Search Results - "ALBRECHTSEN, Reidar"

Proteomic maps of breast cancer subtypes by Tyanova, Stefka, Albrechtsen, Reidar, Kronqvist, Pauliina, Cox, Juergen, Mann, Matthias, Geiger, Tamar

“…Systems-wide profiling of breast cancer has almost always entailed RNA and DNA analysis by microarray and sequencing techniques. Marked developments in…”
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Bile acids are important direct and indirect regulators of the secretion of appetite- and metabolism-regulating hormones from the gut and pancreas by Kuhre, Rune E., Wewer Albrechtsen, Nicolai J., Larsen, Olav, Jepsen, Sara L., Balk-Møller, Emilie, Andersen, Daniel B., Deacon, Carolyn F., Schoonjans, Kristina, Reimann, Frank, Gribble, Fiona M., Albrechtsen, Reidar, Hartmann, Bolette, Rosenkilde, Mette M., Holst, Jens J.

“…Bile acids (BAs) facilitate fat absorption and may play a role in glucose and metabolism regulation, stimulating the secretion of gut hormones. The relative…”
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ADAM12-Generated Basigin Ectodomain Binds β1 Integrin and Enhances the Expression of Cancer-Related Extracellular Matrix Proteins by Mygind, Kasper J, Nikodemus, Denise, Gnosa, Sebastian, Kweder, Ramya, Albrechtsen, Nicolai J Wewer, Kveiborg, Marie, Erler, Janine T, Albrechtsen, Reidar

“…Desmoplasia is a common feature of aggressive cancers, driven by a complex interplay of protein production and degradation. Basigin is a type 1 integral…”
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Identification of ADAM12 as a Novel Basigin Sheddase by Albrechtsen, Reidar, Albrechtsen, Nicolai J Wewer, Gnosa, Sebastian, Schwarz, Jeanette, Dyrskjøt, Lars, Kveiborg, Marie

“…The transmembrane glycoprotein basigin, a member of the immunoglobulin superfamily, stimulates matrix metalloproteinase (MMP)-mediated extracellular matrix…”
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Glucagon-like Peptide 1 Receptor Signaling in Acinar Cells Causes Growth-Dependent Release of Pancreatic Enzymes by Wewer Albrechtsen, Nicolai J., Albrechtsen, Reidar, Bremholm, Lasse, Svendsen, Berit, Kuhre, Rune E., Poulsen, Steen S., Christiansen, Charlotte B., Jensen, Elisa P., Janus, Charlotte, Hilsted, Linda, Deacon, Carolyn F., Hartmann, Bolette, Holst, Jens J.

“…Incretin-based therapies are widely used for type 2 diabetes and now also for obesity, but they are associated with elevated plasma levels of pancreatic…”
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Evaluation of commercially available glucagon receptor antibodies and glucagon receptor expression by Bomholt, Anna Billeschou, Johansen, Christian Dall, Christensen, Jens Bager, Kjeldsen, Sasha Alexandra Sampson, Galsgaard, Katrine Douglas, Winther-Sørensen, Marie, Serizawa, Reza, Hornum, Mads, Porrini, Esteban, Pedersen, Jens, Ørskov, Cathrine, Gluud, Lise Lotte, Sørensen, Charlotte Mehlin, Holst, Jens Juul, Albrechtsen, Reidar, Wewer Albrechtsen, Nicolai Jacob

“…Glucagon is a major regulator of metabolism and drugs targeting the glucagon receptor (GCGR) are being developed. Insight into tissue and cell-specific…”
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ADAM12 produced by tumor cells rather than stromal cells accelerates breast tumor progression by Fröhlich, Camilla, Nehammer, Camilla, Albrechtsen, Reidar, Kronqvist, Pauliina, Kveiborg, Marie, Sehara-Fujisawa, Atsuko, Mercurio, Arthur M, Wewer, Ulla M

“…Expression of ADAM12 is low in most normal tissues but is markedly increased in numerous human cancers, including breast carcinomas. We have previously shown…”
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Oxyntomodulin Identified as a Marker of Type 2 Diabetes and Gastric Bypass Surgery by Mass-spectrometry Based Profiling of Human Plasma by Wewer Albrechtsen, Nicolai J., Hornburg, Daniel, Albrechtsen, Reidar, Svendsen, Berit, Toräng, Signe, Jepsen, Sara L., Kuhre, Rune E., Hansen, Marie, Janus, Charlotte, Floyd, Andrea, Lund, Asger, Vilsbøll, Tina, Knop, Filip K., Vestergaard, Henrik, Deacon, Carolyn F., Meissner, Felix, Mann, Matthias, Holst, Jens J., Hartmann, Bolette

“…Low-abundance regulatory peptides, including metabolically important gut hormones, have shown promising therapeutic potential. Here, we present a streamlined…”
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Molecular Profiling of ADAM12 in Human Bladder Cancer by FRÖHLICH, Camilla, ALBRECHTSEN, Reidar, DYRSKJØT, Lars, RUDKJAER, Lise, ØRNTOFT, Torben F, WEWER, Ulla M

