Search Results - "ALPERT, N. R"

Alterations in Sarcoplasmic Reticulum Gene Expression in Human Heart Failure A Possible Mechanism for Alterations in Systolic and Diastolic Properties of the Failing Myocardium by Arai, Masashi, Alpert, Norman R, MacLennan, David H, Barton, Paul, Periasamy, Muthu

“…Recent studies have shown that intracellular Ca handling is abnormal in the myocardium of patients with end-stage heart failure. Muscles from the failing…”
Get full text

Altered myocardial force-frequency relation in human heart failure by Mulieri, L A, Hasenfuss, G, Leavitt, B, Allen, P D, Alpert, N R

“…In congestive heart failure (idiopathic dilated cardiomyopathy), exercise is accompanied by a smaller-than-normal decrease in end-diastolic left ventricular…”
Get full text

Alterations of Myocardial Dynamic Stiffness Implicating Abnormal Crossbridge Function in Human Mitral Regurgitation Heart Failure by Mulieri, L A, Barnes, W, Leavitt, B J, Ittleman, F P, LeWinter, M M, Alpert, N R, Maughan, D W

“…Mitral regurgitation (MR) causes ventricular dilation, a blunted myocardial force-frequency relation, and increased crossbridge force-time integral (FTI). The…”
Get full text

Effect of Thyroid Hormone on the Expression of mRNA Encoding Sarcoplasmic Reticulum Proteins by Arai, Masashi, Otsu, Kinya, MacLennan, David H, Alpert, Norman R, Periasamy, Muthu

“…The purpose of this study was to determine the expression of genes encoding various sarcoplasmic reticulum components that are functionally coupled with…”
Get full text

Sarcoplasmic reticulum gene expression in pressure overload-induced cardiac hypertrophy in rabbit by Matsui, H, MacLennan, D H, Alpert, N R, Periasamy, M

“…Pressure overload (PO)-induced cardiac hypertrophy in rabbits has been utilized extensively to study alterations in systolic and diastolic functions of the…”
Get full text

Protection of Human Left Ventricular Myocardium From Cutting Injury With 2,3 -Butanedione Monoxime by Mulieri, Louis A, Hasenfuss, Gerd, Ittleman, Frank, Blanchard, Edward M, Alpert, Norman R

“…To prevent dissection injury when cutting strip preparations from human left ventricular papillary muscle tissue, dissections were carried out with…”
Get full text

Alteration of Contractile Function and Excitation-Contraction Coupling in Dilated Cardiomyopathy by Hasenfuss, Gerd, Mulieri, Louis A, Leavitt, Bruce J, Allen, Paul D, Haeberle, Joe R, Alpert, Norman R

“…Myocardial failure in dilated cardiomyopathy may result from subcellular alterations in contractile protein function, excitation-contraction coupling…”
Get full text

Smooth, cardiac and skeletal muscle myosin force and motion generation assessed by cross-bridge mechanical interactions in vitro by Harris, D E, Work, S S, Wright, R K, Alpert, N R, Warshaw, D M

“…Differences in the mechanical properties of mammalian smooth, skeletal, and cardiac muscle have led to the proposal that the myosin isozymes expressed by these…”
Get full text

Energetics of Isometric Force Development in Control and Volume-Overload Human Myocardium: Comparison With Animal Species by Hasenfuss, Gerd, Mulieri, Louis A, Blanchard, Edward M, Holubarsch, Christian, Leavitt, Bruce J, Ittleman, Frank, Alpert, Norman R

“…Alteration in crossbridge behavior and myocardial performance have been associated with myosin isoenzyme composition in animal models of myocardial hypertrophy…”
Get full text

Influence of isoproterenol and Ouabain on Excitation-contraction coupling, cross-bridge function, and energetics in failing human myocardium by HASENFUSS, G, MULIERI, L. A, ALLEN, P. D, JUST, H, ALPERT, N. R

