Search Results - "ALLEN, Theresa M."

Ligand-targeted therapeutics in anticancer therapy by Allen, Theresa M

“…Cytotoxic chemotherapy or radiotherapy of cancer is limited by serious, sometimes life-threatening, side effects that arise from toxicities to sensitive normal…”
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The ratio of phosphatidylcholine to phosphatidylethanolamine influences membrane integrity and steatohepatitis by Li, Zhaoyu, Agellon, Luis B., Allen, Theresa M., Umeda, Masato, Jewell, Larry, Mason, Andrew, Vance, Dennis E.

“…Phosphatidylcholine (PC) and phosphatidylethanolamine (PE) are major phospholipids in mammalian membranes. In liver, PC is synthesized via the choline pathway…”
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Determination of Doxorubicin Levels in Whole Tumor and Tumor Nuclei in Murine Breast Cancer Tumors by LAGINHA, Kimberley M, VERWOERT, Sylvia, CHARROIS, Gregory J. R, ALLEN, Theresa M

“…Purpose: Pharmacokinetic studies on liposomal drugs have previously measured total drug levels in tumors, which include nonbioavailable drug. However, drugs…”
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Drug release rate influences the pharmacokinetics, biodistribution, therapeutic activity, and toxicity of pegylated liposomal doxorubicin formulations in murine breast cancer by Charrois, Gregory J.R, Allen, Theresa M

“…The pharmacokinetics (PK), biodistribution (BD), and therapeutic activity of pegylated liposomal doxorubicin formulations with different drug release rates…”
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Targeted delivery of anti-CD19 liposomal doxorubicin in B-cell lymphoma: A comparison of whole monoclonal antibody, Fab′ fragments and single chain Fv by Cheng, Wilson W.K., Allen, Theresa M.

“…As part of an ongoing effort to develop a clinically acceptable doxorubicin formulation, targeted against B-cell malignancies, this study compared…”
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Targeting liposomal chemotherapy via both tumor cell-specific and tumor vasculature- specific ligands potentiates therapeutic efficacy by PASTORINO, Fabio, BRIGNOLE, Chiara, RIBATTI, Domenico, CORTI, Angelo, ALLEN, Theresa M, PONZONI, Mirco, DI PAOLO, Daniela, NICO, Bice, PEZZOLO, Annalisa, MARIMPIETRI, Danilo, PAGNAN, Gabriella, PICCARDI, Federica, CILLI, Michele, LONGHI, Renato

“…Neuroblastoma, the most common solid tumor of infancy derived from the sympathetic nervous system, continues to present a formidable clinical challenge…”
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Liposomal drug delivery systems: From concept to clinical applications by Allen, Theresa M., Cullis, Pieter R.

“…The first closed bilayer phospholipid systems, called liposomes, were described in 1965 and soon were proposed as drug delivery systems. The pioneering work of…”
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Neuroblastoma-targeted Nanoparticles Entrapping siRNA Specifically Knockdown ALK by Di Paolo, Daniela, Brignole, Chiara, Pastorino, Fabio, Carosio, Roberta, Zorzoli, Alessia, Rossi, Marzia, Loi, Monica, Pagnan, Gabriella, Emionite, Laura, Cilli, Michele, Bruno, Silvia, Chiarle, Roberto, Allen, Theresa M, Ponzoni, Mirco, Perri, Patrizia

“…RNA interference molecules have some advantages as cancer therapeutics, including a proved efficacy on both wild-type (WT) and mutated transcripts and an…”
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Improved Outcome When B-Cell Lymphoma Is Treated with Combinations of Immunoliposomal Anticancer Drugs Targeted to Both the CD19 and CD20 Epitopes by SAPRA, Puja, ALLEN, Theresa M

“…Purpose: We have reported previously that successful immunoliposomal drug therapy with liposomal doxorubicin (DXR) against xenograft B-lymphoma models required…”
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Antitumor activity of an epithelial cell adhesion molecule–targeted nanovesicular drug delivery system by Hussain, Sajid, Plückthun, Andreas, Allen, Theresa M, Zangemeister-Wittke, Uwe

“…Site-specific delivery of anticancer agents to tumors represents a promising therapeutic strategy because it increases efficacy and reduces toxicity to normal…”
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Rate of biodistribution of STEALTH® liposomes to tumor and skin: influence of liposome diameter and implications for toxicity and therapeutic activity by Charrois, Gregory J.R., Allen, Theresa M.

