Search Results - "ALMERICO, A. M"

Molecular modeling approaches in the discovery of new drugs for anti-cancer therapy: the investigation of p53-MDM2 interaction and its inhibition by small molecules by Lauria, A, Tutone, M, Ippolito, M, Pantano, L, Almerico, A M

“…The mdm2 oncogene product, MDM2, is an ubiquitin protein ligase that inhibits the transcriptional activity of the tumor suppressor p53 and promotes its…”
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Derivatives of the New Ring System Indolo[1,2-c]benzo[1,2,3]triazine with Potent Antitumor and Antimicrobial Activity by Cirrincione, Girolamo, Almerico, Anna Maria, Barraja, Paola, Diana, Patrizia, Lauria, Antonino, Passannanti, Alessandra, Musiu, Chiara, Pani, Alessandra, Murtas, Paola, Minnei, Carla, Marongiu, M. Elena, La Colla, Paolo

“…Derivatives of the new ring system indolo[1,2-c]benzo[1,2,3]triazine 5 were synthesized by diazotization of substituted 2-(2-aminophenyl)indoles followed by an…”
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Synthesis and antiproliferative activity of 2-triazenothiophenes by Diana, P, Barraja, P, Lauria, A, Almerico, A M, Cirrincione, G, Minnei, C, Longu, S, Congiu, D, Musiu, C, La Colla, P

“…A series of 2-triazenothiophene derivatives was prepared and tested to evaluate their biological activity. Two compounds inhibited the proliferation of…”
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Glycosidopyrroles. Part 2. Acyclic derivatives: 1-(1,3-dihydroxy-2-propoxy)methylpyrroles as potential antiviral agents by Almerico, A M, Diana, P, Barraja, P, Dattolo, G, Mingoia, F, Putzolu, M, Perra, G, Milia, C, Musiu, C, Marongiu, M E

“…The series of 1-(1,3-dihydroxy-2-propoxy)methylpyrroles 2a-o were prepared in good overall yields according to Scheme I. When evaluated for antiviral activity…”
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Glycosidopyrroles Part 1. Acyclic derivatives: 1-(2-hydroxyethoxy) methylpyrroles as potential anti-viral agents by Almerico, Anna Maria, Diana, Patrizia, Barraja, Paola, Dattolo, Gaetano, Mingoia, Francesco, Loi, Anna Giulia, Scintu, Franca, Milia, Carlo, Puddu, Ivana, La Colla, Paolo

“…Acyclic glycosidopyrroles of type 1, synthesized in good overall yields, were evaluated for anti-viral activity. Compound 10i was found to inhibit the HIV-1…”
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1-Methyl-3H-pyrazolo[1,2-a]benzo[1,2,3,4]tetrazin-3-ones. Design, Synthesis, and Biological Activity of New Antitumor Agents by Almerico, Anna Maria, Mingoia, Francesco, Diana, Patrizia, Barraja, Paola, Lauria, Antonino, Montalbano, Alessandra, Cirrincione, Girolamo, Dattolo, Gaetano

“…1-Methylpyrazolo[1,2-a]benzo[1,2,3,4]tetrazin-3-ones 4, synthesized in good to excellent yields, were designed as novel alkylating agents because of their…”
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2-Diazopyrroles: synthesis and antileukemic activity by Cirrincione, G, Almerico, A M, Diana, P, Grimaudo, S, Barraja, P, Dattolo, G, Aiello, E, Mingola, F

“…The title compounds were synthesised in preparative yields by diazotization of the corresponding 2-aminopyrroles. In preliminary screening tests as…”
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Pyrrolo[2,1- d][1,2,3,5]tetrazinones deaza analogues of temozolomide with potent antitumor activity by Diana, P., Barraja, P., Lauria, A., Almerico, A.M., Dattolo, G., Cirrincione, G.

“…The title compounds, that hold the deaza skeleton of temozolomide, exhibited potent in vitro antiproliferative activity. An evaluation of such a biological…”
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3-Triazenopyrroles: synthesis and antineoplastic activity by Dattolo, G, Cirrincione, G, Almerico, A M, Aiello, E, Grimaudo, S, Diana, P, Rausa, L, Dusonchet, L, Crosta, L, Tolomeo, M

“…Some 3-triazenopyrroles were prepared by coupling 3-diazopyrroles and secondary amines. In preliminary in vitro screening tests derivatives 3 showed to be…”
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Indolo[3,2-c]cinnolines with antiproliferative, antifungal, and antibacterial activity by Barraja, P, Diana, P, Lauria, A, Passannanti, A, Almerico, A M, Minnei, C, Longu, S, Congiu, D, Musiu, C, La Colla, P

