Search Results - "ALANEN, Kalle"

High-throughput transcriptomic and RNAi analysis identifies AIM1, ERGIC1, TMED3 and TPX2 as potential drug targets in prostate cancer by Vainio, Paula, Mpindi, John-Patrick, Kohonen, Pekka, Fey, Vidal, Mirtti, Tuomas, Alanen, Kalle A, Perälä, Merja, Kallioniemi, Olli, Iljin, Kristiina

“…Prostate cancer is a heterogeneous group of diseases and there is a need for more efficient and targeted methods of treatment. In this study, the potential of…”
Get full text

FZD4 as a Mediator of ERG Oncogene―Induced WNT Signaling and Epithelial-to-Mesenchymal Transition in Human Prostate Cancer Cells by GUPTA, Santosh, ILJIN, Kristiina, SARA, Henri, MPINDI, John Patrick, MIRTTI, Tuomas, VAINIO, Paula, RANTALA, Juha, ALANEN, Kalle, NEES, Matthias, KALLIONIEMI, Olli

“…TMPRSS2-ERG and other gene fusions involving ETS factors and genes with strong promoter elements are common in prostate cancer. Although ERG activation has…”
Get full text

Arachidonic Acid Pathway Members PLA2G7 , HPGD , EPHX2 , and CYP4F8 Identified as Putative Novel Therapeutic Targets in Prostate Cancer by Vainio, Paula, Gupta, Santosh, Ketola, Kirsi, Mirtti, Tuomas, Mpindi, John-Patrick, Kohonen, Pekka, Fey, Vidal, Perälä, Merja, Smit, Frank, Verhaegh, Gerald, Schalken, Jack, Alanen, Kalle A, Kallioniemi, Olli, Iljin, Kristiina

“…The arachidonic acid and prostaglandin pathway has been implicated in prostate carcinogenesis, but comprehensive studies of the individual members in this key…”
Get full text

A Prospective Diagnostic Accuracy Study of 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography, Multidetector Row Computed Tomography, and Magnetic Resonance Imaging in Primary Diagnosis and Staging of Pancreatic Cancer by KAUHANEN, Saila P, KOMAR, Gaber, NUUTILA, Pirjo, OVASKA, Jari T, SEPPÄNEN, Marko P, DEAN, Kirsti I, MINN, Heikki R, KAJANDER, Sami A, RINTA-KIIKKA, Irina, ALANEN, Kalle, BORRA, Ronald J, PUOLAKKAINEN, Pauli A

“…To prospectively compare the accuracy of combined positron emission tomography/computed tomography using F-fluorodeoxyglucose (FDG-PET/CT), multidetector row…”
Get full text

Significance of site-specific prognosis of cancer stem cell marker CD44 in head and neck squamous-cell carcinoma by Kokko, Linda-Lotta, Hurme, Saija, Maula, Sanna-Mari, Alanen, Kalle, Grénman, Reidar, Kinnunen, Ilpo, Ventelä, Sami

“…Summary In several recent studies, CD44 expression has been associated with aggressive behavior in cancers of different types. CD44 expression is also linked…”
Get full text

Stat3 Promotes Metastatic Progression of Prostate Cancer by Abdulghani, Junaid, Gu, Lei, Dagvadorj, Ayush, Lutz, Jacqueline, Leiby, Benjamin, Bonuccelli, Gloria, Lisanti, Michael P, Zellweger, Tobias, Alanen, Kalle, Mirtti, Tuomas, Visakorpi, Tapio, Bubendorf, Lukas, Nevalainen, Marja T

“…There are currently no effective therapies for metastatic prostate cancer because the molecular mechanisms that underlie the metastatic spread of primary…”
Get full text

