Search Results - "ALAMINOS, Miguel"
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Novel Desmin Mutation p.Glu401Asp Impairs Filament Formation, Disrupts Cell Membrane Integrity, and Causes Severe Arrhythmogenic Left Ventricular Cardiomyopathy/Dysplasia
Published in Circulation (New York, N.Y.) (10-04-2018)“…BACKGROUND:Desmin (DES) mutations cause severe skeletal and cardiac muscle disease with heterogeneous phenotypes. Recently, DES mutations were described in…”
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Bioactive Polymeric Nanoparticles for Periodontal Therapy
Published in PloS one (07-11-2016)“…to design calcium and zinc-loaded bioactive and cytocompatible nanoparticles for the treatment of periodontal disease. PolymP-nActive nanoparticles were zinc…”
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Cryopreserved nanostructured fibrin-agarose hydrogels are efficient and safe hemostatic agents
Published in Scientific reports (21-08-2024)“…Uncontrolled bleeding during surgery is associated with high mortality and prolonged hospital stay, necessitating the use of hemostatic agents. Fibrin sealant…”
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Spatiotemporal characterization of extracellular matrix maturation in human artificial stromal-epithelial tissue substitutes
Published in BMC biology (18-11-2024)“…Tissue engineering techniques offer new strategies to understand complex processes in a controlled and reproducible system. In this study, we generated…”
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Epigenetic inactivation of the Sotos overgrowth syndrome gene histone methyltransferase NSD1 in human neuroblastoma and glioma
Published in Proceedings of the National Academy of Sciences - PNAS (22-12-2009)“…Sotos syndrome is an autosomal dominant condition characterized by overgrowth resulting in tall stature and macrocephaly, together with an increased risk of…”
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Increased PON lactonase activity in morbidly obese patients is associated with impaired lipid profile
Published in International journal of clinical practice (Esher) (01-06-2019)“…The paraoxonase-1 (PON1) enzyme could play an important role in the anti-oxidant capacity of high-density lipoprotein. However, there are no studies which…”
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Genipin crosslinking promotes biomechanical reinforcement and pro-regenerative macrophage polarization in bioartificial tubular substitutes
Published in Biomedicine & pharmacotherapy (01-05-2024)“…Traumatic nerve injuries are nowadays a significant clinical challenge and new substitutes with adequate biological and mechanical properties are in need. In…”
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Histological, histochemical, and immunohistochemical characterization of NANOULCOR nanostructured fibrin-agarose human cornea substitutes generated by tissue engineering
Published in BMC medicine (13-11-2024)“…Background Human artificial corneas (HAC) generated by tissue engineering recently demonstrated clinical usefulness in the management of complex corneal…”
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Evaluation of small intestine grafts decellularization methods for corneal tissue engineering
Published in PloS one (14-06-2013)“…Advances in the development of cornea substitutes by tissue engineering techniques have focused on the use of decellularized tissue scaffolds. In this work, we…”
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Combination of fibrin-agarose hydrogels and adipose-derived mesenchymal stem cells for peripheral nerve regeneration
Published in Journal of neural engineering (01-04-2013)“…The objective was to study the effectiveness of a commercially available collagen conduit filled with fibrin-agarose hydrogels alone or with fibrin-agarose…”
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Optimization of human skin keratinocyte culture protocols using bioactive molecules derived from olive oil
Published in Biomedicine & pharmacotherapy (01-08-2023)“…Skin damage due to severe burns can compromise patient life. Current tissue engineering methods allow the generation of human skin substitutes for clinical…”
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Evaluation of myelin sheath and collagen reorganization pattern in a model of peripheral nerve regeneration using an integrated histochemical approach
Published in Histochemistry and cell biology (01-12-2011)“…Peripheral nerves are complex histological structures that can be affected by a variety of conditions with different degree of axonal degeneration and…”
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Generation and Characterization of Novel Magnetic Field-Responsive Biomaterials
Published in PloS one (24-07-2015)“…We report the preparation of novel magnetic field-responsive tissue substitutes based on biocompatible multi-domain magnetic particles dispersed in a…”
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Evaluation of Marine Agarose Biomaterials for Tissue Engineering Applications
Published in International journal of molecular sciences (15-02-2021)“…Five agarose types (D1LE, D2LE, LM, MS8 and D5) were evaluated in tissue engineering and compared for the first time using an array of analysis methods…”
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In vivo Evaluation of Nanostructured Fibrin-Agarose Hydrogels With Mesenchymal Stem Cells for Peripheral Nerve Repair
Published in Frontiers in cellular neuroscience (18-12-2018)“…The regenerative capability of peripheral nerves is very limited, and several strategies have been proposed to increase nerve regeneration. In the present…”
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Histological assessment in peripheral nerve tissue engineering
Published in Neural regeneration research (15-09-2014)“…The histological analysis of peripheral nerve regeneration is one of the most used methods to demonstrate the success of the regeneration through nerve…”
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Successful restoration of corneal surface integrity with a tissue-engineered allogeneic implant in severe keratitis patients
Published in Biomedicine & pharmacotherapy (01-06-2023)“…Corneal diseases are among the main causes of blindness, with approximately 4.6 and 23 million patients worldwide suffering from bilateral and unilateral…”
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Fibrin and Marine-Derived Agaroses for the Generation of Human Bioartificial Tissues: An Ex Vivo and In Vivo Study
Published in Marine drugs (01-03-2023)“…Development of an ideal biomaterial for clinical use is one of the main objectives of current research in tissue engineering. Marine-origin polysaccharides, in…”
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Effect of the hydration on the biomechanical properties in a fibrin-agarose tissue-like model
Published in Journal of biomedical materials research. Part A (01-08-2014)“…The effect of hydration on the biomechanical properties of fibrin and fibrin‐agarose (FA) tissue‐like hydrogels is reported. Native hydrogels with…”
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Evaluation of Fibrin-Agarose Tissue-Like Hydrogels Biocompatibility for Tissue Engineering Applications
Published in Frontiers in bioengineering and biotechnology (16-06-2020)“…Generation of biocompatible and biomimetic tissue-like biomaterials is crucial to ensure the success of engineered substitutes in tissue repair. Natural…”
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