Search Results - "AMANN, Joseph"

Circulating MicroRNAs and Extracellular Vesicle-Containing MicroRNAs as Response Biomarkers of Anti-programmed Cell Death Protein 1 or Programmed Death-Ligand 1 Therapy in NSCLC by Shukuya, Takehito, Ghai, Vikas, Amann, Joseph M, Okimoto, Tamio, Shilo, Konstantin, Kim, Taek-Kyun, Wang, Kai, Carbone, David P

“…Anti-programmed cell death protein 1 (PD-1) or programmed death-ligand 1 (PD-L1) antibody therapy is a standard treatment for advanced NSCLC, and PD-L1…”
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Small cell lung cancer: Subtypes and therapeutic implications by Wang, Walter Z., Shulman, Alyssa, Amann, Joseph M., Carbone, David P., Tsichlis, Philip N.

“…Small cell lung cancer (SCLC) is an extremely aggressive neuroendocrine tumor, accounting for approximated 13% of all lung cancer cases. SCLC is characterized…”
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EGFR blockade enriches for lung cancer stem-like cells through Notch3-dependent signaling by Arasada, Rajeswara Rao, Amann, Joseph M, Rahman, Mohammad A, Huppert, Stacey S, Carbone, David P

“…Mutations in the epidermal growth factor receptor (EGFR) are the most common actionable genetic abnormalities yet discovered in lung cancer. However, targeting…”
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Metabolic reprogramming by adenosine antagonism and implications in non-small cell lung cancer therapy by Guan, Shuxiao, Suman, Shankar, Amann, Joseph M., Wu, Ruohan, Carbone, David P., Wang, Jie, Dikov, Mikhail M.

“…Non-small cell lung cancer (NSCLC) is a heterogeneous disease with genetic and environmental parameters that influence cell metabolism. Because of the complex…”
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Deletion of Histone Deacetylase 3 Reveals Critical Roles in S Phase Progression and DNA Damage Control by Bhaskara, Srividya, Chyla, Brenda J., Amann, Joseph M., Knutson, Sarah K., Cortez, David, Sun, Zu-Wen, Hiebert, Scott W.

“…Histone deacetylases (HDACs) are enzymes that modify key residues in histones to regulate chromatin architecture, and they play a vital role in cell survival,…”
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Relationship between Overall Survival and Response or Progression-Free Survival in Advanced Non-Small Cell Lung Cancer Patients Treated with Anti-PD-1/PD-L1 Antibodies by Shukuya, Takehito, Mori, Keita, Amann, Joseph M, Bertino, Erin M, Otterson, Gregory A, Shields, Peter G, Morita, Satoshi, Carbone, David P

“…Alternative predictive end points for overall survival (OS), such as tumor response and progression-free survival (PFS), are useful in the early detection of…”
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Liver-specific deletion of histone deacetylase 3 disrupts metabolic transcriptional networks by Knutson, Sarah K, Chyla, Brenda J, Amann, Joseph M, Bhaskara, Srividya, Huppert, Stacey S, Hiebert, Scott W

“…Histone deacetylase 3 (Hdac3) is an enzymatic component of transcriptional repression complexes recruited by the nuclear hormone receptors. Inactivation of…”
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Histone Deacetylase Inhibition Enhances the Antitumor Activity of a MEK Inhibitor in Lung Cancer Cells Harboring RAS Mutations by Yamada, Tadaaki, Amann, Joseph M, Tanimoto, Azusa, Taniguchi, Hirokazu, Shukuya, Takehito, Timmers, Cynthia, Yano, Seiji, Shilo, Konstantin, Carbone, David P

“…Non-small cell lung cancer (NSCLC) can be identified by precise molecular subsets based on genomic alterations that drive tumorigenesis and include mutations…”
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LKB1 Loss induces characteristic patterns of gene expression in human tumors associated with NRF2 activation and attenuation of PI3K-AKT by Kaufman, Jacob M, Amann, Joseph M, Park, Kyungho, Arasada, Rajeswara Rao, Li, Haotian, Shyr, Yu, Carbone, David P

“…Inactivation of serine/threonine kinase 11 (STK11 or LKB1) is common in lung cancer, and understanding the pathways and phenotypes altered as a consequence…”
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Notch3-dependent β-catenin signaling mediates EGFR TKI drug persistence in EGFR mutant NSCLC by Arasada, Rajeswara Rao, Shilo, Konstantin, Yamada, Tadaaki, Zhang, Jianying, Yano, Seiji, Ghanem, Rashelle, Wang, Walter, Takeuchi, Shinji, Fukuda, Koji, Katakami, Nobuyuki, Tomii, Keisuke, Ogushi, Fumitaka, Nishioka, Yasuhiko, Talabere, Tiffany, Misra, Shrilekha, Duan, Wenrui, Fadda, Paolo, Rahman, Mohammad A., Nana-Sinkam, Patrick, Evans, Jason, Amann, Joseph, Tchekneva, Elena E., Dikov, Mikhail M., Carbone, David P.

“…EGFR tyrosine kinase inhibitors cause dramatic responses in EGFR-mutant lung cancer, but resistance universally develops. The involvement of β-catenin in EGFR…”
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Identification of Recurrent Activating HER2 Mutations in Primary Canine Pulmonary Adenocarcinoma by Lorch, Gwendolen, Sivaprakasam, Karthigayini, Zismann, Victoria, Perdigones, Nieves, Contente-Cuomo, Tania, Nazareno, Alexandra, Facista, Salvatore, Wong, Shukmei, Drenner, Kevin, Liang, Winnie S, Amann, Joseph M, Sinicropi-Yao, Sara L, Koenig, Michael J, La Perle, Krista, Whitsett, Timothy G, Murtaza, Muhammed, Trent, Jeffrey M, Carbone, David P, Hendricks, William P D

“…Naturally occurring primary canine lung cancers share clinicopathologic features with human lung cancers in never-smokers, but the genetic underpinnings of…”
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Predicting ROR1/BCL2 combination targeted therapy of small cell carcinoma of the lung by Wang, Walter Z., Shilo, Konstantin, Amann, Joseph M., Shulman, Alyssa, Hojjat-Farsangi, Mohammad, Mellstedt, Håkan, Schultz, Johan, Croce, Carlo M., Carbone, David P.

