Search Results - "ALTOMARE, D"

Homeostasis and the importance for a balance between AKT/mTOR activity and intracellular signaling by Altomare, D A, Khaled, A R

“…The AKT family of serine threonine kinases is of critical importance with regard to growth factor signaling, cell proliferation, survival and oncogenesis…”
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Reply to the letter “The first report on the effect of sacral neuromodulation on intestinal transit time and colonic motility in chronic constipation” by Altomare, D. F.

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Exhaled volatile organic compounds identify patients with colorectal cancer by Altomare, D. F., Di Lena, M., Porcelli, F., Trizio, L., Travaglio, E., Tutino, M., Dragonieri, S., Memeo, V., de Gennaro, G.

“…Background: An effective screening tool for colorectal cancer is still lacking. Analysis of the volatile organic compounds (VOCs) linked to cancer is a new…”
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Volatile organic compounds as new biomarkers for colorectal cancer: a review by Di Lena, M., Porcelli, F., Altomare, D. F.

“…Analysis of the volatile part of the metabolome (volatile organic compounds, VOC) present in the gas phase of excreted materials is a promising new screening…”
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European Society of ColoProctology: guideline for haemorrhoidal disease by Tol, R. R., Kleijnen, J., Watson, A. J. M., Jongen, J., Altomare, D. F., Qvist, N., Higuero, T., Muris, J. W. M., Breukink, S. O., Henquet, C.J.M.

“…Aim The goal of this European Society of ColoProctology project was to establish a multidisciplinary, international guideline for haemorrhoidal disease (HD)…”
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Big data papers and COVID-19: a “false friend” for academic surgeons by Picciariello, A., Altomare, D. F.

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Assessing the Role of a Malonamide Linker in the Design of Potent Dual Inhibitors of Factor Xa and Cholinesterases by Purgatorio, Rosa, Gambacorta, Nicola, Samarelli, Francesco, Lopopolo, Gianfranco, de Candia, Modesto, Catto, Marco, Nicolotti, Orazio, Altomare, Cosimo D.

“…The rational discovery of new peptidomimetic inhibitors of the coagulation factor Xa (fXa) could help set more effective therapeutic options (to prevent atrial…”
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First-in-Class Isonipecotamide-Based Thrombin and Cholinesterase Dual Inhibitors with Potential for Alzheimer Disease by Purgatorio, Rosa, Gambacorta, Nicola, de Candia, Modesto, Catto, Marco, Rullo, Mariagrazia, Pisani, Leonardo, Nicolotti, Orazio, Altomare, Cosimo D.

“…Recently, the direct thrombin (thr) inhibitor dabigatran has proven to be beneficial in animal models of Alzheimer’s disease (AD). Aiming at discovering novel…”
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Scientific requisites for academic advancements in Italy: time to change the rules by Altomare, D. F., Galizia, G., Mingoli, A., Raffaelli, M., Roviello, F.

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Structure-Based Design and Optimization of Multitarget-Directed 2H‑Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases by Farina, Roberta, Pisani, Leonardo, Catto, Marco, Nicolotti, Orazio, Gadaleta, Domenico, Denora, Nunzio, Soto-Otero, Ramon, Mendez-Alvarez, Estefania, Passos, Carolina S., Muncipinto, Giovanni, Altomare, Cosimo D., Nurisso, Alessandra, Carrupt, Pierre-Alain, Carotti, Angelo

“…The multifactorial nature of Alzheimer’s disease calls for the development of multitarget agents addressing key pathogenic processes. To this end, by following…”
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Italian society of colorectal surgery recommendations for good clinical practice in colorectal surgery during the novel coronavirus pandemic by Gallo, G., La Torre, M., Pietroletti, R., Bianco, F., Altomare, D. F., Pucciarelli, S., Gagliardi, G., Perinotti, R.

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Long-term outcomes of sacral nerve stimulation for faecal incontinence by Altomare, D. F., Giuratrabocchetta, S., Knowles, C. H., Muñoz Duyos, A., Robert-Yap, J., Matzel, K. E.