Accuracy of 18F-FDG PET/CT, Multidetector CT, and MR Imaging in the Diagnosis of Pancreatic Cysts: A Prospective Single-Center Study by Kauhanen, Saila, Rinta-Kiikka, Irina, Kemppainen, Jukka, Grönroos, Juha, Kajander, Sami, Seppänen, Marko, Alanen, Kalle, Gullichsen, Risto, Nuutila, Pirjo, Ovaska, Jari

“…Accurate diagnosis of the nature of pancreatic cysts is challenging but more important than ever, in part because of the increasing number of incidental cystic…”
Get full text

Stat5 promotes metastatic behavior of human prostate cancer cells in vitro and in vivo by Gu, Lei, Vogiatzi, Paraskevi, Puhr, Martin, Dagvadorj, Ayush, Lutz, Jacqueline, Ryder, Amy, Addya, Sankar, Fortina, Paolo, Cooper, Carlton, Leiby, Benjamin, Dasgupta, Abhijit, Hyslop, Terry, Bubendorf, Lukas, Alanen, Kalle, Mirtti, Tuomas, Nevalainen, Marja T

“…There are no effective therapies for disseminated prostate cancer. Constitutive activation of Stat5 in prostate cancer is associated with cancer lesions of…”
Get full text

Nuclear Stat5a/b predicts early recurrence and prostate cancer–specific death in patients treated by radical prostatectomy by Mirtti, Tuomas, MD, PhD, Leiby, Benjamin E., PhD, Abdulghani, Junaid, MD, PhD, Aaltonen, Elina, MD, Pavela, Miia, MD, Mamtani, Anita, MD, Alanen, Kalle, MD, PhD, Egevad, Lars, MD, PhD, Granfors, Torvald, MD, PhD, Josefsson, Andreas, MD, PhD, Stattin, Par, MD, PhD, Bergh, Anders, MD, PhD, Nevalainen, Marja T., MD, PhD

“…Summary There is an urgent need for reliable markers to identify patients whose prostate cancer (PCa) will recur after initial therapy and progress to lethal…”
Get full text

Inhibition of Transcription Factor Stat5 Induces Cell Death of Human Prostate Cancer Cells by Ahonen, Tommi J., Xie, Jianwu, LeBaron, Matthew J., Zhu, Jianqiong, Nurmi, Martti, Alanen, Kalle, Rui, Hallgeir, Nevalainen, Marja T.

“…Identifying regulators of prostate cancer cell survival may lead to new therapeutic strategies for prostate cancer. We now report prevalent activation of…”
Get full text

Mannose receptor is a novel ligand for L-selectin and mediates lymphocyte binding to lymphatic endothelium by Irjala, H, Johansson, E L, Grenman, R, Alanen, K, Salmi, M, Jalkanen, S

“…Continuous lymphocyte recirculation between blood and lymphoid tissues forms a basis for the function of the immune system. Lymphocyte entrance from the blood…”
Get full text

Group IIA phospholipase A₂ as a prognostic marker in prostate cancer: relevance to clinicopathological variables and disease-specific mortality by MIRTTI, TUOMAS, LAINE, VELI JUKKA O, HIEKKANEN, HEIKKI, HURME, SAIJA, ROWE, OUTI, NEVALAINEN, TIMO J, KALLAJOKI, MARKKU, ALANEN, KALLE

“…Group IIA Phospholipase A₂ (PLA2-IIA), a key enzyme in arachidonic acid and eicosanoid metabolism, participates in a variety of inflammatory processes but…”
Get full text

Improved detection of localized prostate cancer using co-registered MRI and 11C-acetate PET/CT by Jambor, Ivan, Borra, Ronald, Kemppainen, Jukka, Lepomäki, Virva, Parkkola, Riitta, Dean, Kirsti, Alanen, Kalle, Arponen, Eveliina, Nurmi, Martti, Aronen, Hannu J., Minn, Heikki

“…We aimed to study the ability of contrast enhanced MRI at 1.5T and 11C-acetate PET/CT, both individually and using fused data, to detect localized prostate…”
Get full text

