Search Results - "AMBIKA, G"

Overcoming negatively charged tissue barriers: Drug delivery using cationic peptides and proteins by Vedadghavami, Armin, Zhang, Chenzhen, Bajpayee, Ambika G.

“…[Display omitted] •Human body comprises of several negatively charged tissues like cartilage, eye, gastrointestinal mucin and skin.•Their dense negatively…”
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Recent advances in targeted drug delivery for treatment of osteoarthritis by Mehta, Shikhar, He, Tengfei, Bajpayee, Ambika G.

“…PURPOSE OF REVIEWOsteoarthritis is associated with severe joint pain, inflammation, and cartilage degeneration. Drugs injected directly into intra-articular…”
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Cartilage-targeting drug delivery: can electrostatic interactions help? by Bajpayee, Ambika G., Grodzinsky, Alan J.

“…Current osteoarthritis therapies cannot sufficiently target cartilage and guarantee a biological response owing to limitations in the delivery methods. This…”
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Tipping induced by multiplexing on two-layer networks by Verma, Umesh Kumar, Ambika, G.

“…We report the study of sudden transitions or tipping induced in a collection of systems due to multiplexing with another network of systems. The emergent…”
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Bimodality and scaling in recurrence networks from ECG data by Kachhara, Sneha, Ambika, G.

“…Human heart is a complex system that can be studied using its electrical activity recorded as Electrocardiogram (ECG). Any variations or anomalies in the ECG…”
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Effects of polycationic drug carriers on the electromechanical and swelling properties of cartilage by Warren, Matthew R, Vedadghavami, Armin, Bhagavatula, Sanjana, Bajpayee, Ambika G

“…Cationic nanocarriers offer a promising solution to challenges in delivering drugs to negatively charged connective tissues, such as to articular cartilage for…”
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Synapse loss and progress of Alzheimer’s disease -A network model by Kashyap, G., Bapat, D., Das, D., Gowaikar, R., Amritkar, R. E., Rangarajan, G., Ravindranath, V., Ambika, G.

“…We present observational evidence from studies on primary cortical cultures from AD transgenic mice, APPSwe/PS1ΔE9 (APP/PS1) mice, for significant decrease in…”
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Interleukin-1 receptor antagonist (IL-1Ra) is more effective in suppressing cytokine-induced catabolism in cartilage-synovium co-culture than in cartilage monoculture by Mehta, Shikhar, Akhtar, Sumayyah, Porter, Ryan M, Önnerfjord, Patrik, Bajpayee, Ambika G

“…Most in vitro studies of potential osteoarthritis (OA) therapies have used cartilage monocultures, even though synovium is a key player in mediating joint…”
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Cartilage penetrating cationic peptide carriers for applications in drug delivery to avascular negatively charged tissues by Vedadghavami, Armin, Wagner, Erica K., Mehta, Shikhar, He, Tengfei, Zhang, Chenzhen, Bajpayee, Ambika G.

“…[Display omitted] Drug delivery to avascular, negatively charged tissues like cartilage remains a challenge. The constant turnover of synovial fluid results in…”
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Tipping in complex systems: theory, methods and applications by Ambika, G., Kurths, Jürgen

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Harnessing exosomes for advanced osteoarthritis therapy by Selvadoss, Andrew, Baby, Helna M, Zhang, Hengli, Bajpayee, Ambika G

“…Exosomes are nanosized, lipid membrane vesicles secreted by cells, facilitating intercellular communication by transferring cargo from parent to recipient…”
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Cationic peptide carriers enable long-term delivery of insulin-like growth factor-1 to suppress osteoarthritis-induced matrix degradation by Vedadghavami, Armin, Hakim, Bill, He, Tengfei, Bajpayee, Ambika G

“…Insulin-like growth factor-1 (IGF-1) has the potential to be used for osteoarthritis (OA) treatment but has not been evaluated in clinics yet owing to toxicity…”
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Multi-arm Avidin nano-construct for intra-cartilage delivery of small molecule drugs by He, Tengfei, Zhang, Chenzhen, Vedadghavami, Armin, Mehta, Shikhar, Clark, Heather A., Porter, Ryan M., Bajpayee, Ambika G.

“…Targeted drug delivery to joint tissues like cartilage remains a challenge that has prevented clinical translation of promising osteoarthritis (OA) drugs…”
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Charge-Based Multiarm Avidin Nanoconstruct as a Platform Technology for Applications in Drug Delivery by He, Tengfei, Zhang, Chenzhen, Bajpayee, Ambika G

“…Here we describe methods for synthesizing cationic multiarm Avidin (mAv) nanoconstruct that has a wide range of applications in drug delivery and imaging for a…”
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Cationic Contrast Agents for Computed Tomography of Cartilage for Early Diagnosis of Osteoarthritis by Zhang, Chenzhen, Bajpayee, Ambika G

“…Here we describe methods for synthesizing cationic contrast agents for computed tomography (CT) of cartilage for early diagnosis of tissue degeneration. CT…”
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Frequency locking and travelling burst sequences in community structured network of inhibitory neurons with differing time-scales by Mozumdar, Kunal, Ambika, G.

“…We report the emergent dynamics of a community structured modular network of chaotic Hindmarsh-Rose (HR) neurons with inhibitory synapses. We find the…”
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Structure and stability of the Indian power transmission network by Tamhane, Vedang, Ambika, G

“…Abstract We present the study on the Indian power transmission network using the framework of a complex network and quantify its structural properties. For…”
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Early warning signals for critical transitions in complex systems by George, Sandip V, Kachhara, Sneha, Ambika, G

“…Abstract In this topical review, we present a brief overview of the different methods and measures to detect the occurrence of critical transitions in complex…”
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Virus antibody dynamics in primary and secondary dengue infections by Gujarati, Tanvi P., Ambika, G.

“…Dengue viral infections show unique infection patterns arising from its four serotypes, (DENV-1,2,3,4). Its effects range from simple fever in primary…”
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Cationic Carrier Mediated Delivery of Anionic Contrast Agents in Low Doses Enable Enhanced Computed Tomography Imaging of Cartilage for Early Osteoarthritis Diagnosis by Zhang, Chenzhen, Vedadghavami, Armin, He, Tengfei, Charles, Julia F., Bajpayee, Ambika G.

“…Cartilage tissue exhibits early degenerative changes with onset of osteoarthritis (OA). Early diagnosis is critical as there is only a narrow time window…”
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