Search Results - "ALTON, Kevin B"

Intestinal lymphatic transport for drug delivery by Yáñez, Jaime A., Wang, Stephen W.J., Knemeyer, Ian W., Wirth, Mark A., Alton, Kevin B.

“…Intestinal lymphatic transport has been shown to be an absorptive pathway following oral administration of lipids and an increasing number of lipophilic drugs,…”
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Application of mass spectrometry for metabolite identification by Ma, Shuguang, Chowdhury, Swapan K, Alton, Kevin B

“…Metabolism studies play a pivotal role in drug discovery and development. Characterization of metabolic "hot-spots" as well as reactive and pharmacologically…”
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Characterization of Human Liver Enzymes Involved in the Biotransformation of Boceprevir, a Hepatitis C Virus Protease Inhibitor by GHOSAL, Anima, YUAN YUAN, WEI TONG, SU, Ai-Duen, CHUNYAN GU, CHOWDHURY, Swapan K, KISHNANI, Narendra S, ALTON, Kevin B

“…Boceprevir (SCH 503034), a protease inhibitor, is under clinical development for the treatment of human hepatitis C virus infections. In human liver…”
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Comparison of the activity and disposition of the novel cholesterol absorption inhibitor, SCH58235, and its glucuronide, SCH60663 by Van Heek, Margaret, Farley, Constance, Compton, Douglas S, Hoos, Lizbeth, Alton, Kevin B, Sybertz, Edmund J, Davis, Harry R

“…Previous studies described the metabolism‐based discovery of a potent, selective inhibitor of intestinal absorption of cholesterol, SCH58235 (Ezetimibe). Here…”
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Disposition of the Selective Cholesterol Absorption Inhibitor Ezetimibe in Healthy Male Subjects by PATRICK, James E, KOSOGLOU, Teddy, CAYEN, Mitchell N, STAUBER, Kathe L, ALTON, Kevin B, MAXWELL, Stephen E, YALI ZHU, STATKEVICH, Paul, IANNUCCI, Robert, CHOWDHURY, Swapan, AFFRIME, Melton

“…Ezetimibe [SCH 58235; 1-(4-fluorophenyl)-3( R )-[3-(4-fluorophenyl)-3( S )-hydroxypropyl]-4( S )-(4-hydroxyphenyl)-2-azetidinone], a selective cholesterol…”
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CCD photometry, Roche modelling and period analysis of the W UMa eclipsing binary star system AR CrB by Alton, Kevin B, Nelson, Robert H

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Identification of Human Liver Cytochrome P450 Enzymes Involved in Biotransformation of Vicriviroc, a CCR5 Receptor Antagonist by GHOSAL, Anima, RAMANATHAN, Ragu, YUAN YUAN, HAPANGAMA, Neil, CHOWDHURY, Swapan K, KISHNANI, Narendra S, ALTON, Kevin B

“…Vicriviroc (SCH 417690), a CCR5 receptor antagonist, is currently under investigation for the treatment of human immunodeficiency virus infection. The…”
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The Rise and Fall of the King: The Correlation between FO Aquarii's Low States and the White Dwarf's Spin-down by Littlefield, Colin, Garnavich, Peter, Kennedy, Mark R., Patterson, Joseph, Kemp, Jonathan, Stiller, Robert A., Hambsch, Franz-Josef, Heras, Teófilo Arranz, Myers, Gordon, Stone, Geoffrey, Sjöberg, George, Dvorak, Shawn, Nelson, Peter, Popov, Velimir, Bonnardeau, Michel, Vanmunster, Tonny, Miguel, Enrique de, Alton, Kevin B., Harris, Barbara, Cook, Lewis M., Graham, Keith A., Brincat, Stephen M., Lane, David J., Foster, James, Pickard, Roger, Sabo, Richard, Vietje, Brad, Lemay, Damien, Briol, John, Krumm, Nathan, Dadighat, Michelle, Goff, William, Solomon, Rob, Padovan, Stefano, Bolt, Greg, Kardasis, Emmanuel, Debackère, André, Thrush, Jeff, Stein, William, Walter, Bradley, Coulter, Daniel, Tsehmeystrenko, Valery, Gout, Jean-François, Lewin, Pablo, Galdies, Charles, Fernandez, David Cejudo, Walker, Gary, Boardman, James, Pellett, Emil

“…The intermediate polar FO Aquarii (FO Aqr) experienced its first reported low-accretion states in 2016, 2017, and 2018, and, using newly available photographic…”
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A comprehensive investigation of the variable overcontact system EH Cancri by Alton, Kevin B., Nelson, Robert H., Stȩpień, Kazimierz

“…Precise multi-color CCD-derived photometric data were obtained from EH Cnc at two sites during 2010, 2014 and 2018 wherein each epoch used a different…”
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Ezetimibe : A review of its metabolism, pharmacokinetics and drug interactions by KOSOGLOU, Teddy, STATKEVICH, Paul, JOHNSON-LEVONAS, Amy O, PAOLINI, John F, BERGMAN, Arthur J, ALTON, Kevin B

“…Ezetimibe is the first lipid-lowering drug that inhibits intestinal uptake of dietary and biliary cholesterol without affecting the absorption of fat-soluble…”
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Metabolomics analysis reveals elevation of 3-indoxyl sulfate in plasma and brain during chemically-induced acute kidney injury in mice: Investigation of nicotinic acid receptor agonists by Zgoda-Pols, Joanna R., Chowdhury, Swapan, Wirth, Mark, Milburn, Michael V., Alexander, Danny C., Alton, Kevin B.

