The discovery and synthesis of highly potent, A2a receptor agonists

The discovery and synthesis of highly potent, A2a receptor agonists

A series of N6,2-disubstituted adenosine analogues have been synthesized and their functional activity measured against A2a and A1 receptors. Examples of compounds with both a lipophilic N6-substituent and amino-functionalized 2-position were highly active at the A2a receptor on the human neutrophil...

Full description

Saved in:
Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters Vol. 10; no. 4; pp. 403 - 406
Main Authors: KEELING, S. E, ALBINSON, F. D, MILLS, K, RAVENSCROFT, P, REYNOLDS, L. H, SANJAR, S, SHEEHAN, M. J, AYRES, B. E, BUTCHERS, P. R, CHAMBERS, C. L, CHERRY, P. C, ELLIS, F, EWAN, G. B, GREGSON, M, KNIGHT, J
Format: Journal Article
Language:English
Published: Oxford Elsevier 21-02-2000
Subjects:
Adenosine - analogs & derivatives
Adenosine - chemistry
Adenosine - pharmacology
Anti-Inflammatory Agents - chemistry
Biological and medical sciences
Bones, joints and connective tissue. Antiinflammatory agents
GTP-Binding Proteins
Medical sciences
Neuropharmacology
Neurotransmitters. Neurotransmission. Receptors
Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems
Pharmacology. Drug treatments
Purinergic P1 Receptor Agonists
Solubility
Structure-Activity Relationship
Human
Agonist
Purine nucleoside
Solubility
In vitro
A2 Adenosine receptor
Amine
Structure activity relation
Uronic acid
Organic amide
Neutrophil
Chemical synthesis
Physicochemical properties
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A series of N6,2-disubstituted adenosine analogues have been synthesized and their functional activity measured against A2a and A1 receptors. Examples of compounds with both a lipophilic N6-substituent and amino-functionalized 2-position were highly active at the A2a receptor on the human neutrophil.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0960-894X
1464-3405