“…Background Sacral nerve stimulation (SNS) has proven short‐ to medium‐term effectiveness for the treatment of faecal incontinence (FI); fewer long‐term…”
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Synchronous "skip" facial metastases from colorectal adenocarcinoma: a case report and review of literature by Picciariello, A, Tomasicchio, G, Lantone, G, Martines, G, Dibra, R, Trigiante, G, d'Amati, A, Piscitelli, D, Altomare, D F

“…Skin metastases from colorectal adenocarcinoma are rare conditions that are metachronous in most of cases and may represent the first sign of a recurrence…”
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Investigation on Novel E/Z 2-Benzylideneindan-1-One-Based Photoswitches with AChE and MAO-B Dual Inhibitory Activity by Paolino, Marco, de Candia, Modesto, Purgatorio, Rosa, Catto, Marco, Saletti, Mario, Tondo, Anna Rita, Nicolotti, Orazio, Cappelli, Andrea, Brizzi, Antonella, Mugnaini, Claudia, Corelli, Federico, Altomare, Cosimo D

“…The multitarget therapeutic strategy, as opposed to the more traditional 'one disease-one target-one drug', may hold promise in treating multifactorial…”
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Obstructed defaecation syndrome: European consensus guidelines on the surgical management by Picciariello, A, O'Connell, P R, Hahnloser, D, Gallo, G, Munoz-Duyos, A, Schwandner, O, Sileri, P, Milito, G, Riss, S, Boccasanta, P A, Naldini, G, Arroyo, A, de laPortilla, F, Tsarkov, P, Roche, B, Isbert, C, Trompetto, M, d'Hoore, A, Matzel, K, Xynos, E, Lundby, L, Ratto, C, Consten, E, Infantino, A, Panis, Y, Terrosu, G, Espin, E, Faucheron, J-L, Guttadauro, A, Adamina, M, Lehur, P A, Altomare, D F

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Post-operative clinical, manometric, and defecographic findings in patients undergoing unsuccessful STARR operation for obstructed defecation by Picciariello, A., Papagni, V., Martines, G., De Fazio, M., Digennaro, R., Altomare, D. F.

“…Aim To evaluate the reason for failure of STARR (stapled transanal rectal resection) operation for obstructed defecation. Methods A retrospective study (June…”
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Synthesis of Novel Benzo[ b ][1,6]naphthyridine Derivatives and Investigation of Their Potential as Scaffolds of MAO Inhibitors by Kulikova, Larisa N, Raesi, Ghulam Reza, Levickaya, Daria D, Purgatorio, Rosa, Spada, Gabriella La, Catto, Marco, Altomare, Cosimo D, Voskressensky, Leonid G

“…In this work, 2-alkyl-10-chloro-1,2,3,4-tetrahydrobenzo[ ][1,6]naphthyridines were obtained and their reactivity was studied. Novel derivatives of the…”
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Anal fistula closure with FiLaC: new hope or the same old story? by Altomare, D. F.

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Synthesis of Isomeric 3-Benzazecines Decorated with Endocyclic Allene Moiety and Exocyclic Conjugated Double Bond and Evaluation of Their Anticholinesterase Activity by Titov, Alexander A., Purgatorio, Rosa, Obydennik, Arina Y., Listratova, Anna V., Borisova, Tatiana N., de Candia, Modesto, Catto, Marco, Altomare, Cosimo D., Varlamov, Alexey V., Voskressensky, Leonid G.

“…Transformations of 1-methoxymethylethynyl substituted isoquinolines triggered by terminal alkynes in alcohols were studied and new 3-benzazecine-containing…”
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Restorative perineal anorectal amputation for a locally advanced desmoid tumour by Picciariello, Arcangelo, Rinaldi, M., De Fazio, M., Trigiante, G., Papagni, V., Bucaria, V., Altomare, D. F.

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