Search Results - "AMATO, Robert J"

Phase I Study of Recombinant Human Interleukin-7 Administration in Subjects with Refractory Malignancy by Sportès, Claude, Babb, Rebecca R, Krumlauf, Michael C, Hakim, Frances T, Steinberg, Seth M, Chow, Catherine K, Brown, Margaret R, Fleisher, Thomas A, Noel, Pierre, Maric, Irina, Stetler-Stevenson, Maryalice, Engel, Julie, Buffet, Renaud, Morre, Michel, Amato, Robert J, Pecora, Andrew, Mackall, Crystal L, Gress, Ronald E

“…Purpose: Interleukin-7 (IL-7) has critical and nonredundant roles in T-cell development, hematopoiesis, and postdevelopmental immune functions as a prototypic…”
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Quantitation of circulating tumor cells in blood samples from ovarian and prostate cancer patients using tumor‐specific fluorescent ligands by He, Wei, Kularatne, Sumith A., Kalli, Kimberly R., Prendergast, Franklyn G., Amato, Robert J., Klee, George G., Hartmann, Lynn C., Low, Philip S.

“…Quantitation of circulating tumor cells (CTCs) can provide information on the stage of a malignancy, onset of disease progression and response to therapy. In…”
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Validation and Clinical Applications of a Comprehensive Next Generation Sequencing System for Molecular Characterization of Solid Cancer Tissues by Dehghani, Mehdi, Rosenblatt, Kevin P., Li, Lei, Rakhade, Mrudula, Amato, Robert J.

“…Identification of somatic molecular alterations in primary and metastatic solid tumor specimens can provide critical information regarding tumor biology and…”
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Clinical prognostic factors associated with outcome in patients with renal cell cancer with prior tyrosine kinase inhibitors or immunotherapy treated with everolimus by Amato, Robert J., D.O, Flaherty, Amber, M.D, Zhang, Yufeng, Ouyang, Fangqian, Mohlere, Virginia

“…Abstract Background The mTOR inhibitor, everolimus, is approved for the treatment of metastatic renal cell carcinoma (RCC). However, prognostic models are…”
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A dose-response relationship for time to bone pain resolution after stereotactic body radiotherapy (SBRT) for renal cell carcinoma (RCC) bony metastases by Jhaveri, Pavan M, Teh, Bin S, Paulino, Arnold C, Blanco, Angel I, Lo, Simon S, Butler, E Brian, Amato, Robert J

“…To investigate the utility of stereotactic body radiotherapy (SBRT) in the treatment of painful renal cell carcinoma (RCC) bone metastases, and for a possible…”
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Vaccination of Renal Cell Cancer Patients with Modified Vaccinia Ankara Delivering Tumor Antigen 5T4 (TroVax) Administered with Interleukin 2: A Phase II Trial by AMATO, Robert J, SHINGLER, William, NAYLOR, Stuart, JAC, Jaroslaw, WILLIS, James, SAXENA, Somyata, HERNANDEZ-MCCLAIN, Joan, HARROP, Richard

“…Purpose: The attenuated vaccinia virus modified vaccinia ankara (MVA) has been engineered to deliver the tumor antigen 5T4 (TroVax). TroVax has been evaluated…”
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Inhibition of DNA Methylation by Antisense Oligonucleotide MG98 as Cancer Therapy by Amato, Robert J

“…Abstract Results of preclinical studies and clinical phase I/II trials suggest that the antisense oligodeoxynucleotide and DNA methyltransferase inhibitor MG98…”
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Evaluation of MVA-5T4 as a novel immunotherapeutic vaccine in colorectal, renal and prostate cancer by Amato, Robert J, Stepankiw, Mika

“…This paper reviews the development of the combination of modified vaccinia Ankara (MVA) to deliver the tumor-associated antigen 5T4 as a novel…”
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Kidney-specific cadherin, a specific marker for the distal portion of the nephron and related renal neoplasms by Shen, Steven S, Krishna, Bhuvaneswari, Chirala, Rukmini, Amato, Robert J, Truong, Luan D

“…Renal cell neoplasms are presumably derived from different cell types of the nephron. Clear cell and papillary renal cell carcinoma (RCC) are thought to be of…”
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Early Predicted Time to Normalization of Tumor Markers Predicts Outcome in Poor-Prognosis Nonseminomatous Germ Cell Tumors by FIZAZI, Karim, CULINE, Stéphane, KRAMAR, Andrew, AMATO, Robert J, BOUZY, Jeannine, CHEN, Isan, DROZ, Jean-Pierre, LOGOTHETIS, Christopher J

“…The prognostic relevance of the rate of decline of serum alpha-fetoprotein (AFP) and human chorionic gonadotropin (HCG) during the first 3 weeks of…”
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A phase 2 study with a daily regimen of the oral mTOR inhibitor RAD001 (everolimus) in patients with metastatic clear cell renal cell cancer by Amato, Robert J., Jac, Jaroslaw, Giessinger, Sarah, Saxena, Somyata, Willis, James P.

