Search Results - "ALMENDRO, Vanessa"

Cellular heterogeneity and molecular evolution in cancer by Almendro, Vanessa, Marusyk, Andriy, Polyak, Kornelia

“…Intratumor heterogeneity represents a major obstacle to effective cancer treatment and personalized medicine. However, investigators are now elucidating…”
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Inference of Tumor Evolution during Chemotherapy by Computational Modeling and In Situ Analysis of Genetic and Phenotypic Cellular Diversity by Almendro, Vanessa, Cheng, Yu-Kang, Randles, Amanda, Itzkovitz, Shalev, Marusyk, Andriy, Ametller, Elisabet, Gonzalez-Farre, Xavier, Muñoz, Montse, Russnes, Hege G., Helland, Åslaug, Rye, Inga H., Borresen-Dale, Anne-Lise, Maruyama, Reo, van Oudenaarden, Alexander, Dowsett, Mitchell, Jones, Robin L., Reis-Filho, Jorge, Gascon, Pere, Gönen, Mithat, Michor, Franziska, Polyak, Kornelia

“…Cancer therapy exerts a strong selection pressure that shapes tumor evolution, yet our knowledge of how tumors change during treatment is limited. Here, we…”
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The JAK2/STAT3 signaling pathway is required for growth of CD44⁺CD24⁻ stem cell-like breast cancer cells in human tumors by Marotta, Lauren L C, Almendro, Vanessa, Marusyk, Andriy, Shipitsin, Michail, Schemme, Janina, Walker, Sarah R, Bloushtain-Qimron, Noga, Kim, Jessica J, Choudhury, Sibgat A, Maruyama, Reo, Wu, Zhenhua, Gönen, Mithat, Mulvey, Laura A, Bessarabova, Marina O, Huh, Sung Jin, Silver, Serena J, Kim, So Young, Park, So Yeon, Lee, Hee Eun, Anderson, Karen S, Richardson, Andrea L, Nikolskaya, Tatiana, Nikolsky, Yuri, Liu, X Shirley, Root, David E, Hahn, William C, Frank, David A, Polyak, Kornelia

“…Intratumor heterogeneity is a major clinical problem because tumor cell subtypes display variable sensitivity to therapeutics and may play different roles in…”
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JAK-STAT Signaling in Inflammatory Breast Cancer Enables Chemotherapy-Resistant Cell States by Stevens, Laura E, Peluffo, Guillermo, Qiu, Xintao, Temko, Daniel, Fassl, Anne, Li, Zheqi, Trinh, Anne, Seehawer, Marco, Jovanović, Bojana, Alečković, Maša, Wilde, Callahan M, Geck, Renee C, Shu, Shaokun, Kingston, Natalie L, Harper, Nicholas W, Almendro, Vanessa, Pyke, Alanna L, Egri, Shawn B, Papanastasiou, Malvina, Clement, Kendell, Zhou, Ningxuan, Walker, Sarah, Salas, Jacqueline, Park, So Yeon, Frank, David A, Meissner, Alexander, Jaffe, Jacob D, Sicinski, Piotr, Toker, Alex, Michor, Franziska, Long, Henry W, Overmoyer, Beth A, Polyak, Kornelia

“…Inflammatory breast cancer (IBC) is a difficult-to-treat disease with poor clinical outcomes due to high risk of metastasis and resistance to treatment. In…”
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8q24 prostate, breast, and colon cancer risk loci show tissue-specific long-range interaction with MYC by Ahmadiyeh, Nasim, Pomerantz, Mark M, Grisanzio, Chiara, Herman, Paula, Jia, Li, Almendro, Vanessa, He, Housheng Hansen, Brown, Myles, Liu, X. Shirley, Davis, Matt, Caswell, Jennifer L, Beckwith, Christine A, Hills, Adam, MacConaill, Laura, Coetzee, Gerhard A, Regan, Meredith M, Freedman, Matthew L