Functional imaging of localized prostate cancer aggressiveness using 11C-acetate PET/CT and 1H-MR spectroscopy by Jambor, Ivan, Borra, Ronald, Kemppainen, Jukka, Lepomäki, Virva, Parkkola, Riitta, Dean, Kirsti, Alanen, Kalle, Arponen, Eveliina, Nurmi, Martti, Aronen, Hannu J, Minn, Heikki

“…We assessed the ability of (11)C-acetate PET/CT, MRI, and proton MR spectroscopy ((1)H-MRS) to image localized prostate cancer and detect its aggressiveness,…”
Get full text

Vascular Adhesion Protein 1 Mediates Binding of Immunotherapeutic Effector Cells to Tumor Endothelium by Irjala, Heikki, Salmi, Marko, Alanen, Kalle, Grenman, Reidar, Jalkanen, Sirpa

“…Tumor-infiltrating lymphocytes (TIL) can be used as an immunotherapeutic tool to treat cancer. Success of this therapy depends on the homing and killing…”
Get full text

Activating mutation (V617F) in the tyrosine kinase JAK2 is absent in locally-confined or castration-resistant prostate cancer by Gu, Lei, Zhu, Xian-Hua, Visakorpi, Tapio, Alanen, Kalle, Mirtti, Tuomas, Edmonston, Tina Bocker, Nevalainen, Marja T

“…BACKGROUNDTranscription factor Stat5a/b is highly critical for the viability of human prostate cancer cells in vitro and for prostate tumor growth in vivo…”
Get full text

Altered expression of syndecan-1 in prostate cancer by KIVINIEMI, JOHANNA, KALLAJOKI, MARKKU, KUJALA, IINA, MATIKAINEN, MARJA-TERTTU, ALANEN, KALLE, JALKANEN, MARKKU, SALMIVIRTA, MARKKU

“…Syndecan‐1 is a cell surface heparan sulfate proteoglycan expressed by epithelial cells. It interacts with growth factors, matrix components, and other…”
Get full text

In Vivo Imaging of Prostate Cancer Using [68Ga]-Labeled Bombesin Analog BAY86-7548 by KÄHKÖNEN, Esa, JAMBOR, Ivan, SILEN, Jonna, KALLAJOKI, Markku, ROIVAINEN, Anne, SCHÄFER, Niklaus, SCHIBLI, Roger, DRAGIC, Martina, JOHAYEM, Anass, VALENCIA, Ray, BORKOWSKI, Sandra, MINN, Heikki, KEMPPAINEN, Jukka, LEHTIÖ, Kaisa, GRÖNROOS, Tove J, KUISMA, Anna, LUOTO, Pauliina, SIPILÄ, Henri J, TOLVANEN, Tuula, ALANEN, Kalle

“…A novel [(68)Ga]-labeled DOTA-4-amino-1-carboxymethyl-piperidine-D-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2 peptide (BAY86-7548) having high affinity to…”
Get full text

Prebiopsy multiparametric 3T prostate MRI in patients with elevated PSA, normal digital rectal examination, and no previous biopsy by Jambor, Ivan, Kähkönen, Esa, Taimen, Pekka, Merisaari, Harri, Saunavaara, Jani, Alanen, Kalle, Obsitnik, Branislav, Minn, Heikki, Lehotska, Viera, Aronen, Hannu J.

“…Purpose To find the diagnostic accuracy of 3T multiparametric magnetic resonance imaging (mpMRI) and mpMRI targeted transrectal ultrasound (TRUS)‐guided biopsy…”
Get full text

Immunohistochemical labelling for prostate-specific antigen in breast carcinomas by ALANEN, K. A, KUOPIO, T, COLLAN, Y. U, KRONQVIST, P, JUNTTI, L, NEVALAINEN, T. J

“…Immunohistochemical detection of prostate-specific antigen (PSA) is an aid in determining the prostatic origin of metastatic cells. However, small amounts of…”
Get full text