“…An investigative renal toxicity study using metabolomics was conducted with a potent nicotinic acid receptor (NAR) agonist, SCH 900424. Liquid…”
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Identification of Human Liver Cytochrome P450 Enzymes Involved in the Metabolism of SCH 530348 (Vorapaxar), a Potent Oral Thrombin Protease-Activated Receptor 1 Antagonist by GHOSAL, Anima, XIAOWEN LU, PENNER, Natalia, LAN GAO, RAMANATHAN, Ragu, CHOWDHURY, Swapan K, KISHNANI, Narendra S, ALTON, Kevin B

“…Vorapaxar (SCH 530348), a potent oral thrombin protease-activated receptor 1 antagonist, is being developed as an antiplatelet agent for patients with…”
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Response Normalized Liquid Chromatography Nanospray Ionization Mass Spectrometry by Ramanathan, Ragu, Zhong, Ruyun, Blumenkrantz, Neil, Chowdhury, Swapan K., Alton, Kevin B.

“…The widely different LC-MS response observed for many structurally different compounds limits the use of LC-MS in full scan detection mode for quantitative…”
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Identification of human UDP-glucuronosyltransferase enzyme(s) responsible for the glucuronidation of 3-hydroxydesloratadine by Ghosal, Anima, Yuan, Yuan, Hapangama, Neil, Su, Ai Duen (Iris), Alvarez, Narciso, Chowdhury, Swapan K., Alton, Kevin B., Patrick, James E., Zbaida, Shmuel

“…Desloratadine is a non‐sedating antihistamine recently approved for the treatment of seasonal allergic rhinitis. The major metabolite of desloratadine in human…”
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Quantitation of Parent Drug and Its Unstable Metabolites by in Situ Coulometric Oxidation and Liquid Chromatography−Tandem Mass Spectrometry by Tong, Wei, Chowdhury, Swapan K, Su, Ai-Duen, Alton, Kevin B

“…Recent FDA and ICH guidances on safety testing of drug metabolites have challenged the way we traditionally think about quantitative bioanalytical methods…”
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Identification of Two Novel Metabolites of SCH 486757, a Nociceptin/Orphanin FQ Peptide Receptor Agonist, in Humans by PENNER, Natalia A, HO, Ginny, BERCOVICI, Ana, CHOWDHURY, Swapan K, ALTON, Kevin B

“…The study of human metabolism of endo-8[bis(2-chlorophenyl)methyl]-3-(2-pyrimidinyl)-8-azabicyclo[3.2.1]octan-3-ol (SCH 486757) after a 200-mg oral dose of the…”
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Thermally Induced N-to-O Rearrangement of tert-N-Oxides in Atmospheric Pressure Chemical Ionization and Atmospheric Pressure Photoionization Mass Spectrometry:  Differentiation of N-Oxidation from Hydroxylation and Potential Determination of N-Oxidation Site by Ma, Shuguang, Chowdhury, Swapan K, Alton, Kevin B

“…N-Oxides are known to undergo deoxygenation during atmospheric pressure chemical ionization (Ramanathan, R.; Su, A.-D.; Alvarez, N.; Blumenkrantz, N.;…”
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In vivo metabolism-based discovery of a potent cholesterol absorption inhibitor, SCH58235, in the rat and rhesus monkey through the identification of the active metabolites of SCH48461 by Van Heek, M, France, C F, Compton, D S, McLeod, R L, Yumibe, N P, Alton, K B, Sybertz, E J, Davis, Jr, H R

“…SCH48461 is a selective and highly potent inhibitor of cholesterol absorption. In rats, SCH48461 is rapidly and completely metabolized in the first pass…”
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The synergistic hypocholesterolemic activity of the potent cholesterol absorption inhibitor, ezetimibe, in combination with 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors in dogs by Davis, Harry R., Pula, Kathyrn K., Alton, Kevin B., Burrier, Robert E., Watkins, Robert W.

“…Ezetimibe (SCH 58235) and SCH 48461 are potent cholesterol absorption inhibitors, which cause significant decreases in plasma cholesterol levels in…”
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Identification of unstable metabolites of Lonafarnib using liquid chromatography-quadrupole time-of-flight mass spectrometry, stable isotope incorporation and ion source temperature alteration by Tong, Wei, Chowdhury, Swapan K., Su, Ai-Duen, Feng, Wenqing, Ghosal, Anima, Alton, Kevin B.

“…Structural characterization of unstable metabolites and other drug‐derived entities poses a serious challenge to the analytical chemist using instrumentation…”
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