Search Results - "ALLEN, Darin"

Discovery of a potent and selective Aurora kinase inhibitor by Oslob, Johan D., Romanowski, Michael J., Allen, Darin A., Baskaran, Subramanian, Bui, Minna, Elling, Robert A., Flanagan, William M., Fung, Amy D., Hanan, Emily J., Harris, Shannon, Heumann, Stacey A., Hoch, Ute, Jacobs, Jeffrey W., Lam, Joni, Lawrence, Chris E., McDowell, Robert S., Nannini, Michelle A., Shen, Wang, Silverman, Jeffrey A., Sopko, Michelle M., Tangonan, Bradley T., Teague, Juli, Yoburn, Josh C., Yu, Chul H., Zhong, Min, Zimmerman, Kristin M., O’Brien, Tom, Lew, Willard

“…The discovery of a novel series of Aurora kinase inhibitors is disclosed. This communication describes the discovery of a novel series of Aurora kinase…”
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Metabolism of (+)-1,4-Dihydro-7-(trans-3-methoxy-4-methylamino-1-pyrrolidinyl)-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic Acid (Voreloxin; Formerly SNS-595), a Novel Replication-Dependent DNA-Damaging Agent by EVANCHIK, Marc J, ALLEN, Darin, YOBURN, Josh C, SILVERMAN, Jeffrey A, HOCH, Ute

“…(+)-1,4-Dihydro-7-(trans-3-methoxy-4-methylamino-1-pyrrolidinyl)-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid (voreloxin; formerly SNS-595 or…”
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2-Aminobenzimidazoles as potent Aurora kinase inhibitors by Zhong, Min, Bui, Minna, Shen, Wang, Baskaran, Subramanian, Allen, Darin A., Elling, Robert A., Flanagan, W. Michael, Fung, Amy D., Hanan, Emily J., Harris, Shannon O., Heumann, Stacey A., Hoch, Ute, Ivy, Sheryl N., Jacobs, Jeffrey W., Lam, Stuart, Lee, Heman, McDowell, Robert S., Oslob, Johan D., Purkey, Hans E., Romanowski, Michael J., Silverman, Jeffrey A., Tangonan, Bradley T., Taverna, Pietro, Yang, Wenjin, Yoburn, Josh C., Yu, Chul H., Zimmerman, Kristin M., O’Brien, Tom, Lew, Willard

“…This Letter describes the discovery and key structure–activity relationship (SAR) of a series of 2-aminobenzimidazoles as potent Aurora kinase inhibitors…”
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Identification of Potent and Selective Small-Molecule Inhibitors of Caspase-3 through the Use of Extended Tethering and Structure-Based Drug Design by Choong, Ingrid C, Lew, Willard, Lee, Dennis, Pham, Phuongly, Burdett, Matthew T, Lam, Joni W, Wiesmann, Christian, Luong, Tinh N, Fahr, Bruce, DeLano, Warren L, McDowell, Robert S, Allen, Darin A, Erlanson, Daniel A, Gordon, Eric M, O'Brien, Tom

“…The design, synthesis, and in vitro activities of a series of potent and selective small-molecule inhibitors of caspase-3 are described. From extended…”
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Development of Serine Protease Inhibitors Displaying a Multicentered Short (<2.3 Å) Hydrogen Bond Binding Mode:  Inhibitors of Urokinase-Type Plasminogen Activator and Factor Xa by Verner, Erik, Katz, Bradley A, Spencer, Jeffrey R, Allen, Darin, Hataye, Jason, Hruzewicz, Witold, Hui, Hon C, Kolesnikov, Aleksandr, Li, Yong, Luong, Christine, Martelli, Arnold, Radika, Kesavan, Rai, Roopa, She, Miles, Shrader, William, Sprengeler, Paul A, Trapp, Sean, Wang, Jing, Young, Wendy B, Mackman, Richard L

“…Novel scaffolds that bind to serine proteases through a unique network of short hydrogen bonds to the catalytic Ser195 have been developed. The resulting…”
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Water-soluble prodrugs of an Aurora kinase inhibitor by Oslob, Johan D., Heumann, Stacey A., Yu, Chul H., Allen, Darin A., Baskaran, Subramanian, Bui, Minna, Delarosa, Erlie, Fung, Amy D., Hashash, Ahmad, Hau, Jonathan, Ivy, Sheryl, Jacobs, Jeffrey W., Lew, Willard, Maung, Jack, McDowell, Robert S., Ritchie, Sean, Romanowski, Michael J., Silverman, Jeffrey A., Yang, Wenjin, Zhong, Min, Fuchs-Knotts, Tarra

“…In vitro and in vivo properties of prodrug derivatives of the Aurora kinase inhibitor SNS-314 are described. Compound 1 (SNS-314) is a potent and selective…”
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Identification of potent and novel small-molecule inhibitors of caspase-3 by ALLEN, Darin A, PHUONGLY PHAM, LEER, Dennis, CHOONG, Ingrid C, FAHR, Bruce, BURDETT, Matthew T, LEW, Willard, DELANO, Warren L, GORDON, Eric M, LAM, Joni W, O'BRIEN, Tom

