Search Results - "ALEXANDER, Stephen I"

Biopsy transcriptome expression profiling to identify kidney transplants at risk of chronic injury: a multicentre, prospective study by O'Connell, Philip J, MD, Zhang, Weijia, PhD, Menon, Madhav C, MD, Yi, Zhengzi, MS, Schröppel, Bernd, MD, Gallon, Lorenzo, MD, Luan, Yi, PhD, Rosales, Ivy A, MD, Ge, Yongchao, PhD, Losic, Bojan, PhD, Xi, Caixia, MS, Woytovich, Christopher, BS, Keung, Karen L, MD, Wei, Chengguo, PhD, Greene, Ilana, MS, Overbey, Jessica, MS, Bagiella, Emilia, PhD, Najafian, Nader, MD, Samaniego, Milagros, MD, Djamali, Arjang, MD, Alexander, Stephen I, MD, Nankivell, Brian J, MD, Chapman, Jeremy R, MD, Smith, Rex Neal, MD, Colvin, Robert, MD, Murphy, Barbara, Dr

“…Summary Background Chronic injury in kidney transplants remains a major cause of allograft loss. The aim of this study was to identify a gene set capable of…”
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Potentiating Tissue-Resident Type 2 Innate Lymphoid Cells by IL-33 to Prevent Renal Ischemia-Reperfusion Injury by Cao, Qi, Wang, Yiping, Niu, Zhiguo, Wang, Chengshi, Wang, Ruifeng, Zhang, Zhiqiang, Chen, Titi, Wang, Xin Maggie, Li, Qing, Lee, Vincent W S, Huang, Qingsong, Tan, Jing, Guo, Minghao, Wang, Yuan Min, Zheng, Guoping, Yu, Di, Alexander, Stephen I, Wang, Hui, Harris, David C H

“…The IL-33-type 2 innate lymphoid cell (ILC2) axis has an important role in tissue homeostasis, inflammation, and wound healing. However, the relative…”
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TLR4 activation mediates kidney ischemia/reperfusion injury by Wu, Huiling, Chen, Gang, Wyburn, Kate R, Yin, Jianlin, Bertolino, Patrick, Eris, Josette M, Alexander, Stephen I, Sharland, Alexandra F, Chadban, Steven J

“…Ischemia/reperfusion injury (IRI) may activate innate immunity through the engagement of TLRs by endogenous ligands. TLR4 expressed within the kidney is a…”
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One for All and All for One: The Triumph of the One Study by Alexander, Stephen I., Hu, Min, O’Connell, Philip J.

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Renal F4/80+ CD11c+ mononuclear phagocytes display phenotypic and functional characteristics of macrophages in health and in adriamycin nephropathy by Cao, Qi, Wang, Yiping, Wang, Xin Maggie, Lu, Junyu, Lee, Vincent W S, Ye, Qianling, Nguyen, Hanh, Zheng, Guoping, Zhao, Ye, Alexander, Stephen I, Harris, David C H

“…Conventional markers of macrophages (Mфs) and dendritic cells (DCs) lack specificity and often overlap, leading to confusion and controversy regarding the…”
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A mutation affecting laminin alpha 5 polymerisation gives rise to a syndromic developmental disorder by Jones, Lynelle K, Lam, Rachel, McKee, Karen K, Aleksandrova, Maya, Dowling, John, Alexander, Stephen I, Mallawaarachchi, Amali, Cottle, Denny L, Short, Kieran M, Pais, Lynn, Miner, Jeffery H, Mallett, Andrew J, Simons, Cas, McCarthy, Hugh, Yurchenco, Peter D, Smyth, Ian M

“…Laminin alpha 5 (LAMA5) is a member of a large family of proteins that trimerise and then polymerise to form a central component of all basement membranes…”
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Hepatic and renal end-organ damage in the Fontan circulation: A report from the Australian and New Zealand Fontan Registry by Wilson, Thomas G., d'Udekem, Yves, Winlaw, David S., Cordina, Rachael L., Celermajer, David S., Wheaton, Gavin R., Bullock, Andrew, Gentles, Thomas L., Weintraub, Robert G., Justo, Robert N., Grigg, Leeanne E., Radford, Dorothy J., Hardikar, Winita, Cheung, Michael, Cain, Timothy M., Rao, Padma, Alexander, Stephen I., Ayer, Julian, Verrall, Charlotte, Du Plessis, Karin, Chapman, Janina, Rice, Kathryn, Barry, Judith, Zannino, Diana, Iyengar, Ajay J.

