopoietic-specific Rho GTPase, Rac2, is associated with a human phagocyte immunodeficiency by Williams, David A., Tao, Wen, Yang, Fengchun, Kim, Chaekyun, Gu, Yi, Mansfield, Pamela, Levine, John E., Petryniak, Bronia, Derrow, Caroline W., Harris, Chad, Jia, Baoqing, Zheng, Yi, Ambruso, Daniel R., Lowe, John B., Atkinson, Simon J., Dinauer, Mary C., Boxer, Laurence

“…Rho GTPases control a variety of cellular processes, including actin polymerization, integrin complex formation, cell adhesion, gene transcription, cell cycle…”
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Measures to prevent transfusion-related acute lung injury (TRALI) by Reesink, H. W., Lee, J., Keller, A., Dennington, P., Pink, J., Holdsworth, R., Schennach, H., Goldman, M., Petraszko, T., Sun, J., Meng, Y., Qian, K., Rehacek, V., Turek, P., Krusius, T., Juvonen, E., Tiberghien, P., Legrand, D., Semana, G., Muller, J. Y., Bux, J., Reil, A., Lin, C. K., Daly, H., McSweeney, E., Porretti, L., Greppi, N., Rebulla, P., Okazaki, H., Sánchez-Guerrero, S. A., Baptista-González, H. A., Martínez-Murillo, C., Guerra-Márquez, A., Rodriguez-Moyado, H., Middelburg, R. A., Wiersum-Osselton, J. C., Brand, A., van Tilburg, C., Dinesh, D., Dagger, J., Dunn, P., Brojer, E., Letowska, M., Maslanka, K., Lachert, E., Uhrynowska, M., Zhiburt, E., Palfi, M., Berlin, G., Frey, B. M., Puig Rovira, L., Muñiz-Diaz, E., Castro, E., Chapman, C., Green, A., Massey, E., Win, N., Williamson, L., Silliman, C. C., Chaffin, D. J., Ambruso, D. R., Blumberg, N., Tomasulo, P., Land, K. J., Norris, P. J., Illoh, O. C., Davey, R. J., Benjamin, R. J., Eder, A. F., McLaughlin, L., Kleinman, S., Panzer, S.

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The association of biologically active lipids with the development of transfusion-related acute lung injury: a retrospective study by Silliman, Christopher C., Paterson, Andrew J., Dickey, William O., Stroncek, David F., Popovsky, Mark A., Caldwell, Sherrie A., Ambruso, Daniel R.

“…BACKGROUND: Transfusion‐related acute lung injury (TRALI) is clinically similar to the adult respiratory distress syndrome (ARDS) and has been linked to the…”
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Plasma and lipids from stored packed red blood cells cause acute lung injury in an animal model by Silliman, C C, Voelkel, N F, Allard, J D, Elzi, D J, Tuder, R M, Johnson, J L, Ambruso, D R

“…Transfusion-related acute lung injury (TRALI) is a serious complication of hemotherapy. During blood storage, lipids are generated and released into the…”
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Human Neutrophil Immunodeficiency Syndrome Is Associated with an Inhibitory Rac2 Mutation by Ambruso, Daniel R., Knall, Cindy, Abell, Amy N., Panepinto, Julie, Kurkchubasche, Arlet, Thurman, Gail, Gonzalez-Aller, Carolina, Hiester, Andrew, deBoer, Martin, Harbeck, Ronald J., Oyer, Ryan, Johnson, Gary L., Roos, Dirk

“…A 5-week-old male infant presented with severe bacterial infections and poor wound healing, suggesting a neutrophil defect. Neutrophils from this patient…”
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Hypotension and acute pulmonary insufficiency following transfusion of autologous red blood cells during surgery: a case report and review of the literature by Covin, R. B., Ambruso, D. R., England, K. M., Kelher, M. R., Mehdizadehkashi, Z., Boshkov, L. K., Masuno, T., Moore, E. E., Kim, F. J., Silliman, C. C.

“…Transfusion of autologous blood is associated with fewer complications, although all untoward events of transfusion may not be negated with this strategy. We…”
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Analysis of the priming activity of lipids generated during routine storage of platelet concentrates by Silliman, C C, Dickey, W O, Paterson, A J, Thurman, G W, Clay, K L, Johnson, C A, Ambruso, D R

“…Compounds generated during the routine storage of platelet concentrates may have deleterious effects on the transfusion recipient. Daily plasma samples from…”
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Functional characteristics of neutrophils collected and stored after administration of G-CSF by Leavey, P.J., Thurman, G., Ambruso, D.R.

