Search Results - "ALDERSON, M. R"

Immunogenicity of Mycobacterium tuberculosis Antigens in Mycobacterium bovis BCG-Vaccinated and M. bovis-Infected Cattle by Mustafa, A.S, Skeiky, Y.A, Al-Attiyah, R, Alderson, M.R, Hewinson, R.G, Vordermeier, H.M

“…The development of novel vaccine strategies supplementing Mycobacterium bovis BCG (BCG) constitutes an urgent research challenge. To identify potential subunit…”
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Molecular and immunological characterization of Mycobacterium tuberculosis CFP-10, an immunodiagnostic antigen missing in Mycobacterium bovis BCG by DILLON, D. C, ALDERSON, M. R, DAY, C. H, BEMENT, T, CAMPOS-NETO, A, SKEIKY, Y. A. W, VEDVICK, T, BADARO, R, REED, S. G, HOUGHTON, R

“…In order to identify antigens that may be used in the serodiagnosis of active tuberculosis (TB), we screened a Mycobacterium tuberculosis genomic expression…”
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CD40 expression by human monocytes : regulation by cytokines and activation of monocytes by the ligand for CD40 by ALDERSON, M. R, ARMITAGE, R. J, TOUGH, T. W, STROCKBINE, L, FANSLOW, W. C, SPRIGGS, M. K

“…CD40 is a member of the tumor necrosis factor (TNF) receptor family of cell surface proteins and was originally described as a B cell restricted antigen…”
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Interleukin 1 Signaling Occurs Exclusively via the Type I Receptor by Sims, John E., Gayle, Margit A., Slack, Jennifer L., Alderson, Mark R., Bird, Timothy A., Giri, Judith G., Colotta, Francesco, Re, Fabio, Mantovani, Alberto, Shanebeck, Kurt, Grabstein, Kenneth H., Dower, Steven K.

“…Two receptors for the proinflammatory cytokine interleukin 1 (IL-1) have been cloned and characterized biochemically. While it has been well established that…”
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Cloning of a T Cell Growth Factor That Interacts with the β Chain of the Interleukin-2 Receptor by Grabstein, Kenneth H., Eisenman, June, Shanebeck, Kurt, Rauch, Charles, Srinivasan, Subhashini, Fung, Victor, Beers, Courtney, Richardson, Jane, Schoenborn, Michael A., Ahdieh, Minoo, Johnson, Lisabeth, Alderson, Mark R., Watson, James D., Anderson, Dirk M., Giri, Judith G.

“…A cytokine was identified that stimulated the proliferation of T lymphocytes, and a complementary DNA clone encoding this new T cell growth factor was…”
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Upregulation of Fas ligand expression by human immunodeficiency virus in human macrophages mediates apoptosis of uninfected T lymphocytes by Badley, A D, McElhinny, J A, Leibson, P J, Lynch, D H, Alderson, M R, Paya, C V

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Fas transduces activation signals in normal human T lymphocytes by ALDERSON, M. R, ARMITAGE, R. J, MARASKOVSKY, E, TOUGH, T. W, ROUX, E, SCHOOLEY, K, RAMSDELL, F, LYNCH, D. H

“…The Fas gene encodes a cell surface molecule that is a member of the the nerve growth factor/tumor necrosis factor receptor family of proteins and can mediate…”
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T Cell Expression Cloning of a Mycobacterium tuberculosis Gene Encoding a Protective Antigen Associated with the Early Control of Infection by Skeiky, Yasir A. W, Ovendale, Pamela J, Jen, Shyian, Alderson, Mark R, Dillon, Davin C, Smith, Sherilyn, Wilson, Christopher B, Orme, Ian M, Reed, Steven G, Campos-Neto, Antonio

“…Infection of C57BL/6 mice with Mycobacterium tuberculosis results in the development of a progressive disease during the first 2 wk after challenge…”
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Molecular characterization and human T-cell responses to a member of a novel Mycobacterium tuberculosis mtb39 gene family by DILLON, D. C, ALDERSON, M. R, STEEN, S, DALEMANS, W, BADARO, R, REED, S. G, DAY, C. H, LEWINSOHN, D. M, COLER, R, BEMENT, T, CAMPOS-NETO, A, SKEIKY, Y. A. W, ORME, I. M, ROBERTS, A