“…The design and synthesis of a series of novel, reversible, small molecule inhibitors of caspase-3 are described…”
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Silica-based monoliths for capillary electrochromatography: Methods of fabrication and their applications in analytical separations by Allen, Darin, El Rassi, Ziad

“…This review article is intended to provide the reader with the recent advances made in the fabrication of silica‐based monolithic capillary columns for use in…”
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Capillary electrochromatography with monolithic silica column: I. Preparation of silica monoliths having surface-bound octadecyl moieties and their chromatographic characterization and applications to the separation of neutral and charged species by Allen, Darin, El Rassi, Ziad

“…Monolithic silica columns with surface‐bound octadecyl (C18) moieties have been prepared by a sol‐gel process in 100  μm ID fused‐silica capillaries for…”
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Capillary electrochromatography with monolithic silica columns: III. Preparation of hydrophilic silica monoliths having surface-bound cyano groups: chromatographic characterization and application to the separation of carbohydrates, nucleosides, nucleic acid bases and other neutral polar species by Allen, Darin, El Rassi, Ziad

“…Two synthetic routes have been introduced and evaluated for the preparation of hydrophilic silica-based monoliths possessing surface-bound cyano functions. In…”
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Erratum to “Capillary electrochromatography with monolithic silica columns. III. Preparation of hydrophilic silica monoliths having surface-bound cyano groups: chromatographic characterization and application to the separation of carbohydrates, nucleosides, nucleic acid bases and other neutral polar species” [J. Chromatogr. A 1029 (2004) 239–247] by Allen, Darin, El Rassi, Ziad

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Capillary electrochromatography with monolithic silica columns by Allen, Darin, El Rassi, Ziad

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Capillary electrochromatography with monolithic-silica columns. II. Preparation of amphiphilic silica monoliths having surface-bound cationic octadecyl moieties and their chromatographic characterization and application to the separation of proteins and other neutral and charged species by Allen, Darin, El Rassi, Ziad

“…Three different synthetic routes have been introduced and evaluated for the preparation of amphiphilic silica-based monoliths possessing surface-bound…”
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Headbanging by pigeons III. A systematic replication and extension of an animal model of psychopathology by Casler, Darin Allen

“…Headbanging is a self-injurious behavior commonly associated with many forms of developmental and personality disorders, as well as a variety of mental…”
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Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-directed Serine Protease Inhibitors by Katz, Bradley A., Elrod, Kyle, Verner, Erik, Mackman, Richard L., Luong, Christine, Shrader, William D., Sendzik, Martin, Spencer, Jeffrey R., Sprengeler, Paul A., Kolesnikov, Aleks, Tai, Vincent W.-F., Hui, Hon C., Guy Breitenbucher, J., Allen, Darin, Janc, James W.

“…An extensive structural manifold of short hydrogen bond-mediated, active site-directed, serine protease inhibition motifs is revealed in a set of over 300…”
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Contribution of Multicentered Short Hydrogen Bond Arrays to Potency of Active Site-Directed Serine Protease Inhibitors by Katz, Bradley A, Spencer, Jeffrey R, Elrod, Kyle, Luong, Christine, Mackman, Richard L, Rice, Mark, Sprengeler, Paul A, Allen, Darin, Janc, James

“…We describe and compare the pH dependencies of the potencies and of the bound structures of two inhibitor isosteres that form multicentered short hydrogen bond…”
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4-Aminoarylguanidine and 4-aminobenzamidine derivatives as potent and selective urokinase-type plasminogen activator inhibitors by Spencer, Jeffrey R, McGee, Danny, Allen, Darin, Katz, Bradley A, Luong, Christine, Sendzik, Martin, Squires, Neil, Mackman, Richard L

“…The structure-based design of potent and selective urokinase-type plasminogen activator (uPA) inhibitors with 4-aminoarylamidine or 4-aminoarylguanidine S1…”
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Synthesis of Indole-2-Carboxylic Acid Esters by Allen, Darin A.

“…The title compounds were prepared via lateral lithiation of N-Boc protected toluidines with sec-BuLi, quench with diethyl oxalate, followed by dehydration in…”
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Robust design for distributed computing systems by England, Darin Allen

“…Robust systems have the ability to maintain performance under a wide variety of operating conditions. Although the notion of robustness is very intuitive and…”
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An enantiomeric assay for the flavonoids medicarpin and vestitone using capillary electrophoresis by Allen, Darin J., Gray, Jason C., Paiva, Nancy L., Smith, Joel T.

“…An enantiomeric assay for the flavonoids vestitone and medicarpin from transgenic plant extracts was developed using capillary electrophoresis. It was found…”
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