Search Results - "ALBRECHT, Christiane"
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Revisited role of the placenta in bile acid homeostasis
Published in Frontiers in physiology (21-07-2023)“…To date, the discussion concerning bile acids (BAs) during gestation is almost exclusively linked to pregnancy complications such as intrahepatic cholestasis…”
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Revisiting Steroidogenic Pathways in the Human Placenta and Primary Human Trophoblast Cells
Published in International journal of molecular sciences (08-02-2021)“…Steroid hormones play a crucial role in supporting a successful pregnancy and ensuring proper fetal development. The placenta is one of the principal tissues…”
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3
The Placenta-A New Source of Bile Acids during Healthy Pregnancy? First Results of a Gene Expression Study in Humans and Mice
Published in International journal of molecular sciences (30-05-2023)“…Bile acids (BAs) are natural ligands for several receptors modulating cell activities. BAs are synthesized via the classic (neutral) and alternative (acidic)…”
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Identification of placental nutrient transporters associated with intrauterine growth restriction and pre-eclampsia
Published in BMC genomics (02-03-2018)“…Gestational disorders such as intrauterine growth restriction (IUGR) and pre-eclampsia (PE) are main causes of poor perinatal outcomes worldwide. Both diseases…”
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5
Placental Expression of Bile Acid Transporters in Intrahepatic Cholestasis of Pregnancy
Published in International journal of molecular sciences (28-09-2021)“…Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-related condition characterized by increased maternal circulating bile acids (BAs) having adverse…”
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Novel Insights into Concepts and Directionality of Maternal⁻Fetal Cholesterol Transfer across the Human Placenta
Published in International journal of molecular sciences (09-08-2018)“…Cholesterol is indispensable for cellular membrane composition and function. It is also a precursor for the synthesis of steroid hormones, which promote, among…”
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7
Functional reorganization of monoamine transport systems during villous trophoblast differentiation: evidence of distinct differences between primary human trophoblasts and BeWo cells
Published in Reproductive biology and endocrinology (04-08-2022)“…Abstract Background Three primary monoamines—serotonin, norepinephrine, and dopamine—play major roles in the placenta-fetal brain axis. Analogously to the…”
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The ABCA subfamily--gene and protein structures, functions and associated hereditary diseases
Published in Pflügers Archiv (01-02-2007)“…To date, 12 members of the human ABCA subfamily are identified. They share a high degree of sequence conservation and have been mostly related with lipid…”
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Placental secretion of apolipoprotein A1 and E: the anti-atherogenic impact of the placenta
Published in Scientific reports (17-04-2019)“…High levels of atherogenic lipids in pregnancy are associated with health complications for the mother, the fetus and the newborn. As endocrine secretory…”
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10
Response of the cholesterol metabolism to a negative energy balance in dairy cows depends on the lactational stage
Published in PloS one (02-06-2015)“…The response of cholesterol metabolism to a negative energy balance (NEB) induced by feed restriction for 3 weeks starting at 100 days in milk (DIM) compared…”
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Placental miR-340 mediates vulnerability to activity based anorexia in mice
Published in Nature communications (23-04-2018)“…Anorexia nervosa (AN) is a devastating eating disorder characterized by self-starvation that mainly affects women. Its etiology is unknown, which impedes…”
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Cryo-EM structures and functional properties of CALHM channels of the human placenta
Published in eLife (06-05-2020)“…The transport of substances across the placenta is essential for the development of the fetus. Here, we were interested in the role of channels of the calcium…”
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Dynamics of Tryptophan Metabolic Pathways in Human Placenta and Placental-Derived Cells: Effect of Gestation Age and Trophoblast Differentiation
Published in Frontiers in cell and developmental biology (18-09-2020)“…L-Tryptophan is an essential amino acid and a precursor of several physiologically active metabolites. In the placenta, the serotonin and kynurenine metabolic…”
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14
Nutrient Transport in the Mammary Gland: Calcium, Trace Minerals and Water Soluble Vitamins
Published in Journal of mammary gland biology and neoplasia (01-03-2014)“…Milk nutrients are secreted by epithelial cells in the alveoli of the mammary gland by several complex and highly coordinated systems. Many of these nutrients…”
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New Insights into the Physiology of Iron Transport: An Interdisciplinary Approach
Published in Chimia (21-12-2022)“…The TransCure project entitled 'Iron Transporters DMT1 and FPN1' took an interdisciplinary approach combining structural biology, chemistry and physiology to…”
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The Consequences of Assisted Reproduction Technologies on the Offspring Health Throughout Life: A Placental Contribution
Published in Frontiers in cell and developmental biology (20-05-2022)“…The use of assisted reproductive technologies (ART) worldwide has led to the conception and birth of over eight million babies since being implemented in 1978…”
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Structure, Function and Pharmacology of SLC7 Family Members and Homologues
Published in Chimia (21-12-2022)“…Amino acids are essential components of all living cells serving as building blocks of proteins, as energy source, and as precursors of metabolites and…”
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Two immunoassay formats for fully automated CRP detection in human serum
Published in Analytical and bioanalytical chemistry (01-07-2008)“…Immunoassays are a proven approach towards fast, sensitive, cost-effective and easy-to-use analytical systems which are able to measure a variety of…”
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Type 2 diabetes is associated with reduced ATP-binding cassette transporter A1 gene expression, protein and function
Published in PloS one (27-07-2011)“…Increasing plasma glucose levels are associated with increasing risk of vascular disease. We tested the hypothesis that there is a glycaemia-mediated…”
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Primary Human Trophoblasts Mimic the Preeclampsia Phenotype after Acute Hypoxia–Reoxygenation Insult
Published in Cells (Basel, Switzerland) (11-06-2022)“…Preeclampsia (PE) is a pregnancy-specific disorder that affects 3 to 5% of pregnancies worldwide and is one of the leading causes of maternal and fetal…”
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