Search Results - "ALLADA, Ravi"

Circadian Mechanisms in Medicine by Allada, Ravi, Bass, Joseph

“…Molecular insights into diurnal variations in human physiology and behavior are extending our understanding of a wide range of disease processes. Chronobiology…”
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Emerging roles for post-transcriptional regulation in circadian clocks by Lim, Chunghun, Allada, Ravi

“…Here the authors review emerging evidence from circadian systems, indicating an important role for post-transcriptional regulation, from splicing,…”
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Molecular Mechanisms of Sleep Homeostasis in Flies and Mammals by Allada, Ravi, Cirelli, Chiara, Sehgal, Amita

“…Sleep is homeostatically regulated with sleep pressure accumulating with the increasing duration of prior wakefulness. Yet, a clear understanding of the…”
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Cul3 and the BTB adaptor insomniac are key regulators of sleep homeostasis and a dopamine arousal pathway in Drosophila by Pfeiffenberger, Cory, Allada, Ravi

“…Sleep is homeostatically regulated, such that sleep drive reflects the duration of prior wakefulness. However, despite the discovery of genes important for…”
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Circadian organization of behavior and physiology in Drosophila by Allada, Ravi, Chung, Brian Y

“…Circadian clocks organize behavior and physiology to adapt to daily environmental cycles. Genetic approaches in the fruit fly, Drosophila melanogaster, have…”
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Universal method for robust detection of circadian state from gene expression by Braun, Rosemary, Kath, William L., Iwanaszko, Marta, Kula-Eversole, Elzbieta, Abbott, Sabra M., Reid, Kathryn J., Zee, Phyllis C., Allada, Ravi

“…Circadian clocks play a key role in regulating a vast array of biological processes, with significant implications for human health. Accurate assessment of…”
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Bootstrapping and Empirical Bayes Methods Improve Rhythm Detection in Sparsely Sampled Data by Hutchison, Alan L., Allada, Ravi, Dinner, Aaron R.

“…There is much interest in using genome-wide expression time series to identify circadian genes. However, the cost and effort of such measurements often limit…”
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Circadian programming of the ellipsoid body sleep homeostat in Drosophila by Andreani, Tomas, Rosensweig, Clark, Sisobhan, Shiju, Ogunlana, Emmanuel, Kath, William, Allada, Ravi

“…Homeostatic and circadian processes collaborate to appropriately time and consolidate sleep and wake. To understand how these processes are integrated, we…”
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Dual PDF signaling pathways reset clocks via TIMELESS and acutely excite target neurons to control circadian behavior by Seluzicki, Adam, Flourakis, Matthieu, Kula-Eversole, Elzbieta, Zhang, Luoying, Kilman, Valerie, Allada, Ravi

“…Molecular circadian clocks are interconnected via neural networks. In Drosophila, PIGMENT-DISPERSING FACTOR (PDF) acts as a master network regulator with dual…”
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A Circuit Encoding Absolute Cold Temperature in Drosophila by Alpert, Michael H., Frank, Dominic D., Kaspi, Evan, Flourakis, Matthieu, Zaharieva, Emanuela E., Allada, Ravi, Para, Alessia, Gallio, Marco

“…Animals react to environmental changes over timescales ranging from seconds to days and weeks. An important question is how sensory stimuli are parsed into…”
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TimeTrial: An Interactive Application for Optimizing the Design and Analysis of Transcriptomic Time-Series Data in Circadian Biology Research by Ness-Cohn, Elan, Iwanaszko, Marta, Kath, William L., Allada, Ravi, Braun, Rosemary

“…The circadian rhythm drives the oscillatory expression of thousands of genes across all tissues, coordinating physiological processes. The effect of this…”
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Temperature-driven coordination of circadian transcriptional regulation by Xu, Bingxian, Hwangbo, Dae-Sung, Saurabh, Sumit, Rosensweig, Clark, Allada, Ravi, Kath, William L, Braun, Rosemary

“…The circadian clock is an evolutionarily-conserved molecular oscillator that enables species to anticipate rhythmic changes in their environment. At a…”
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The GABAA Receptor RDL Acts in Peptidergic PDF Neurons to Promote Sleep in Drosophila by Chung, Brian Y., Kilman, Valerie L., Keath, J. Russel, Pitman, Jena L., Allada, Ravi

“…Sleep is regulated by a circadian clock that times sleep and wake to specific times of day and a homeostat that drives sleep as a function of prior wakefulness…”
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Circadian Clocks Function in Concert with Heat Shock Organizing Protein to Modulate Mutant Huntingtin Aggregation and Toxicity by Xu, Fangke, Kula-Eversole, Elzbieta, Iwanaszko, Marta, Hutchison, Alan L., Dinner, Aaron, Allada, Ravi

“…Neurodegenerative diseases commonly involve the disruption of circadian rhythms. Studies indicate that mutant Huntingtin (mHtt), the cause of Huntington’s…”
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Ataxin2 functions via CrebA to mediate Huntingtin toxicity in circadian clock neurons by Xu, Fangke, Kula-Eversole, Elzbieta, Iwanaszko, Marta, Lim, Chunghun, Allada, Ravi

“…Disrupted circadian rhythms is a prominent and early feature of neurodegenerative diseases including Huntington's disease (HD). In HD patients and animal…”
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Surprising gene expression patterns within and between PDF-containing circadian neurons in Drosophila by Kula-Eversole, Elzbieta, Nagoshi, Emi, Shang, Yuhua, Rodriguez, Joseph, Allada, Ravi, Rosbash, Michael, Takahashi, Joseph S.

“…To compare circadian gene expression within highly discrete neuronal populations, we separately purified and characterized two adjacent but distinct groups of…”
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dynamic role for the mushroom bodies in promoting sleep in Drosophila by Pitman, J.L, McGill, J.J, Keegan, K.P, Allada, R

“…The fruitfly, Drosophila melanogaster, exhibits many of the cardinal features of sleep, yet little is known about the neural circuits governing its sleep. Here…”
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DN1p Circadian Neurons Coordinate Acute Light and PDF Inputs to Produce Robust Daily Behavior in Drosophila by Zhang, Luoying, Chung, Brian Y., Lear, Bridget C., Kilman, Valerie L., Liu, Yixiao, Mahesh, Guruswamy, Meissner, Rose-Anne, Hardin, Paul E., Allada, Ravi

“…Daily behaviors in animals are determined by the interplay between internal timing signals from circadian clocks and environmental stimuli such as light. How…”
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Glial immune-related pathways mediate effects of closed head traumatic brain injury on behavior and lethality in Drosophila by van Alphen, Bart, Stewart, Samuel, Iwanaszko, Marta, Xu, Fangke, Li, Keyin, Rozenfeld, Sydney, Ramakrishnan, Anujaianthi, Itoh, Taichi Q, Sisobhan, Shiju, Qin, Zuoheng, Lear, Bridget C, Allada, Ravi

“…In traumatic brain injury (TBI), the initial injury phase is followed by a secondary phase that contributes to neurodegeneration, yet the mechanisms leading to…”
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The neuropeptide PDF acts directly on evening pacemaker neurons to regulate multiple features of circadian behavior by Lear, Bridget C, Zhang, Luoying, Allada, Ravi

“…Discrete clusters of circadian clock neurons temporally organize daily behaviors such as sleep and wake. In Drosophila, a network of just 150 neurons drives…”
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