“…A series of indolo[3,2-c]cinnoline derivatives was prepared and tested to evaluate their biological activity. Most of them inhibited the proliferation of…”
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Azolophenanthridines as antineoplastic agents by Aiello, E, Dattolo, G, Cirrincione, G, Almerico, A M, Diana, P, Grimaudo, S, Mingoia, F, Barraja, P

“…Pyrrolo-, pyrazolo- and triazolo-phenanthridines were synthetized by using a Pschorrtype cyclization reaction or an intramolecular cyclization of arylnitrenium…”
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Glycosidopyrroles Part 3. Effect of the benzocondensation on acyclic derivatives: 1-(2-hydroxyethoxy) methylindoles as potential antiviral agents by Almerico, Anna Maria, Barraja, Paola, Diana, Patrizia, Cirrincione, Girolamo, Mingoia, Francesco, Musiu, Chiara, Perra, Graziella, Putzolu, Monica, Marongiu, Maria Elena

“…The new of 1-(2-hydroxyethoxy)methylindole derivatives 3a-i were prepared in good yields. None of them showed any significant anti-HIV activity and therefore…”
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Acyclic glycosidopyrroles analogues of ganciclovir: synthesis and biological activity by Diana, P, Barraja, P, Almerico, A M, Dattolo, G, Mingoia, F, Loi, A G, Congeddu, E, Musiu, C, Putzolu, M, La Colla, P

“…Acyclic glycosidopyrroles of type 3 were synthetized in good overall yields, according to the Scheme. When evaluated for antiviral activity against DNA and RNA…”
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Pyrrolo[3,4-e][1,2,3]triazolo[1,5-a]pyrimidine and pyrrolo[3,4-d] [1,2,3]triazolo[1,5-a]pyrimidine. New tricyclic ring systems of biological interest by Lauria, Antonino, Diana, Patrizia, Barraja, Paola, Almerico, Anna Maria, Cirrincione, Girolamo, Dattolo, Gaetano

“…Derivatives of the new ring system pyrrolo[3,4‐e][1,2,3] triazolo[1,5‐a]pyrimidine 6 were prepared in high yields in one step by reaction of 3‐azidopyrrole 3…”
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2-Triazenopyrroles: synthesis and biological activity by Diana, Patrizia, Barraja, Paola, Lauria, Antonino, Almerico, Anna Maria, Cirrincione, Girolamo, Loi, Anna Giulia, Musiu, Chiara, Pani, Alessandra, La Colla, Paolo, Marongiu, Maria Elena

“…2-Triazenopyrroles were synthesized by coupling the corresponding 2-diazopyrroles with secondary amines and tested for antiproliferative, antifungal, antiviral…”
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Inside the Hsp90 inhibitors binding mode through induced fit docking by Lauria, Antonino, Ippolito, Mario, Almerico, Anna Maria

“…During the last few decades, the development of new anticancer strategies had to face the instability of many tumors, occurring when the genetic plasticity of…”
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DNA minor groove binders: an overview on molecular modeling and QSAR approaches by Lauria, Antonino, Montalbano, Alessandra, Barraja, Paola, Dattolo, Gaetano, Almerico, Anna Maria

“…Molecular recognition of DNA by small molecules and proteins is a fundamental problem in structural biology and drug design. Understanding of recognition in…”
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3-Diazopyrroles. Part 6. Mutagenic activity of 3-diazopyrroles in Streptomyces coelicolor A3(2) during various phases of growth by Cirrincione, G, Almerico, A M, Grimaudo, S, Diana, P, Mingoia, F, Barraja, P, Misuraca, F

“…3-Diazopyrroles, a class of compounds particularly interesting from a chemical and biological point of view, were assayed for their ability to induce gene…”
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Intercalation of Daunomycin into Stacked DNA Base Pairs. DFT Study of an Anticancer Drug by Barone, Giampaolo, Guerra, Célia Fonseca, Gambino, Noemi, Silvestri, Arturo, Lauria, Antonino, Almerico, Anna Maria, Bickelhaupt, F. Matthias

“…We have computationally studied the intercalation of the antitumor drug daunomycin into six stacks of Watson-Crick DNA base pairs i.e., AT-AT, AT-TA, GC-AT,…”
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Mono and bis(bioreductive) alkylating agents: synthesis and antitumor activities in a B16 melanoma model by Witiak, Donald T, Loper, John T, Ananthan, Subramaniam, Almerico, Anna Maria, Verhoef, Vernon L, Filppi, Joyce A

“…Several potentially bis(alkylating) bis(quinones) (3-5) and 1,4- and 1,3-bis(alkylating) monoquinones (6-13) belonging to general structure…”
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