“…BACKGROUND: Granulocyte transfusion may be used in neutropenic patients with severe bacterial or fungal infections that are unresponsive to antibiotic therapy…”
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In vitro release of vascular endothelial growth factor during platelet aggregation by Maloney, J P, Silliman, C C, Ambruso, D R, Wang, J, Tuder, R M, Voelkel, N F

“…Platelet aggregation is a cardinal feature of both vascular repair and vascular disease. During aggregation platelets release a variety of vasoactive…”
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Successful allogeneic hematopoietic stem cell transplantation (HSCT) for Shwachman-Diamond syndrome by FLEITZ, J, RUMELHART, S, GILLER, R, GOLDMAN, F, AMBRUSO, D, SOKOL, R. J, PACINI, D, QUINONES, R, HOLIDA, M, LEE, N, TANNOUS, R

“…Shwachman-Diamond syndrome (SDS) is a rare genetic disorder characterized by pancreatic insufficiency, short stature, skeletal abnormalities and bone marrow…”
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Neutrophils from patients after burn injury express a deficiency of the oxidase components p47-phox and p67-phox by ROSENTHAL, J, THURMAN, G. W, CUSACK, N, PETERSON, V. M, MALECH, H. L, AMBRUSO, D. R

“…Infection is a major cause of morbidity and mortality in patients after thermal injury. This predisposition to infections is related, in part, to abnormal…”
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Successful allogeneic hematopoietic stem cell transplantation for Shwachman-Diamond syndrome by Fleitz, J, Rumelhart, S, Goldman, F, Ambruso, D, Sokol, R J, Pacini, D, Quinones, R, Holida, M, Lee, N, Tannous, R, Giller, R

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The effect of leukocyte-reduction method on the amount of human cytomegalovirus in blood products: a comparison of apheresis and filtration methods by Dumont, Larry J., Luka, Janos, VandenBroeke, Tania, Whitley, Pamella, Ambruso, Daniel R., Elfath, M. Dean

“…This study examined the effectiveness of 3 leukocyte-reduction (LR) methods in depleting the residual level of cytomegalovirus (CMV) in blood products measured…”
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Assembly and activation of the NADPH:O2 oxidoreductase in human neutrophils after stimulation with phorbol myristate acetate by AMBRUSO, D. R, BOLSCHER, B. G. J. M, STOKMAN, P. M, VERHOEVEN, A. J, ROOS, D

“…Phagocytic leukocytes contain an activatable NADPH:O2 oxidoreductase. Components of this enzyme system include cytochrome b558, and three soluble oxidase…”
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Stored blood components contain agents that prime the neutrophil NADPH oxidase through the platelet-activating-factor receptor by Silliman, C C, Thurman, G W, Ambruso, D R

“…Neutrophils (PMNs) initiate production of toxic oxygen metabolites through stimulation of an NADPH oxidase resulting in the reduction of oxygen to superoxide…”
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Clinical features of a human Rac2 mutation: A complex neutrophil dysfunction disease by Kurkchubasche, Arlet G., Panepinto, Julie A., Tracy, Thomas F., Thurman, Gail W., Ambruso, Daniel R.

“…The case of an infant with multiple, rapidly progressive, soft-tissue infections is presented. Despite features suggesting a neutrophil disorder, results of…”
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Microchimerism and tolerance following intrauterine transplantation and transfusion for alpha-thalassemia-1 by Hayward, A, Ambruso, D, Battaglia, F, Donlon, T, Eddelman, K, Giller, R, Hobbins, J, Hsia, Y E, Quinones, R, Shpall, E, Trachtenberg, E, Giardina, P

“…A fetus homozygous for alpha-thalassemia-1 was given haploidentical paternal CD34 cells at 13, 19 and 24 weeks' gestation and supported through pregnancy by…”
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Lactoferrin enhances hydroxyl radical production by human neutrophils, neutrophil particulate fractions, and an enzymatic generating system by Ambruso, D R, Johnston, Jr, R B

“…During phagocytosis, neutrophils take oxygen from the surrounding medium and convert it to superoxide anion (O2-) and hydrogen peroxide (H2O2). Hydroxyl…”
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Hyponatremia and seizures in young children given DDAVP by Smith, T J, Gill, J C, Ambruso, D R, Hathaway, W E

“…Desmopressin (DDAVP), a synthetic vasopressin, temporarily corrects bleeding abnormalities associated with mild hemophilia A, von Willebrand disease, and…”
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