Search Results - "ALBER, Sean"

Autophagy is increased in mice after traumatic brain injury and is detectable in human brain after trauma and critical illness by Clark, Robert S.B., Bayir, Hülya, Chu, Charleen T., Alber, Sean M., Kochanek, Patrick M., Watkins, Simon C.

“…Autophagy is a homeostatic process for recycling of proteins and organelles, that increases during times of nutrient deprivation and is regulated by reactive…”
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Comprehensive Gene Expression Profiles Reveal Pathways Related to the Pathogenesis of Chronic Obstructive Pulmonary Disease by Ning, Wen, Li, Chao-Jun, Kaminski, Naftali, Feghali-Bostwick, Carol A., Alber, Sean M., Di, Yuanpu P., Otterbein, Sherrie L., Song, Ruiping, Hayashi, Shizu, Zhou, Zhihong, Pinsky, David J., Watkins, Simon C., Pilewski, Joseph M., Sciurba, Frank C., Peters, David G., Hogg, James C., Augustine M. K. Choi, Vogelstein, Bert

“…To better understand the molecular basis of chronic obstructive pulmonary disease (COPD), we used serial analysis of gene expression (SAGE) and microarray…”
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Carbon Monoxide Induces Cytoprotection in Rat Orthotopic Lung Transplantation via Anti-Inflammatory and Anti-Apoptotic Effects by Song, Ruiping, Kubo, Masatoshi, Morse, Danielle, Zhou, Zhihong, Zhang, Xuchen, Dauber, James H., Fabisiak, James, Alber, Sean M., Watkins, Simon C., Zuckerbraun, Brian S., Otterbein, Leo E., Ning, Wen, Oury, Tim D., Lee, Patty J., McCurry, Kenneth R., Choi, Augustine M.K.

“…Successful lung transplantation has been limited by the high incidence of acute graft rejection. There is mounting evidence that the stress response gene heme…”
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Downregulation of Endothelin-1 by Farnesoid X Receptor in Vascular Endothelial Cells by He, Fengtian, Li, Jiang, Mu, Ying, Kuruba, Ramalinga, Ma, Zheng, Wilson, Annette, Alber, Sean, Jiang, Yu, Stevens, Troy, Watkins, Simon, Pitt, Bruce, Xie, Wen, Li, Song

“…The farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily that is highly expressed in liver, kidney, adrenals, and intestine. FXR may play…”
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Nitric oxide and ionizing radiation synergistically promote apoptosis and growth inhibition of cancer by activating p53 by COOK, Tracy, ZIFA WANG, ALBER, Sean, KAIHONG LIU, WATKINS, Simon C, VODOVOTZ, Yoram, BILLIAR, Timothy R, BLUMBERG, David

“…Nitric oxide (NO) is a potent tumor radiosensitizer; however, its clinical use is limited by systemic side effects. We have demonstrated previously that gene…”
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Intratumoral delivery of dendritic cells engineered to secrete both interleukin (IL)-12 and IL-18 effectively treats local and distant disease in association with broadly reactive Tc1-type immunity by TATSUMI, Tomohide, JIAN HUANG, GOODING, William E, GAMBOTTO, Andrea, ROBBINS, Paul D, VUJANOVIC, Nikola L, ALBER, Sean M, WATKINS, Simon C, OKADA, Hideho, STORKUS, Walter J

“…Dendritic cells (DCs) were adenovirally engineered to constitutively and durably secrete the potent Th1-biasing cytokines interleukin (IL)-12 (AdIL12DC) and/or…”
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Intratumoral IL-12 Gene Therapy Results in the Crosspriming of Tc1 Cells Reactive Against Tumor-associated Stromal Antigens by Zhao, Xi, Bose, Anamika, Komita, Hideo, Taylor, Jennifer L, Kawabe, Mayumi, Chi, Nina, Spokas, Laima, Lowe, Devin B, Goldbach, Christina, Alber, Sean, Watkins, Simon C, Butterfield, Lisa H, Kalinski, Pawel, Kirkwood, John M, Storkus, Walter J

“…HLA-A2 transgenic mice bearing established HLA-A2neg B16 melanomas were effectively treated by intratumoral (i.t.) injection of syngeneic dendritic cells (DCs)…”
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Microbubbles targeted to intercellular adhesion molecule-1 bind to activated coronary artery endothelial cells by VILLANUEVA, F. S, JANKOWSKI, R. J, KLIBANOV, S, PINA, M. L, ALBER, S. M, WATKINS, S. C, BRANDENBURGER, G. H, WAGNER, W. R

“…Preclinical atherosclerosis is associated with increased endothelial cell (EC) expression of leukocyte adhesion molecules (LAMs), which mediate monocyte…”
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Ethyl pyruvate ameliorates distant organ injury in a murine model of acute necrotizing pancreatitis by Yang, Runkuan, Uchiyama, Takashi, Alber, Sean M, Han, Xiaonan, Watkins, Simon K, Delude, Russell L, Fink, Mitchell P