“…BACKGROUND: Everolimus, an oral mammalian target of rapamycin (mTOR) inhibitor, affects tumor growth by blocking growth factor stimulation, arresting cell…”
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The association between treatment‐specific optimism and depressive symptomatology in patients enrolled in a Phase I cancer clinical trial by Cohen, Lorenzo, de Moor, Carl, Amato, Robert J.

“…BACKGROUND Previous research has found that cancer patients often overestimate the likelihood that they will achieve a positive response in Phase I trials…”
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Clinical Efficacy of TroVax in the Treatment of Progressive Castration-resistant Prostate Cancer by Amato, Robert J., Stepankiw, Mika

“…With approximately 240,890 new cases expected in 2011, prostate cancer remains the leading cause of non-melanoma cancer deaths in men. Immunotherapies using…”
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Heat shock protein-peptide complex-96 (Vitespen) for the treatment of cancer by Robert J. Amato

“…Heat shock proteins (HSPs) are the most abundant and ubiquitous soluble intracellular proteins. Members of the HSP family bind peptides, they include antigenic…”
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Angiogenesis in Wounds Treated by Microdeformational Wound Therapy by ERBA, Paolo, OGAWA, Rei, KONERDING, Moritz A, ORGILL, Dennis P, ACKERMANN, Maximilian, ADINI, Avner, MIELE, Lino F, DASTOURI, Pouya, HELM, Doug, MENTZER, Steven J, D'AMATO, Robert J, MURPHY, George F

“…Mechanical forces play an important role in tissue neovascularization and are a constituent part of modern wound therapies. The mechanisms by which vacuum…”
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Angiogenic responses in a 3D micro-engineered environment of primary endothelial cells and pericytes by Bai, Jing, Khajavi, Mehrdad, Sui, Lufei, Fu, Haojie, Tarakkad Krishnaji, Subrahmanian, Birsner, Amy E., Bazinet, Lauren, Kamm, Roger D., D’Amato, Robert J.

“…Angiogenesis plays a key role in the pathology of diseases such as cancer, diabetic retinopathy, and age-related macular degeneration. Understanding the…”
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Thrombospondin 1 missense alleles induce extracellular matrix protein aggregation and TM dysfunction in congenital glaucoma by Fu, Haojie, Siggs, Owen M, Knight, Lachlan Sw, Staffieri, Sandra E, Ruddle, Jonathan B, Birsner, Amy E, Collantes, Edward Ryan, Craig, Jamie E, Wiggs, Janey L, D'Amato, Robert J

“…Glaucoma is a highly heritable disease that is a leading cause of blindness worldwide. Here, we identified heterozygous thrombospondin 1 (THBS1) missense…”
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Anti-angiogenic properties of microRNA-29a in preclinical ocular models by Peng, De-Wei, Lan, Chun-Lin, Dong, Ling-Qin, Jiang, Meng-Xi, Xiao, Huan, D’Amato, Robert J., Chi, Zai-Long

“…Abnormal neovascularization is an important cause of blindness in many ocular diseases, for which the etiology and pathogenic mechanisms remain incompletely…”
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The Prominin-1-Derived Peptide Improves Cardiac Function Following Ischemia by Adini, Avner, Adini, Irit, Grad, Etty, Tal, Yuval, Danenberg, Haim D, Kang, Peter M, Matthews, Benjamin D, D'Amato, Robert J

“…Myocardial infarction (MI) remains the leading cause of death in the western world. Despite advancements in interventional revascularization technologies, many…”
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Vaccination of Metastatic Renal Cancer Patients with MVA-5T4: A Randomized, Double-Blind, Placebo-Controlled Phase III Study by AMATO, Robert J, HAWKINS, Robert E, GOONEWARDENA, Madusha, NAYLOR, Stuart, HARROP, Richard, KAUFMAN, Howard L, THOMPSON, John A, TOMCZAK, Piotr, SZCZYLIK, Cezary, MCDONALD, Mike, EASTTY, Sarah, SHINGLER, William H, DE BELIN, Jackie

“…The TroVax Renal Immunotherapy Survival Trial was a randomized, placebo-controlled phase III study that investigated whether modified vaccinia Ankara encoding…”
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