Search Results - "AMARA, S. G"

ErbB4 signaling in dopaminergic axonal projections increases extracellular dopamine levels and regulates spatial/working memory behaviors by Skirzewski, M, Karavanova, I, Shamir, A, Erben, L, Garcia-Olivares, J, Shin, J H, Vullhorst, D, Alvarez, V A, Amara, S G, Buonanno, A

“…Genetic variants of Neuregulin 1 (NRG1) and its neuronal tyrosine kinase receptor ErbB4 are associated with risk for schizophrenia, a neurodevelopmental…”
Get full text

Excitatory amino acid transporters: a family in flux by Seal, R P, Amara, S G

“…As the most predominant excitatory neurotransmitter, glutamate has the potential to influence the function of most neuronal circuits in the central nervous…”
Get full text

An excitatory amino-acid transporter with properties of a ligand-gated chloride channel by Fairman, W. A, Vandenberg, R. J, Arriza, J. L, Kavanaught, M. P, Amara, S. G

“…Excitatory amino-acid transporters (EAATs) in the central nervous system maintain extracellular glutamate concentrations below excitotoxic levels and may limit…”
Get full text

Reboxetine: a pharmacologically potent, selective, and specific norepinephrine reuptake inhibitor by Wong, Erik H.F., Sonders, Mark S., Amara, Susan G., Tinholt, Paula M., Piercey, Montford F.P., Hoffmann, William P., Hyslop, Deborah K., Franklin, Stanley, Porsolt, Roger D., Bonsignori, Alberto, Carfagna, Nicola, McArthur, Robert A.

“…Background: Reboxetine is a potent antidepressant, with efficacy comparable to that of imipramine, desipramine, and fluoxetine, and has improved side-effect…”
Get full text

Amphetamine, 3,4-methylenedioxymethamphetamine, lysergic acid diethylamide, and metabolites of the catecholamine neurotransmitters are agonists of a rat trace amine receptor by Bunzow, J R, Sonders, M S, Arttamangkul, S, Harrison, L M, Zhang, G, Quigley, D I, Darland, T, Suchland, K L, Pasumamula, S, Kennedy, J L, Olson, S B, Magenis, R E, Amara, S G, Grandy, D K

“…The trace amine para-tyramine is structurally and functionally related to the amphetamines and the biogenic amine neurotransmitters. It is currently thought…”
Get more information

Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex by Arriza, JL, Fairman, WA, Wadiche, JI, Murdoch, GH, Kavanaugh, MP, Amara, SG

“…Reuptake plays an important role in regulating synaptic and extracellular concentrations of glutamate. Three glutamate transporters expressed in human motor…”
Get full text

Segmenting and classifying skin lesions using a fruit fly optimization algorithm with a machine learning framework by Sonia, R., Joseph, Jesla, Kalaiyarasi, D., Kalyani, N., Gopala Gupta, Amara S. A. L. G., Ramkumar, G., Almoallim, Hesham S., Alharbi, Sulaiman Ali, Raghavan, S.S.

“…The deadliest forms of skin cancer, melanomas have a large fatality rate. In the United States of America, 196,060 new cases of melanoma are anticipated in…”
Get full text

Neurotransmitter transporters : recent progress by AMARA, S. G, KUHAR, M. J

Get full text

Functional diversity of excitatory amino acid transporters: ion channel and transport modes by Fairman, W A, Amara, S G

“…Recent studies of glutamate transporters in the central nervous system indicate that in addition to their fundamental role in mediating neurotransmitter…”
Get full text

Excitatory Amino Acid Transporter 5, a Retinal Glutamate Transporter Coupled to a Chloride Conductance by Arriza, Jeffrey L., Eliasof, Scott, Kavanaugh, Michael P., Amara, Susan G.

“…Although a glutamate-gated chloride conductance with the properties of a sodium-dependent glutamate transporter has been described in vertebrate retinal…”
Get full text

Cloning and expression of a human neutral amino acid transporter with structural similarity to the glutamate transporter gene family by ARRIZA, J. L, KAVANAUGH, M. P, FAIRMAN, W. A, YAN-NA WU, MURDOCH, G. H, NORTH, R. A, AMARA, S. G

“…A cDNA was isolated from human brain that encodes an amino acid sequence 34-39% identical to previously published glutamate transporter sequences. Injection of…”
Get full text

Chimeric Dopamine-Norepinephrine Transporters Delineate Structural Domains Influencing Selectivity for Catecholamines and 1-Methyl-4-Phenylpyridinium by Buck, Kari J., Amara, Susan G.

“…The dopamine (DA) and norephinephrine (NE) transporters demonstrate important differences in their selectivity for catecholamines and the parkinsonism-inducing…”
Get full text

Cell-type-specific expression of catecholamine transporters in the rat brain by Lorang, D, Amara, SG, Simerly, RB

“…The dopamine transporter (DAT) and norepinephrine transporter (NET) terminate catecholaminergic neurotransmission at synapses by high-affinity sodium-dependent…”
Get full text

Distinct proteomic profiles of amphetamine self-administration transitional states by Freeman, W M, Brebner, K, Amara, S G, Reed, M S, Pohl, J, Phillips, A G

“…In the rat, continuous access to d-amphetamine (d-AMPH) leads to lengthy bouts of self-administration, voluntary abstinence, and relapse to…”
Get full text

G protein βγ subunits play a critical role in the actions of amphetamine by Mauna, J. C., Harris, S. S., Pino, J. A., Edwards, C. M., DeChellis-Marks, M. R., Bassi, C. D., Garcia-Olivares, J., Amara, S. G., Guajardo, F. G., Sotomayor-Zarate, R., Terminel, M., Castañeda, E., Vergara, M., Baust, T., Thiels, E., Torres, G. E.

“…Abnormal levels of dopamine (DA) are thought to contribute to several neurological and psychiatric disorders including drug addiction. Extracellular DA levels…”
Get full text

Electrogenic uptake of gamma-aminobutyric acid by a cloned transporter expressed in Xenopus oocytes by KAVANAUGH, M. P, ARRIZA, J. L, NORTH, R. A, AMARA, S. G

“…GAT-1, a gamma-aminobutyric acid (GABA) transporter cloned from rat brain, was expressed in Xenopus oocytes. Voltage-clamp measurements showed…”
Get full text

Structural domains of catecholamine transporter chimeras involved in selective inhibition by antidepressants and psychomotor stimulants by Buck, K J, Amara, S G

“…Reuptake systems for monoamines are the initial sites of action for a wide range of therapeutic antidepressants and drugs of abuse, such as cocaine. To…”
Get more information

Gβγ subunit activation promotes dopamine efflux through the dopamine transporter by Garcia-Olivares, J, Baust, T, Harris, S, Hamilton, P, Galli, A, Amara, S G, Torres, G E

“…The dopamine transporter (DAT) is an important regulator of brain dopamine (DA) homeostasis, controlling the intensity and duration of DA signaling. DAT is the…”
Get full text

Functional expression and CNS distribution of a beta-alanine-sensitive neuronal GABA transporter by Clark, J A, Deutch, A Y, Gallipoli, P Z, Amara, S G

“…The synaptic action of gamma-aminobutyric acid (GABA) is terminated by high affinity, Na(+)-dependent transport processes in both neurons and glia. We have…”
Get more information

Regulated trafficking of the human dopamine transporter. Clathrin-mediated internalization and lysosomal degradation in response to phorbol esters by Daniels, G M, Amara, S G

“…The dopamine transporter plays an essential role in the modulation of dopaminergic neurotransmission by mediating the reuptake of dopamine into presynaptic…”
Get full text