Search Results - "ALPHS, Larry"

Efficacy and Safety of Intranasal Esketamine for the Rapid Reduction of Symptoms of Depression and Suicidality in Patients at Imminent Risk for Suicide: Results of a Double-Blind, Randomized, Placebo-Controlled Study by Canuso, Carla M, Singh, Jaskaran B, Fedgchin, Maggie, Alphs, Larry, Lane, Rosanne, Lim, Pilar, Pinter, Christine, Hough, David, Sanacora, Gerard, Manji, Husseini, Drevets, Wayne C

“…Objective:The authors compared the efficacy of standard-of-care treatment plus intranasal esketamine or placebo for rapid reduction of symptoms of major…”
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Earlier Use of Long-Acting Injectable Paliperidone Palmitate Versus Oral Antipsychotics in Patients With Schizophrenia: An Integrated Patient-Level Post Hoc Analysis by Lopena, Oliver J., Alphs, Larry D., Sajatovic, Martha, Turkoz, Ibrahim, Sun, Liping, Johnston, Karen L., Sliwa, Jennifer K., Najarian, Dean M., Starr, H. Lynn

“…Objective: To assess the efficacy and safety of paliperidone palmitate (PP) long-acting injectable antipsychotic (LAI) versus oral antipsychotic (OAP)…”
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A 3-week, randomized, placebo-controlled trial of asenapine in the treatment of acute mania in bipolar mania and mixed states by McIntyre, Roger S, Cohen, Miriam, Zhao, Jun, Alphs, Larry, Macek, Thomas A, Panagides, John

“…Objective:  Asenapine is approved for bipolar disorder and schizophrenia. This was a 3‐week, randomized, double‐blind, placebo‐controlled trial of asenapine…”
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Long-acting injectable versus daily oral antipsychotic treatment trials in schizophrenia: pragmatic versus explanatory study designs by Bossie, Cynthia A, Alphs, Larry D, Correll, Christoph U

“…Trial design characteristics related to the explanatory : pragmatic spectrum may contribute toward the inconsistent results reported in studies comparing…”
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An episode level evaluation of the treatment journey of patients with major depressive disorder and treatment-resistant depression by Wu, Bingcao, Cai, Qian, Sheehan, John J, Benson, Carmela, Connolly, Nancy, Alphs, Larry

“…Many patients with major depressive disorder (MDD) fail to respond to antidepressant (AD) pharmacotherapy. The objectives of this study were to characterize…”
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Genome-wide association study of paliperidone efficacy by Li, Qingqin, Wineinger, Nathan E, Fu, Dong-Jing, Libiger, Ondrej, Alphs, Larry, Savitz, Adam, Gopal, Srihari, Cohen, Nadine, Schork, Nicholas J

“…OBJECTIVEClinical response to the atypical antipsychotic paliperidone is known to vary among schizophrenic patients. We carried out a genome-wide association…”
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Paliperidone palmitate once-monthly reduces risk of relapse of psychotic, depressive, and manic symptoms and maintains functioning in a double-blind, randomized study of schizoaffective disorder by Fu, Dong-Jing, Turkoz, Ibrahim, Simonson, R Bruce, Walling, David P, Schooler, Nina R, Lindenmayer, Jean-Pierre, Canuso, Carla M, Alphs, Larry

“…Schizoaffective disorder is a complex illness for which optimal treatment is not well established. Results of the first controlled, relapse-prevention study of…”
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Feasibility study to evaluate capabilities for conducting psychiatric clinical research within the Rwandan mental healthcare system by Alphs, Larry, Turkoz, Ibrahim, Smith-Swintosky, Virginia, Keenan, Alexander, Abraham, Emily, Schotte, Alain, Hooker, Eileen, Damascene Iyamuremye, Jean, Kayiteshonga, Yvonne, Bizoza, Rutakayile, Mancevski, Branislav

“…ObjectiveTo evaluate the feasibility of conducting a large clinical trial within the Rwandan mental healthcare system that would establish the safety, efficacy…”
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Ensuring Stakeholder Feedback in the Design and Conduct of Clinical Trials for Rare Diseases: ISCTM Position Paper of the Orphan Disease Working Group by Pandina, Gahan J, Busner, Joan, Kempf, Lucas, Fallon, Joan, Alphs, Larry D, Acosta, Maria T, Berger, Anna-Karin, Day, Simon, Dunn, Judith, Villalta-Gil, Victoria, Grabb, Margaret C, Horrigan, Joseph P, Jacobson, William, Kando, Judith C, Macek, Thomas A, Singh, Manpreet K, Stanford, Arielle D, Domingo, Silvia Zaragoza

“…The 1983 Orphan Drug Act in the United States (US) changed the landscape for development of therapeutics for rare or orphan diseases, which collectively affect…”
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Using Artificial Intelligence-based Methods to Address the Placebo Response in Clinical Trials by Smith, Erica A, Horan, William P, Demolle, Dominique, Schueler, Peter, Fu, Dong-Jing, Anderson, Ariana E, Geraci, Joseph, Butlen-Ducuing, Florence, Link, Jasmine, Khin, Ni A, Morlock, Robert, Alphs, Larry D

