Search Results - "ALLMAN, David"

mTORC1 coordinates an immediate unfolded protein response-related transcriptome in activated B cells preceding antibody secretion by Gaudette, Brian T., Jones, Derek D., Bortnick, Alexandra, Argon, Yair, Allman, David

“…How activated B cells build biosynthetic pathways and organelle structures necessary for subsequent robust antibody secretion is still unclear. The dominant…”
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mTOR has distinct functions in generating versus sustaining humoral immunity by Jones, Derek D, Gaudette, Brian T, Wilmore, Joel R, Chernova, Irene, Bortnick, Alexandra, Weiss, Brendan M, Allman, David

“…Little is known about the role of mTOR signaling in plasma cell differentiation and function. Furthermore, for reasons not understood, mTOR inhibition reverses…”
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Hif1a Deletion Reveals Pro-Neoplastic Function of B Cells in Pancreatic Neoplasia by Lee, Kyoung Eun, Spata, Michelle, Bayne, Lauren J, Buza, Elizabeth L, Durham, Amy C, Allman, David, Vonderheide, Robert H, Simon, M Celeste

“…Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer-related deaths worldwide, with an exceedingly low 5-year survival rate. PDAC tumors are…”
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Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy by Sotillo, Elena, Barrett, David M, Black, Kathryn L, Bagashev, Asen, Oldridge, Derek, Wu, Glendon, Sussman, Robyn, Lanauze, Claudia, Ruella, Marco, Gazzara, Matthew R, Martinez, Nicole M, Harrington, Colleen T, Chung, Elaine Y, Perazzelli, Jessica, Hofmann, Ted J, Maude, Shannon L, Raman, Pichai, Barrera, Alejandro, Gill, Saar, Lacey, Simon F, Melenhorst, Jan J, Allman, David, Jacoby, Elad, Fry, Terry, Mackall, Crystal, Barash, Yoseph, Lynch, Kristen W, Maris, John M, Grupp, Stephan A, Thomas-Tikhonenko, Andrei

“…The CD19 antigen, expressed on most B-cell acute lymphoblastic leukemias (B-ALL), can be targeted with chimeric antigen receptor-armed T cells (CART-19), but…”
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381 BiP knockdown decreases antibody production in malignant and non-malignant plasma cells by Hasanali, Zainul, Allman, David

“…OBJECTIVES/GOALS: Numerous diseases, including AL amyloidosis, are due to expression of aberrant antibodies. Significant effort has gone into plasma cell toxic…”
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Single-cell transcriptomic analysis of renal allograft rejection reveals insights into intragraft TCR clonality by Shi, Tiffany, Burg, Ashley R, Caldwell, J Timothy, Roskin, Krishna M, Castro-Rojas, Cyd M, Chukwuma, P Chukwunalu, Gray, George I, Foote, Sara G, Alonso, Jesus A, Cuda, Carla M, Allman, David A, Rush, James S, Regnier, Catherine H, Wieczorek, Grazyna, Alloway, Rita R, Shields, Adele R, Baker, Brian M, Woodle, E Steve, Hildeman, David A

“…Bulk analysis of renal allograft biopsies (rBx) identified RNA transcripts associated with acute cellular rejection (ACR); however, these lacked cellular…”
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Lasting antibody responses are mediated by a combination of newly formed and established bone marrow plasma cells drawn from clonally distinct precursors by Chernova, Irene, Jones, Derek D, Wilmore, Joel R, Bortnick, Alexandra, Yucel, Mesut, Hershberg, Uri, Allman, David

“…Current models hold that serum Ab titers are maintained chiefly by long-lived bone marrow (BM) plasma cells (PCs). In this study, we characterize the role of…”
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Plasma cell targeting to prevent antibody‐mediated rejection by Woodle, E. Steve, Tremblay, Simon, Rossi, Amy, Rojas, Cyd C., Alloway, Rita, Roskin, Krishna, Allman, David, Hildeman, David

“…Plasma cells (PCs) are the major source of pathogenic allo‐ and autoantibodies and have historically demonstrated resistance to therapeutic targeting. However,…”
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Editorial: The nose knows by Cancro, Michael P., Allman, David M.

“…Discussion on how nasal epithelial cells govern the quality of local humoral immunity…”
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T Regulatory Cells Support Plasma Cell Populations in the Bone Marrow by Glatman Zaretsky, Arielle, Konradt, Christoph, Dépis, Fabien, Wing, James B., Goenka, Radhika, Atria, Daniela Gomez, Silver, Jonathan S., Cho, Sunglim, Wolf, Amaya I., Quinn, William J., Engiles, Julie B., Brown, Dorothy C., Beiting, Daniel, Erikson, Jan, Allman, David, Cancro, Michael P., Sakaguchi, Shimon, Lu, Li-Fan, Benoist, Christophe O., Hunter, Christopher A.