“…Purpose: We have previously found ADAM12, a disintegrin and metalloprotease, to be an interesting biomarker for breast cancer. The purpose of this study was to…”
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Differential actions of the endocytic collagen receptor uPARAP/Endo180 and the collagenase MMP-2 in bone homeostasis by Madsen, Daniel H, Jürgensen, Henrik J, Ingvarsen, Signe, Melander, Maria C, Albrechtsen, Reidar, Hald, Andreas, Holmbeck, Kenn, Bugge, Thomas H, Behrendt, Niels, Engelholm, Lars H

“…A well-coordinated remodeling of uncalcified collagen matrices is a pre-requisite for bone development and homeostasis. Collagen turnover proceeds through…”
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A role for ADAM12 in breast tumor progression and stromal cell apoptosis by KVEIBORG, Marie, FRÖHLICH, Camilla, ALBRECHTSEN, Reidar, TISCHLER, Verena, DIETRICH, Nikolaj, HOLCK, Peter, KRONQVIST, Pauliina, RANK, Fritz, MERCURIO, Arthur M, WEWER, Ulla M

“…As in developmental and regenerative processes, cell survival is of fundamental importance in cancer. Thus, a tremendous effort has been devoted to dissecting…”
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ADAM12 induces actin cytoskeleton and extracellular matrix reorganization during early adipocyte differentiation by regulating β1 integrin function by Kawaguchi, Nobuko, Sundberg, Christina, Kveiborg, Marie, Moghadaszadeh, Behzad, Asmar, Meena, Dietrich, Nikolaj, Thodeti, Charles K., Nielsen, Finn C., Möller, Peter, Mercurio, Arthur M., Albrechtsen, Reidar, Wewer, Ulla M.

“…Changes in cell shape are a morphological hallmark of differentiation. In this study we report that the expression of ADAM12, a disintegrin and…”
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Heparan Sulfate Regulates ADAM12 through a Molecular Switch Mechanism by Sørensen, Hans Peter, Vivès, Romain R., Manetopoulos, Christina, Albrechtsen, Reidar, Lydolph, Magnus C., Jacobsen, Jonas, Couchman, John R., Wewer, Ulla M.

“…The disintegrin and metalloproteases (ADAMs) are emerging as therapeutic targets in human disease, but specific drug design is hampered by potential…”
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A Novel, Secreted Form of Human ADAM 12 (Meltrin α) Provokes Myogenesis in Vivo by Gilpin, Brent J., Loechel, Frosty, Mattei, Marie-Geneviève, Engvall, Eva, Albrechtsen, Reidar, Wewer, Ulla M.

“…The ADAM (A DisintegrinAnd Metalloprotease) family of cell-surface proteins may have an important role in cellular interactions and in modulating cellular…”
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Cysteine-Rich Domain of Human ADAM 12 (Meltrin α) Supports Tumor Cell Adhesion by Iba, Kousuke, Albrechtsen, Reidar, Gilpin, Brent J., Loechel, Frosty, Wewer, Ulla M.

“…The ADAMs (A disintegrin and metalloprotease) comprise a family of membrane-anchored cell surface proteins with a putative role in cell-cell and/or cell-matrix…”
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Human ADAM 12 (Meltrin α) Is an Active Metalloprotease by Loechel, F, Gilpin, B J, Engvall, E, Albrechtsen, R, Wewer, U M

“…The ADAMs ( a d isintegrin a nd m etalloprotease) are a family of multidomain proteins with structural homology to snake venom metalloproteases. We recently…”
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ADAM12: a novel first-trimester maternal serum marker for Down syndrome by Laigaard, Jennie, Sørensen, Tina, Fröhlich, Camilla, Pedersen, Bent Nørgaard, Christiansen, Michael, Schiøtt, Kirsten, Uldbjerg, Niels, Albrechtsen, Reidar, Clausen, Helle V., Ottesen, Bent, Wewer, Ulla M.

“…Objectives The concentration of bioavailable insulin‐like growth factor (IGF) I and II is important to foetal growth. It is regulated by insulin‐like growth…”
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ADAM12-mediated focal adhesion formation is differently regulated by β1 and β3 integrins by Thodeti, Charles Kumar, Fröhlich, Camilla, Nielsen, Christian Kamp, Takada, Yoshikazu, Fässler, Reinhard, Albrechtsen, Reidar, Wewer, Ulla M.

“…ADAM12, a disintegrin and metalloprotease, has been demonstrated to be upregulated in human malignant tumors and to accelerate the malignant phenotype in a…”
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Hierarchy of ADAM12 binding to integrins in tumor cells by Thodeti, Charles Kumar, Fröhlich, Camilla, Nielsen, Christian Kamp, Holck, Peter, Sundberg, Christina, Kveiborg, Marie, Mahalingam, Yashithra, Albrechtsen, Reidar, Couchman, John R., Wewer, Ulla M.

“…ADAMs (a disintegrin and metalloprotease) comprise a family of cell surface proteins with protease and cell-binding activities. Using different forms and…”
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Mice with a Targeted Deletion of the Tetranectin Gene Exhibit a Spinal Deformity by Iba, Kousuke, Durkin, Marian E., Johnsen, Lise, Hunziker, Ernst, Damgaard-Pedersen, Karen, Zhang, Hong, Engvall, Eva, Albrechtsen, Reidar, Wewer, Ulla M.

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