“…The placebo response is a highly complex psychosocial-biological phenomenon that has challenged drug development for decades, particularly in neurological and…”
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Blinded prospective evaluation of computer-based mechanistic schizophrenia disease model for predicting drug response by Geerts, Hugo, Spiros, Athan, Roberts, Patrick, Twyman, Roy, Alphs, Larry, Grace, Anthony A

“…The tremendous advances in understanding the neurobiological circuits involved in schizophrenia have not translated into more effective treatments. An…”
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Suicidality and Risk of Suicide—Definition, Drug Safety Concerns, and a Necessary Target for Drug Development: A Brief Report by MEYER, Roger E, SALZMAN, Carl, MELTZER, Herbert Y, NORMAND, Sharon-Lise T, POSNER, Kelly, SHAFFER, David, OQUENDO, Maria A, STANLEY, Barbara, TRIVEDI, Madhukar H, TURECKI, Gustavo, BEASLEY, Charles M, BEAUTRAIS, Annette L, YOUNGSTROM, Eric A, BRIDGE, Jeffrey A, BROWN, Gregory K, REVICKI, Dennis A, RYAN, Neal D, SHEEHAN, David V, CLAYTON, Paula J, GOODWIN, Frederick K, MANN, J. John, ALPHS, Larry D, BROICH, Karl, GOODMAN, Wayne K, GREDEN, John F

“…To address issues concerning potential treatment-emergent "suicidality," a consensus conference was convened March 23-24, 2009. This gathering of participants…”
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Dispersion of cognitive performance test scores on the MATRICS Consensus Cognitive Battery: A different perspective by Williamson, David J., Nuechterlein, Keith H., Tishler, Todd, Ventura, Joseph, Ellingson, Benjamin M., Turkoz, Ibrahim, Keefe, Richard S.E., Alphs, Larry

“…ObjectivePersons with schizophrenia exhibit greater neurocognitive test score dispersion. Here, we seek to characterize dispersion on the Neurocognitive…”
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ASPECT-R-A Tool to Rate the Pragmatic and Explanatory Characteristics of a Clinical Trial Design by Alphs, Larry D, Bossie, Cynthia A

“…Clinical and observational trials can be broadly categorized into having explanatory or pragmatic approaches with specific trial designs located somewhere…”
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Suicidality and risk of suicide--definition, drug safety concerns, and a necessary target for drug development: a consensus statement by Meyer, Roger E, Salzman, Carl, Youngstrom, Eric A, Clayton, Paula J, Goodwin, Frederick K, Mann, J John, Alphs, Larry D, Broich, Karl, Goodman, Wayne K, Greden, John F, Meltzer, Herbert Y, Normand, Sharon-Lise T, Posner, Kelly, Shaffer, David, Oquendo, Maria A, Stanley, Barbara, Trivedi, Madhukar H, Turecki, Gustavo, Beasley, Jr, Charles M, Beautrais, Annette L, Bridge, Jeffrey A, Brown, Gregory K, Revicki, Dennis A, Ryan, Neal D, Sheehan, David V

“…To address issues concerning potential treatment-emergent "suicidality," a consensus conference was convened March 23-24, 2009. This gathering of participants…”
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Inter-rater Reliability Assessment of ASPECT-R: (A Study Pragmatic-Explanatory Characterization Tool-Rating) by Bossie, Cynthia A, Alphs, Larry D, Williamson, David, Mao, Lian, Kurut, Clennon

“…The increasing importance of real-world data for clinical and policy decision making is driving a need for close attention to the pragmatic versus explanatory…”
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Onset of efficacy with acute long-acting injectable paliperidone palmitate treatment in markedly to severely ill patients with schizophrenia: post hoc analysis of a randomized, double-blind clinical trial by Alphs, Larry, Bossie, Cynthia A, Sliwa, Jennifer K, Ma, Yi-Wen, Turner, Norris

“…This post hoc analysis (trial registration: ClinicalTrials.gov NCT00590577) assessed onset of efficacy and tolerability of acute treatment with once-monthly…”
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Long-acting injectable paliperidone palmitate versus oral paliperidone extended release: a comparative analysis from two placebo-controlled relapse prevention studies by Markowitz, Michael, Fu, Dong-Jing, Levitan, Bennett, Gopal, Srihari, Turkoz, Ibrahim, Alphs, Larry

“…Increasing availability and use of long-acting injectable antipsychotics have generated a need to compare these formulations with their oral equivalents;…”
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Adjunctive long-acting risperidone in patients with bipolar disorder who relapse frequently and have active mood symptoms by Macfadden, Wayne, Adler, Caleb M, Turkoz, Ibrahim, Haskins, John T, Turner, Norris, Alphs, Larry

“…The objective of this exploratory analysis was to characterize efficacy and onset of action of a 3-month treatment period with risperidone long-acting…”
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Poster #185 REMISSION WITH CONTINUED PALIPERIDONE PALMITATE TREATMENT IN STABLE SUBJECTS WITH SCHIZOPHRENIA by Hulihan, loseph, Bossie, Cynthia A, Fu, Dong-Jing, Sliwa, Jennifer Kern, Ma, Yi-Wen, Alphs, Larry D

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