“…Hepatic and renal dysfunction have been observed in survivors of the Fontan procedure, however their incidence and associated factors remain poorly defined. A…”
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A Comparison of the Systems for the Identification of Postoperative Acute Kidney Injury in Pediatric Cardiac Patients by Lex, Daniel J., MD, Tóth, Roland, MD, Cserép, Zsuzsanna, MD, Alexander, Stephen I., MBBS, MPH, Breuer, Tamás, MD, Sápi, Erzsébet, MD, Szatmári, András, MD, PhD, Székely, Edgár, MD, Gál, János, MD, PhD, Székely, Andrea, MD, PhD

“…Background The pediatric-modified Risk, Injury, Failure and Loss, and End-Stage (pRIFLE) criteria and a different but conceptually similar system termed Acute…”
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Antigen Specific Regulatory T Cells in Kidney Transplantation and Other Tolerance Settings by Hu, Min, Rogers, Natasha M, Li, Jennifer, Zhang, Geoff Y, Wang, Yuan Min, Shaw, Karli, O'Connell, Philip J, Alexander, Stephen I

“…Kidney transplantation is the most common solid organ transplant and the best current therapy for end-stage kidney failure. However, with standard…”
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Matrix metalloproteinase-9 of tubular and macrophage origin contributes to the pathogenesis of renal fibrosis via macrophage recruitment through osteopontin cleavage by Kui Tan, Thian, Zheng, Guoping, Hsu, Tzu-Ting, Ra Lee, So, Zhang, Jianlin, Zhao, Ye, Tian, Xinrui, Wang, Yiping, Min Wang, Yuan, Cao, Qi, Wang, Ya, Lee, Vincent WS, Wang, Changqi, Zheng, Dong, Alexander, Stephen I, Thompson, Erik, Harris, David C H

“…A pro-fibrotic role of matrix metalloproteinase-9 (MMP-9) in tubular cell epithelial–mesenchymal transition (EMT) is well established in renal fibrosis;…”
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Disruption of E-Cadherin by Matrix Metalloproteinase Directly Mediates Epithelial-Mesenchymal Transition Downstream of Transforming Growth Factor-β1 in Renal Tubular Epithelial Cells by Zheng, Guoping, Lyons, James Guy, Tan, Thian Kui, Wang, Yiping, Hsu, Tzu-Ting, Min, Danqing, Succar, Lena, Rangan, Gopala K, Hu, Min, Henderson, Beric R, Alexander, Stephen I, Harris, David C.H

“…Epithelial-mesenchymal transition (EMT) plays an important role in organ fibrosis, including that of the kidney. Loss of E-cadherin expression is a hallmark of…”
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Mutation in mitochondrial ribosomal protein S7 (MRPS7) causes congenital sensorineural deafness, progressive hepatic and renal failure and lactic acidemia by Menezes, Minal J, Guo, Yiran, Zhang, Jianguo, Riley, Lisa G, Cooper, Sandra T, Thorburn, David R, Li, Jiankang, Dong, Daoyuan, Li, Zhijun, Glessner, Joseph, Davis, Ryan L, Sue, Carolyn M, Alexander, Stephen I, Arbuckle, Susan, Kirwan, Paul, Keating, Brendan J, Xu, Xun, Hakonarson, Hakon, Christodoulou, John

“…Functional defects of the mitochondrial translation machinery, as a result of mutations in nuclear-encoded genes, have been associated with combined oxidative…”
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Membranous nephropathy: Clearer pathology and mechanisms identify potential strategies for treatment by Chung, Edmund Y M, Wang, Yuan M, Keung, Karen, Hu, Min, McCarthy, Hugh, Wong, Germaine, Kairaitis, Lukas, Bose, Bhadran, Harris, David C H, Alexander, Stephen I

“…Primary membranous nephropathy (PMN) is one of the common causes of adult-onset nephrotic syndrome and is characterized by autoantibodies against podocyte…”
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Brief Report: Identification of a Pathogenic Variant in TREX1 in Early‐Onset Cerebral Systemic Lupus Erythematosus by Whole‐Exome Sequencing by Ellyard, Julia I., Jerjen, Rebekka, Martin, Jaime L., Lee, Adrian Y. S., Field, Matthew A., Jiang, Simon H., Cappello, Jean, Naumann, Svenja K., Andrews, T. Daniel, Scott, Hamish S., Casarotto, Marco G., Goodnow, Christopher C., Chaitow, Jeffrey, Pascual, Virginia, Hertzog, Paul, Alexander, Stephen I., Cook, Matthew C., Vinuesa, Carola G.

