Long‐term follow‐up of leukaemia patients after related cryopreserved allogeneic bone marrow transplantation

We have previously shown that allogeneic bone marrow transplantation (BMT) with cryopreserved donor marrow cells can be used without prolonging the engraftment time or interfering with the reconstitution of haemopoiesis. In this report we extend our initial observations of the first 40 patients who...

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Bibliographic Details
Published in:	British journal of haematology Vol. 96; no. 2; pp. 382 - 386
Main Authors:	STOCKSCHLA¨DER, MARCUS, HASSAN, HASSAN T., KROG, CORNELIA, KRU¨GER, WILLIAM, LO¨LIGER, CORNELIUS, HORSTMAN, MARTIN, ALTNO¨DER, M., CLAUSEN, JOHANNES, GRIMM, JAN, KABISCH, HARTMUT, ZANDER, AXEL
Format:	Journal Article
Language:	English
Published:	Oxford, U.K. and Cambridge, USA Blackwell Science Ltd 01-02-1997 Blackwell
Subjects:	Adolescent Adult allogeneic Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences bone marrow transplantation Bone Marrow Transplantation - methods Bone marrow, stem cells transplantation. Graft versus host reaction Child Child, Preschool chimaerism Cryopreservation engraftment Graft Survival Graft vs Host Disease - etiology GvHD Hematopoietic Stem Cells - pathology Humans leukaemia Leukemia, Myelogenous, Chronic, BCR-ABL Positive - therapy Leukemia, Myeloid, Acute - therapy Leukocyte Count Medical sciences Middle Aged Neutrophils Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy Survival Rate Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transplantation Chimera Transplantation, Homologous Human Transfusion Prognosis Acute Related donor Homograft Malignant hemopathy Long term Myeloproliferative syndrome Chronic Treatment Cryopreservation Follow up study Lymphoproliferative syndrome Chronic myelocytic leukemia Bone marrow Engraftment Graft Acute lymphocytic leukemia Acute myelocytic leukemia
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Summary:	We have previously shown that allogeneic bone marrow transplantation (BMT) with cryopreserved donor marrow cells can be used without prolonging the engraftment time or interfering with the reconstitution of haemopoiesis. In this report we extend our initial observations of the first 40 patients who underwent allogeneic bone marrow transplantation from related donors with cryopreserved donor bone marrow for haematological malignancies, including the long‐term follow‐up data of the previously reported patients. The outcome of these patients was compared with that of 40 related BMT recipients receiving fresh donor bone marrow (historic control group). Time until engraftment of all patients receiving cryopreserved bone marrow was not different from the control group (ANC > 0.5 × 109/l 17 d (range 11–24 d) versus 17.5 d (range 10–28 d); platelets > 20 × 109/l 21 d (range 11–85 d) versus 22 d (range 13–69 d), respectively). There was the same incidence of acute and chronic GvHD in patients receiving either cryopreserved bone marrow or fresh bone marrow (acute GvHD ≥ II 61% v 60% and chronic GvHD 56% v 52%, respectively). Chimaerism studies showed no difference between the patient groups. Furthermore, the two groups did not differ in day 100 survival (82% v 72%). With a median follow‐up of 520 d (range 47–1365 d) and 1289 d (range 48–1849 d), 60% of the patients receiving cryopreserved and 53% of the patients receiving fresh allogeneic donor bone marrow, respectively, are alive. We conclude that cryopreservation of allogeneic related donor bone marrow does not adversely affect engraftment, does not decrease the incidence of severe acute GvHD, and does not seem to affect the day 100 survival or long‐term haemopoiesis.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0007-1048 1365-2141
DOI:	10.1046/j.1365-2141.1997.d01-2032.x