Search Results - "ALFORD, F"

The Rosetta All-Atom Energy Function for Macromolecular Modeling and Design by Alford, Rebecca F, Leaver-Fay, Andrew, Jeliazkov, Jeliazko R, O’Meara, Matthew J, DiMaio, Frank P, Park, Hahnbeom, Shapovalov, Maxim V, Renfrew, P. Douglas, Mulligan, Vikram K, Kappel, Kalli, Labonte, Jason W, Pacella, Michael S, Bonneau, Richard, Bradley, Philip, Dunbrack, Roland L, Das, Rhiju, Baker, David, Kuhlman, Brian, Kortemme, Tanja, Gray, Jeffrey J

“…Over the past decade, the Rosetta biomolecular modeling suite has informed diverse biological questions and engineering challenges ranging from interpretation…”
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Protein Structure Prediction and Design in a Biologically Realistic Implicit Membrane by Alford, Rebecca F., Fleming, Patrick J., Fleming, Karen G., Gray, Jeffrey J.

“…Protein design is a powerful tool for elucidating mechanisms of function and engineering new therapeutics and nanotechnologies. Although soluble protein design…”
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Glucose effectiveness is a critical pathogenic factor leading to glucose intolerance and type 2 diabetes: An ignored hypothesis by Alford, F.P., Henriksen, J.E., Rantzau, C., Beck‐Nielsen, H.

“…Background Although the ability of glucose to mediate its own in vivo metabolism is long documented, the quantitative measurement of whole body…”
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A cyber-linked undergraduate research experience in computational biomolecular structure prediction and design by Alford, Rebecca F, Leaver-Fay, Andrew, Gonzales, Lynda, Dolan, Erin L, Gray, Jeffrey J

“…Computational biology is an interdisciplinary field, and many computational biology research projects involve distributed teams of scientists. To accomplish…”
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Glucose Effectiveness in Nondiabetic Relatives: Dysglycemia and β-Cell Function at 10 Years by Egede, M. B, Henriksen, J.-E, Durck, T. T, Levin, K, Rantzau, C, Ward, G, Beck-Nielsen, H, Alford, F. P

“…Aims: Reduced glucose effectiveness is a predictor of future glucose tolerance in individuals with a family history of type 2 diabetes. We examined…”
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An Integrated Framework Advancing Membrane Protein Modeling and Design by Alford, Rebecca F, Koehler Leman, Julia, Weitzner, Brian D, Duran, Amanda M, Tilley, Drew C, Elazar, Assaf, Gray, Jeffrey J

“…Membrane proteins are critical functional molecules in the human body, constituting more than 30% of open reading frames in the human genome. Unfortunately, a…”
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Texture evolution during equal channel angular extrusion: Part I. Effect of route, number of passes and initial texture by Ferrasse, S, Segal, V.M, Kalidindi, S.R, Alford, F

“…It is shown that equal channel angular extrusion (ECAE) is an effective technique to control texture of metals and alloys. Two processing parameters, the route…”
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Morphometric documentation of abnormal intramyocellular fat storage and reduced glycogen in obese patients with Type II diabetes by LEVIN, K, DAA SCHROEDER, H, ALFORD, F. P, BECK-NIELSEN, H

“…Insulin resistance of skeletal muscle has been associated with increased lipid availability. This study aimed to estimate volume fractions of intramyocellular…”
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Ensuring scientific reproducibility in bio-macromolecular modeling via extensive, automated benchmarks by Koehler Leman, Julia, Lyskov, Sergey, Lewis, Steven M., Adolf-Bryfogle, Jared, Alford, Rebecca F., Barlow, Kyle, Ben-Aharon, Ziv, Farrell, Daniel, Fell, Jason, Hansen, William A., Harmalkar, Ameya, Jeliazkov, Jeliazko, Kuenze, Georg, Krys, Justyna D., Ljubetič, Ajasja, Loshbaugh, Amanda L., Maguire, Jack, Moretti, Rocco, Mulligan, Vikram Khipple, Nance, Morgan L., Nguyen, Phuong T., Ó Conchúir, Shane, Roy Burman, Shourya S., Samanta, Rituparna, Smith, Shannon T., Teets, Frank, Tiemann, Johanna K. S., Watkins, Andrew, Woods, Hope, Yachnin, Brahm J., Bahl, Christopher D., Bailey-Kellogg, Chris, Baker, David, Das, Rhiju, DiMaio, Frank, Khare, Sagar D., Kortemme, Tanja, Labonte, Jason W., Lindorff-Larsen, Kresten, Meiler, Jens, Schief, William, Schueler-Furman, Ora, Siegel, Justin B., Stein, Amelie, Yarov-Yarovoy, Vladimir, Kuhlman, Brian, Leaver-Fay, Andrew, Gront, Dominik, Gray, Jeffrey J., Bonneau, Richard