“…Long-lived plasma cells (PCs) in the bone marrow (BM) are a critical source of antibodies after infection or vaccination, but questions remain about the…”
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IgA Plasma Cells Are Long-Lived Residents of Gut and Bone Marrow That Express Isotype- and Tissue-Specific Gene Expression Patterns by Wilmore, Joel R, Gaudette, Brian T, Gómez Atria, Daniela, Rosenthal, Rebecca L, Reiser, Sarah Kim, Meng, Wenzhao, Rosenfeld, Aaron M, Luning Prak, Eline T, Allman, David

“…Antibody secreting plasma cells are made in response to a variety of pathogenic and commensal microbes. While all plasma cells express a core gene…”
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Stromal Notch ligands foster lymphopenia-driven functional plasticity and homeostatic proliferation of naïve B cells by Gómez Atria, Daniela, Gaudette, Brian T, Londregan, Jennifer, Kelly, Samantha, Perkey, Eric, Allman, Anneka, Srivastava, Bhaskar, Koch, Ute, Radtke, Freddy, Ludewig, Burkhard, Siebel, Christian W, Ryan, Russell Jh, Robertson, Tanner F, Burkhardt, Janis K, Pear, Warren S, Allman, David, Maillard, Ivan

“…In lymphopenic environments, secondary lymphoid organs regulate the size of B and T-cell compartments by supporting homeostatic proliferation of mature…”
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Transcription factor EBF restricts alternative lineage options and promotes B cell fate commitment independently of Pax5 by Lancki, David W, Northrup, Daniel L, Singh, Harinder, Grosschedl, Rudolf, Medina, Kay L, Thomas, Matthew, Treiber, Thomas, Bertolino, Eric, Allman, David, Pongubala, Jagan M R

“…Alternative lineage restriction and B cell fate commitment require the transcription factor Pax5, but the function of early B cell factor (EBF) in these…”
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Transcriptional Repression of Gata3 Is Essential for Early B Cell Commitment by Banerjee, Anupam, Northrup, Daniel, Boukarabila, Hanane, Jacobsen, Sten Erik W., Allman, David

“…The mechanisms underlying the silencing of alternative fate potentials in very early B cell precursors remain unclear. Using gain- and loss-of-function…”
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The Decline in B Lymphopoiesis in Aged Mice Reflects Loss of Very Early B-Lineage Precursors by Miller, Juli P, Allman, David

“…The primary age-related loss in B cell progenitors is thought to be at the pro- to pre-B cell transition. However, we show that the frequencies and absolute…”
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Akt1 and Akt2 promote peripheral B-cell maturation and survival by Calamito, Marco, Juntilla, Marisa M., Thomas, Matthew, Northrup, Daniel L., Rathmell, Jeffrey, Birnbaum, Morris J., Koretzky, Gary, Allman, David

“…Although the 3 isoforms of Akt regulate cell growth, proliferation, and survival in a wide variety of cell types, their role in B-cell development is unknown…”
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Generation of peripheral B cells occurs via two spatially and temporally distinct pathways by Lindsley, Robert Coleman, Thomas, Matthew, Srivastava, Bhaskar, Allman, David

“…We have identified a population of newly formed bone marrow (BM) B cells that shares multiple characteristics with late transitional B cells in the spleen…”
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Resolution of Three Nonproliferative Immature Splenic B Cell Subsets Reveals Multiple Selection Points During Peripheral B Cell Maturation by Allman, David, Lindsley, R. Coleman, DeMuth, William, Rudd, Kristina, Shinton, Susan A, Hardy, Richard R

“…Although immature/transitional peripheral B cells may remain susceptible to selection pressures before full maturation, the nature and timing of these…”
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Characterization of marginal zone B cell precursors by Srivastava, Bhaskar, Quinn, 3rd, William J, Hazard, Kristin, Erikson, Jan, Allman, David

“…Selection of recently formed B cells into the follicular or marginal zone (MZ) compartments is proposed to occur by way of proliferative intermediates…”
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Mastermind critically regulates Notch-mediated lymphoid cell fate decisions by Maillard, Ivan, Weng, Andrew P., Carpenter, Andrea C., Rodriguez, Carlos G., Sai, Hong, Xu, Lanwei, Allman, David, Aster, Jon C., Pear, Warren S.

“…During lymphoid development, Notch1 plays a critical role in the T-cell/B-cell lineage decision, while Notch2 is essential for marginal zone B-cell (MZB)…”
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