Search Results - "ALITALO, KARI"

Vascular endothelial growth factor signaling in development and disease by Karaman, Sinem, Leppänen, Veli-Matti, Alitalo, Kari

“…Vascular endothelial growth factors (VEGFs) are best known for their involvement in orchestrating the development and maintenance of the blood and lymphatic…”
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Therapeutic targeting of the angiopoietin–TIE pathway by Saharinen, Pipsa, Eklund, Lauri, Alitalo, Kari

“…Key Points Angiopoietin ligands (ANG1–ANG4) and the TIE (TIE1 and TIE2) receptor tyrosine kinases form an endothelial signalling pathway that is necessary for…”
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Lymphatic Vessels in Tumor Dissemination versus Immunotherapy by Vaahtomeri, Kari, Alitalo, Kari

“…During the growth of various cancers, primary tumors can escape antitumor immune responses of their host and eventually disseminate into distant organs…”
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Lymphangiogenic factors, mechanisms, and applications by Zheng, Wei, Aspelund, Aleksanteri, Alitalo, Kari

“…Lymphangiogenesis, the growth of lymphatic vessels, is essential in embryonic development. In adults, it is involved in many pathological processes such as…”
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Lymphangiogenesis guidance by paracrine and pericellular factors by Vaahtomeri, Kari, Karaman, Sinem, Mäkinen, Taija, Alitalo, Kari

“…Lymphatic vessels are important for tissue fluid homeostasis, lipid absorption, and immune cell trafficking and are involved in the pathogenesis of several…”
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Development and plasticity of meningeal lymphatic vessels by Antila, Salli, Karaman, Sinem, Nurmi, Harri, Airavaara, Mikko, Voutilainen, Merja H, Mathivet, Thomas, Chilov, Dmitri, Li, Zhilin, Koppinen, Tapani, Park, Jun-Hee, Fang, Shentong, Aspelund, Aleksanteri, Saarma, Mart, Eichmann, Anne, Thomas, Jean-Léon, Alitalo, Kari

“…The recent discovery of meningeal lymphatic vessels (LVs) has raised interest in their possible involvement in neuropathological processes, yet little is known…”
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Lymphatic Malformations: Genetics, Mechanisms and Therapeutic Strategies by Mäkinen, Taija, Boon, Laurence M., Vikkula, Miikka, Alitalo, Kari

“…Lymphatic vessels maintain tissue fluid homeostasis by returning to blood circulation interstitial fluid that has extravasated from the blood capillaries. They…”
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Understanding the functions and relationships of the glymphatic system and meningeal lymphatics by Louveau, Antoine, Plog, Benjamin A, Antila, Salli, Alitalo, Kari, Nedergaard, Maiken, Kipnis, Jonathan

“…Recent discoveries of the glymphatic system and of meningeal lymphatic vessels have generated a lot of excitement, along with some degree of skepticism. Here,…”
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Lymphatic System in Cardiovascular Medicine by Aspelund, Aleksanteri, Robciuc, Marius R, Karaman, Sinem, Makinen, Taija, Alitalo, Kari

“…The mammalian circulatory system comprises both the cardiovascular system and the lymphatic system. In contrast to the blood vascular circulation, the…”
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VEGFR3 Modulates Vascular Permeability by Controlling VEGF/VEGFR2 Signaling by Heinolainen, Krista, Karaman, Sinem, D’Amico, Gabriela, Tammela, Tuomas, Sormunen, Raija, Eklund, Lauri, Alitalo, Kari, Zarkada, Georgia

“…RATIONALE:Vascular endothelial growth factor (VEGF) is the main driver of angiogenesis and vascular permeability via VEGF receptor 2 (VEGFR2), whereas…”
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VEGF and angiopoietin signaling in tumor angiogenesis and metastasis by Saharinen, Pipsa, Eklund, Lauri, Pulkki, Kristina, Bono, Petri, Alitalo, Kari

“…Solid tumors require blood vessels for growth and dissemination, and lymphatic vessels as additional conduits for metastatic spread. The identification of…”
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Molecular biology and pathology of lymphangiogenesis by Karpanen, Terhi, Alitalo, Kari