“…The 8q24 gene desert contains risk loci for multiple epithelial cancers, including colon, breast, and prostate. Recent evidence suggests these risk loci…”
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JARID1B Is a Luminal Lineage-Driving Oncogene in Breast Cancer by Yamamoto, Shoji, Wu, Zhenhua, Russnes, Hege G., Takagi, Shinji, Peluffo, Guillermo, Vaske, Charles, Zhao, Xi, Moen Vollan, Hans Kristian, Maruyama, Reo, Ekram, Muhammad B., Sun, Hanfei, Kim, Jee Hyun, Carver, Kristopher, Zucca, Mattia, Feng, Jianxing, Almendro, Vanessa, Bessarabova, Marina, Rueda, Oscar M., Nikolsky, Yuri, Caldas, Carlos, Liu, X. Shirley, Polyak, Kornelia

“…Recurrent mutations in histone-modifying enzymes imply key roles in tumorigenesis, yet their functional relevance is largely unknown. Here, we show that…”
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Intratumor heterogeneity defines treatment‐resistant HER2+ breast tumors by Rye, Inga H., Trinh, Anne, Sætersdal, Anna B., Nebdal, Daniel, Lingjærde, Ole Christian, Almendro, Vanessa, Polyak, Kornelia, Børresen‐Dale, Anne‐Lise, Helland, Åslaug, Markowetz, Florian, Russnes, Hege G.

“…Targeted therapy for patients with HER2‐positive (HER2+) breast cancer has improved overall survival, but many patients still suffer relapse and death from the…”
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The Transmodulation of HER2 and EGFR by Substance P in Breast Cancer Cells Requires c-Src and Metalloproteinase Activation by Garcia-Recio, Susana, Pastor-Arroyo, Eva M, Marín-Aguilera, Mercedes, Almendro, Vanessa, Gascón, Pedro

“…Substance P (SP) is a pleiotropic cytokine/neuropeptide that enhances breast cancer (BC) aggressiveness by transactivating tyrosine kinase receptors like EGFR…”
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Tyrosine kinase receptor transactivation associated to G protein-coupled receptors by Almendro, Vanessa, García-Recio, Susana, Gascón, Pedro

“…G protein-coupled receptors (GPCRs) comprise a large family of membrane receptors involved in signal transduction. These receptors are linked to a variety of…”
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Evolutionary pathways in BRCA1-associated breast tumors by Martins, Filipe C, De, Subhajyoti, Almendro, Vanessa, Gönen, Mithat, Park, So Yeon, Blum, Joanne L, Herlihy, William, Ethington, Gabrielle, Schnitt, Stuart J, Tung, Nadine, Garber, Judy E, Fetten, Katharina, Michor, Franziska, Polyak, Kornelia

“…BRCA1-associated breast tumors display loss of BRCA1 and frequent somatic mutations of PTEN and TP53. Here we describe the analysis of BRCA1, PTEN, and p53 at…”
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Glucocorticoids promote transition of ductal carcinoma in situ to invasive ductal carcinoma by inducing myoepithelial cell apoptosis by Zubeldia-Plazaola, Arantzazu, Recalde-Percaz, Leire, Moragas, Núria, Alcaraz, Mireia, Chen, Xieng, Mancino, Mario, Fernández-Nogueira, Patricia, Prats de Puig, Miquel, Guzman, Flavia, Noguera-Castells, Aleix, López-Plana, Anna, Enreig, Estel, Carbó, Neus, Almendro, Vanessa, Gascón, Pedro, Bragado, Paloma, Fuster, Gemma

“…The microenvironment and stress factors like glucocorticoids have a strong influence on breast cancer progression but their role in the first stages of breast…”
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The role of MMP7 and its cross-talk with the FAS/FASL system during the acquisition of chemoresistance to oxaliplatin by Almendro, Vanessa, Ametller, Elisabet, García-Recio, Susana, Collazo, Olga, Casas, Ignasi, Augé, Josep M, Maurel, Joan, Gascón, Pedro