“…We have used expression screening of a genomic Mycobacterium tuberculosis library with tuberculosis (TB) patient sera to identify novel genes that may be used…”
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Cloning, expression, and immunological evaluation of two putative secreted serine protease antigens of Mycobacterium tuberculosis by SKEIKY, Y. A. W, LODES, M. J, GUDERIAN, J. A, MOHAMATH, R, BEMENT, T, ALDERSON, M. R, REED, S. G

“…Culture filtrate proteins (CFP) of Mycobacterium tuberculosis have been shown to contain immunogenic components that elicit at least partial protective…”
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A metalloprotease inhibitor blocks shedding of the IL-6 receptor and the p60 TNF receptor by Mullberg, J, Durie, FH, Otten-Evans, C, Alderson, MR, Rose-John, S, Cosman, D, Black, RA, Mohler, KM

“…Many cytokines and soluble cytokine receptors are generated by limited proteolysis of membrane-bound precursors. We have examined the ability of the recently…”
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Prospects for a better vaccine against tuberculosis by Reed, S.G., Alderson, M.R., Dalemans, W., Lobet, Y., Skeiky, Y.A.W.

“…There have been many new promising approaches to developing human vaccines against tuberculosis (TB). Advances in gene and antigen identification, availability…”
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Classically Restricted Human CD8+ T Lymphocytes Derived from Mycobacterium tuberculosis-Infected Cells: Definition of Antigenic Specificity by Lewinsohn, David M, Zhu, Liqing, Madison, Valerie J, Dillon, Davin C, Fling, Steven P, Reed, Steven G, Grabstein, Kenneth H, Alderson, Mark R

“…Previous studies in murine and human models have suggested an important role for HLA Ia-restricted CD8(+) T cells in host defense to Mycobacterium tuberculosis…”
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Interleukin 7 induces cytokine secretion and tumoricidal activity by human peripheral blood monocytes by ALDERSON, M. R, TOUGH, T. W, ZIEGLER, S. F, GRABSTEIN, K. H

“…Peripheral blood monocytes can be induced by stimuli such as bacterial lipopolysaccharide (LPS) to secrete an array of cytokines. We have studied the effects…”
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Molecular characterization of murine and human OX40/OX40 ligand systems: identification of a human OX40 ligand as the HTLV‐1‐regulated protein gp34 by Baum, P.R., Gayle, R.B., Ramsdell, F., Srinivasan, S., Sorensen, R.A., Watson, M.L., Seldin, M.F., Baker, E., Sutherland, G.R., Clifford, K.N.

“…A ligand was cloned for murine OX40, a member of the TNF receptor family, using a T cell lymphoma cDNA library. The ligand (muOX40L) is a type II membrane…”
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Molecular and biological characterization of a ligand for CD27 defines a new family of cytokines with homology to tumor necrosis factor by Goodwin, R G, Alderson, M R, Smith, C A, Armitage, R J, VandenBos, T, Jerzy, R, Tough, T W, Schoenborn, M A, Davis-Smith, T, Hennen, K

“…CD27 is a surface antigen found on T and B cells that has homology to a family of molecules including the receptors for tumor necrosis factor (TNF) and nerve…”
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Expression cloning of an immunodominant family of Mycobacterium tuberculosis antigens using human CD4(+) T cells by Alderson, M R, Bement, T, Day, C H, Zhu, L, Molesh, D, Skeiky, Y A, Coler, R, Lewinsohn, D M, Reed, S G, Dillon, D C

“…Development of a subunit vaccine for Mycobacterium tuberculosis (Mtb) is likely to be dependent on the identification of T cell antigens that induce strong…”
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The extracellular domain of the Epstein-Barr virus BZLF2 protein binds the HLA-DR beta chain and inhibits antigen presentation by Spriggs, M K, Armitage, R J, Comeau, M R, Strockbine, L, Farrah, T, Macduff, B, Ulrich, D, Alderson, M R, Müllberg, J, Cohen, J I

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gld/gld mice are unable to express a functional ligand for Fas by Ramsdell, F, Seaman, M S, Miller, R E, Tough, T W, Alderson, M R, Lynch, D H

“…Mice homozygous for either the lpr or gld genes develop phenotypically identical autoimmune disorders. The gene responsible for the pathology in lpr/lpr mice…”
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CD40 ligand is a T cell growth factor by Armitage, R J, Tough, T W, Macduff, B M, Fanslow, W C, Spriggs, M K, Ramsdell, F, Alderson, M R

“…CD40 ligand (CD40L) is a 33-kDa type II membrane glycoprotein induced on T cells upon activation. CD40L has previously been shown to induce proliferation of…”
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