“…Each year vast international resources are wasted on irreproducible research. The scientific community has been slow to adopt standard software engineering…”
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Tensile testing of ultra fine grained metals by Segal, V.M., Ferrasse, S., Alford, F.

“…A simple model of neck evolution during tensile testing is suggested. Approximate true stress–true strain diagrams are calculated and analyzed for fine grained…”
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Contrasting effects of exercise, AICAR, and increased fatty acid supply on in vivo and skeletal muscle glucose metabolism by Rantzau, C, Christopher, M, Alford, F. P

“…Department of Endocrinology and Diabetes and Department of Medicine, St. Vincent's Hospital, Fitzroy, and University of Melbourne, Parkville, Victoria,…”
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Diverse Scientific Benchmarks for Implicit Membrane Energy Functions by Alford, Rebecca F, Samanta, Rituparna, Gray, Jeffrey J

“…Energy functions are fundamental to biomolecular modeling. Their success depends on robust physical formalisms, efficient optimization, and high-resolution…”
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Impaired non-esterified fatty acid suppression to intravenous glucose during late pregnancy persists postpartum in gestational diabetes : a dominant role for decreased insulin secretion rather than insulin resistance by MCLACHLAN, K. A, BOSTON, R, ALFORD, F. P

“…Non-esterified fatty acids are implicated in the pathogenesis of gestational (GDM) and type 2 diabetes. We examined the relationship between NEFA dynamics,…”
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Effect of additional processing on texture evolution of Al0.5Cu alloy processed by equal channel angular extrusion (ECAE) by Ferrasse, S, Segal, V.M, Alford, F

“…The texture development of equal channel angular extrusion (ECAE) processed Al.5Cu alloy submitted to further ECAE or rolling is analyzed. Initial…”
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Membrane Protein Engineering with Rosetta by Alford, Rebecca F, Gray, Jeffrey J

“…Protein engineering can yield new molecular tools for nanotechnology and therapeutic applications through modulating physiochemical and biological properties…”
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Skeletal muscle 11βHSD1 activity of nondiabetic subjects is unaltered in central obesity-associated insulin resistance by Inder, W J, Obeyesekere, V R, Alford, F P, Jang, C

“…Local activation of glucocorticoids in insulin target tissues by the enzyme 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) has been implicated in the…”
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Protein docking and steered molecular dynamics suggest alternative phospholamban-binding sites on the SERCA calcium transporter by Alford, Rebecca F., Smolin, Nikolai, Young, Howard S., Gray, Jeffrey J., Robia, Seth L.

“…The transport activity of the sarco(endo)plasmic reticulum calcium ATPase (SERCA) in cardiac myocytes is modulated by an inhibitory interaction with a…”
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Texture evolution during equal channel angular extrusion (ECAE): Part II. An effect of post-deformation annealing by Ferrasse, S., Segal, V.M., Alford, F.

“…The influence of annealing on texture after ECAE of Al–0.5Cu alloy is described. It is shown that annealing presents multiple opportunities to control texture,…”
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Protein Structure Prediction and Design in a Biologically Realistic Implicit Membrane by Alford, Rebecca F., Fleming, Patrick J., Fleming, Karen G., Gray, Jeffrey J.

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Robust classification of protein variation using structural modelling and large-scale data integration by Baugh, Evan H, Simmons-Edler, Riley, Müller, Christian L, Alford, Rebecca F, Volfovsky, Natalia, Lash, Alex E, Bonneau, Richard

“…Existing methods for interpreting protein variation focus on annotating mutation pathogenicity rather than detailed interpretation of variant deleteriousness…”
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