“…The efficacy of oxaliplatin in cancer chemotherapy is limited by the development of drug resistance. MMP7 has been related to the loss of tumor cell response…”
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Amplified loci on chromosomes 8 and 17 predict early relapse in ER-positive breast cancers by Bilal, Erhan, Vassallo, Kristen, Toppmeyer, Deborah, Barnard, Nicola, Rye, Inga H, Almendro, Vanessa, Russnes, Hege, Børresen-Dale, Anne-Lise, Levine, Arnold J, Bhanot, Gyan, Ganesan, Shridar

“…Adjuvant hormonal therapy is administered to all early stage ER+ breast cancers, and has led to significantly improved survival. Unfortunately, a subset of ER+…”
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Substance P Autocrine Signaling Contributes to Persistent HER2 Activation That Drives Malignant Progression and Drug Resistance in Breast Cancer by GARCIA-RECIO, Susana, FUSTER, Gemma, ENGEL, Pablo, COSTAMAGNA, Domiziana, FERNANDEZ, Pedro L, GASCÓN, Pedro, ALMENDRO, Vanessa, FERNANDEZ-NOGUEIRA, Patricia, PASTOR-ARROYO, Eva M, SO YEON PARK, MAYORDOMO, Cristina, AMETLLER, Elisabet, MANCINO, Mario, GONZALEZ-FARRE, Xavier, RUSSNES, Hege G

“…ERBB receptor transmodulation by heterologous G-protein-coupled receptors (GPCR) generates functional diversity in signal transduction. Tachykinins are…”
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Interleukin-15 increases glucose uptake in skeletal muscle An antidiabetogenic effect of the cytokine by Busquets, Sílvia, Figueras, Maite, Almendro, Vanessa, López-Soriano, Francisco J., Argilés, Josep M.

“…Previous studies have demonstrated that interleukin-15 (IL-15) has important anabolic effects on muscle protein metabolism. In the present investigation we…”
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Intra-tumour heterogeneity: a looking glass for cancer? by Marusyk, Andriy, Almendro, Vanessa, Polyak, Kornelia

“…Key Points Primary human tumours consist of cells that differ in clinically important phenotypic features. This phenotypic heterogeneity is a result of the…”
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Interleukin-15 Affects Differentiation and Apoptosis in Adipocytes: Implications in Obesity by Fuster, Gemma, Almendro, Vanessa, Fontes-Oliveira, Cibely Cristine, Toledo, Míriam, Costelli, Paola, Busquets, Sílvia, López-Soriano, Francisco J., Argilés, Josep M.

“…Interleukin-15 (IL-15) is an anabolic factor for skeletal muscle and several reports have described its important role as a regulator of energy homeostasis. In…”
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Differential expression of neurogenes among breast cancer subtypes identifies high risk patients by Fernández-Nogueira, Patricia, Bragado, Paloma, Almendro, Vanessa, Ametller, Elisabet, Rios, Jose, Choudhury, Sibgat, Mancino, Mario, Gascón, Pedro

“…The nervous system is now recognized to be a relevant component of the tumor microenvironment. Receptors for neuropeptides and neurotransmitters have been…”
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Effects of IL-15 on Rat Brown Adipose Tissue: Uncoupling Proteins and PPARs by Almendro, Vanessa, Fuster, Gemma, Busquets, Sílvia, Ametller, Elisabet, Figueras, Maite, Argilés, Josep M., López‐Soriano, Francisco J.

“…Objectives: Interleukin‐15 (IL‐15) plays an important role in lipid metabolism as its administration to rats causes a marked depletion of white adipose tissue…”
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Comparison of methods for the isolation of human breast epithelial and myoepithelial cells by Zubeldia-Plazaola, Arantzazu, Ametller, Elisabet, Mancino, Mario, Prats de Puig, Miquel, López-Plana, Anna, Guzman, Flavia, Vinyals, Laia, Pastor-Arroyo, Eva M, Almendro, Vanessa, Fuster, Gemma, Gascón, Pedro

“…Two lineages, epithelial, and myoepithelial cells are the main cell populations in the normal mammary gland and in breast cancer. Traditionally, cancer…”
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