Search Results - "ALTON, Eric W. F. W"

Pseudomonas aeruginosa induces p38MAP kinase-dependent IL-6 and CXCL8 release from bronchial epithelial cells via a Syk kinase pathway by Coates, Matthew S, Alton, Eric W F W, Rapeport, Garth W, Davies, Jane C, Ito, Kazuhiro

“…Pseudomonas aeruginosa (Pa) infection is a major cause of airway inflammation in immunocompromised and cystic fibrosis (CF) patients. Mitogen-activated protein…”
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Distinct patterns of inflammation in the airway lumen and bronchial mucosa of children with cystic fibrosis by Regamey, Nicolas, Tsartsali, Lemonia, Hilliard, Tom N, Fuchs, Oliver, Tan, Hui-Leng, Zhu, Jie, Qiu, Yu-Sheng, Alton, Eric W F W, Jeffery, Peter K, Bush, Andrew, Davies, Jane C

“…Studies in cystic fibrosis (CF) generally focus on inflammation present in the airway lumen. Little is known about inflammation occurring in the airway wall,…”
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Gene therapy in cystic fibrosis by Armstrong, David K, Cunningham, Steve, Davies, Jane C, Alton, Eric W FW

“…The principal cause of morbidity and mortality in cystic fibrosis (CF) is pulmonary disease, so the focus of new treatments in this condition is primarily…”
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CpG-free plasmids confer reduced inflammation and sustained pulmonary gene expression by Hyde, Stephen C, Pringle, Ian A, Abdullah, Syahril, Lawton, Anna E, Davies, Lee A, Varathalingam, Anusha, Nunez-Alonso, Graciela, Green, Anne-Marie, Bazzani, Reto P, Sumner-Jones, Stephanie G, Chan, Mario, Li, Hongyu, Yew, Nelson S, Cheng, Seng H, Christopher Boyd, A, Davies, Jane C, Griesenbach, Uta, Porteous, David J, Sheppard, David N, Munkonge, Felix M, Alton, Eric W F W, Gill, Deborah R

“…Pulmonary delivery of plasmid DNA (pDNA)/cationic liposome complexes is associated with an acute unmethylated CG dinucleotide (CpG)-mediated inflammatory…”
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Lytic Bacteriophage Is a Promising Adjunct to Common Antibiotics across Cystic Fibrosis Clinical Strains and Culture Models of Pseudomonas aeruginosa Infection by Martin, Isaac, Morales, Sandra, Alton, Eric W F W, Davies, Jane C

“…Bacteriophages (phages) are antimicrobials with resurgent interest that are being investigated for the treatment of antibiotic refractory infection, including…”
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Antipseudomonal Bacteriophage Reduces Infective Burden and Inflammatory Response in Murine Lung by Pabary, Rishi, Singh, Charanjit, Morales, Sandra, Bush, Andrew, Alshafi, Khalid, Bilton, Diana, Alton, Eric W F W, Smithyman, Anthony, Davies, Jane C

“…As antibiotic resistance increases, there is a need for new therapies to treat infection, particularly in cystic fibrosis (CF), where Pseudomonas aeruginosa is…”
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Progress in gene and cell therapy for cystic fibrosis lung disease by Griesenbach, Uta, Alton, Eric W F W

“…Although the development of gene therapy for cystic fibrosis (CF) was high priority for many groups in academia and industry in the first 10 to 15 years after…”
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Cystic fibrosis by Davies, Jane C, Alton, Eric W F W, Bush, Andrew

“…Age group Common presentations Less common presentations Antenatal Chorionic villous sampling or amniocentesis in high risk family; echogenic bowel on…”
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Whole-Gene Sequencing of CFTR Reveals a High Prevalence of the Intronic Variant c.3874-4522A>G in Cystic Fibrosis by Morris-Rosendahl, Deborah J, Edwards, Matthew, McDonnell, Melissa J, John, Shibu, Alton, Eric W F W, Davies, Jane C, Simmonds, Nicholas J

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Lung Clearance Index and High-Resolution Computed Tomography Scores in Primary Ciliary Dyskinesia by IRVING, Samantha J, IVES, Andrew, HANSELL, David, HOGG, Claire, DAVIES, Jane C, BUSH, Andrew, DAVIES, Gwyneth, DONOVAN, Jackie, EDEY, Anthony J, GILL, Simon S, NAIR, Arjun, SAUNDERS, Clare, WIJESEKERA, Nevin T, ALTON, Eric W. F. W

“…Lung clearance index (LCI) is a more sensitive measure of lung function than spirometry in cystic fibrosis (CF) and correlates well with abnormalities in…”
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Assessment of F/HN-Pseudotyped Lentivirus as a Clinically Relevant Vector for Lung Gene Therapy by GRIESENBACH, Uta, INOUE, Makoto, BOYD, A. Christopher, DAVIES, Jane C, HIGGINS, Tracy E, GILL, Deborah R, HYDE, Stephen C, INNES, J. Alastair, PORTEOUS, David J, HASEGAWA, Mamoru, ALTON, Eric W. F. W, CUIXIANG MENG, FARLEY, Raymond, CHAN, Mario, NEWMAN, Nikki K, BRUM, Andrea, JUN YOU, KERTON, Angela, SHOEMARK, Amelia

