Search Results - "ALFIERI, Alan"

Bone marrow stromal cell transplantation mitigates radiation-induced gastrointestinal syndrome in mice by Saha, Subhrajit, Bhanja, Payel, Kabarriti, Rafi, Liu, Laibin, Alfieri, Alan A, Guha, Chandan

“…Nuclear accidents and terrorism presents a serious threat for mass casualty. While bone-marrow transplantation might mitigate hematopoietic syndrome, currently…”
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TLR9 agonist protects mice from radiation-induced gastrointestinal syndrome by Saha, Subhrajit, Bhanja, Payel, Liu, Laibin, Alfieri, Alan A, Yu, Dong, Kandimalla, Ekambar R, Agrawal, Sudhir, Guha, Chandan

“…Radiation-induced gastrointestinal syndrome (RIGS) is due to the clonogenic loss of crypt cells and villi depopulation, resulting in disruption of mucosal…”
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Protective role of R-spondin1, an intestinal stem cell growth factor, against radiation-induced gastrointestinal syndrome in mice by Bhanja, Payel, Saha, Subhrajit, Kabarriti, Rafi, Liu, Laibin, Roy-Chowdhury, Namita, Roy-Chowdhury, Jayanta, Sellers, Rani S, Alfieri, Alan A, Guha, Chandan

“…Radiation-induced gastrointestinal syndrome (RIGS) results from a combination of direct cytocidal effects on intestinal crypt and endothelial cells and…”
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Snai2 Maintains Bone Marrow Niche Cells by Repressing Osteopontin Expression by Wei, Qiaozhi, Nakahara, Fumio, Asada, Noboru, Zhang, Dachuan, Gao, Xin, Xu, Chunliang, Alfieri, Alan, Brodin, N. Patrik, Zimmerman, Samuel E., Mar, Jessica C., Guha, Chandan, Guo, Wenjun, Frenette, Paul S.

“…Bone marrow (BM) mesenchymal stem and progenitor cells (MSPCs) are a critical constituent of the hematopoietic stem cell (HSC) niche. Previous studies have…”
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Sustained release nitric oxide releasing nanoparticles: Characterization of a novel delivery platform based on nitrite containing hydrogel/glass composites by Friedman, Adam J., Han, George, Navati, Mahantesh S., Chacko, Manju, Gunther, Leslie, Alfieri, Alan, Friedman, Joel M.

“…A new platform using biocompatible materials is presented for generating powders comprised of nanoparticles that release therapeutic levels of nitric oxide…”
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Nitric oxide-releasing nanoparticles accelerate wound healing in NOD-SCID mice by Blecher, Karin, BA, Martinez, Luis R., PhD, Tuckman-Vernon, Chaim, BS, Nacharaju, Parimala, PhD, Schairer, David, BA, Chouake, Jason, BA, Friedman, Joel M., MD, PhD, Alfieri, Alan, MS, Guha, Chandan, MD, PhD, Nosanchuk, Joshua D., MD, Friedman, Adam J., MD, FAAD

“…Abstract Wound healing is a complex process, coordinated by various biological factors. In immunocompromised states wound healing can be interrupted as a…”
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Rigosertib Is a More Effective Radiosensitizer Than Cisplatin in Concurrent Chemoradiation Treatment of Cervical Carcinoma, In Vitro and In Vivo by Agoni, Lorenzo, MD, PhD, Basu, Indranil, PhD, Gupta, Seema, PhD, Alfieri, Alan, MS, Gambino, Angela, MD, Goldberg, Gary L., MD, Reddy, E. Premkumar, PhD, Guha, Chandan, MBBS, PhD

“…Purpose To compare rigosertib versus cisplatin as an effective radiosensitizing agent for cervical malignancies. Methods and Materials Rigosertib and cisplatin…”
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Identifying Urinary and Serum Exosome Biomarkers for Radiation Exposure Using a Data Dependent Acquisition and SWATH-MS Combined Workflow by Kulkarni, Shilpa, PhD, Koller, Antonius, PhD, Mani, Kartik M., MD, PhD, Wen, Ruofeng, PhD, Alfieri, Alan, MS, Saha, Subhrajit, PhD, Wang, Jian, BS, Patel, Purvi, MS, Bandeira, Nuno, PhD, Guha, Chandan, MD, PhD, Chen, Emily I., PhD

“…Purpose Early and accurate assessment of radiation injury by radiation-responsive biomarkers is critical for triage and early intervention. Biofluids such as…”
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Identification and Characterization of Mesenchymal-Epithelial Progenitor-Like Cells in Normal and Injured Rat Liver by Liu, Daqing, Yovchev, Mladen I, Zhang, Jinghang, Alfieri, Alan A, Tchaikovskaya, Tatyana, Laconi, Ezio, Dabeva, Mariana D

“…In normal rat liver, thymocyte antigen 1 (Thy1) is expressed in fibroblasts / myofibroblasts and in some blood progenitor cells. Thy1-expressing cells also…”
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An Autologous In Situ Tumor Vaccination Approach for Hepatocellular Carcinoma. 2. Tumor-Specific Immunity and Cure after Radio-Inducible Suicide Gene Therapy and Systemic CD40-Ligand and Flt3-Ligand Gene Therapy in an Orthotopic Tumor Model by Kawashita, Yujo, Deb, Niloy J., Garg, Madhur K., Kabarriti, Rafi, Fan, Zuoheng, Alfieri, Alan A., Roy-Chowdhury, Jayanta, Guha, Chandan