“…OBJECTIVE:Ethyl pyruvate has been shown to be an effective anti-inflammatory agent in a variety of in vitro and in vivo model systems. Herein, we used a murine…”
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Identification of c-kit-positive cells in the mouse ureter: the interstitial cells of Cajal of the urinary tract by Pezzone, Michael A, Watkins, Simon C, Alber, Sean M, King, William E, de Groat, William C, Chancellor, Michael B, Fraser, Matthew O

“…The existence of a pacemaker system in the urinary tract capable of orchestrating the movement of filtrated urine from the ureteral pelvis to the distal ureter…”
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NLRP3 inflammasome-dependent HMGB1 release induced by a bacterial pore-forming toxin (136.15) by Chu, Jessica, Alber, Sean, Watkins, Simon, Núñez, Gabriel, Salter, Russell

“…Abstract The NLRP3 inflammasome is a caspase-1-containing complex involved in the maturation of pro-inflammatory cytokines IL-1β and IL-18. NLRP3, independent…”
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Combinational FLt3 ligand and granulocyte macrophage colony- stimulating factor treatment promotes enhanced tumor infiltration by dendritic cells and antitumor CD8+ T-cell cross-priming but is ineffective as a therapy by BERHANU, Aklile, JIAN HUANG, ALBER, Sean M, WATKINS, Simon C, STORKUS, Walter J

“…Dendritic cells play significant roles in the development and maintenance of antitumor immune responses. Therapeutic recruitment of dendritic cells into the…”
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boc-Aspartyl(OMe)-Fluoromethylketone Attenuates Mitochondrial Release of Cytochrome c and Delays Brain Tissue Loss after Traumatic Brain Injury in Rats by Clark, Robert SB, Nathaniel, Paula D, Zhang, Xiaopeng, Dixon, C Edward, Alber, Sean M, Watkins, Simon C, Melick, John A, Kochanek, Patrick M, Graham, Steven H

“…The pathobiology of traumatic brain injury (TBI) includes activation of multiple caspases followed by cell death with a spectrum of apoptotic phenotypes. There…”
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HIV-1 infection of DC: evidence for the acquisition of virus particles from infected T cells by antigen uptake mechanism by Venkatachari, Narasimhan J, Alber, Sean, Watkins, Simon C, Ayyavoo, Velpandi

“…Dendritic cells (DC) play a pivotal role in transmission and dissemination of HIV-1. Earlier studies reported that DC present at the site of infection trap…”
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Immunotherapy of NOD mice with bone marrow-derived dendritic cells by FEILI-HARIRI, M, XIN DONG, ALBER, S. M, WATKINS, S. C, SALTER, R. D, MOREL, P. A

“…Immunotherapy of NOD mice with bone marrow-derived dendritic cells. M Feili-Hariri , X Dong , S M Alber , S C Watkins , R D Salter and P A Morel Department of…”
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Ectopic expression of interferon regulatory factor-1 promotes human breast cancer cell death and results in reduced expression of survivin by PIZZOFERRATO, Eva, YE LIU, YIM, John H, GAMBOTTO, Andrea, ARMSTRONG, Michaele J, STANG, Michael T, GOADING, William E, ALBER, Sean M, SHAND, Stuart H, WATKINS, Simon C, STORKUS, Walter J

“…The overexpression of the inhibitor of apoptosis protein, survivin, may provide tumor cells with a distinct survival advantage in situ; hence, therapeutic…”
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Inhibition of tumor necrosis factor receptor-1-mediated pathways has beneficial effects in a murine model of postischemic remodeling by Ramani, Ravi, Mathier, Michael, Wang, Ping, Gibson, Gregory, Tögel, Sandra, Dawson, Jennifer, Bauer, Anthony, Alber, Sean, Watkins, Simon C, McTiernan, Charles F, Feldman, Arthur M

“…The aim of the present study was to investigate the importance of tumor necrosis factor (TNF)-alpha receptor-1 (TNFR1)-mediated pathways in a murine model of…”
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Intestinal cytokine gene expression in infants with acute necrotizing enterocolitis: Interleukin-11 mRNA expression inversely correlates with extent of disease by Nadler, Evan P., Stanford, Ala, Zhang, Xiao-Ru, Schall, Laura C., Alber, Sean M., Watkins, Simon C., Ford, Henri R.

“…Background/Purpose: The authors have shown previously that surgical specimens from infants with acute necrotizing enterocolitis (NEC) show upregulation of…”
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NOX, a novel nitric oxide scavenger, reduces bacterial translocation in rats after endotoxin challenge by Dickinson, E, Tuncer, R, Nadler, E, Boyle, P, Alber, S, Watkins, S, Ford, H

“…Endotoxemia promotes gut barrier failure and bacterial translocation (BT) by upregulating inducible nitric oxide synthase (iNOS) in the gut. We hypothesized…”
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IL-18-induced CD83+CCR7+ NK helper cells by Mailliard, Robbie B, Alber, Sean M, Shen, Hongmei, Watkins, Simon C, Kirkwood, John M, Herberman, Ronald B, Kalinski, Pawel

“…In addition to their cytotoxic activities, natural killer (NK) cells can have immunoregulatory functions. We describe a distinct "helper" differentiation…”
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