“…The influence of diameter on the pharmacokinetic and biodistribution of STEALTH® liposomes into the tumor (4T1 murine mammary carcinoma) and cutaneous tissues…”
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Targeting combinations of liposomal drugs to both tumor vasculature cells and tumor cells for the treatment of HER2-positive breast cancer by Hare, Jennifer I., Moase, Elaine H., Allen, Theresa M.

“…Purpose: We used two ligand-modified liposomal drugs to selectively deliver two different chemotherapeutics to tumor cells (TC) and tumor vasculature…”
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Anti-CD19-Targeted Liposomal Doxorubicin Improves the Therapeutic Efficacy in Murine B-Cell Lymphoma and Ameliorates the Toxicity of Liposomes with Varying Drug Release Rates by Allen, Theresa M, Mumbengegwi, Davis R, Charrois, Gregory J R

“…Some formulations of liposomal doxorubicin with intermediate rates of drug release have shown increased levels of toxicity in mice. Because antibody-mediated…”
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Treatment of colorectal cancer using a combination of liposomal irinotecan (Irinophore C™) and 5-fluorouracil by Hare, Jennifer I, Neijzen, Robert W, Anantha, Malathi, Dos Santos, Nancy, Harasym, Natashia, Webb, Murray S, Allen, Theresa M, Bally, Marcel B, Waterhouse, Dawn N

“…To investigate the use of liposomal irinotecan (Irinophore C™) plus or minus 5-fluorouracil (5-FU) for the treatment of colorectal cancer. The effect of…”
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Enhanced Antitumor Efficacy of Clinical-Grade Vasculature-Targeted Liposomal Doxorubicin by PASTORINO, Fabio, DI PAOLO, Daniela, MARIMPIETRI, Danilo, PAGNAN, Gabriella, CILLI, Michele, LEPEKHIN, Eugene A, GARDE, Seema V, LONGHI, Renato, CORTI, Angelo, ALLEN, Theresa M, WU, Jinzi J, PONZONI, Mirco, PICCARDI, Federica, NICO, Beatrice, RIBATTI, Domenico, DAGA, Antonio, BAIO, Gabriella, NEUMAIER, Carlo E, BRIGNOLE, Chiara, LOI, Monica

“…Purpose: In vivo evaluation of good manufacturing practice-grade targeted liposomal doxorubicin (TVT-DOX), bound to a CD13 isoform expressed on the vasculature…”
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Improved Therapeutic Responses in a Xenograft Model of Human B Lymphoma (Namalwa) for Liposomal Vincristine versus Liposomal Doxorubicin Targeted via Anti-CD19 IgG2a or Fab′ Fragments by SAPRA, Puja, MOASE, Elaine H, JIE MA, ALLEN, Theresa M

“…Purpose: Monoclonal antibody-mediated targeting of liposomal anticancer drugs to surface antigens expressed on malignant B cells can be an effective strategy…”
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Pharmacokinetics and pharmacodynamics of lipidic nano-particles in cancer by Allen, Theresa M, Cheng, Wilson W K, Hare, Jennifer I, Laginha, Kimberley M

“…Nanoscale drug delivery systems (DDS) are used to circumvent some of the non-ideal properties of conventional anticancer chemotherapy drugs. Manipulation of…”
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Multiple injections of pegylated liposomal Doxorubicin: pharmacokinetics and therapeutic activity by Charrois, Gregory J R, Allen, Theresa M

“…Effects of multiple injections of liposomal doxorubicin on pharmacokinetics, therapeutic outcome, and toxicity were studied in mice using different dosing…”
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A combinatorial approach to producing sterically stabilized (Stealth) immunoliposomal drugs by Ishida, Tatsuhiro, Iden, Debbie L, Allen, Theresa M

“…We have developed a method for producing sterically stabilized immunoliposomal drugs (SIL) readily applicable to a ‘mix and match’ combinatorial approach for…”
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Chemosensitization of carcinoma cells using epithelial cell adhesion molecule–targeted liposomal antisense against bcl-2/bcl-xL by Hussain, Sajid, Plückthun, Andreas, Allen, Theresa M, Zangemeister-Wittke, Uwe

“…Nanoscale drug delivery systems, such as sterically stabilized immunoliposomes binding to internalizing tumor-associated antigens, can increase therapeutic…”
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