Search Results - "ALTMAN, J"

From Krebs to clinic: glutamine metabolism to cancer therapy by Altman, Brian J., Stine, Zachary E., Dang, Chi V.

“…Key Points Cancer cells show increased consumption of and dependence on glutamine. Glutamine metabolism fuels the tricarboxylic acid (TCA) cycle, nucleotide…”
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Lactic acidosis: relationship between metformin levels, lactate concentration and mortality by Boucaud-Maitre, D., Ropers, J., Porokhov, B., Altman, J.-J., Bouhanick, B., Doucet, J., Girardin, E., Kaloustian, E., Lassmann Vague, V., Emmerich, J.

“…Aim The role of metformin in lactic acidosis is regularly questioned. Arguments against a causal role for metformin in lactic acidosis occurrence are the lack…”
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MYC, Metabolism, and Cancer by Stine, Zachary E, Walton, Zandra E, Altman, Brian J, Hsieh, Annie L, Dang, Chi V

“…The MYC oncogene encodes a transcription factor, MYC, whose broad effects make its precise oncogenic role enigmatically elusive. The evidence to date suggests…”
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Metabolic stress in autophagy and cell death pathways by Altman, Brian J, Rathmell, Jeffrey C

“…Growth factors and oncogenic kinases play important roles in stimulating cell growth during development and transformation. These processes have significant…”
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MYC disrupts transcriptional and metabolic circadian oscillations in cancer and promotes enhanced biosynthesis by Cazarin, Juliana, DeRollo, Rachel E, Shahidan, Siti Noor Ain Binti Ahmad, Burchett, Jamison B, Mwangi, Daniel, Krishnaiah, Saikumari, Hsieh, Annie L, Walton, Zandra E, Brooks, Rebekah, Mello, Stephano S, Weljie, Aalim M, Dang, Chi V, Altman, Brian J

“…The molecular circadian clock, which controls rhythmic 24-hour oscillation of genes, proteins, and metabolites in healthy tissues, is disrupted across many…”
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Efficacy of rosiglitazone in a genetically defined population with mild-to-moderate Alzheimer's disease by Risner, M E, Saunders, A M, Altman, J F B, Ormandy, G C, Craft, S, Foley, I M, Zvartau-Hind, M E, Hosford, D A, Roses, A D

“…Mild-to-moderate AD patients were randomized to placebo or rosiglitazone (RSG) 2, 4 or 8 mg. Primary end points at Week 24 were mean change from baseline in AD…”
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Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis by Xiang, Yan, Stine, Zachary E, Xia, Jinsong, Lu, Yunqi, O'Connor, Roddy S, Altman, Brian J, Hsieh, Annie L, Gouw, Arvin M, Thomas, Ajit G, Gao, Ping, Sun, Linchong, Song, Libing, Yan, Benedict, Slusher, Barbara S, Zhuo, Jingli, Ooi, London L, Lee, Caroline G L, Mancuso, Anthony, McCallion, Andrew S, Le, Anne, Milone, Michael C, Rayport, Stephen, Felsher, Dean W, Dang, Chi V

“…Glutaminase (GLS), which converts glutamine to glutamate, plays a key role in cancer cell metabolism, growth, and proliferation. GLS is being explored as a…”
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Clock Regulation of Metabolites Reveals Coupling between Transcription and Metabolism by Krishnaiah, Saikumari Y, Wu, Gang, Altman, Brian J, Growe, Jacqueline, Rhoades, Seth D, Coldren, Faith, Venkataraman, Anand, Olarerin-George, Anthony O, Francey, Lauren J, Mukherjee, Sarmistha, Girish, Saiveda, Selby, Christopher P, Cal, Sibel, Er, Ubeydullah, Sianati, Bahareh, Sengupta, Arjun, Anafi, Ron C, Kavakli, I Halil, Sancar, Aziz, Baur, Joseph A, Dang, Chi V, Hogenesch, John B, Weljie, Aalim M

“…The intricate connection between the circadian clock and metabolism remains poorly understood. We used high temporal resolution metabolite profiling to explore…”
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TRADER: A package for Tree Ring Analysis of Disturbance Events in R by Altman, J., Fibich, P., Dolezal, J., Aakala, T.

“…Studies using tree-rings to reconstruct forest disturbance dynamics are common and their number has been increasing in the recent years. Despite the evident…”
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MYC Ran Up the Clock: The Complex Interplay between MYC and the Molecular Circadian Clock in Cancer by Burchett, Jamison B., Knudsen-Clark, Amelia M., Altman, Brian J.

