Search Results - "ALVAREZ, L. I"

Impact on beef cattle productivity of infection with anthelmintic-resistant nematodes by Canton, C, Ceballos, L, Domínguez, MP, Fiel, C, Lirón, JP, Moreno, L, Canton, L, Bernat, G, Lanusse, C, Alvarez, LI

“…Aims: The main goal of the current study was to evaluate, on a commercial beef cattle farm, the impact of infection with gastrointestinal nematodes resistant…”
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Altered drug influx/efflux and enhanced metabolic activity in triclabendazole-resistant liver flukes by Alvarez, L I, Solana, H D, Mottier, M L, Virkel, G L, Fairweather, I, Lanusse, C E

“…Triclabendazole (TCBZ) is a halogenated benzimidazole compound that possesses high activity against immature and adult stages of the liver fluke, Fasciola…”
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Inhibition of cytochrome P450-mediated metabolism enhances ex vivo susceptibility of Fasciola hepatica to triclabendazole by Devine, C, Brennan, G P, Lanusse, C E, Alvarez, L I, Trudgett, A, Hoey, E, Fairweather, I

“…A study has been carried out to investigate whether the action of triclabendazole (TCBZ) against Fasciola hepatica is altered by inhibition of drug metabolism…”
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Effect of the metabolic inhibitor, methimazole on the drug susceptibility of a triclabendazole-resistant isolate of Fasciola hepatica by Devine, C, Brennan, G P, Lanusse, C E, Alvarez, L I, Trudgett, A, Hoey, E, Fairweather, I

“…A study has been carried out to investigate whether the action of triclabendazole (TCBZ) is altered in the presence of a metabolic inhibitor. The flavin…”
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Piperonyl butoxide enhances triclabendazole action against triclabendazole-resistant Fasciola hepatica by Devine, C, Brennan, G P, Lanusse, C E, Alvarez, L I, Trudgett, A, Hoey, E, Fairweather, I

“…A study has been carried out to determine whether the action of triclabendazole (TCBZ) against the liver fluke, Fasciola hepatica is altered by inhibition of…”
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Inhibition of triclabendazole metabolism in vitro by ketoconazole increases disruption to the tegument of a triclabendazole-resistant isolate of Fasciola hepatica by Devine, C., Brennan, G. P., Lanusse, C. E., Alvarez, L. I., Trudgett, A., Hoey, E., Fairweather, I.

“…A study has been carried out to investigate whether the action of triclabendazole (TCBZ) against Fasciola hepatica is altered by inhibition of drug metabolism…”
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Transtegumental diffusion of benzimidazole anthelmintics into Moniezia benedeni: correlation with their octanol–water partition coefficients by Mottier, M.L., Alvarez, L.I., Pis, M.A., Lanusse, C.E.

“…The experiments described here report on the correlation between the ex vivo diffusion of different benzimidazole (BZD) anthelmintics into the cestode parasite…”
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Comparative assessment of the access of albendazole, fenbendazole and triclabendazole to Fasciola hepatica: effect of bile in the incubation medium by Alvarez, L I, Mottier, M L, Lanusse, C E

“…The work reported here describes the comparative ability of albendazole (ABZ), fenbendazole (FBZ) and triclabendazole (TCBZ) to penetrate through the tegument…”
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Gaining Insights Into the Pharmacology of Anthelmintics Using Haemonchus contortus as a Model Nematode by Lanusse, C E, Alvarez, L I, Lifschitz, A L

“…Progress made in understanding pharmacokinetic behaviour and pharmacodynamic mechanisms of drug action/resistance has allowed deep insights into the…”
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Uptake of albendazole and albendazole sulphoxide by Haemonchus contortus and Fasciola hepatica in sheep by Alvarez, L.I, Imperiale, F.A, Sánchez, S.F, Murno, G.A, Lanusse, C.E

“…The pattern of in vivo uptake of albendazole (ABZ) and its major metabolite, ABZ-sulphoxide (ABZSO), by Haemonchus contortus and Fasciola hepatica recovered…”
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Potentiation of triclabendazole action in vivo against a triclabendazole-resistant isolate of Fasciola hepatica following its co-administration with the metabolic inhibitor, ketoconazole by Devine, C., Brennan, G.P., Lanusse, C.E., Alvarez, L.I., Trudgett, A., Hoey, E., Fairweather, I.

