Amplification of the antitumor activity of phleomycins and bleomycins in rats and mice by caffeine

While having no antitumor effect per se, caffeine substantially enhanced the antitumor effects of the phleomycins PLM-CHP and PLM-PEP, and the bleomycins BLM-CHP and Blenoxane in rats carrying Walker 256 carcinosarcoma and/or mice carrying Ehrlich ascites tumor, even at doses of phleomycin and bleom...

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Bibliographic Details
Published in:	Cancer research (Chicago, Ill.) Vol. 45; no. 6; pp. 2516 - 2521
Main Authors:	ALLEN, T. E, ALIANO, N. A, COWAN, R. J, GRIGG, G. W, HART, N. K, LAMBERTON, J. A, LANE, A
Format:	Journal Article
Language:	English
Published:	Philadelphia, PA American Association for Cancer Research 01-06-1985
Subjects:	Animals Antineoplastic agents Biological and medical sciences Bleomycin - therapeutic use Caffeine - pharmacology Carcinoma 256, Walker - drug therapy Carcinoma, Ehrlich Tumor - drug therapy Chemotherapy DNA - biosynthesis DNA Repair - drug effects Drug Synergism Male Medical sciences Mice Mice, Inbred Strains Neoplasms, Experimental - drug therapy Pharmacology. Drug treatments Phleomycins - therapeutic use Rats Rats, Inbred Strains Antineoplastic agent Potentiation Vertebrata Mammalia Rat Mouse Walker carcinosarcoma 256 Animal Rodentia Drug interaction Caffeine
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Summary:	While having no antitumor effect per se, caffeine substantially enhanced the antitumor effects of the phleomycins PLM-CHP and PLM-PEP, and the bleomycins BLM-CHP and Blenoxane in rats carrying Walker 256 carcinosarcoma and/or mice carrying Ehrlich ascites tumor, even at doses of phleomycin and bleomycin below the minimum effective level. Positive but less conclusive results were also obtained with PLM-A4A4G and PLM-G.
ISSN:	0008-5472 1538-7445