Search Results - "ALDRED, MICHEALA A"

Genetics and genomics of pulmonary arterial hypertension by Morrell, Nicholas W, Aldred, Micheala A, Chung, Wendy K, Elliott, C Gregory, Nichols, William C, Soubrier, Florent, Trembath, Richard C, Loyd, James E

“…Since 2000 there have been major advances in our understanding of the genetic and genomics of pulmonary arterial hypertension (PAH), although there remains…”
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Pulmonary Arterial Hypertension: A Current Perspective on Established and Emerging Molecular Genetic Defects by Machado, Rajiv D., Southgate, Laura, Eichstaedt, Christina A., Aldred, Micheala A., Austin, Eric D., Best, D. Hunter, Chung, Wendy K., Benjamin, Nicola, Elliott, C. Gregory, Eyries, Mélanie, Fischer, Christine, Gräf, Stefan, Hinderhofer, Katrin, Humbert, Marc, Keiles, Steven B., Loyd, James E., Morrell, Nicholas W., Newman, John H., Soubrier, Florent, Trembath, Richard C., Viales, Rebecca Rodríguez, Grünig, Ekkehard

“…ABSTRACT Pulmonary arterial hypertension (PAH) is an often fatal disorder resulting from several causes including heterogeneous genetic defects. While…”
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Low-Dose FK506 (Tacrolimus) in End-Stage Pulmonary Arterial Hypertension by Spiekerkoetter, Edda, Sung, Yon K, Sudheendra, Deepti, Bill, Matthew, Aldred, Micheala A, van de Veerdonk, Mariëlle C, Vonk Noordegraaf, Anton, Long-Boyle, Janel, Dash, Rajesh, Yang, Phillip C, Lawrie, Allan, Swift, Andrew J, Rabinovitch, Marlene, Zamanian, Roham T

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Correction of nonsense BMPR2 and SMAD9 mutations by ataluren in pulmonary arterial hypertension by Drake, Kylie M, Dunmore, Benjamin J, McNelly, Lauren N, Morrell, Nicholas W, Aldred, Micheala A

“…Heritable pulmonary arterial hypertension (HPAH) is a serious lung vascular disease caused by heterozygous mutations in the bone morphogenetic protein (BMP)…”
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Human Lungs Airway Epithelium Upregulate MicroRNA-17 and MicroRNA-548b in Response to Cold Ischemia and Ex Vivo Reperfusion by Elgharably, Haytham, Okamoto, Toshihiro, Ayyat, Kamal S., Niikawa, Hiromichi, Meade, Sirena, Farver, Carol, Chan, E. Ricky, Aldred, Micheala A., McCurry, Kenneth R.

“…BACKGROUND.Lung ischemia-reperfusion injury after transplantation is associated with worse clinical outcomes. MicroRNA (miR) are critical regulators of gene…”
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Identification and validation of a novel pathogenic variant in GDF2 (BMP9) responsible for hereditary hemorrhagic telangiectasia and pulmonary arteriovenous malformations by Balachandar, Srimmitha, Graves, Tamara J., Shimonty, Anika, Kerr, Katie, Kilner, Jill, Xiao, Sihao, Slade, Richard, Sroya, Manveer, Alikian, Mary, Curetean, Emanuel, Thomas, Ellen, McConnell, Vivienne P. M., McKee, Shane, Boardman‐Pretty, Freya, Devereau, Andrew, Fowler, Tom A., Caulfield, Mark J., Alton, Eric W., Ferguson, Teena, Redhead, Julian, McKnight, Amy J., Thomas, Geraldine A., Aldred, Micheala A., Shovlin, Claire L.

“…Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant multisystemic vascular dysplasia, characterized by arteriovenous malformations (AVMs),…”
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Mitochondrial Haplogroups and Risk of Pulmonary Arterial Hypertension by Farha, Samar, Hu, Bo, Comhair, Suzy, Zein, Joe, Dweik, Raed, Erzurum, Serpil C, Aldred, Micheala A

“…Pulmonary arterial hypertension (PAH) is a serious and often fatal disease. It is a panvasculopathy of the pulmonary microcirculation characterized by…”
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Circulating Angiogenic Precursors in Idiopathic Pulmonary Arterial Hypertension by Asosingh, Kewal, Aldred, Micheala A, Vasanji, Amit, Drazba, Judith, Sharp, Jacqueline, Farver, Carol, Comhair, Suzy A.A, Xu, Weiling, Licina, Lauren, Huang, Lan, Anand-Apte, Bela, Yoder, Mervin C, Tuder, Rubin M, Erzurum, Serpil C

“…Vascular remodeling in idiopathic pulmonary arterial hypertension (IPAH) involves hyperproliferative and apoptosis-resistant pulmonary artery endothelial…”
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Food for Thought: The Emerging Role of Intestinal Microbiota in Pulmonary Arterial Hypertension by Aldred, Micheala A

“…Aldred discusses the paper by Huang et al which examines the emerging role of intestinal microbiota in pulmonary arterial hypertension. To elucidate the…”
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BMPR2 gene rearrangements account for a significant proportion of mutations in familial and idiopathic pulmonary arterial hypertension by Aldred, Micheala A., Vijayakrishnan, Jairam, James, Victoria, Soubrier, Florent, Gomez-Sanchez, Miguel A., Martensson, Gunnar, Galie, Nazzareno, Manes, Alessandra, Corris, Paul, Simonneau, Gerald, Humbert, Marc, Morrell, Nicholas W., Trembath, Richard C.