“…An in vivo study in the laboratory rat model has been carried out to monitor morphological changes in adult Fasciola hepatica over a 4-day period resulting…”
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Enhancement of triclabendazole action in vivo against a triclabendazole-resistant isolate of Fasciola hepatica by co-treatment with ketoconazole by Devine, C., Brennan, G.P., Lanusse, C.E., Alvarez, L.I., Trudgett, A., Hoey, E., Fairweather, I.

“…An in vivo study in the laboratory rat model was carried out to monitor morphological changes in adult Fasciola hepatica over a 4-day period resulting from…”
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Ex vivo diffusion of albendazole and its sulfoxide metabolite into Ascaris suum and Fasciola hepatica by ALVAREZ, L. I, MOTTIER, M. L, SANCHEZ, S. F, LANUSSE, C. E

“…The current experiments compare the pattern of ex vivo uptake (diffusion) of albendazole (ABZ) and albendazole sulfoxide (ABZSO) by Ascaris suum and Fasciola…”
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In vivo and ex vivo uptake of albendazole and its sulphoxide metabolite by cestode parasites: relationship with their kinetic behavior in sheep by Alvarez, L.I, Sanchez, S.F, Lanusse, C.E

“…The current experiments correlate the disposition kinetics of albendazole (ABZ) following its intravenous (i.v.) and intraruminal (i.r.) administrations to…”
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Erratum to: Inhibition of triclabendazole metabolism in vitro by ketoconazole increases disruption to the tegument of a triclabendazole-resistant isolate of Fasciola hepatica by Devine, C., Brennan, G. P., Lanusse, C. E., Alvarez, L. I., Trudgett, A., Hoey, E., Fairweather, I.

“…A study has been carried out to investigate whether the action of triclabendazole (TCBZ) against Fasciola hepatica is altered by inhibition of drug metabolism…”
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FASTING-INDUCED CHANGES TO THE PHARMACOKINETIC BEHAVIOUR OF ALBENDAZOLE AND ITS METABOLITES IN CALVES by SÁnchez, S.F., Alvarez, L.I., Lanusse, C.E.

“…The influence of fasting on the bioavailability and disposition kinetics of albendazole (ABZ) and its metabolites in cattle was investigated. ABZ (10 mg/kg)…”
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Nutritional condition affects the disposition kinetics of albendazole in cattle by Sánchez, S F, Alvarez, L I, Lanusse, C E

“…1. The influence of nutritional status on the plasma and abomasal fluid disposition kinetics of albendazole (ABZ) and its metabolites, albendazole sulphoxide…”
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Ricobendazole kinetics and availability following subcutaneous administration of a novel injectable formulation to calves by Lanusse, C.E., Virkel, G.L., Sanchez, S.F., Alvarez, L.I., Lifschitz, A.L., Imperiale, F., Monfrinotti, A.

“…The plasma and abomasal fluid disposition kinetics of ricobendazole (RBZ) after subcutaneous (SC) administration of novel injectable formulation to calves, and…”
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Modified plasma and abomasal disposition of albendazole in nematode-infected sheep by Alvarez, L.I., Sánchez, S.F., Lanusse, C.E.

“…The influence of gastrointestinal nematode infection on the kinetics of albendazole (ABZ) and its metabolites, albendazole sulphoxide (ABZSO) and sulphone…”
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Plasma disposition kinetics of albendazole metabolites in pigs fed different diets by Alvarez, L.I, Saumell, C.A, Sanchez, S.F, Lanusse, C.E

“…The influence of diet on the disposition kinetics of albendazle ( abz) and its metabolites in pigs was investigated. abz was administered orally at 10 mg kg −1…”
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