“…The MYC oncoprotein and its family members N-MYC and L-MYC are known to drive a wide variety of human cancers. Emerging evidence suggests that MYC has a…”
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Optimization of Amorphization Kinetics during Hot Melt Extrusion by Particle Engineering: An Experimental and Computational Study by Moseson, Dana E, Eren, Ayse, Altman, Kevin J, Corum, Isaac D, Li, Mingyue, Su, Yongchao, Nagy, Zoltan K, Taylor, Lynne S

“…Hot melt extrusion (HME) to prepare amorphous solid dispersions (ASDs) at temperatures below the drug’s melting point requires the crystalline drug to dissolve…”
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Myc-mediated transcriptional regulation of the mitochondrial chaperone TRAP1 controls primary and metastatic tumor growth by Agarwal, Ekta, Altman, Brian J., Seo, Jae Ho, Ghosh, Jagadish C., Kossenkov, Andrew V., Tang, Hsin-Yao, Krishn, Shiv Ram, Languino, Lucia R., Gabrilovich, Dmitry I., Speicher, David W., Dang, Chi V., Altieri, Dario C.

“…The role of mitochondria in cancer continues to be debated, and whether exploitation of mitochondrial functions is a general hallmark of malignancy or a tumor-…”
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Myc Regulation of a Mitochondrial Trafficking Network Mediates Tumor Cell Invasion and Metastasis by Agarwal, Ekta, Altman, Brian J., Ho Seo, Jae, Bertolini, Irene, Ghosh, Jagadish C., Kaur, Amanpreet, Kossenkov, Andrew V., Languino, Lucia R., Gabrilovich, Dmitry I., Speicher, David W., Dang, Chi V., Altieri, Dario C.

“…The Myc gene is a universal oncogene that promotes aggressive cancer, but its role in metastasis has remained elusive. Here, we show that Myc transcriptionally…”
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Correspondence: Oncogenic MYC persistently upregulates the molecular clock component REV-ERBα by Altman, Brian J., Hsieh, Annie L., Gouw, Arvin M., Dang, Chi V.

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Autophagy is essential to suppress cell stress and to allow BCR-Abl-mediated leukemogenesis by Altman, B J, Jacobs, S R, Mason, E F, Michalek, R D, MacIntyre, A N, Coloff, J L, Ilkayeva, O, Jia, W, He, Y-W, Rathmell, J C

“…Hematopoietic cells normally require cell extrinsic signals to maintain metabolism and survival. In contrast, cancer cells can express constitutively active…”
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Do macrophages follow the beat of circadian rhythm in TIME (Tumor Immune Microenvironment)? [version 1; peer review: 2 approved] by Knudsen-Clark, Amelia M., Cazarin, Juliana, Altman, Brian J.

“…Advances in cancer research have made clear the critical role of the immune response in clearing tumors. This breakthrough in scientific understanding was…”
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ER stress modulates cellular metabolism by Wang, Xiaoli, Eno, Colins O, Altman, Brian J, Zhu, Yanglong, Zhao, Guoping, Olberding, Kristen E, Rathmell, Jeffrey C, Li, Chi

“…Changes in metabolic processes play a critical role in the survival or death of cells subjected to various stresses. In the present study, we have investigated…”
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AKT is a therapeutic target in myeloproliferative neoplasms by Khan, I, Huang, Z, Wen, Q, Stankiewicz, M J, Gilles, L, Goldenson, B, Schultz, R, Diebold, L, Gurbuxani, S, Finke, C M, Lasho, T L, Koppikar, P, Pardanani, A, Stein, B, Altman, J K, Levine, R L, Tefferi, A, Crispino, J D

“…The majority of patients with BCR-ABL1 -negative myeloproliferative neoplasms (MPN) harbor mutations in JAK2 or MPL, which lead to constitutive activation of…”
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Clock Regulation of Metabolites Reveals Coupling between Transcription and Metabolism by Krishnaiah, Saikumari Y., Wu, Gang, Altman, Brian J., Growe, Jacqueline, Rhoades, Seth D., Coldren, Faith, Venkataraman, Anand, Olarerin-George, Anthony O., Francey, Lauren J., Mukherjee, Sarmistha, Girish, Saiveda, Selby, Christopher P., Cal, Sibel, ER, Ubeydullah, Sianati, Bahareh, Sengupta, Arjun, Anafi, Ron C., Kavakli, I. Halil, Sancar, Aziz, Baur, Joseph A., Dang, Chi V., Hogenesch, John B., Weljie, Aalim M.

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Clinical trial: alvimopan for the management of post‐operative ileus after abdominal surgery: results of an international randomized, double‐blind, multicentre, placebo‐controlled clinical study by BÜCHLER, M. W., SEILER, C. M., MONSON, J. R. T., FLAMANT, Y., THOMPSON‐FAWCETT, M. W., BYRNE, M. M., MORTENSEN, E. R., ALTMAN, J. F. B., WILLIAMSON, R.

“…Aliment Pharmacol Ther 28, 312–325 Summary Background  Post‐operative ileus (POI) affects most patients undergoing abdominal surgery. Aim  To evaluate the…”
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