“…Ongoing efforts to improve pulmonary gene transfer thereby enabling gene therapy for the treatment of lung diseases, such as cystic fibrosis (CF), has led to…”
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Unsupervised home spirometry is not equivalent to supervised clinic spirometry in children and young people with cystic fibrosis: Results from the CLIMB‐CF study by Edmondson, Claire, Westrupp, Nicole, Short, Christopher, Seddon, Paul, Olden, Catherine, Wallis, Colin, Brodlie, Malcolm, Baxter, Francis, McCormick, Jonathan, MacFarlane, Susan, Brooker, Richard, Connon, Margaret, Ghayyda, Salim, Blaikie, Lesley, Thursfield, Rebecca, Brown, Lynsey, Price, April, Fleischer, Erin, Hughes, Daniel, Donnelly, Christine, Rosenthal, Mark, Wallenburg, John, Brownlee, Keith, Alton, Eric W. F. W., Bush, Andrew, Davies, Jane C.

“…Background Handheld spirometry allows monitoring of lung function at home, of particular importance during the COVID‐19 pandemic. Pediatric studies are unclear…”
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Increased Airway Smooth Muscle Mass in Children with Asthma, Cystic Fibrosis, and Non-Cystic Fibrosis Bronchiectasis by Regamey, Nicolas, Ochs, Matthias, Hilliard, Tom N, Muhlfeld, Christian, Cornish, Nikki, Fleming, Louise, Saglani, Sejal, Alton, Eric W. F. W, Bush, Andrew, Jeffery, Peter K, Davies, Jane C

“…Structural alterations to airway smooth muscle (ASM) are a feature of asthma and cystic fibrosis (CF) in adults. We investigated whether increase in ASM mass…”
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Metabolic Phenotyping and Strain Characterisation of Pseudomonas aeruginosa Isolates from Cystic Fibrosis Patients Using Rapid Evaporative Ionisation Mass Spectrometry by Bardin, Emmanuelle E., Cameron, Simon J. S., Perdones-Montero, Alvaro, Hardiman, Kate, Bolt, Frances, Alton, Eric W. F. W., Bush, Andrew, Davies, Jane C., Takáts, Zoltan

“…Rapid evaporative ionisation mass spectrometry (REIMS) is a novel technique for the real-time analysis of biological material. It works by conducting an…”
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Cyanide levels found in infected cystic fibrosis sputum inhibit airway ciliary function by NAIR, Chandrika, SHOEMARK, Amelia, CHAN, Mario, OLLOSSON, Sarah, DIXON, Mellissa, HOGG, Claire, ALTON, Eric W. F. W, DAVIES, Jane C, WILLIAMS, Huw D

“…We have previously reported cyanide at concentrations of up to 150 μM in the sputum of cystic fibrosis patients infected with Pseudomonas aeruginosa and a…”
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Airway remodelling in children with cystic fibrosis by Hilliard, Tom N, Regamey, Nicolas, Shute, Janis K, Nicholson, Andrew G, Alton, Eric W F W, Bush, Andrew, Davies, Jane C

“…Background:The relationship between airway structural changes and inflammation is unclear in early cystic fibrosis (CF) lung disease. A study was undertaken to…”
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Transepithelial nasal potential difference in patients with, and at risk of acute respiratory distress syndrome by Mac Sweeney, Rob, Reddy, Kiran, Davies, Jane C, Parker, Mike, Kelly, Barry, Elborn, J Stuart, Conlon, John, Verghis, Rejina M, Calfee, Carolyn S, Matthay, Michael A, Alton, Eric W F W, McAuley, Daniel F

“…Impaired alveolar fluid clearance, determined in part by alveolar sodium transport, is associated with acute respiratory distress syndrome (ARDS). Nasal sodium…”
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Oral contraceptives do not appear to affect cystic fibrosis disease severity by KERNAN, Natalie G, ALTON, Eric W. F. W, CULLINAN, Paul, GRIESENBACH, Uta, BILTON, Diana

“…Several studies suggest that sex may affect cystic fibrosis (CF) disease severity, with females with CF being more severely affected. In this context, it has…”
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The murine lung as a factory to produce secreted intrapulmonary and circulatory proteins by Paul-Smith, Michael C., Pytel, Kamila M., Gelinas, Jean-François, McIntosh, Jenny, Pringle, Ian, Davies, Lee, Chan, Mario, Meng, Cuixiang, Bell, Robyn, Cammack, Lidia, Moran, Caroline, Cameron, Loren, Inoue, Makoto, Tsugumine, Shu, Hironaka, Takashi, Gill, Deborah R., Hyde, Stephen C., Nathwani, Amit, Alton, Eric W. F. W., Griesenbach, Uta

“…We have shown that a lentiviral vector (rSIV.F/HN) pseudotyped with the F and HN proteins from Sendai virus generates high levels of intracellular proteins…”
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A Phase I/IIa Safety and Efficacy Study of Nebulized Liposome-mediated Gene Therapy for Cystic Fibrosis Supports a Multidose Trial by Alton, Eric W F W, Boyd, A Christopher, Porteous, David J, Davies, Gwyneth, Davies, Jane C, Griesenbach, Uta, Higgins, Tracy E, Gill, Deborah R, Hyde, Stephen C, Innes, J Alastair

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