“…Diffuse hepatocellular carcinoma (HCC) is a lethal disease that radiation therapy (RT) currently has a limited role in treating because of the potential for…”
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Aspiration rate following chemoradiation for head and neck cancer: An underreported occurrence by Nguyen, Nam P., Frank, Cheryl, Moltz, Candace C., Vos, Paul, Smith, Herbert J., Bhamidipati, Prabhakar V., Karlsson, Ulf, Nguyen, Phuc D., Alfieri, Alan, Nguyen, Ly M., Lemanski, Claire, Chan, Wayne, Rose, Sue, Sallah, Sabah

“…We would like to assess the prevalence of aspiration before and following chemoradiation for head and neck cancer. We reviewed retrospectively the Modified…”
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Safety and effectiveness of prophylactic gastrostomy tubes for head and neck cancer patients undergoing chemoradiation by Nguyen, Nam P., North, Debra, Smith, Herbert J., Dutta, Suresh, Alfieri, Alan, Karlsson, Ulf, Lee, Howard, Martinez, Tomas, Lemanski, Claire, Nguyen, Ly M., Ludin, Adir, Sallah, Sabah

“…We would like to assess the safety and effectiveness of prophylactic percutaneous endoscopic gastrostomy (PEG) tube feedings during concurrent chemoradiation…”
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Nanoparticle-Encapsulated Doxorubicin Demonstrates Superior Tumor Cell Kill in Triple Negative Breast Cancer Subtypes Intrinsically Resistant to Doxorubicin by Friedman, Adam, Ye, Kenny, Rodriguez-Gabin, Alicia, Noshancuk, Joshua, Friedman, Joel, Alfieri, Alan, Navanti, Mahantesh, Landriscina, Angelo, Rosen, Jamie, Schairer, David, Makdisi, Joy, Adler, Brandon, Krausz, Aimee, McDaid, Hayley

“…The effect of size and release kinetics of doxorubicin-nanoparticles on anti-tumor efficacy was evaluated in a panel of human cancer cell lines, including…”
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Tumor Biology-Guided Radiotherapy Treatment Planning: Gross Tumor Volume Versus Functional Tumor Volume by Guha, Chandan, MD, PhD, Alfieri, Alan, MS, Blaufox, M. Donald, MD, PhD, Kalnicki, Shalom, MD

“…This issue of Seminars in Nuclear Medicine deals with a watershed event in cancer treatment—the combined use of functional and anatomical information to guide…”
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Aspiration Occurence During Chemoradiation For Head and Neck Cancer by NGUYEN, Nam P, SMITH, Herbert J, NGUYEN, Ly M, SALLAH, Sabah, DUTTA, Suresh, ALFIERI, Alan, NORTH, Debra, NGUYEN, Phuc D, LEE, Howard, MARTINEZ, Tomas, LEMANSKI, Claire, LUDIN, Adir

“…Aim: To assess the risk of developing aspiration during chemoradiation for head and neck cancer. Patients and Methods: A retrospective review of 114 patients…”
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Concurrent chemoradiation for locally advanced oropharyngeal cancer by Nguyen, Nam P., MD, Vos, Paul, PhD, Smith, Herbert J., MD, Nguyen, Phuc D., MD, Alfieri, Alan, PhD, Karlsson, Ulf, MD, PhD, Dutta, Suresh, MD, Lemanski, Claire, MD, Nguyen, Ly M., BS, Sallah, Sabah, MD

“…Abstract Purpose The aim of this study was to assess the survival, pattern of failure, morbidity, and prognostic factors of concurrent chemoradiation for…”
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Metabolic Signatures Associated with a NAD Synthesis Inhibitor–Induced Tumor Apoptosis Identified by 1H-Decoupled-31P Magnetic Resonance Spectroscopy by MURUGANANDHAM, Manickam, ALFIERI, Alan A, MATEI, Cornelia, YUCHUN CHEN, SUKENICK, George, SCHEMAINDA, Isabel, HASMANN, Max, SALTZ, Leonard B, KOUTCHER, Jason A

“…Purpose: Attempts to selectively initiate tumor cell death through inducible apoptotic pathways are increasingly being exploited as a potential anticancer…”
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Quantitation of metabolic and radiobiological effects of 6-aminonicotinamide in RIF-1 tumor cells in vitro by STREET, J. C, ALFIERI, A. A, KOUTCHER, J. A

“…6-Aminonicotinamide (6AN) can be metabolized to 6-amino-NAD(P+), a competitive inhibitor of NAD(P+)-requiring processes, especially the pentose phosphate…”
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Combined immunotherapy with Listeria monocytogenes-based PSA vaccine and radiation therapy leads to a therapeutic response in a murine model of prostate cancer by Hannan, Raquibul, Zhang, Huagang, Wallecha, Anu, Singh, Reshma, Liu, Laibin, Cohen, Patrice, Alfieri, Alan, Rothman, John, Guha, Chandan

“…Radiation therapy (RT) is an integral part of prostate cancer treatment across all stages and risk groups. Immunotherapy using a live, attenuated, Listeria…”
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Quantitative changes in tumor metabolism, partial pressure of oxygen, and radiobiological oxygenation status postradiation by Koutcher, J A, Alfieri, A A, Devitt, M L, Rhee, J G, Kornblith, A B, Mahmood, U, Merchant, T E, Cowburn, D

“…Hypoxia is considered to be a major cause of tumor radioresistance. Reoxygenation of previously hypoxic areas after a priming dose of radiation is associated…”
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