“…Small cell lung cancer (SCLC) remains a deadly form of cancer, with a 5-year survival rate of less than 10 percent, necessitating novel therapies. Receptor…”
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A Transcriptional Signature Identifies LKB1 Functional Status as a Novel Determinant of MEK Sensitivity in Lung Adenocarcinoma by Kaufman, Jacob M, Yamada, Tadaaki, Park, Kyungho, Timmers, Cynthia D, Amann, Joseph M, Carbone, David P

“…LKB1 is a commonly mutated tumor suppressor in non-small cell lung cancer that exerts complex effects on signal transduction and transcriptional regulation. To…”
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STK11/LKB1 Loss of Function Is Associated with Global DNA Hypomethylation and S -Adenosyl-Methionine Depletion in Human Lung Adenocarcinoma by Koenig, Michael J, Agana, Bernice A, Kaufman, Jacob M, Sharpnack, Michael F, Wang, Walter Z, Weigel, Christoph, Navarro, Fabio C P, Amann, Joseph M, Cacciato, Nicole, Arasada, Rajeswara Rao, Gerstein, Mark B, Wysocki, Vicki H, Oakes, Christopher, Carbone, David P

“…STK11 (liver kinase B1, LKB1) is the fourth most frequently mutated gene in lung adenocarcinoma, with loss of function observed in up to 30% of all cases. Our…”
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Verification of a Blood-Based Targeted Proteomics Signature for Malignant Pleural Mesothelioma by Cerciello, Ferdinando, Choi, Meena, Sinicropi-Yao, Sara L, Lomeo, Katie, Amann, Joseph M, Felley-Bosco, Emanuela, Stahel, Rolf A, Robinson, Bruce W S, Creaney, Jenette, Pass, Harvey I, Vitek, Olga, Carbone, David P

“…We have verified a mass spectrometry (MS)-based targeted proteomics signature for the detection of malignant pleural mesothelioma (MPM) from the blood. A…”
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Co-Expression Analysis Reveals Mechanisms Underlying the Varied Roles of NOTCH1 in NSCLC by Sinicropi-Yao, Sara L, Amann, Joseph M, Lopez, David Lopez Y, Cerciello, Ferdinando, Coombes, Kevin R, Carbone, David P

“…Notch receptor family dysregulation can be tumor promoting or suppressing depending on cellular context. Our studies shed light on the mechanistic differences…”
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In-depth Proteomic Analysis of Nonsmall Cell Lung Cancer to Discover Molecular Targets and Candidate Biomarkers by Kikuchi, Takefumi, Hassanein, Mohamed, Amann, Joseph M., Liu, Qinfeng, Slebos, Robbert J.C., Rahman, S.M. Jamshedur, Kaufman, Jacob M., Zhang, Xueqiong, Hoeksema, Megan D., Harris, Bradford K., Li, Ming, Shyr, Yu, Gonzalez, Adriana L., Zimmerman, Lisa J., Liebler, Daniel C., Massion, Pierre P., Carbone, David P.

“…Advances in proteomic analysis of human samples are driving critical aspects of biomarker discovery and the identification of molecular pathways involved in…”
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RANBP9 affects cancer cells response to genotoxic stress and its overexpression is associated with worse response to platinum in NSCLC patients by Tessari, Anna, Parbhoo, Kareesma, Pawlikowski, Meghan, Fassan, Matteo, Rulli, Eliana, Foray, Claudia, Fabbri, Alessandra, Embrione, Valerio, Ganzinelli, Monica, Capece, Marina, Campbell, Moray J., Broggini, Massimo, La Perle, Krista, Farina, Gabriella, Cole, Sara, Marabese, Mirko, Hernandez, Marianna, Amann, Joseph M., Pruneri, Giancarlo, Carbone, David P., Garassino, Marina C., Croce, Carlo M., Palmieri, Dario, Coppola, Vincenzo

“…Although limited by severe side effects and development of resistance, platinum-based therapies still represent the most common first-line treatment for…”
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Genomic Characterization of Non-Small-Cell Lung Cancer in African Americans by Targeted Massively Parallel Sequencing by Araujo, Luiz H, Timmers, Cynthia, Bell, Erica Hlavin, Shilo, Konstantin, Lammers, Philip E, Zhao, Weiqiang, Natarajan, Thanemozhi G, Miller, Clinton J, Zhang, Jianying, Yilmaz, Ayse S, Liu, Tom, Coombes, Kevin, Amann, Joseph, Carbone, David P

“…Technologic advances have enabled the comprehensive analysis of genetic perturbations in non-small-cell lung cancer (NSCLC); however, African Americans have…”
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Akt Kinase-Interacting Protein 1 Signals through CREB to Drive Diffuse Malignant Mesothelioma by Yamada, Tadaaki, Amann, Joseph M, Fukuda, Koji, Takeuchi, Shinji, Fujita, Naoya, Uehara, Hisanori, Iwakiri, Shotaro, Itoi, Kazumi, Shilo, Konstantin, Yano, Seiji, Carbone, David P

“…Diffuse malignant mesothelioma (DMM) is a tumor of serosal membranes with propensity for progressive local disease. Because current treatment options are…”
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