“…Objective Systemic lupus erythematosus (SLE) is a chronic and heterogeneous autoimmune disease. Both twin and sibling studies indicate a strong genetic…”
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Obesity in pediatric kidney transplant recipients and the risks of acute rejection, graft loss and death by Ladhani, Maleeka, Lade, Samantha, Alexander, Stephen I., Baur, Louise A., Clayton, Philip A., McDonald, Stephen, Craig, Jonathan C., Wong, Germaine

“…Background Obesity is prevalent in children with chronic kidney disease (CKD), but the health consequences of this combination of comorbidities are uncertain…”
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Failed renoprotection by alternatively activated bone marrow macrophages is due to a proliferation-dependent phenotype switch in vivo by Cao, Qi, Wang, Yiping, Zheng, Dong, Sun, Yan, Wang, Changqi, Wang, Xin M, Lee, Vincent W S, Wang, Ya, Zheng, Guoping, Tan, Thian K, Wang, Yuan M, Alexander, Stephen I, Harris, David C H

“…Alternatively activated macrophages (M2) regulate immune responses and ex vivo polarized splenic M2 are able to ameliorate renal injury including models of…”
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Range and Heterogeneity of Outcomes in Randomized Trials of Pediatric Chronic Kidney Disease by Chong, Lauren S.H., MD, Sautenet, Benedicte, PhD, Tong, Allison, PhD, Hanson, Camilla S., BPsych (Hons), Samuel, Susan, MD, Zappitelli, Michael, MD, Dart, Allison, MD, Furth, Susan, PhD, Eddy, Allison A., MD, Groothoff, Jaap, PhD, Webb, Nicholas J.A., MD, Yap, Hui-Kim, MD, Bockenhauer, Detlef, PhD, Sinha, Aditi, MD, Alexander, Stephen I., PhD, Goldstein, Stuart L., MD, Gipson, Debbie S., MD, Raman, Gayathri, MBBS, Craig, Jonathan C., PhD

“…Objective To determine the range and heterogeneity of outcomes reported in randomized controlled trials of interventions for children with chronic kidney…”
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Chimerism and Tolerance in a Recipient of a Deceased-Donor Liver Transplant by Alexander, Stephen I, Smith, Neil, Smith, Arabella, Hu, Min, Verran, Deborah, Shun, Albert, Dorney, Stuart, Webster, Boyd, Shaw, Peter John, Lammi, Ahti, Stormon, Michael O

“…Complete hematopoietic chimerism and tolerance to a liver allograft developed in a 9-year-old girl who received a liver transplant from a deceased male donor…”
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Matrix metalloproteinase 9 induces endothelial-mesenchymal transition via Notch activation in human kidney glomerular endothelial cells by Zhao, Ye, Qiao, Xi, Wang, Lihua, Tan, Tian Kui, Zhao, Hong, Zhang, Yun, Zhang, Jianlin, Rao, Padmashree, Cao, Qi, Wang, Yiping, Wang, Ya, Wang, Yuan Min, Lee, Vincent W S, Alexander, Stephen I, Harris, David C H, Zheng, Guoping

“…Endothelial-mesenchymal transition (EndoMT) is a major source of myofibroblast formation in kidney fibrosis. Our previous study showed a profibrotic role for…”
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DEC205-DC targeted DNA vaccine against CX3CR1 protects against atherogenesis in mice by Zhou, Jimmy Jianheng, Wang, Yuan Min, Lee, Vincent W S, Zhang, Geoff Yu, Medbury, Heather, Williams, Helen, Wang, Ya, Tan, Thian Kui, Harris, David C H, Alexander, Stephen I, Durkan, Anne M

“…Studies disrupting the chemokine pathway CX3CL1 (fractalkine)/ CX3CR1 have shown decreased atherosclerosis in animal models but the techniques used to…”
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