“…In patients with heart failure, long-term treatment with catecholamines and phosphodiesterase inhibitors, both of which increase cyclic AMP levels, may be…”
Get full text

The effects of 2,3-butanedione monoxime on initial heat, tension, and aequorin light output of ferret papillary muscles by BLANCHARD, E. M, SMITH, G. L, ALLEN, D. G, ALPERT, N. R

“…At low concentrations (up to 5 mM) the compound 2,3-butanedione monoxime (BDM) was found to reduce twitch tension and initial heat production in isolated…”
Get full text

Tension-independent heat in rabbit papillary muscle by Alpert, N R, Blanchard, E M, Mulieri, L A

“…1. Heat and force were measured from isometrically contracting (0.2 Hz) rabbit papillary muscles at 21 degrees C during a single contraction-relaxation cycle…”
Get full text

The Economy of Isometric Force Development, Myosin Isoenzyme Pattern and Myofibrillar ATPase Activity in Normal and Hypothyroid Rat Myocardium by Holubarsch, Ch, Goulette, R P, Litten, R Z, Martin, B J, Mulieri, L A, Alpert, N R

“…Hypothyroidism was induced in Wistar-Kyoto rats by adding propylthiouracil to the drinking water (0.8 mg/ml). Initial heat, total activity-related heat, and…”
Get full text

Myocardial force-frequency defect in mitral regurgitation heart failure is reversed by forskolin by MULIERI, L. A, LEAVITT, B. J, MARTIN, B. J, HAEBERLE, J. R, ALPERT, N. R

“…Postoperative ejection phase parameters and patient survival rates for mitral valve replacement surgery are considerably lower than for similar aortic valve…”
Get full text

Cellular basis of negative inotropic effect of 2,3-butanedione monoxime in human myocardium by Perreault, C L, Mulieri, L A, Alpert, N R, Ransil, B J, Allen, P D, Morgan, J P

“…2,3-Butanedione monoxime (BDM) exerts a marked negative inotropic effect and has been shown to have protective actions on human myocardial force production…”
Get full text

Maximal Actomyosin ATPase Activity and In Vitro Myosin Motility Are Unaltered in Human Mitral Regurgitation Heart Failure by Nguyen, The-Tin T, Hayes, Eric, Mulieri, Louis A, Leavitt, Bruce J, ter Keurs, Henk E.D.J, Alpert, Norman R, Warshaw, David M

“…Myofibrillar but not actomyosin ATPase is depressed in failing myocardium from patients with dilated cardiomyopathy. Since there is a similar depression of…”
Get full text

Cardiac V1 and V3 myosins differ in their hydrolytic and mechanical activities in vitro by VANBUREN, P, HARRIS, D. E, ALPERT, N. R, WARSHAW, D. M

“…The two mammalian cardiac myosin heavy chain isoforms, alpha and beta, have 93% amino acid homology, but hearts expressing these myosins exhibit marked…”
Get full text

Effects of calcium sensitizers on intracellular calcium handling and myocardial energetics by Hasenfuss, G, Pieske, B, Kretschmann, B, Holubarsch, C, Alpert, N R, Just, H

“…Calcium sensitizers may influence myocardial energetics by their action on calcium turnover and on crossbridge behavior. Using a myothermal method, the effects…”
Get more information

Cloning and characterization of the gene encoding rabbit cardiac calsequestrin by Arai, M, Alpert, N R, Periasamy, M

“…A cDNA encoding rabbit cardiac calsequestrin was isolated and characterized. The deduced nascent cardiac calsequestrin contains 409 amino acids of which 26%…”
Get more information

Role of cAMP in modulating relaxation kinetics and the force-frequency relation in mitral regurgitation heart failure by Mulieri, L A, Leavitt, B J, Wright, R K, Alpert, N R

“…The report is a discussion of previously published and newly analyzed results concerning the association between heart diseases and alterations in the…”
Get full text