Search Results - "ALEKU, Manuela"

Atu027, a liposomal small interfering RNA formulation targeting protein kinase N3, inhibits cancer progression by Aleku, Manuela, Schulz, Petra, Keil, Oliver, Santel, Ansgar, Schaeper, Ute, Dieckhoff, Britta, Janke, Oliver, Endruschat, Jens, Durieux, Birgit, Röder, Nadine, Löffler, Kathrin, Lange, Christian, Fechtner, Melanie, Möpert, Kristin, Fisch, Gerald, Dames, Sibylle, Arnold, Wolfgang, Jochims, Karin, Giese, Klaus, Wiedenmann, Bertram, Scholz, Arne, Kaufmann, Jörg

“…We have previously described a small interfering RNA (siRNA) delivery system (AtuPLEX) for RNA interference (RNAi) in the vasculature of mice. Here we report…”
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Atu027 Prevents Pulmonary Metastasis in Experimental and Spontaneous Mouse Metastasis Models by SANTEL, Ansgar, ALEKU, Manuela, EISERMANN, Mona, LÖFFLER, Kathrin, FECHTNER, Melanie, FISCH, Gerald, VANK, Christiane, SCHAEPER, Ute, GIESE, Klaus, KAUFMANN, Jörg, RÖDER, Nadine, MÖPERT, Kristin, DURIEUX, Birgit, JANKE, Oliver, KEIL, Oliver, ENDRUSCHAT, Jens, DAMES, Sibylle, LANGE, Christian

“…Atu027, a novel RNA interference therapeutic, has been shown to inhibit lymph node metastasis in orthotopic prostate cancer mouse models. The aim of this study…”
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Intracellular localization of lipoplexed siRNA in vascular endothelial cells of different mouse tissues by Aleku, Manuela, Fisch, Gerald, Möpert, Kristin, Keil, Oliver, Arnold, Wolfgang, Kaufmann, Jörg, Santel, Ansgar

“…Liposomally formulated siRNA can be used for RNAi applications in vivo. Intravenous bolus administration of lipoplexed siRNA has been shown to reduce gene…”
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Pre-clinical assessment of SLN360, a novel siRNA targeting LPA, developed to address elevated lipoprotein (a) in cardiovascular disease by Rider, David A., Eisermann, Mona, Löffler, Kathrin, Aleku, Manuela, Swerdlow, Daniel I., Dames, Sibylle, Hauptmann, Judith, Morrison, Eliot, Lindholm, Marie Wikström, Schubert, Steffen, Campion, Giles

“…The LPA gene encodes apolipoprotein (a), a key component of Lp(a), a potent risk factor for cardiovascular disease with no specific pharmacotherapy. Here we…”
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SLN124, a GalNAc Conjugated 19-Mer Double-Stranded SiRNA Reduces Iron and Increases Hepcidin Levels of Healthy Volunteers in a Phase 1 Clinical Study by Porter, John B., Scrimgeour, Alison, Martinez, Alberto, James, Leo, Aleku, Manuela, Wilson, Rosamund, Muckenthaler, Martina U., Schaeper, Ute, Campion, Giles V

“…▪ Background Hepcidin, a peptide hormone consisting of 25-amino-acids, is the central regulator of systemic iron homeostasis. It is synthesized predominantly…”
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SLN124, a GalNAc conjugated 19‐mer siRNA targeting tmprss6, reduces plasma iron and increases hepcidin levels of healthy volunteers by Porter, John B., Scrimgeour, Alison, Martinez, Alberto, James, Leo, Aleku, Manuela, Wilson, Rosamund, Muckenthaler, Martina, Boyce, Malcolm, Wilkes, Denise, Schaeper, Ute, Campion, Giles V.

“…SLN124, an N‐acetylgalactosamine conjugated 19‐mer short interfering RNA, is being developed to treat iron‐loading anemias (including beta‐thalassemia and…”
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SLN124, a Galnac-siRNA Conjugate Targeting TMPRSS6, for the Treatment of Iron Overload and Ineffective Erythropoiesis Such As in Beta-Thalassemia by Altamura, Sandro, Altamura, Sandro, Muckenthaler, Martina U., Dames, Sibylle, Frauendorf, Christian, Schubert, Steffen, Aleku, Manuela, Vadolas, Jim, Grigoriadis, George, Zügel, Ulrich

“…Accumulation of excess iron in tissues causes organ damage and dysfunction and may lead to serious clinical consequences including liver cirrhosis, diabetes,…”
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PKN3 is required for malignant prostate cell growth downstream of activated PI 3-kinase by Leenders, Frauke, Möpert, Kristin, Schmiedeknecht, Anett, Santel, Ansgar, Czauderna, Frank, Aleku, Manuela, Penschuck, Silke, Dames, Sibylle, Sternberger, Maria, Röhl, Thomas, Wellmann, Axel, Arnold, Wolfgang, Giese, Klaus, Kaufmann, Jörg, Klippel, Anke

“…Chronic activation of the phosphoinositide 3‐kinase (PI3K)/PTEN signal transduction pathway contributes to metastatic cell growth, but up to now effectors…”
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Abstract 9538: A Novel Short Interfering Ribonucleic Acid Shows Potent and Sustained Reduction of Serum Lipoprotein (a) in Cynomolgus Monkeys by Aleku, Manuela, Eisermann, Mona, Löffler, Kathrin, Dames, Sibylle, Frauendorf, Christian, Wikstrom Lindholm, Marie, Schubert, Steffen, Rider, David

“…IntroductionSLN360 is a liver targeted GalNAc-conjugated siRNA developed for the treatment of cardiovascular disorders associated with elevated Lp(a). Lp(a) is…”
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