“…The lymphatic vasculature is essential for the maintenance of tissue fluid balance, immune surveillance, and adsorption fatty acids in the gut. The lymphatic…”
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Blockade of VEGF-C signaling inhibits lymphatic malformations driven by oncogenic PIK3CA mutation by Martinez-Corral, Ines, Zhang, Yan, Petkova, Milena, Ortsäter, Henrik, Sjöberg, Sofie, Castillo, Sandra D., Brouillard, Pascal, Libbrecht, Louis, Saur, Dieter, Graupera, Mariona, Alitalo, Kari, Boon, Laurence, Vikkula, Miikka, Mäkinen, Taija

“…Lymphatic malformations (LMs) are debilitating vascular anomalies presenting with large cysts (macrocystic) or lesions that infiltrate tissues (microcystic)…”
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Endothelial Cells Regulate Physiological Cardiomyocyte Growth via VEGFR2-Mediated Paracrine Signaling by Kivelä, Riikka, Hemanthakumar, Karthik Amudhala, Vaparanta, Katri, Robciuc, Marius, Izumiya, Yasuhiro, Kidoya, Hiroyasu, Takakura, Nobuyuki, Peng, Xuyang, Sawyer, Douglas B, Elenius, Klaus, Walsh, Kenneth, Alitalo, Kari

“…BACKGROUND:Heart failure, which is a major global health problem, is often preceded by pathological cardiac hypertrophy. The expansion of the cardiac…”
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Vascular endothelial growth factor-B in physiology and disease by Bry, Maija, Kivelä, Riikka, Leppänen, Veli-Matti, Alitalo, Kari

“…Vascular endothelial growth factor-B (VEGF-B), discovered over 15 years ago, has long been seen as one of the more ambiguous members of the VEGF family. VEGF-B…”
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Distinct fibroblast subsets regulate lacteal integrity through YAP/TAZ-induced VEGF-C in intestinal villi by Hong, Seon Pyo, Yang, Myung Jin, Cho, Hyunsoo, Park, Intae, Bae, Hosung, Choe, Kibaek, Suh, Sang Heon, Adams, Ralf H., Alitalo, Kari, Lim, Daesik, Koh, Gou Young

“…Emerging evidence suggests that intestinal stromal cells (IntSCs) play essential roles in maintaining intestinal homeostasis. However, the extent of…”
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Opposing actions of angiopoietin-2 on Tie2 signaling and FOXO1 activation by Kim, Minah, Allen, Breanna, Korhonen, Emilia A, Nitschké, Maximilian, Yang, Hee Won, Baluk, Peter, Saharinen, Pipsa, Alitalo, Kari, Daly, Christopher, Thurston, Gavin, McDonald, Donald M

“…Angiopoietin-2 (ANG2) regulates blood vessel remodeling in many pathological conditions through differential effects on Tie2 signaling. While ANG2 competes…”
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VEGFR3 does not sustain retinal angiogenesis without VEGFR2 by Zarkada, Georgia, Heinolainen, Krista, Makinen, Taija, Kubota, Yoshiaki, Alitalo, Kari

“…Angiogenesis, the formation of new blood vessels, is regulated by vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs). VEGFR2 is abundant…”
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Nonvenous Origin of Dermal Lymphatic Vasculature by Martinez-Corral, Ines, Ulvmar, Maria H, Stanczuk, Lukas, Tatin, Florence, Kizhatil, Krishnakumar, John, Simon W.M, Alitalo, Kari, Ortega, Sagrario, Makinen, Taija

“…RATIONALE:The formation of the blood vasculature is achieved via 2 fundamentally different mechanisms, de novo formation of vessels from endothelial…”
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Distinct roles of the meningeal layers in CNS autoimmunity by Merlini, Arianna, Haberl, Michael, Strauß, Judith, Hildebrand, Luisa, Genc, Nafiye, Franz, Jonas, Chilov, Dmitri, Alitalo, Kari, Flügel-Koch, Cassandra, Stadelmann, Christine, Flügel, Alexander, Odoardi, Francesca

“…The meninges, comprising the leptomeninges (pia and arachnoid layers) and the pachymeninx (dura layer), participate in central nervous system (CNS)…”
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