“…Mutations of the BMPR2 gene predispose to pulmonary arterial hypertension (PAH), a serious, progressive disease of the pulmonary vascular system. However,…”
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Regulating the Regulators: Epigenetic Modulation of Regulatory T Cells in Pulmonary Hypertension by Farha, Samar, Aldred, Micheala A

“…Farha and Aldred discuss the study by Chen and colleagues on the role of histone acetylation in regulating FOXP3 Tregs in human and experimental pulmonary…”
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PHorecasting Heritable Pulmonary Arterial Hypertension: Are We Nearly There Yet? by Aldred, Micheala A

“…Aldred discusses two case studies by Amin and colleagues that gives a snapshot of clinical "conversion" from healthy to a diagnosis of PAH in two teenagers who…”
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Loss of Heterozygosity at 2q37 in Sporadic Wilms' Tumor: Putative Role for miR-562 by Drake, Kylie M, Ruteshouser, E Cristy, Natrajan, Rachael, Harbor, Phyllis, Wegert, Jenny, Gessler, Manfred, Pritchard-Jones, Kathy, Grundy, Paul, Dome, Jeffrey, Huff, Vicki, Jones, Chris, Aldred, Micheala A

“…Purpose: Wilms' tumor is a childhood cancer of the kidney with an incidence of ∼1 in 10,000. Cooccurrence of Wilms' tumor with 2q37 deletion syndrome, an…”
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Genetic Classification of Benign and Malignant Thyroid Follicular Neoplasia Based on a Three-Gene Combination by Weber, Frank, Shen, Lei, Aldred, Micheala A., Morrison, Carl D., Frilling, Andrea, Saji, Motoyasu, Schuppert, Frank, Broelsch, Christoph E., Ringel, Matthew D., Eng, Charis

“…Thyroid carcinoma is a common endocrine cancer with a favorable prognosis if subjected to timely treatment. However, the clinical identification of follicular…”
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RASA3 is a candidate gene in sickle cell disease‐associated pulmonary hypertension and pulmonary arterial hypertension by Prohaska, Clare C., Zhang, Xu, Schwantes‐An, Tae‐Hwi L., Stearman, Robert S., Hooker, Stanley, Kittles, Rick A., Aldred, Micheala A., Lutz, Katie A., Pauciulo, Michael W., Nichols, William C., Desai, Ankit A., Gordeuk, Victor R., Machado, Roberto F.

“…Pulmonary hypertension (PH) is associated with significant morbidity and mortality. RASA3 is a GTPase activating protein integral to angiogenesis and…”
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New Mutations and Pathogenesis of Pulmonary Hypertension: Progress and Puzzles in Disease Pathogenesis by Aldred, Micheala A., Morrell, Nicholas W., Guignabert, Christophe

“…Pulmonary arterial hypertension (PAH) is a complex multifactorial disease with poor prognosis characterized by functional and structural alterations of the…”
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Papillary and Follicular Thyroid Carcinomas Show Distinctly Different Microarray Expression Profiles and Can Be Distinguished by a Minimum of Five Genes by ALDRED, Micheala A, YING HUANG, LIYANARACHCHI, Sandya, PELLEGATA, Natalia S, GIMM, Oliver, JHIANG, Sissy, DAVULURI, Ramana V, DE LA CHAPELLE, Albert, ENG, Charis

“…We have previously conducted independent microarray expression analyses of the two most common types of nonmedullary thyroid carcinoma, namely papillary…”
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Human Primary Lung Endothelial Cells in Culture by Comhair, Suzy A. A., Xu, Weiling, Mavrakis, Lori, Aldred, Micheala A., Asosingh, Kewal, Erzurum, Serpil C.

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DNA Damage and Repair in Pulmonary Arterial Hypertension by Sharma, Samantha, Aldred, Micheala A.

“…Pulmonary arterial hypertension (PAH) is a complex multifactorial disease with both genetic and environmental dynamics contributing to disease progression…”
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Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension by Long, Lu, Ormiston, Mark L, Yang, Xudong, Southwood, Mark, Gräf, Stefan, Machado, Rajiv D, Mueller, Matthias, Kinzel, Bernd, Yung, Lai Ming, Wilkinson, Janine M, Moore, Stephen D, Drake, Kylie M, Aldred, Micheala A, Yu, Paul B, Upton, Paul D, Morrell, Nicholas W

“…BMP9 activates signaling through the BMPR-II receptor in endothelial cells and reverses established disease in three animal models of pulmonary hypertension,…”
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