SIGNALING PATHWAYS REGULATED BY BRASSICACEAE EXTRACT INHIBIT THE FORMATION OF ADVANCED GLYCATED END PRODUCTS IN RAT BRAIN

The goal of this study was identification signaling molecules mediated the formation of AGEs in brain of rats injected with CdCl2 and the role of camel whey proteins and extract on formation of AGEs in brain. Ninety male rats were randomly grouped into five groups; Normal control (GpI) and the other...

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Published in:	African journal of traditional, complementary, and alternative medicines Vol. 14; no. 2; pp. 234 - 240
Main Authors:	Al-Malki, Abdulrahman L, Barbour, Elie K, Ea, Huwait, Moselhy, Said S, ALZahrani, Anas Hassan Saeed, Kumosani, Taha A
Format:	Journal Article
Language:	English
Published:	Nigeria African Traditional Herbal Medicine Supporters Initiative (ATHMSI) 2017
Subjects:	Animals Antioxidants - metabolism Antioxidants - pharmacology Antioxidants - therapeutic use Brain - drug effects Brain - metabolism Brassicaceae Cadmium Chloride Camelus Cyclic AMP - metabolism Drug Therapy, Combination Glycation End Products, Advanced - blood Glycation End Products, Advanced - metabolism Interleukin-6 - metabolism Male Neurodegenerative Diseases - blood Neurodegenerative Diseases - drug therapy Neurodegenerative Diseases - metabolism Plant Extracts - pharmacology Plant Extracts - therapeutic use Random Allocation Rats Signal Transduction Tumor Necrosis Factor-alpha - blood Whey Proteins - pharmacology Whey Proteins - therapeutic use neurodegeneration Brassicaceae extract rats Whey protein
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Summary:	The goal of this study was identification signaling molecules mediated the formation of AGEs in brain of rats injected with CdCl2 and the role of camel whey proteins and extract on formation of AGEs in brain. Ninety male rats were randomly grouped into five groups; Normal control (GpI) and the other rats (groups II-V) were received a single dose of cadmium chloride (5 μg/kg/b.w) for induction of neurodegeneration. Rats in groups III-V were treated daily with whey protein (1g/kg b.w) or extract (1mg/kg b.w) or combined respectively for 12 weeks. It was found that whey protein combined with extract prevented the formation of AGEs and enhance the antioxidant activity compared with untreated group (p <0.001). Serum tumor necrosis factor (TNF-α) and interleukine (IL-6) levels were significantly decreased (p<0.01) in rats treated with whey protein and extract formation compared with untreated. The combined treatment showed a better impact than individual ones (p<0.001). The level of cAMP but not cGMP were lowered in combined treatment than individual (p<0.01). It can be postulated that Whey protein + extract formation could have potential benefits in the prevention of the onset and progression of neuropathy in patients.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0189-6016 2505-0044
DOI:	10.21010/ajtcam.v14i2.25