Search Results - "ALFIREVIC, A"

Phenotype Standardization for Statin-Induced Myotoxicity by Alfirevic, A, Neely, D, Armitage, J, Chinoy, H, Cooper, R G, Laaksonen, R, Carr, D F, Bloch, K M, Fahy, J, Hanson, A, Yue, Q-Y, Wadelius, M, Maitland-van Der Zee, A H, Voora, D, Psaty, B M, Palmer, C N A, Pirmohamed, M

“…Statins are widely used lipid‐lowering drugs that are effective in reducing cardiovascular disease risk. Although they are generally well tolerated, they can…”
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Low dose aspirin and pregnancy: how important is aspirin resistance? by Navaratnam, K, Alfirevic, A, Alfirevic, Z

“…Antiplatelet agents are pivotal for prevention of coronary artery disease and cerebrovascular disease worldwide. Individual patient data meta‐analysis…”
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Predictive Genetic Testing for Drug-Induced Liver Injury: Considerations of Clinical Utility by Alfirevic, A, Pirmohamed, M

“…Genetic predisposition to drug‐induced liver injury may be due to variation in both pharmacokinetic and pharmacodynamic pathways. Recent genome‐wide…”
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HLA Genotype and Carbamazepine-Induced Cutaneous Adverse Drug Reactions: A Systematic Review by Yip, V L, Marson, A G, Jorgensen, A L, Pirmohamed, M, Alfirevic, A

“…Carbamazepine (CBZ) therapy is associated with cutaneous adverse reactions in up to 10% of patients. Predisposition to these hypersensitivity reactions has…”
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Vaginal bacterial load in the second trimester is associated with early preterm birth recurrence: a nested case–control study by Goodfellow, L, Verwijs, MC, Care, A, Sharp, A, Ivandic, J, Poljak, B, Roberts, D, Bronowski, C, Gill, AC, Darby, AC, Alfirevic, A, Muller‐Myhsok, B, Alfirevic, Z, van de Wijgert, JHHM

“…Objective To assess the association between vaginal microbiome (VMB) composition and recurrent early spontaneous preterm birth (sPTB)/preterm prelabour rupture…”
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Genetics of Immune-Mediated Adverse Drug Reactions: a Comprehensive and Clinical Review by Yip, V. L. M., Alfirevic, A., Pirmohamed, M.

“…Adverse drug reactions (ADRs) are common and are a major problem in drug therapy. Patients experience unnecessary morbidity and mortality whilst many effective…”
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GATM gene variants and statin myopathy risk by Carr, D. F., Alfirevic, A., Johnson, R., Chinoy, H., van Staa, T., Pirmohamed, M.

“…Arising from L. M. Mangravite et al. Nature502, 377–380 (2013); doi:10.1038/nature12508 Mangravite et al. 1 identified six expression quantitative loci (eQTLs)…”
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HLA-DQ allele-restricted activation of nitroso sulfamethoxazole-specific CD4-positive T lymphocytes from patients with cystic fibrosis by Ogese, M. O., Saide, K., Faulkner, L., Whitaker, P., Peckham, D., Alfirevic, A., Baker, D. M., Sette, A., Pirmohamed, M., Park, B. K., Naisbitt, D. J.

“…Summary Background For certain HLA allele‐associated drug hypersensitivity reactions, the parent drug has been shown to associate directly with the risk…”
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A microRNA-based prediction algorithm for diagnosis of non-small lung cell carcinoma in minimal biopsy material by Bediaga, N G, Davies, M P A, Acha-Sagredo, A, Hyde, R, Raji, O Y, Page, R, Walshaw, M, Gosney, J, Alfirevic, A, Field, J K, Liloglou, T

“…Background: Diagnosis is jeopardised when limited biopsy material is available or histological quality compromised. Here we developed and validated a…”
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Human leucocyte antigen–adverse drug reaction associations: from a perspective of ethnicity by Ghattaoraya, G. S., Middleton, D., Santos, E. J. M., Dickson, R., Jones, A. R., Alfirevic, A.

“…Summary Whilst immune‐mediated adverse drug reactions (ADRs) are rare, they are potentially life‐threatening and present a major problem for clinicians. The…”
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Response to "HLA Allelic Variants and Carbamazepine-Induced Hypersensitivity" by Yip, V L M, Pirmohamed, M, Alfirevic, A

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Investigation of inter-individual variability of the one-carbon folate pathway: a bioinformatic and genetic review by Carr, D F, Whiteley, G, Alfirevic, A, Pirmohamed, M

“…Genetic polymorphisms in the one-carbon folate pathway have been widely studied in association with a number of conditions. Most of the research has focused on…”
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Phenotype Standardization of Angioedema in the Head and Neck Region Caused by Agents Acting on the Angiotensin System by Wadelius, M, Marshall, S E, Islander, G, Nordang, L, Karawajczyk, M, Yue, Q-Y, Terreehorst, I, Baranova, E V, Hugosson, S, Sköldefors, K, Pirmohamed, M, Maitland-van der Zee, A-H, Alfirevic, A, Hallberg, P, Palmer, C N A

“…Angioedema is a potentially life‐threatening adverse reaction to angiotensin‐converting enzyme inhibitors and angiotensin receptor blockers. To study the…”
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PP126—In-vitro reactivity of drug-specific t-cells from a HLA-A31:01 positive carbamazepine hypersensitive patient by Lichtenfels, M, Naisbitt, D.J, Alfirevic, A, Park, K.B, Pirmohamed, M

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121 Extended HLA analysis in a cohort of patients hypersensitive to beta-lactam antibiotics by Whitaker, P, Alfirevic, A, Etherington, C, Clifton, I, Fitch, G, Pirmohamed, M, Peckham, D

“…Objectives Hypersensitivity reactions to beta-lactam antibiotics remain a major clinical problem in the management of patients with CF. Whilst reactions are…”
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Cost Effectiveness of Pharmacogenetic Screening Prior to Initiation of Carbamazepine Treatment for Epilepsy by Plumpton, C.O, Yip, V, Alfirevic, A, Marson, A, Pirmohamed, M, Hughes, D.A

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The d3/fl-GH receptor gene polymorphism does not influence quality of life and body composition in GH-deficient adults receiving GH replacement therapy by Adetunji, O R, MacFarlane, I A, Javadpour, M, Alfirevic, A, Pirmohamed, M, Blair, J C

“…ContextThe growth response to recombinant human growth hormone (rhGH) in GH deficient (GHD) patients may be influenced by polymorphisms in the growth hormone…”
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PP122—Regulation of human leukocyte antigen expression and nevirapine-induced adverse drug reactions in a malawian hiv-positive population by Cornejo Castro, E.M, Carr, D.F, Marshall, V.A, Chaponda, M, Lane, S, Alfirevic, A, Whitby, D, Carrington, M, Pirmohamed, M

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Deletion of exon 3 in the growth hormone receptor gene in adults with growth hormone deficiency: comparison of symptomatic and asymptomatic patients by Adetunji, O.R., Blair, J.C., Javadpour, M., Alfirevic, A., Pirmohamed, M., MacFarlane, I.A.

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Predictive GeneticTesting for Drug-Induced Liver Injury: Considerations of Clinical Utility by ALFIREVIC, A, PIRMOHAMED, M

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