Novel antiplatelet therapies for treatment of patients with ischemic heart disease : inhibitors of the platelet glycoprotein IIb/IIIa integrin receptor

Blood platelets play essential roles in normal coagulation and in coronary atherosclerotic disease and its complications. Various antiplatelet therapies, including aspirin, ticlopidine, and dipyridamole, have been developed for use in patients with known coronary artery artery disease to prevent isc...

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Bibliographic Details
Published in:	The American heart journal Vol. 130; no. 4; pp. 877 - 892
Main Authors:	FRISHMAN, W. H, BURNS, B, ATAC, B, ALTURK, N, ALTAJAR, B, LERRICK, K
Format:	Journal Article
Language:	English
Published:	New York, NY Elsevier 01-10-1995
Subjects:	Abciximab Amino Acid Sequence Animals Antibodies, Monoclonal - pharmacology Antibodies, Monoclonal - therapeutic use Arteriosclerosis - blood Arteriosclerosis - drug therapy Arteriosclerosis - physiopathology Aspirin - therapeutic use Biological and medical sciences Cardiology. Vascular system Coronary heart disease Disintegrins Fibrinolytic Agents - pharmacology Fibrinolytic Agents - therapeutic use Heart Humans Immunoglobulin Fab Fragments - pharmacology Immunoglobulin Fab Fragments - therapeutic use Medical sciences Mesylates - pharmacology Mesylates - therapeutic use Molecular Sequence Data Myocardial Ischemia - blood Myocardial Ischemia - drug therapy Myocardial Ischemia - physiopathology Peptides - pharmacology Peptides - therapeutic use Peptides, Cyclic - pharmacology Peptides, Cyclic - therapeutic use Platelet Activation - drug effects Platelet Activation - physiology Platelet Adhesiveness - drug effects Platelet Adhesiveness - physiology Platelet Aggregation - drug effects Platelet Aggregation - physiology Platelet Aggregation Inhibitors - therapeutic use Platelet Glycoprotein GPIIb-IIIa Complex - antagonists & inhibitors Platelet Glycoprotein GPIIb-IIIa Complex - chemistry Platelet Glycoprotein GPIIb-IIIa Complex - physiology Thrombosis - blood Thrombosis - drug therapy Thrombosis - physiopathology Human Chemotherapy Treatment Cardiovascular disease Glycoproteins Coronary heart disease Antiplatelet agent
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Summary:	Blood platelets play essential roles in normal coagulation and in coronary atherosclerotic disease and its complications. Various antiplatelet therapies, including aspirin, ticlopidine, and dipyridamole, have been developed for use in patients with known coronary artery artery disease to prevent ischemic complications. More recently a more complete anti-aggregation effect has been accomplished by the use of monoclonal antibodies and specific peptide and nonpeptide compounds that bind to the platelet GP IIb/IIIa surface receptor. This receptor becomes activated by platelet stimulation and binds fibrinogen molecules between platelets in the aggregation process. These new antiplatelet drugs are now being evaluated in clinical trials in patients undergoing balloon coronary angioplasty, in whom fewer ischemic events occur when the receptor blocker is used intravenously than with standard therapy, and in patients with stable and unstable angina. Excessive bleeding is an important problem with these agents, and efforts must be made to eliminate this side effect.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	0002-8703 1097-6744
DOI:	10.1016/0002-8703(95)90091-8